无托槽隐形矫治器与固定矫治器对牙周病正畸治疗患者龈下菌群、 龈沟液炎症因子和氧化应激的影响.

Objective: To compare the effects of fixed appliance and non bracket invisible appliance on gingival crevicular fluid inflammatory factors, subgingival flora and oxidative stress in patients with periodontal disease undergoing orthodontic treatment. Methods:112 patients with periodontal disease who received orthodontic treatment in the Orthodontic Department of Hebei Provincial Eye Hospital from January 2016 to October 2021 were selected, and they were divided into the control group (fixed appliance, n=54) and the experimental group (non bracket invisible appliance, n=58) according to the different of appliance. The changes of periodontal health indicators, subgingival microflora, gingival crevicular fluid inflammatory factors, oxidative stress indicators and pain scores were compared in the two groups. Results: 10 months after correction, the gingival index, plaque index, gingival sulcus bleeding index and periodontal probing depth in the two groups decreased, and the experimental group was lower than the control group (P＜0.05). 10 months after correction, the contents of Porphyromonas gingivalis (Pg), Fusobacterium nucleatum (Fn), Pseudomonas forsythiae (Tf) and Prevotella intermedia (Pi) in the experimental group were lower than those in the control group (P＜0.05). The tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) in the two groups at 10 months after correction decreased, and the experimental group was lower than the control group (P＜0.05). 10 months after correction, the levels of malondialdehyde (MDA) and reactive oxygen species (ROS) in two groups decreased, and the experimental group was lower than the control group. Superoxide dismutase (SOD) increased, and the experimental group was higher than the control group (P＜0.05). The visual analogue score (VAS) of pain in the two groups increased and decreased at 1d and 7d after correction, and the experimental group was lower than the control group (P＜0.05). Conclusion: Both non bracket invisible appliance and fixed appliance have good curative effect on periodontal orthodontic treatment, among which the non bracket invisible appliance has a significant effect on improving periodontal health indicators, subgingival microflora, inflammatory factors of gingival crevicular fluid and oxidative stress. [ABSTRACT FROM AUTHOR]