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Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To evaluate the efficacy of abdominal acupuncture combined with neuromuscular electrical stimulation (NMES) in the treatment of dysphagia after stroke based on video fluoroscophic swallowing study (VFSS) analysis. Methods: 120 patients with dysphagia after stroke who were admitted to the Rehabilitation Medicine Department of Ruikang Hospital affiliated to Guangxi University of Traditional Chinese Medicine from June 2020 to December 2022 were divided into control group (60 cases,NMES treatment) and experimental group (60 cases, combine with abdominal acupuncture on the basis of control group) by random number table method. Patients in control group were evaluated based on VFSS analysis to evaluate the efficacy of abdominal acupuncture combine with NMES in the treatment of dysphagia after stroke, the VFSS score, the mobility of the hyoid-laryngeal complex and the openness of the upper esophageal sphincter (UES), pharyngeal contraction rate (PCR), nutritional indicators [hemoglobin (Hb), serum albumin (ALB), serum transferrin (s F) ], standard swallowing function (SSA) score, and Watian drinking water test were compared between two groups. Results: Compared with control group, the total clinical effective rate in experimental group was higher (P＜0. 05) . Compared with control group after treatment, the VFSS score in experimental group was higher, the UES openness was greater, and the PCR was smaller (P＜0. 05) . Compared with control group after treatment, Hb, ALB and s F in experimental group were higher (P＜0. 05) . Compared with control group after treatment, the SSA score in experimental group was lower (P＜0. 05) . After treatment, Watian drinking water test in experimental group was better than that in control group (P＜0. 05) . Conclusion: Abdominal acupuncture combined with NMES can effectively improve swallowing dysfunction and nutritional status in patients with post stroke swallowing disorders. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the relationship between serum osteopontin (OPN), vascular endothelial growth factor (VEGF), homocysteine (Hcy) and renal function and cognitive dysfunction (CD) in elderly patients with type 2 diabetic kidney disease (T2DKD). Methods: 140 patients with T2DKD who were admitted to the Second Affiliated Hospital of Anhui Medical University from January 2017 to June 2022 were selected as T2DKD group. According to the occurrence of CD, they were divided into CD group with 41 cases and non-CD group with 99 cases, 60 patients with simple T2DM were selected as T2DM group, and 50 healthy volunteers during the same period were selected as control group. Serum OPN, VEGF, Hcy were measured and renal function indexes[urinary albumin/creatinine ratio (UACR) and estimated glomerular filtration rate (eGFR)] were calculated. Spearman correlation was used to analyze the correlation between serum OPN, VEGF, Hcy levels and renal function indexes in elderly patients with T2DKD, and multivariate Logistic regression was used to analyze the influencing factors of CD in elderly patients with T2DKD. Results: Serum OPN, VEGF, Hcy levels and UACR in the control group, T2DM group and T2DKD group were increased successively, while eGFR was decreased successively(P＜0.05). Spearman correlation analysis showed that serum OPN, VEGF and Hcy levels in elderly patients with T2DKD were positively correlated with UACR, and negatively correlated with eGFR(P＜0.05). Multivariate Logistic regression analysis showed that homeostasis model assessment-insulin resistance (HOMA-IR), OPN, VEGF and Hcy were elevated as independent risk factors for CD in elderly patients with T2DKD, and eGFR was elevated as an independent protective factor(P<0.05). Conclusion: Elevated serum OPN, VEGF and Hcy levels in elderly patients with T2DKD are closely related to renal function and CD, and which may be an auxiliary predictor of CD in elderly patients with T2DKD. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To evaluate the percutaneous bilirubin (TcB) percentile curve combined with associated risk factors of neonatal at 72 hours after birth, and to predict the occurrence of neonatal hyperbilirubinemia. Methods: Late preterm infants and term infants born in the First Affiliated Hospital of Anhui University of Technology from January 2018 to December 2019 were selected, the jaundice value was monitored by percutaneous jaundice instrument, the TcB percentile nomogram was drawed. The value of predicting neonatal hyperbilirubinemia was predicted by the risk area corresponding to the last TcB value within 72 h after birth combined with the risk factors. Results: Among 3818 neonates at 72h after birth, 278 (7.28%) were in the high risk area. The value of TcB increased fastest from 4 h to 48 h, and the peak value appeared from 84h to 120h postnatal. The peak values of P40, P75 and P95 were 193.75 滋mol/L, 224.75 滋mol/L and 282.25 滋mol/L, respectively, and the peak value of P95 appeared last. There were 244 