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Researchers from Zhejiang University in China have conducted a study on drug-related tinnitus using data from the FDA Adverse Event Reporting System. The study analyzed the top 25 drugs associated with tinnitus and found that duloxetine, ciprofloxacin, and adalimumab had the strongest associations. The research aimed to provide insights into adverse drug reactions related to tinnitus and concluded that their findings could guide safe clinical drug applications. [Extracted from the article]

Researchers from the Department of Urinary Surgery in Zhejiang, China, conducted a study on the use of the flexible vacuum-assisted ureteral access sheath combined with a flexible ureteroscope for treating large renal stones over 3 cm. The study included 122 patients and compared outcomes between an observation group and a control group. Results showed that the new method was effective in improving perioperative indexes, stone-free rate, inflammation levels, kidney function, and reducing complications. The research was published in the American Journal of Translational Research and concluded that the new approach shows promise in treating large renal stones. [Extracted from the article]

A study conducted by the Department of Pediatrics in Zhejiang, People's Republic of China, focused on the potential diagnostic biomarker Long Non-coding Rna Ssc4d in promoting gastric cell proliferation and metastasis. The research found that SSC4D, when silenced, inhibited gastric cancer cell malignancy and tumorigenesis. The study concluded that SSC4D plays an oncogenic role in promoting gastric cancer cell growth, migration, invasiveness, and tumor growth. This research has been peer-reviewed and provides valuable insights into the role of biomarkers in cancer progression. [Extracted from the article]

Researchers from Hangzhou Normal University conducted a study on the application of MRI radiomics in differentiating between osteoporotic and malignant neoplastic vertebral compression fractures (VCFs). The study included 51 patients with VCFs caused by malignant tumors and 49 patients with osteoporosis-induced VCFs. Radiomics features extracted from T2WI images were used to build a prediction model, which showed high efficiency in differentiating between the two types of VCFs. The research was published in the International Journal of Radiation Research and has been peer-reviewed. [Extracted from the article]

A study conducted at First People's Hospital in Zhejiang, China, focused on exploring effective combination antibacterial therapies against multidrug-resistant Gram-negative bacteria. The research found that a combination of polymyxin B and tetracycline exhibited potent antibacterial activity both in vitro and in vivo, showing significant synergistic effects and reducing bacterial counts effectively. The study concluded that this combination therapy strategy could be promising in combating antibiotic resistance. [Extracted from the article]

Researchers at the Chinese Academy of Sciences have developed a responsive degradable bottlebrush polymer platform for cancer therapy. This platform allows for precise drug release within tumor cells, minimizing systemic toxicity and enhancing drug efficacy. The study highlights the potential of this platform as a versatile tool for cancer drug delivery, addressing safety concerns associated with synthetic BBP nanomedicines. The research was funded by various institutions and has been peer-reviewed, offering promising implications for future cancer treatments. [Extracted from the article]

Researchers at Hangzhou Dianzi University in Zhejiang, China, have developed a domain generalization model for Motor Imagery EEG classification, aiming to improve generalization performance in real-life applications without user-specific calibration. The model utilizes EEGNet and ShallowConvNet to extract features and multiple classification networks to learn a broad range of data distributions, resulting in enhanced classification performance on target subjects. The research, supported by the National Natural Science Foundation of China and the Natural Science Foundation of Zhejiang Province, has been peer-reviewed and offers valuable insights into improving EEG-based brain-computer interface systems for motor function rehabilitation. [Extracted from the article]

A study conducted at Zhejiang University in China explored the potential causal relationship between childhood obesity and dentofacial anomalies using Mendelian randomization. The research found that childhood obesity and higher body mass index (BMI) were associated with a reduced risk of dentofacial anomalies, suggesting a possible link. However, the study emphasized the need for further research and cautious interpretation due to the overall health risks associated with childhood obesity. The findings were published in the Journal of Clinical Pediatric Dentistry and have undergone peer review. [Extracted from the article]

Researchers at Wenzhou Medical University in Zhejiang, China, have developed a dual-enzyme-instructed peptide self-assembly platform that utilizes camptothecin and capsaicin to enhance immunogenic cell death and stimulate systemic adaptive immunity for tumor rejection. This innovative approach synergizes two distinct apoptosis pathways to increase tumor immunogenicity, elicit T-cell-based immunity, and suppress both primary and distant tumors. The study, published in ACS Nano, demonstrates the potential of combining low ICD-stimulating chemotherapeutic drugs with peptide self-assembly to boost cancer immunotherapy. [Extracted from the article]

