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Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To compare the effects of fixed appliance and non bracket invisible appliance on gingival crevicular fluid inflammatory factors, subgingival flora and oxidative stress in patients with periodontal disease undergoing orthodontic treatment. Methods:112 patients with periodontal disease who received orthodontic treatment in the Orthodontic Department of Hebei Provincial Eye Hospital from January 2016 to October 2021 were selected, and they were divided into the control group (fixed appliance, n=54) and the experimental group (non bracket invisible appliance, n=58) according to the different of appliance. The changes of periodontal health indicators, subgingival microflora, gingival crevicular fluid inflammatory factors, oxidative stress indicators and pain scores were compared in the two groups. Results: 10 months after correction, the gingival index, plaque index, gingival sulcus bleeding index and periodontal probing depth in the two groups decreased, and the experimental group was lower than the control group (P＜0.05). 10 months after correction, the contents of Porphyromonas gingivalis (Pg), Fusobacterium nucleatum (Fn), Pseudomonas forsythiae (Tf) and Prevotella intermedia (Pi) in the experimental group were lower than those in the control group (P＜0.05). The tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) in the two groups at 10 months after correction decreased, and the experimental group was lower than the control group (P＜0.05). 10 months after correction, the levels of malondialdehyde (MDA) and reactive oxygen species (ROS) in two groups decreased, and the experimental group was lower than the control group. Superoxide dismutase (SOD) increased, and the experimental group was higher than the control group (P＜0.05). The visual analogue score (VAS) of pain in the two groups increased and decreased at 1d and 7d after correction, and the experimental group was lower than the control group (P＜0.05). Conclusion: Both non bracket invisible appliance and fixed appliance have good curative effect on periodontal orthodontic treatment, among which the non bracket invisible appliance has a significant effect on improving periodontal health indicators, subgingival microflora, inflammatory factors of gingival crevicular fluid and oxidative stress. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of high frequency repetitive transcranial magnetic stimulation（r TMS) combined with Brunnstrom staging training on the rehabilitation effect of stroke patients in convalescent stage. Methods: According to the random number table method, 80 cases of stroke patients in convalescent stage who were admitted to The First Affiliated Hospital of Xinjiang Medical University from January 2020 to February 2022 were divided into control group（40 cases, Brunnstrom staging training) and study group(40 cases, high frequency r TMS combined with Brunnstrom staging training. The efficacy, National Institutes of Health Stroke Scale（NIHSS) score, Functional Independence Scale（FIM) score, quality of life score, serum neurological indexes [myelin basic protein（MBP),neuron-specific enolase（NSE), nerve growth factor-1（NGF-1)] were compared between the two groups. Results: The total effective rate of the study group（92.50%) was significantly higher than that of the control group（70.00%)（P＜0.05). 4 weeks after treatment, MBP and NSE of the study group were lower than those of the control group, and NGF-1 was higher than that of the control group（P＜0.05). Compared with the control group, the NIHSS score of the study group at 4 weeks after treatment decreased and the FIM score increased（P＜0.05). 4 weeks after treatment, the psychological/physical/material/social function score of the study group were higher than those of the control group（P＜0.05). Conclusion: High frequency r TMS combined with Brunnstrom staging training is helpful to improve the rehabilitation effect of stroke patients in convalescent stage, and can also adjust the serum neurological indexes, and improve the quality of life. [ABSTRACT FROM AUTHOR]

Objective: Multifunctional Mn3O4@CuS core-shell nanoparticles were designed and prepared for imaging guided phototherapy of tumor, in order to achieve localized tumor photoablation with near infrared irradiation under the guidance of contrast enhanced magnetic resonance imaging (MRI). Methods: (1) Oleylamine-stabilized Mn3O4 nanoparticles were synthesized using thermal decomposition method, followed by surface coating of CuS nanoshell and PEGylation, resulting in water-solubleMn3O4@CuS core-shell nanoparticles. (2) Transmission electron microscope (TEM) morphology, UV-vis-NIR absorption spectra, size distribution and other physical-chemical properties of Mn3O4@CuS core-shell nanoparticles were evaluated, as well as its performance in MRI contrast enhanced and photo-induced hyperthermia. Results: Mn3O4@CuS core-shell nanoparticles had uniform spherical morphology with average size of 9.30±2.29 nm, and UV-vis-NIR absorption spectra showed their obvious and strong absorption in the near infrared region with peak absorbance at the range of 1100~1200 nm; The longitudinal relaxation rate (r1) of Mn3O4@CuS nanoparticles was calculated to be 1.662 mM-1 s-1, indicating the potential to act as a T1 MRI contrast agent; The temperature of Mn3O4@CuS nanoparticle suspension can be heated up to 73.5 ℃ with 785 nm near infrared laser irradiation, showing great capability to achieve photo-induced hyperthermia. Conclusion: Water-soluble Mn3O4@CuS core-shell nanoparticles were successfully fabricated with preferable MRI contrast enhancement and great photothermal effect, which could be applied for MRI guided phototherapy of tumor. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To investigate the effects of percutaneous vertebroplasty on serum levels of matrix metalloproteinase-3(MMP-3), matrix metalloproteinase-1(TIMP-1) and interleukin-(IL-6) and therapeutic effect. Methods: 60 cases of 2016 years in October 2017 to March 2017 in our hospital admissions of elderly osteoporotic thoracolumbar vertebral compression fractures, according to the random number table method is divided into experimental group and control group, each group of 30 cases, are given conventional On the basis of drug treatment, the control group was given conservative treatment such as reduction pillow and rehabilitation training,and the experimental group was treated by percutaneous vertebroplasty. Results: Before treatment, the levels of serum MMP-3, TIMP-1and IL-6 were not significantly different between the two groups(P> 0.05). After treatment, the levels of serum MMP-3 and IL-6 were decreased(P <0.05). Before treatment, There was no significant difference in VAS score between the two groups(P> 0.05). After 1 week of treatment and after treatment, the VAS score of the experimental group was lower than that of the control group(P <0.05), Before treatment, there was no difference in Cobb angle between the two groups(P> 0.05), after treatment, the Cobb angle of the two groups was significantly lower than that of the control group(P> 0.05). There was no significant difference in the height ratio between the two groups before treatment(P> 0.05), After treatment, the height of the two groups was significantly lower than that of the control group(P<0.05). After treatment, The effective rate was 96.67% in the experimental group and 76.67% in the control group, the difference was significant(P <0.05). Conclusion: Percutaneous vertebroplasty can effectively reduce the levels of serum MMP-3 and IL-6 and restore the level of TIMP-1, which can significantly improve the treatment of osteoporotic thoracolumbar vertebrae compression fractures. [ABSTRACT FROM AUTHOR]