cases of TcB values in the high risk area within 0-48 h after birth, and 92 cases were still in the high risk area after 72 h. The predictive sensitivity was 29.97%, and the specificity was 95.67%. The TcB value of 269 neonates was in the high risk area within 49-72 h, and the TcB value of 116 neonates was still in the high risk area after 72 h, the sensitivity was 36.48%, and the specificity was 95.62%. Multivariate Logistic regression analysis showed that the related risk factors were gestational age, length of hospital stay, delivery mode, premature rupture of membranes and feeding mode(P<0.05). The area under receiver operating characteristic(ROC) curve of TcB risk area within 72 h was 0.75(95%CI: 0.56-0.93), and the area under ROC curve of TcB risk area combined with related risk factors was 0.93(95%CI:0.81-1.00), indicating significantly improved predictive value. Conclusion: TcB percentile curve combined with "high risk factors" has high accuracy in predicting neonatal hyperbilirubinemia, which is easy to operate, and which has good clinical value. [ABSTRACT FROM AUTHOR]

To observe the curative effect situation and the changes of serum cytokines in elderly patients with liver and kidney deficiency knee osteoarthritis (KOA) after time-space acupuncture Linggui eight methods combined with isokinetic muscle strength training. The clinical study cases were 100 elderly patients with liver and kidney deficiency KOA who were treated in the geriatric medicine department of our hospital from July 2019 to July 2021. According to the random number table method, the patients were divided into study group (50 cases, basic treatment and isokinetic muscle strength training combined with time-space acupuncture Linggui eight methods) and control group (50 cases, basic treatment and isokinetic muscle strength training). The clinical efficacy of traditional Chinese medicine, traditional Chinese medicine symptom score, visual pain simulation (VAS) score, McMaster University Osteoarthritis Index Scale (WOMAC), Lysholm knee score, knee extensor, flexor peak torque (PT), total work (TW), serum interleukin-18 (IL-18), interleukin-6 (IL-6) and tumor necrosis factor-琢 (TNF-琢) levels were compared between the two groups. The total clinical effective rate of the study group was significantly higher than that of the control group (P<0.05). After treatment, the Lysholm knee score of the study group was higher than that of the control group, while traditional Chinese medicine symptom, WOMAC and VAS scores were lower than those of the control group (P<0.05). After treatment, IL-6, TNF-琢 and IL-18 of the study group were lower than those of the control group (P<0.05). The PT and TW of knee extensor and flexor of the study group were higher than those of the control group (P<0.05). Isokinetic muscle strength training combined with time-space acupuncture Linggui eight methods in the treatment of elderly patients with liver and kidney deficiency KOA has a significant effect, which can improve clinical symptoms, promote the recovery of knee joint function, and effectively reduce the levels of serum IL-6, IL-18 and TNF-琢, which has certain clinical application value. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To observe the clinical effect of bone cement reinforced pedicle screw combined with interbody fusion in the treatment of elderly patients with severe lumbar spondylolisthesis. Methods: 92 elderly patients with severe lumbar spondylolisthesis who were treated in our hospital from March 2016 to March 2019 were retrospectively analyzed. According to different treatment schemes, the patients were divided into group A (n=44) and group B (n=48). Group A was given pedicle screw combined with intervertebral fusion reduction, and group B was given bone cement reinforced pedicle screw combined with intervertebral fusion reduction. Visual pain simulation score (VAS), Oswestry disability index (ODI) and Japanese Orthopaedic Association (JOA) low back and leg pain score, clinical indicators, slip distance, slip rate, intervertebral space height, intervertebral fusion rate, intervertebral foramina height, complications and screw loosening in the two groups. Results: 12 months after operation, VAS, ODI and JOA scores of the two groups decreased, and the group B was lower than the group A (P<0.05). There was no significant difference in intraoperative blood loss between the two groups (P>0.05). The operation time of group B was longer than that of group A, and the hospitalization time was shorter than that of group A, the intervertebral fusion rate was higher than group A (P<0.05). 12 months after operation, the slip distance and the slip rate in both groups decreased, and the group B was smaller than the group A (P<0.05). 12 months after operation, the intervertebral space height and intervertebral foramen in both groups increased, and the group B was higher than the group A (P<0.05). There was no difference in the incidence of complications between the two groups (P>0.05). Conclusion: Although the intervertebral fusion reduction combined with bone cement enhanced pedicle screw treatment for elderly patients with severe lumbar spondylolisthesis can prolong the operation time to some extent, it can promote clinical symptoms, improve the height of intervertebral space and the degree of lumbar spondylolisthesis, shorten the hospitalization time, and do not increase the incidence of complications. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