A recent meta-analysis conducted at Shaoxing People's Hospital in Zhejiang, China, examined the survival outcomes of venoarterial Extracorporeal Membrane Oxygenation (ECMO) versus standard care for acute high-risk pulmonary embolism (PE). The study, funded by local health science and technology projects, found that ECMO did not significantly improve early mortality rates compared to standard treatment. The research, published in the Pakistan Journal of Medical Sciences, suggests limited evidence supporting the additional survival benefits of ECMO in high-risk PE cases. [Extracted from the article]

A study conducted by Huzhou University in Zhejiang, People's Republic of China, explored the relationship between spatial visualization ability and number representation in Chinese preschool children. The research found a positive correlation between spatial visualization ability and number representation in 5-year-old children, suggesting that enhancing spatial visualization skills could improve numerical abilities. These findings have implications for early education and intervention strategies, highlighting the importance of developing children's spatial visualization abilities to enhance their number representation skills. [Extracted from the article]

A meta-analysis conducted by the First Affiliated Hospital in Zhejiang, China, focused on the impact of psychological interventions on anxiety and depression in hemodialysis patients. The study included 15 randomized controlled trials with a total of 929 patients, showing that psychological interventions significantly improved depressive moods and anxiety status in these patients. The research concluded that psychotherapy could be a promising method for alleviating depression in dialysis patients, ultimately improving their quality of life. [Extracted from the article]

A study conducted at Wenzhou Medical University in Zhejiang, China, explored the relationship between a specific gene polymorphism (rs1859168 C > A) and neuroblastoma susceptibility in Chinese children. The research found that this polymorphism was associated with a reduced likelihood of neuroblastoma, particularly in older children and girls. Further studies with larger and more diverse cohorts are needed to confirm these results. The study was published in the European Journal of Pediatrics and has undergone peer review. [Extracted from the article]

A study conducted by Zhejiang University School of Medicine in China examined alterations in subcortical structural volume in pediatric bipolar disorder (PBD) patients with and without psychotic symptoms. The research found significant differences in the volumes of certain brain regions among PBD patients with psychotic symptoms, PBD patients without psychotic symptoms, and healthy controls. The study suggests that bilateral lateral ventricles may serve as potential neurobiomarkers to distinguish PBD patients with psychotic symptoms from those without. This research provides insights into the biological mechanisms underlying PBD with psychotic symptoms. [Extracted from the article]

A study conducted at Zhejiang University in China compared the outcomes of Da Vinci robot-assisted surgery and laparoscopic-assisted surgery in children under six months with choledochal cysts. The research found that robot-assisted surgery had faster postoperative recovery and fewer complications, making it more recommended for this age group. The study was supported by the Key R&D Program of Zhejiang and was published in the Journal of Laparoendoscopic & Advanced Surgical Techniques in 2024. [Extracted from the article]

A recent study conducted at Zhejiang University in the People's Republic of China focused on the 2024 updates of the Chinese Society of Clinical Oncology (CSCO) Clinical Guidelines for the diagnosis and treatment of colorectal cancer. The research emphasized standardizing cancer treatment in China, addressing disparities in epidemiological trends, clinicopathological characteristics, and treatment approaches for colorectal cancer patients across diverse regions and backgrounds. The guidelines were based on both Chinese and international clinical research, ensuring their relevance and applicability in clinical practice while maintaining scientific rigor and impartiality. [Extracted from the article]

A study conducted at Shaoxing People's Hospital in Zhejiang, China, focused on evaluating the efficacy of Cone-Beam Computed Tomography (CBCT) enhanced scan in interventional therapy for liver cancer. The research compared the outcomes of patients who underwent digital subtraction angiography (DSA) alone versus DSA and CBCT during the operation. Results showed that CBCT enhanced scan was superior in detecting tumor lesions, nutrient arteries, and lipiodol deposition without increasing radiation dose, although it did prolong the operation time. This study provides valuable insights into improving the effectiveness of chemoembolization and radiation for liver cancer patients. [Extracted from the article]

