白细胞介素-1 家族细胞因子水平与非酒精性脂肪性肝病 及非酒精性脂肪性肝炎病程进展的相关性分析

Objective: To investigate and analyze the correlation between serum levels of interleukin-1RA (IL-1RA), interleukin- 1β(IL-1β), interleukin-18 (IL-18) and the progression of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Methods: 54 patients with NAFLD in our hospital were selected as the research object, According to NAFLD activity score (NAS), they were divided into non-NASH group and NASH group. Another 30 healthy people who came to our hospital for physical examination during the same period were selected as the control group. The correlation between serum IL-1RA, IL-1β, IL-18 levels and biochemical indexes and NAS scores was analyzed. Results: The body mass index(BMI), alanine aminotransferase(ALT), glutamyltransferase( GGT), triglyceride(TG), fasting blood glucose (GLU), IL-1βand IL-18 levels in NAFLD patients were significantly higher than those in the control group(P<0.05), and the serumlevels of IL-1RA, high density lipoprotein(HDL) were lower than those in the control group (P<0.05). The levels of ALT, AST, GGT, IL-1βand IL-18 in NASH patients were higher than those in non-NASH patients. The serum level of IL-1RA in non-NASH group was higher than that in NASH group(P<0.05). The results of correlation analysis showed that serum IL-1RA level was negatively correlated with NAS score (P<0.05), positively correlated with BMI, ALT, GGT, TG and low density lipoprotein (LDL)(P<0.05), and the levels of IL-1βand IL-18 were positively correlated with NAS scores (P<0.05). Conclusions: Serum levels of IL-1RA, IL-1βand IL-18 are related to the progression of NAFLD and NASH, and can reflect the severity of NAFLD and NASH. Inadequate secretion of IL-1RA in late stage may be an important reason for the progression of NAFLD to NASH. [ABSTRACT FROM AUTHOR]