To compare the analgesic effect of sufentanil and dexmedetomidine on postoperative patients with gastric cancer and their effects on postoperative rapid recovery. A total of 200 patients with gastric cancer, who were admitted to General Hospital of the Central Theater of the Chinese People's Liberation Army from June 2017 to December 2019, were selected. All the patients required postoperative analgesia after radical gastrectomy. The patients were randomly divided into group A (n=67), group B (n=66) and group C (n=67). Group A was given sufentanil 2 滋g/kg; group B was given sufentanil 2 滋g/kg combined with dexmedetomidine 1 滋g/kg; group C was given sufentanil 2 滋g/kg combined with dexmedetomidine 2 滋g/kg. The pain degree, inflammatory factor level, postoperative recovery and adverse reactions of the three groups were compared at different time after operation. After the VAS scores of three groups of patients 2 h, 6 h, 12 h and 24 h after operation were compared, the VAS scores of the three groups were found gradually decreased with the increase of time (P<0.05), and the VAS scores of the three groups at the same time point were significantly different (P<0.05), and the number of group C was the smallest. Through the comparison of the inflammatory factors levels of the three groups before operation and 1 day after operation, it was found that before the operation, there was no significant difference in TNF-琢, IL-6 and IL-10 (P>0.05), but TNF-琢and IL-6 increased 1 day after operation, and the difference between groups was significant, and the value of group C was the smallest (P<0.05). On the first day after operation, the IL-10 of three groups decreased significantly, and the difference was gradually significant, and the value of group C was the largest (P<0.05). There were significant differences in eating time, ambulation time, gastrointestinal function recovery time and hospitalization time among the three groups, and the time of group C was the shortest (P<0.05). There was no significant difference in the incidence of adverse reactions among the three groups (P>0.05). The application of sufentanil and dexmedetomidine for postoperative gastric cancer patients can reduce the pain and inflammatory reaction of patients, which is good for the rapid recovery of patients after operation. Sufentanil combined with 2 滋g/kg dexmedetomidine is better for the postoperative recovery of patients, and it does not increase the adverse reactions, which is worthy of clinical application and promotion. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the efficacy of docetaxel and pemetrexed combined with cisplatin as second-line therapy for advanced gastric cancer in elderly patients and its effect on the quality of life of patients, so as to provide reference for clinical medication. Methods: 120 elderly patients with advanced gastric cancer who failed first-line chemotherapy in our hospital from June 2014 to June 2017 were selected. According to the random number table method, the patients were divided into observation group and control group with 60 cases each group. The observation group was treated with pernetrexed combined with cisplatin, while the control group was treated with docetaxel alone, the two groups were treated for 3 courses. After 3 courses of treatment, the clinical efficacy of the two groups was evaluated by evaluation criteria for therapeutic efficacy of solid tumors (RECIST). According to the classification standard of common toxicity and side effects of anticancer drugs, the adverse reactions of patients in the course of treatment were counted. Quality of life scale was used to evaluate the quality of life of patients after treatment, the patients were followed up for half a year, and the survival rates of the two groups were counted. Results: The effective rate (RR) of the observation group was 30.00%, which was slightly higher than that of the control group (25.00%), but there was no significant difference between the two groups (P>0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0 .05). After treatment, the scores of daily life, social activities, depression and anxiety in the observation group were significantly higher than those in the control group (P