A study conducted in Zhejiang, People's Republic of China, compared the effects of allylestrenol and progesterone on hormone levels and delivery outcomes in women with threatened abortion. The research found that allylestrenol was comparable to progesterone in improving delivery outcomes, reducing cesarean section rates, and prolonging gestational age without increasing safety risks. The study, conducted at Huzhou Maternity & Child Health Care Hospital, concluded that allylestrenol may be a beneficial treatment option for women with threatened abortion. [Extracted from the article]

A recent study from Zhejiang University in China explores the relationship between scoliosis and Chiari malformation with syringomyelia in adult patients. The study highlights the challenges of surgical intervention due to the complexity of these conditions and emphasizes the importance of accurate preoperative assessment and strategic planning for improved patient outcomes. The research aims to review previous studies and evaluate the efficacy of spinal correction procedures in these patients. [Extracted from the article]

Researchers at Wenzhou Medical University in Zhejiang, China, have developed a novel treatment strategy for spinal cord injury using cryo-shocked M2 macrophages. This treatment involves a biomimetic drug delivery system that promotes axonal regeneration and reduces neuroinflammation. The innovative approach shows promising results in enhancing motor function and accelerating neurological recovery in animal models, suggesting potential future clinical applications for acute spinal cord injury intervention. [Extracted from the article]

A recent study conducted at Zhejiang University in the People's Republic of China explored the use of opioid-free general anesthesia (OFGA) in laparoscopy. The meta-analysis of 14 randomized controlled trials involving 1042 patients found that OFGA did not significantly impact postoperative pain scores compared to opioid-based anesthesia, but it did reduce the need for postoperative analgesics and the incidence of nausea and vomiting. The research concluded that OFGA could be effectively and safely used in laparoscopy, providing valuable insights for clinical practice. [Extracted from the article]

A recent study conducted at Zhejiang Chinese Medicine University compared the efficacy of platelet-rich plasma (PRP) and hyaluronic acid (HA) for knee osteoarthritis (KOA). The study found that PRP may be more effective and safer than HA for treating KOA, although the quality of the included systematic reviews was deemed to be low. Researchers recommended improving the quality of future studies to provide more reliable evidence-based support for clinical practice. For more information, readers can refer to the original article published in Clinical Rheumatology. [Extracted from the article]

A recent study from the Department of Pediatrics in Zhejiang, People's Republic of China, examined the effects of Ureaplasma urealyticum (UU) infection on neonates. The meta-analysis of 13 studies revealed that UU infection significantly increased the risk of bronchopulmonary dysplasia (BPD), intraventricular hemorrhage (IVH), and sepsis in newborns. However, the correlation between UU infection and necrotizing enterocolitis (NEC) was not found to be significant. This research provides valuable insights into the impact of UU infection on neonatal health. [Extracted from the article]

Researchers from Taizhou Municipal Hospital in Zhejiang, China, conducted a study on the role of n-3 fatty acids in acute pancreatitis (AP). Their meta-analysis and Mendelian randomisation (MR) study found that n-3 fatty acids as a complementary therapy significantly reduced mortality and infectious complications in AP patients. The research suggests that n-3 fatty acids may improve the prognosis of AP and genetically predicted serum levels of n-3 fatty acids can lower the risk of AP. This study was supported by UK Biobank and published in the British Journal of Nutrition. [Extracted from the article]

A study conducted by Wenzhou Medical University in Taiwan focused on the prevalence of urinary diseases among prisoners, highlighting disparities based on sex and age groups. The research found that urinary system infections and inflammation are common in prisons, with women and older prisoners being at higher risk. The study emphasized the need for policy reforms to improve healthcare accessibility in prisons, particularly for high-risk groups. Further research linking claims data with prisoner information is recommended to provide more comprehensive medical services and achieve health equity. [Extracted from the article]

A recent study conducted at Hangzhou Normal University in Zhejiang, People's Republic of China, focused on developing a deep learning-based model for early screening of diabetic retinopathy. The model, based on the Vision Transformer architecture, was trained using the EyePACS dataset and validated using subsets of the IDRiD dataset. Results showed high detection accuracy and performance in predicting affected regions, providing interpretable justifications to aid clinicians in diagnosis. This research contributes to the field of Ophthalmology and offers potential advancements in diabetic retinopathy detection methods. [Extracted from the article]

