经皮椎体成形术对老年骨质疏松性胸腰椎压缩骨折患者血清MMP-3、 TIMP-1、IL-6 及疗效的影响

Objective: To investigate the effects of percutaneous vertebroplasty on serum levels of matrix metalloproteinase-3(MMP-3), matrix metalloproteinase-1(TIMP-1) and interleukin-(IL-6) and therapeutic effect. Methods: 60 cases of 2016 years in October 2017 to March 2017 in our hospital admissions of elderly osteoporotic thoracolumbar vertebral compression fractures, according to the random number table method is divided into experimental group and control group, each group of 30 cases, are given conventional On the basis of drug treatment, the control group was given conservative treatment such as reduction pillow and rehabilitation training,and the experimental group was treated by percutaneous vertebroplasty. Results: Before treatment, the levels of serum MMP-3, TIMP-1and IL-6 were not significantly different between the two groups(P> 0.05). After treatment, the levels of serum MMP-3 and IL-6 were decreased(P <0.05). Before treatment, There was no significant difference in VAS score between the two groups(P> 0.05). After 1 week of treatment and after treatment, the VAS score of the experimental group was lower than that of the control group(P <0.05), Before treatment, there was no difference in Cobb angle between the two groups(P> 0.05), after treatment, the Cobb angle of the two groups was significantly lower than that of the control group(P> 0.05). There was no significant difference in the height ratio between the two groups before treatment(P> 0.05), After treatment, the height of the two groups was significantly lower than that of the control group(P<0.05). After treatment, The effective rate was 96.67% in the experimental group and 76.67% in the control group, the difference was significant(P <0.05). Conclusion: Percutaneous vertebroplasty can effectively reduce the levels of serum MMP-3 and IL-6 and restore the level of TIMP-1, which can significantly improve the treatment of osteoporotic thoracolumbar vertebrae compression fractures. [ABSTRACT FROM AUTHOR]