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To evaluate the efficacy of clopidogrel in the treatment of ischemic stroke and its effect on the platelet activity and serum inflammatory factor levels. Methods: 150 patients with ischemic stroke who were treated from August 2016 to August 2018 in our hospital were divided into control groups (83 cases) and research group (67 cases) according to the order of admission. The control group was treated with conventional therapy, and the research group was treated with clopidogrel on the basis of control group. Then the clinical efficacy, changes of platelet activity index, serum hypersensitive c-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α) levels, National Institutes Health Stroke Scale (NIHSS) and the activity of daily living (ADL) scores before and after treatment and the poor reaction occurrence were compared between two groups. Results: After treatment, the total effective rate int he research group was significant higher than that in the control group (91.04% vs. 78.31%,P<0.05). The platelet aggregation rate, platelet adhesion rate, p-selectin, hs-CRP, IL-6, TNF-α and NIHSS scores in both groups were significantly decreased after treatment compared with those before treatment, the above indexes in the research group were significantly lower than those in the control group, the ADL scores of both groups were significantly higher than those before treatment, which were significantly higher in the research group than those of the control group (P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups during treatment (P>0.05). Conclusion: The effect of clopidogrel on ischemic stroke is obviously better than that of conventional treatment, it can effectively inhibit the activity of platelets, reduce the level of inflammatory factors, and improve the neurological function and daily life ability of patients. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To explore the clinical characteristics and outcomes of the remitting seronegative symmetrical synovitis with pitting edema（RS3 PE）, and help the diagnosis and treatment. Methods: A retrospective review of RS3 PE patients diagnosed from January 1, 2004 to February 29, 2016 was performed. The clinical data and follow-up information were collected. The characteristics of RS3 PE were summarized by description, comparison of the means, ratios or medians. Results: We identified 13 males（59.1 %） and nine females（40.9 %） RS3 PE cases. The mean onset age was 65.6 ±10.0 years（40.0 to 79.0 years）. Diagnosis time to onset was 12 days to two years. All patients were acute onset with varying degrees of symmetric polyarthritis and extremity edema. Six cases（27.3 %）presented fever. The means of main laboratory indicators were as following: hemoglobin 109.1 ±16.0 g·L-1, platelet count 277.0 ±91.8× 109·L-1, serum albumin 36.1 ±5.0 g·L-1, c-reactive protein 62.5 ±67.4 mg·L-1, erythrocyte sedimentation rate 58.1 ±33.9 mm/h.Serum ferritins tested in six cases were elevated in five（83 %）. Tumor markers detected in ten cases were all normal. Eighteen cases（86%） underwent joint iconographic examination, and no bone destruction was found. Both five cases performed labial gland mucosal biopsy and two cases received bone marrow biopsy were normal. Symptoms were significantly improved in all cases during hospitalization. Four cases were prescribed with glucocorticoids alone, and 18（81.8 %） also combined with slow-acting drugs. During the telephone follow-up period of four months to eight years（the median was 5.0 years）, the joint symptoms and extremity edema continued to ease in five cases（22.7 %）, and relieved in four cases（18.2 %）. Only one（4.5 %） was recurrent, and three（13.6 %）developed rheumatoid arthritis. Nine cases（40.9 %） were lost. Malignant tumor happened in one case（4.5 %）. The erythrocyte count,hemoglobin, serum total protein and albumin in the elderly RS3 PE patients were lower than those in the non-elderly group. Conclusions:RS3 PE is mostly acute onset in elderly patients, accompanied by symmetrically multiple arthritis with acroedema. In addition to be sensitive to glucocorticoid therapy, RS3 PE often presents as anemia and hypoproteinemia, and sometimes accompanied by tumor. The study of RS3 PE is still insufficient so far. [ABSTRACT FROM AUTHOR]

Objective: To investigate the expression of plasma lysophosphatidic acid(LPA), serum cancer antigen 125(CA125)and human epididymal secretory protein4(HE4) in patients with endometrial carcinoma and its relationship with clinicopathological features. Methods: 76 patients with endometrial carcinoma who were treated in First Maternity and Infant Health Hospital Affiliated to Tongji University from March 2014 to June 2016 were selected as the observation group, 50 patients with endometrial atypical hyperplasia who were treated in our hospital in the same period were selected as benign lesions group, and 50 healthy volunteers who were underwent physical examination in our hospital at the same period were selected as control group. The levels of plasma LPA, CA125 and serum HE4 were compared between the three groups. The sensitivity, specificity, positive predictive value and negative predictive value of plasma LPA, serum CA125 and HE4 in endometrial carcinoma were calculated by using the pathological examination as the gold standard. The relationship between the levels of plasma LPA, serumCA125 and HE4 clinicopathological features in patients with