A study conducted at Hangzhou Medical College in Zhejiang, China, focused on a novel BLK heterozygous mutation in a patient with maturity-onset diabetes mellitus (MODY). The research highlighted the importance of precise diagnosis in treating MODY individuals, as 90% of cases are currently misdiagnosed. This study sheds light on the genetic factors contributing to MODY and emphasizes the need for a better understanding of monogenic diabetes for improved clinical practice. [Extracted from the article]

A recent study conducted at Zhejiang University in the People's Republic of China introduced an Integrated Portable and Automatic Digital Detection System (IPADS) for Hepatitis B Virus (HBV) using a hybrid magnetic system. The device aims to provide rapid, precise, and automated diagnosis of infectious diseases, with a sensitivity as low as 100 copies mL-1 in serum samples. The research findings suggest that IPADS has the potential to be a reliable point-of-care testing solution for HBV detection, offering a more efficient and automated approach compared to traditional methods. [Extracted from the article]

A study conducted by researchers at Ningbo University in Zhejiang, China, explored the potential causal relationship between Helicobacter pylori antibodies and immune thrombocytopenia (ITP). Using Mendelian randomization analysis, the study found a positive association between genetically predicted serum levels of H. pylori GroEL antibodies and an increased risk of ITP. However, the researchers emphasized the need for further studies with larger sample sizes to confirm this correlation. This research provides valuable insights into the complex relationship between H. pylori infection and ITP. [Extracted from the article]

A study conducted at Wenzhou Medical University in Zhejiang, China, focused on the role of Evi1 in myeloid malignancies, using a transgenic mouse model to investigate its effects on hematopoietic stem/progenitor cells. The research found that Evi1 overexpression led to abnormal hematopoiesis, with anemia, thrombocytopenia, and dysplasia in mice, resembling human myelodysplastic syndrome/myeloproliferative neoplasm-like disease. The study identified a signaling pathway involving Evi1, Kdm6b, H3K27me3, and Laptm4b in regulating hematopoietic progenitor cells, highlighting the significance of this pathway in myeloid malignancies. [Extracted from the article]

A recent study conducted by investigators from the University of Electronic Science and Technology of China focuses on the use of multimodal deep learning approaches in precision oncology. The research reviews the applications of deep learning technologies in oncology, particularly in tumor segmentation, detection, diagnosis, prognosis, treatment selection, and therapy response monitoring. The study aims to guide future efforts in leveraging multimodal deep learning to advance precision oncology. The research has been peer-reviewed and provides valuable insights for researchers in the field. [Extracted from the article]

Researchers from Zhejiang University have developed a new strategy to reprogram microglia polarization and remodel the immunosuppressive microenvironment of glioblastoma using biomimetic membrane vesicles. By targeting M2 microglia with specific nanoparticles, they were able to inhibit the progression of glioblastoma and induce a shift from M2 to M1 microglia. This research offers a promising approach to addressing the interaction between tumor cells and immune cells in glioblastoma, potentially leading to improved treatment outcomes. [Extracted from the article]

A recent study conducted in Zhejiang, People's Republic of China, explored the efficacy and safety of combining transcatheter arterial chemoembolization (TACE) with lenvatinib (LVTN) and radiotherapy (RT) for the treatment of hepatocellular carcinoma (HCC). The meta-analysis of five studies revealed that this combination treatment enhanced the total objective response rate and overall survival rate of HCC patients, while reducing the incidence of diarrhea. However, no significant difference was observed in the occurrence of hypertension. The research concluded that LVTN combined with TACE showed superior efficacy in treating HCC, but the associated side effects may impact patient quality of life. [Extracted from the article]

A study conducted at Zhejiang University in China evaluated the effectiveness of 'Internet Plus' remote management in improving cardiac rehabilitation outcomes for patients with acute myocardial infarction (AMI) post-percutaneous coronary intervention (PCI). The research found that patients who received remote management showed better exercise tolerance, cardiac rehabilitation compliance, and mental health outcomes compared to those who received standard care. The study concluded that integrating digital technology into cardiac rehabilitation programs can effectively enhance patient outcomes. [Extracted from the article]