Objective: To study the clinical efficacy of cerebral palsy carotid artery sympathetic nerve net around stripped resection preschool children with cerebral palsy and effect on the cognitive status. Methods: 84 cases of preschool children with cerebral palsy amitted in our hospital from December 2014 to December 2016 were selected and divided into the observation group and the control group according to different methods of treatment with 42 cases in each group. The control group was given routine non-surgical treatment, while the observation group was given common carotid artery sympathetic nerve net around stripped resection treatment. Both groups of children were followed-up for 24 weeks. The comprehensive function, developmental quotient and intelligence quotient and factor C value before and after the treatment were compared between two groups. Results: The total effective rate of comprehensive function was 95.24%(40/42) in the observation group, which was significantly higher than that of the control group [78.57%(33/42)](P0.05). At 24 weeks after treatment, the developmental quotient value was(84.5 ±11.3) in the observation group, which was significantly higher than that of the control group(62.2±12.4)(P0.05); the children's IQ was(80.7±11.4) in the observation group, which was significantly higher than that of the control group(67.3±12.1)(P0.05); the C factor value was(12.8±4.0) in the observation group, which was significantly higher than that of control group(9.9±3.3)(P0.05). Conclusion: Carotid artery sympathetic nerve net around stripped resection can effectively improve the patient's cognitive status in the treatment of preschool children with cerebral palsy. [ABSTRACT FROM AUTHOR]

Objective: To investigate the effect of early dynamic treatment of interlocking intramedullary nail on the healing of traumatic fracture. Methods: 150 cases of tibial fractures were randomly divided into experimental group and control group, with 75 cases in each group. Patients in the control group were treated with routine interlocking intramedullary nailing. Patients in the experimental group were treated with early dynamic method of interlocking intramedullary nail. The treatment method was identical with the control group. According to the patient's recovery, 6-10 weeks after operation, the dynamic treatment of intramedullary nail was carried out. Observation and comparison with human bone protection element (OPG). bone glutamate protein (BGP) level, clinical healing time, bone healing time and the incidence of adverse reactions and complications of the two groups of patients. Results: Compared with before treatment, the OPG. BGP levels of both groups were significantly increased after treatment (P < 0.05). Compared with the control group, the OPG. BGP levels were higher in the experimental group, the clinical healing time, bone healing time were shorter, the incidence of adverse reaction and complication was lower (P<0.05). Conclusion: Early power of interlocking intramedullary nail could increase the level of OPG and BGP of patients with traumatic fracture and accelerate the fracture healing with high safety. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To Analysis the effect of suppressing thyroid carcinoma metastasis process of using total resection of thyroid contrast and half resection. Methods: Selected 90 cases of patients with thyroid cancer in our hospital, for all patients received thyroid resection or subtotal resection, all at the same time using I131 and thyroid hormone suppression therapy as auxiliary treatment, and follow-up for all patients. Results: No statistical difference was found in the bleeding amount, laryngeal recurrent nerve exposure rate between two groups of patients (P>0.05), the incision and operation time in observation group were significantly longer than those of the control group (P<0.01). the parathyroid gland show rate was higher than that in the control group (P<0.01), the temporary and permanent laryngeal recurrent nerve injury, temporary and permanent parathyroid function showed no significant difference between two groups (P>0.05). Recurrence was found in 6 cases of the control group, the recurrence rate was 13.33% (6/45), none was found in the observation group, the postoperative recurrence rate was significantly higher in the control group than that of the observation gr oup (P<0.05). Conclusion: The application of total resection of thyroid gland was better than half resection in the treatment of thyroid carcinoma, which could effectively reduce the postoperative recurrence. [ABSTRACT FROM AUTHOR]

Obejective: To explore the clinical efficacy and safety of hollow screw tension band steel wire for internal fixation in the treatment of patellar fracture patients. Methods: 150 cases of patellar fracture in our hospital were randomly divided into the experimental group and control group, with 75 cases in each group. The patients in the control group underwent cerclage wire fixation, while patients in the experimental group were treated with hollow screw tension band steel wire internal fixation. After operation, the joint function exercise was performed regularly, and the regular patch test was performed to prevent the complications. The fracture healing time, operation time, the excellent rate of clinical treatment and the incidence rate of complications of two groups were observed and compared. Results: Compared with the control group, the fracture healing time was shorter, the operation time was longer, the effective rate was higher, rate of complications was lower of patients in the experimental group (P<0.05). Conclusions: Compared with cerclage wire fixation, hollow screw tension band steel wire had higher clinical efficacy and safety in the treatment of patellar fracture. [ABSTRACT FROM AUTHOR]

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)