endometrial carcinoma were analysed. Results: The levels of plasma LPA, serum CA125 and HE4 in the observation group were significantly higher than those in the control group and benign lesion group(P<0.05). The level of plasma CA125 in benign lesion group was higher than that in the control group(P<0.05). There were no significant differences in the sensitivity, specificity, positive predictive value and negative predictive value of plasma LPA, serum CA125 and HE4 in endometrial cancer(P>0.05). The level of LPA in patients with endometrial carcinoma was not correlated with age and tumor diameter(P>0.05), but there was correlated with lymph node metastasis, clinical stage,differentiation degree and histological type(P<0.05). The levels of CA125 and HE4 were not correlated with age and histological type(P>0.05),but there were correlated with lymph node metastasis, clinical stage, tumor diameter and differentiation degree(P<0.05). Conclusion: The expressions of LPA, serum CA125 and HE4 in patients with endometrial carcinoma are high, LPA, CA125 and HE4 were correlated with some clinicopathological parameters, the three indicators have higher diagnostic value for endometrial carcinoma. [ABSTRACT FROM AUTHOR]

Objective: To investigate and analyze the correlation between serum levels of interleukin-1RA (IL-1RA), interleukin- 1β(IL-1β), interleukin-18 (IL-18) and the progression of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Methods: 54 patients with NAFLD in our hospital were selected as the research object, According to NAFLD activity score (NAS), they were divided into non-NASH group and NASH group. Another 30 healthy people who came to our hospital for physical examination during the same period were selected as the control group. The correlation between serum IL-1RA, IL-1β, IL-18 levels and biochemical indexes and NAS scores was analyzed. Results: The body mass index(BMI), alanine aminotransferase(ALT), glutamyltransferase( GGT), triglyceride(TG), fasting blood glucose (GLU), IL-1βand IL-18 levels in NAFLD patients were significantly higher than those in the control group(P<0.05), and the serumlevels of IL-1RA, high density lipoprotein(HDL) were lower than those in the control group (P<0.05). The levels of ALT, AST, GGT, IL-1βand IL-18 in NASH patients were higher than those in non-NASH patients. The serum level of IL-1RA in non-NASH group was higher than that in NASH group(P<0.05). The results of correlation analysis showed that serum IL-1RA level was negatively correlated with NAS score (P<0.05), positively correlated with BMI, ALT, GGT, TG and low density lipoprotein (LDL)(P<0.05), and the levels of IL-1βand IL-18 were positively correlated with NAS scores (P<0.05). Conclusions: Serum levels of IL-1RA, IL-1βand IL-18 are related to the progression of NAFLD and NASH, and can reflect the severity of NAFLD and NASH. Inadequate secretion of IL-1RA in late stage may be an important reason for the progression of NAFLD to NASH. [ABSTRACT FROM AUTHOR]

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Objective: To investigate the distribution characteristics of bile pathogenic and analysis of drug resistance in patients with choledocholithiasis. Methods: A total of 160 cases of choledocholithiasis combined with biliary tract infection, who were treated in the First Affiliated Hospital of Chengdu Medical College fromJune 2016 to June 2017, were selected as research subjects. All the patients were treated with retrograde endoscopic cholangiopancreatography (ERCP) and extracted the bile samples and bacterial culture and drug resistance experiment were conducted, the distribution characteristics and drug resistance of bile pathogens were analyzed. Among 160 patients, 117 patients (73.13%) were detected pathogenic bacteria, and 130 bacteria were cultured, of which 13 were infected by two bacteria; there were 95 strains of Gram-negative bacteria (73.08%), 31 strains of Gram-positive bacteria (23.85%), 4 strains of fungi (3.08%). The first six pathogens fromhigh to low were in turn: escherichia coli, klebsiella pneumoniae, enterobacter cloacae, enterococcus faecium, pseudomonas aeruginosa and Enterococcus faecalis. The resistance rates of Gram-negative bacteria to imipenem, meropenem, Amikacin, tazobactam, cefepime and three or four generation cephalosporin were lower, the resistance rates to ceftriaxone, ciprofloxacin, levofloxacin, piperacillin and ampicillin were higher. The resistance rates of Gram positive bacteria to Lakaoning, vancomycin, linezolid and other were lower, the resistance rates to tetracycline, ciprofloxacin, levofloxacin, clindamycin and ampicillin were higher. The resistance rates of fungi to ketoconazole, itraconazole and fluconazole were lower, and the resistance rate to amphotericin B was higher. Conclusions: The main pathogenic bacteria in the bile of patients with choledocholithiasis are Gram-negative bacteria, the second is Gram-positive bacteria. The pathogenic bacteria showed different resistance to various antibacterials; therefore, in the clinical treatment, drugs should be reasonably chosen according to the results of drug sensitivity test. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of eucalyptus on pulmonary function and oxidative stress in patients with acute exacerbation of pulmonarly chronic obstructive pulmonary disease (AECOPD). Methods: A total of 126 patients with AECOPD. who were treated in Anhui NO.2 Provincial People's Hospital from September 2010 lo June 2017. were selected and randomly divided into control group (n=63) and study group (n=63). The control group was treated with Ambroxol Hydrochloride Oral Solution, the study group was given eucalyptol linonene pinene enteric soft capsule. The clinical efficacy and the forced vital capacity (FVC), forced expiratory volume in 1 second (FEVI). the forced expiratory' volume in one second (FEV%). the malondialdehyde (MDA) and the 8-heterogeneous prostaglandin (8-isoprostane) level before and after treatment were compared between the two groups. The incidence of adverse reactions during the treatment of the two groups was observed. Results: The total effective rate (95.24% )of the study group was higher than that (82.54%) of the control group (P<0.05). There were no significant differences in FVC, FEV1 and FEV% in the two groups before treatment (P>0.05), the FVC. FEV1 and FEV% of the two groups were significantly increased after the treatment of 28d. and the FVC, FEV1 and FEV% of the study group were higher than those of the control group (P 0.05). There were no significant differences in MDA and 8-isoprostane between the nvo groups before treatment (P>0.05). The MDA and 8-isoprostane decreased significantly in the two groups after the treatment of 28d (P<0.05). the MDA and 8-isoprostane of the study group were lower than those of the control group after the treatment of 28 d (P<0.05). The incidence of adverse reactions in the control group was 7.94% (5.63). and the difference was not statistically significant compared with the 6.35% (4/63) of the study group (P>0.05). Conclusion: Eucalyptus can significantly improve the pulmonary function and oxidative stress in patients with AECOPD. with good clinical effect and low adverse reaction rate, which is worthy of clinical application. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effects of tanshinon on the expression of KIM-1, TGF-β1 in vancomycin-induced HK-2 cells. Methods: HK-2 cells were randomly divided into six groups: normal saline(NS) group, model group, positive control group, high dose group, middle dose group and low dose group of TSII-A, The model were duplicated with addition of VAN(100 μg·L-1). The model group, positive control group, high dose group, middle dose group and low dose group of TSII-A were treated by saline solutions, Amifostine, panax notoginsenosides(100, 50, 25 mg·L-1). The cell viability was detected with MTT method, the content of MDA, NO and the activity of SOD, GSH-PX were measured and cell structure was observed. The concentration of KIM-1, TGF-β1 were measured by ELISA, the expressions of KIM-1, TGF-β1 m RNA were measured by RT-PCR. Results: Compared with the model group, the cell viability and activity of SOD, GSH-PX of TSII-A groups and positive control group were significantly increased(P0.05); the content of MDA,NO, KIM-1 were significantly decreased(P0.05); the expression of KIM-1 m RNA were significantly decreased(P0.05); the cell structure was significantly improved, there was no statistical difference(P0.05) in the concentration of TGF-β1 and the expression of TGF-β1 m RNA. Conclusions: TSII-A can promote the proliferation of HK-2 cells induced by VAN through relieving the oxidation stress. [ABSTRACT FROM AUTHOR]

Objective: To study the clinical efficacy and prognosis of T4K appliance in the treatment of children with class-IImalocclusion in early mixed dentition. Methods: A total of 48 children with class-II malocclusion in early mixed dentition, who were treated in Shenzhen Hospital of Guangzhou University of Chinese Medicine from February 2015 to March 2017, were selected. The children were treated with T4K appliance for 6 months. The model measured values, X-ray cephalometric data, and above height, below height, below high proportion were compared between the two groups before treatment and 6 months after treatment, followed up for 3 years. The examination data of X-ray cephalometric radiographs were analyzed. Results: The overbite value, overjet value, upper arch crowding, lower arch crowding of children after six months of treatment were significantly lower than those before treatment; the upper arch width and lower arch width were significantly higher than those before treatment, the differences were statistically significant(all P<0.05). SNA angle, ANB angle, U1-SN angle and coverage of children after six months of treatment were significantly lower than those before treatment; SNB angle, L1-MP angle, U1-L1 angle and mandibular plane angle were significantly higher than those before treatment, the differences were statistically significant(all P<0.05). The above height, below