Researchers from Zhejiang University conducted a study on the impact of percutaneous coronary intervention (PCI) on echocardiographic parameters in patients with chronic total occlusion (CTO) of the coronary arteries and varying left ventricular ejection fraction (LVEF). The study included 100 patients divided into low to moderate LVEF and high LVEF groups, showing significant improvements in LVEF, LVESV, LVEDV, GLS, and LVWMS in the low to moderate LVEF group after PCI. The research suggests potential benefits of revascularization in patients with low to moderate LVEF. [Extracted from the article]

A study conducted at First People's Hospital Huzhou in Zhejiang, People's Republic of China, focused on the role of long noncoding RNA TUG1 in viral myocarditis caused by Coxsackievirus. The research found that silencing LncRNA TUG1 reduced inflammation and damage in cardiomyocytes by targeting the miR-140-3p/CXCL8 axis. This study sheds light on potential therapeutic targets for viral myocarditis. [Extracted from the article]

A report from Shaoxing Second Hospital in Zhejiang, China, discusses the efficacy of an Information-Motivation-Behavioral skills (IMB) model-based nursing intervention in managing patients with heart failure. The study involved 308 heart failure patients and found that the IMB model-based nursing care significantly improved self-care behaviors, quality of life, and hemodynamic parameters compared to routine nursing care. The research suggests that this mode of nursing care could be a valuable strategy for enhancing heart failure management. [Extracted from the article]

A recent study conducted at Taizhou University in Zhejiang, China, explored the impact of miR-100-5p depletion on osteogenesis through Lysine(K)-specific demethylase 6b (KDM6B) in bone marrow-derived mesenchymal stem cells (BMSCs). The research found that miR-100 depletion promoted bone union and osteogenic differentiation of BMSCs by activating the expression of KDM6B and osteocalcin (OCN) proteins. This study provides valuable insights for the development of strategies for BMSC treatment of fractures, offering a new direction for future research in this field. [Extracted from the article]

Researchers at Ningbo University of Technology in Zhejiang, China, have developed a portable microarray chip platform that visualizes chemical kinetics processes through clock reactions. This platform allows for the visualization of phenomena such as radial diffusion and microscale interfacial reactions, enhancing the understanding of abstract chemical concepts. By controlling variables like reactant concentration and temperature with digital coding, users can calculate key kinetic parameters and gain a deeper understanding of reaction dynamics. The research has been peer-reviewed and demonstrates notable effectiveness in classroom settings, offering a new approach to experimental teaching in the field of Chemicals and Chemistry. [Extracted from the article]

Researchers at Zhejiang Chinese Medicine University conducted a study on Psoriatic Arthritis (PSA) and developed a screening model called Psoriatic Arthritis Inflammation Index (PSAII) based on serologic data to improve efficiency in PSA screening. The study included 719 PSO and PSA patients from the National Health and Nutrition Examination Survey and 135 patients from The First Affiliated Hospital of Zhejiang Chinese Medical University. The Logistic Regression model showed the best performance with an Area Under Curve (AUC) of 0.87 on the test set and 0.82 on the external validation set. The study concluded that while PSAII had a high false positive rate, it could be combined with other screening tools for better accuracy. [Extracted from the article]

A study conducted at Ningbo Yinzhou Second Hospital in Zhejiang, China, evaluated the efficacy and safety of rituximab in treating primary IgA nephropathy. The retrospective study included 22 patients with IgAN who received rituximab treatment, showing a significant increase in serum albumin levels and a reduction in proteinuria. While renal function did not show significant improvement, there was a trend towards better outcomes. The research suggests that rituximab could be a viable alternative for IgAN patients intolerant to traditional treatments like glucocorticoids or immunosuppressants. [Extracted from the article]

A study conducted at Zhejiang University in China focused on the role of a bacterial methyltransferase in initiating biotin synthesis, which is crucial for central metabolism. The research highlighted the importance of understanding this process in combating ESKAPE-type pathogens like Acinetobacter baumannii and Klebsiella pneumoniae. The study identified two BioC isoenzymes that play a key role in biotin synthesis and provided insights into potential anti-ESKAPE drug targets. The findings shed light on the dual roles of BioC methyltransferase in infection and antibiotic resistance. [Extracted from the article]

A study conducted at Zhejiang Chinese Medicine University in China focused on the role of Elf3 overexpression in the malignant transformation of HPV16 E6/E7-immortalized keratinocytes by promoting CCNE2 expression. The research highlighted the upregulation of ELF3 and CCNE2 in head and neck squamous cell carcinoma, with ELF3 silencing inhibiting the malignant transformation process. Funders for the study included the Zhejiang Provincial Medical and Health Plan Project Fund and the National Natural Science Foundation of China. The findings were published in the Journal of Microbiology and Biotechnology and have been peer-reviewed. [Extracted from the article]

Researchers from Ningbo University in Zhejiang, China, have developed a phage-modified dual-peak long-period fiber grating biosensor for ultrasensitive, rapid, and specific detection of foodborne pathogens. The biosensor showed enhanced sensitivity to refractive index changes caused by bacterial adsorption, allowing for quantification of target strains based on wavelength shifts. The study offers a novel approach for the rapid, sensitive, and specific detection of trace pathogenic strains in foods, with promising results in detecting Escherichia coli O157:H7 and Hafnia paralvei in food samples. [Extracted from the article]

A recent study conducted in Zhejiang, People's Republic of China, focused on the use of graphene-based sensors for detecting Salmonella bacteria in food items. The research highlighted the high efficiency of graphene derivatives in detecting bacteria at low concentrations, emphasizing the potential for selective biosensing of Salmonella on graphene electrodes. The study also addressed the challenges and possible remedies associated with current graphene derivatives-based sensors for electrochemical sensing. This peer-reviewed research provides valuable insights into the application of graphene technology in food safety and public health. [Extracted from the article]

A study conducted at Shaoxing University in Zhejiang, China, analyzed the impact of cytokines and neutrophils-to-lymphocytes ratio on febrile seizures (FS) in children during the epidemic of novel coronavirus and influenza virus. The research, which included 422 cases of FS, found that levels of IL-4, IL-10, and TNF-alpha were significantly higher during the viral epidemic period compared to the non-epidemic period. The study concluded that IL-4, IL-10, and NLR may play a crucial role in the pathogenesis of children with FS, particularly those with complex FS. [Extracted from the article]

A study conducted at Zhejiang University School of Medicine in China explored the experience of post-traumatic growth among parents of children with biliary atresia undergoing living-related liver transplantation. The research identified five themes related to the parents' experiences, including intense post-traumatic reactions, emotional fluctuations, and gradual post-traumatic growth. The study suggests tailored intervention strategies should be developed to enhance parents' post-traumatic growth and psychological well-being at different stages of their children's transplantation process. Future research may involve a longitudinal qualitative study to further explore parents' post-traumatic growth experiences. [Extracted from the article]

Researchers from Wenzhou Medical University in Zhejiang, China, have conducted a study on colon cancer cells with KRAS mutations to investigate the role of YY1 in mediating resistance to cetuximab therapy. The study found that YY1 expression was correlated with cetuximab resistance in KRAS mutant colorectal cancer tissues and cell lines. Silencing YY1 in resistant cells re-sensitized them to cetuximab, while overexpressing YY1 in sensitive cells enhanced resistance. The research concluded that YY1 plays a role in mediating resistance of KRAS mutant colorectal cancer cells to cetuximab therapy. [Extracted from the article]

A study conducted by researchers at Zhejiang University of Technology in China explored the potential inhibitory activity of oyster-derived peptides on pancreatic lipase. The peptides NGDAGMV (P-N) and EAGAGGL (P-E) were found to effectively inhibit pancreatic lipase activity through non-competitive inhibition mechanisms. This research provides a theoretical basis for utilizing oyster peptides as natural pancreatic lipase inhibitors, offering insights into their kinetics, molecular interactions, and gastrointestinal stability. [Extracted from the article]

A study conducted by State Grid Zhejiang Electric Power Co. Ltd. in Zhejiang, China, focused on developing a real-time update algorithm for digital twin models of distribution network equipment using IoT and optical imaging technology. The research aimed to address issues of poor real-time performance, accuracy, robustness, and scalability in traditional algorithms. Results showed that the new algorithm significantly outperformed traditional methods in terms of real-time performance, accuracy, robustness, and scalability, highlighting the impact of IoT and optical imaging technology on improving update algorithms for distribution network equipment models. This study offers solutions for real-time monitoring, prediction, and control of distribution network equipment. [Extracted from the article]