height, below high proportion of children 6 months after treatment were significantly higher than before treatment, the differences were statistically significant(all P<0.05). After 3 years of follow-up, the results showed that the ANB angle and L1-MP angle were significantly lower than those 6 months after treatment(P<0.05),while the SNB angle, U1-L1 angle, the mandibular plane angle, above height, below height, below high proportion, coverage were significantly higher than those 6 months after treatment(P<0.05). Conclusion: The application of T4K appliance in the treatment of children with class-II malocclusion in early mixed dentition has better curative effect, and it is beneficial to the rehabilitation and prognosis, which is worthy of clinical promotion. [ABSTRACT FROM AUTHOR]

Objective： To investigate the 125I implantation combined with hyperthermia treatment of metastatic bone tumor pa- tients. Methods： 63 cases with bone metastases were randomly divided into control group 125I implantation combined with hyperthermia treatment group and separately using 125I implantation, comparative analysis of two groups of patients after treatment of pain relief and the difference of clinical efficacy. Results： Two groups of patients during treatment did not appear serious adverse reactions; pain relief after treatment in two groups, but the treatment group was significantly milder, with statistical significance; local lesions of patients in the treatment group complete remission rate was significantly higher than the control group. Conclusion： 125I implantation combined with hyperthermia in boneThe curative effect for the treatment of metastatic tumor in the exact, less adverse reactions, it is worthy of promotion of treatment. [ABSTRACT FROM AUTHOR]

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Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To analyze the correlation between CD1 1b expression and aseptic loosening.Methods: CD1 1b of synovial tissue around the hip joint fiom patients received total hip replacement during 2006 May to 2016 May were immunohistochemical stained, and a follow-up was performed to detect The occurrence of aseptic loosening.Single factor analysis and logistic regression analysis was used to investigate the correlation between CD1 1b expression and aseptic loosening occurrence.Results: 300 patients were followed up; the number ofCD1 lb positive measures was 163, CD1 lb postive mode was 54.33%; 29 patients (9.67%) suffering from aseptic loosening 5 years after operation and 49 patients (16.33%) suffering from aseptic loosening 10 years after operation; the aseptic loosening raio of CD11b-positive patients was higher than that of CD1 lb- Negative patients (P <0.05); logistic regression analysis suggested CD1 1b over-expression was the risk factor of aseptic loosening.Conclusions: CD1 1b o Ver-expression was the risk factor of aseptic loosening and CD1 1b might be an auxiliary hearing indicator and potential therapeutic target of aseptic loosening after total hip replacement. [ABSTRACT FROM AUTHOR]

Objective: To investigate the clinical efficacy of posterior lumbar interbody fusion (PLIF) and transforaminal lumbar interbody fusion (TLIF) operation for elderly patients with single segmental lumbar degenerative disease. Methods: 80 cases of elderly patients with lumbar degenerative disease were selected from January 2009-January 2015, in accordance with the random number table, were divided into group and control group, 40 cases in each group, the observation group were given TLIF operation, and control group were treated with PLIF; Compared with the two groups of patients before and after the operation of lumbar pain degree (VAS score) and activity function (ODI score), clinical index and incidence of complications. Results: The operation time, intraoperative blood loss and postoperative drainage volume in the observation group were significantly shorter than those in the control group (P<0.05) and two groups had no statistical significance in patients with frontal back VAS score and ODI score (P>0.05), 6 months after surgery, the two groups of patients with lumbar back VAS score and ODI score were significantly lower than before surgery (P<0.05), and there was no significant difference between the groups (P>0.05); The incidence of postoperative complications was 5.00%(2/40) in the observation group, which was significantly lower than that in the control group 22.50%(9/40), the difference was statistically significant (P<0.05). Conclusion: PLIF and TLIF in the treatment of elderly patients with single segment lumbar degenerative disease in improving the curative effect of lumbar back pain and activity function of lumbar vertebrae in quite, but TLIF helps to significantly shorten operation time, reduce intraoperative blood loss and postoperative drainage, reduce the postoperative complication risk. It is worthy of clinical application. [ABSTRACT FROM AUTHOR]

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Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)