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A recent report from Tokyo Medical and Dental University (TMDU) discusses a case of cryptogenic new-onset refractory status epilepticus (C-NORSE) in a 76-year-old man. The patient showed abnormal signals in the nucleus accumbens and hyperintense signals on T1-weighted magnetic resonance imaging in the bilateral basal ganglia. Despite various treatments, the patient did not respond and eventually died of sepsis, with autopsy findings indicating severe neuronal loss and hypertrophic astrocytes in the basal ganglia and limbic system. The research suggests that lesions in the basal ganglia may indicate secondary degeneration and predict poor outcomes in C-NORSE cases. [Extracted from the article]

A recent report from the University of Health Sciences discusses a case of a 32-year-old male who experienced a seizure after undergoing ketamine procedural sedation. Despite its benefits in treating various conditions, ketamine can have side effects such as hallucinations, dizziness, and seizures. The patient in this case received a carefully titrated dose of ketamine and successfully underwent a procedure, but experienced a seizure that was stopped with medication. This case underscores the importance of healthcare professionals being aware of potential side effects of ketamine and monitoring patients closely during sedation. [Extracted from the article]

Researchers at Baylor University College of Medicine conducted a case study on an 11-year-old female with anti-GAD 65 encephalitis presenting as New-Onset Refractory Status Epilepticus (NORSE). The patient showed minimal response to standard anti-seizure medications and first-line immunotherapies but improved after receiving intrathecal dexamethasone (IT-DEX) in conjunction with rituximab. The study suggests that IT-DEX may be an effective early intervention for refractory status epilepticus from various causes. The research was peer-reviewed and published in the Journal of Neuroimmunology. [Extracted from the article]

A recent report from the University of Minnesota discusses the history and development of antiseizure medications (ASM) for epilepsy treatment since 1857. The research emphasizes the importance of understanding various ASM options, especially in the context of precision medicine and global medication availability. The study highlights challenges in selecting the most appropriate ASM and provides insights into older and newer medications, precision medicine advancements, and effective treatments for status epilepticus. The full article can be accessed for free online, offering valuable information for clinicians and researchers in the field of epilepsy treatment. [Extracted from the article]

A recent study published in Neurology Genetics discusses a case of refractory epilepsy in an adult patient with a coq8a variant. The patient presented with stroke-like episodes and status epilepticus, and genetic testing revealed compound heterozygous variants of COQ8A. The patient's condition improved with high-dose coenzyme Q10 supplementation. The study suggests that whole-exome sequencing can be a valuable tool for diagnosing rare neurological diseases in critically ill patients, and that coenzyme Q10 supplementation may be beneficial for selected adult patients with refractory epilepsy. [Extracted from the article]

A recent preprint abstract discusses the potential use of a peptide-neurotensin conjugate, VH-N412, in inducing pharmacological hypothermia for the treatment of status epilepticus in mice. The study found that VH-N412, which has enhanced blood-brain barrier permeability, was able to elicit rapid hypothermia, anticonvulsant effects, neuroprotection, and reduced inflammation in a mouse model of status epilepticus. Additionally, VH-N412 demonstrated neuroprotective properties in cultured hippocampal neurons. This research suggests that VH-N412 may have potential as a treatment for status epilepticus, either through hypothermia or intrinsic neuroprotective mechanisms. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]

A recent research article from University College London (UCL) discusses the treatment of status epilepticus, a condition characterized by prolonged seizures. The article highlights 12 significant developments in the treatment of status epilepticus over the past 200 years. The research was presented at a colloquium in London in April 2024 and has been peer-reviewed. For more information, readers can refer to the article "Twelve Landmarks In the Treatment of Status Epilepticus" in the journal Epilepsy & Behavior. [Extracted from the article]

A report from the University of Maryland discusses the current state of simulation-based education in neurocritical care. The review highlights the benefits of simulation in improving learner performance and patient safety, particularly in areas such as interpretation of continuous electroencephalography and management of acute stroke. The research emphasizes the growing access and application of simulation in neurocritical care, but also calls for more rigorous studies to demonstrate improved patient care outcomes. The report provides contact information for further inquiries and is available through a journal article. [Extracted from the article]

A recent study from the Uniformed Services University of the Health Sciences explores the triggers and consequences of status epilepticus (SE), a prolonged seizure that can lead to brain damage and the development of epilepsy. The researchers highlight the role of GABAA receptors in brain damage, epilepsy, and anxiety. They explain that during SE, calcium influx weakens inhibition, exacerbating seizures and excitotoxicity. Protecting interneurons during SE is crucial for preventing epilepsy and anxiety. The study suggests that antiglutamatergic treatments and the preservation of GABAA receptors may be effective in controlling seizures and reducing excitotoxicity. However, benzodiazepines may have limited efficacy and could be ineffective in the immature brain. [Extracted from the article]

A recent study conducted at the University Hospital Zurich in Switzerland explored the use of steroids in the treatment of super-refractory status epilepticus (SRSE) caused by tick-borne encephalitis (TBE). The study focused on a 31-year-old woman who was admitted to the hospital with symptoms of TBE, including fever, headache, vertigo, and meningismus. Despite initial treatment, the patient's condition worsened, leading to coma and SRSE. Steroid treatment was initiated to address elevated intracranial pressure and persistent seizure activity, which resulted in the resolution of electrographic status epilepticus. However, the patient remained in a minimally conscious state at discharge. The study concluded that the use of steroids in TBE is controversial, but in this case, it coincided with the cessation of SRSE, suggesting potential benefits due to its immunomodulatory effects. [Extracted from the article]

A report from researchers at Seoul National University in South Korea discusses the clinical dynamics, prognostic factors, and treatment guidance for cryptogenic new-onset refractory status epilepticus (cNORSE). The study analyzed 74 patients with cNORSE and found that the optimal duration of immunotherapy appeared to be between 18 weeks and 1 year after the onset of cNORSE. Factors such as the presence of mesial temporal lobe and extra-mesial temporal lobe lesions at 3-month MRI and prolonged unconsciousness were associated with poor outcomes. The findings aim to contribute to a standardized understanding and clinical decision-making for cNORSE. [Extracted from the article]

A preprint abstract from biorxiv.org discusses the role of the dorsal striatum in controlling seizures. The study used optogenetic stimulation to activate and inactivate neurons in the dorsal striatum of rats with different models of epilepsy. The results showed that continuous optogenetic activation of the dorsal striatal neurons suppressed seizures, while silencing the neurons increased seizure expression. The study also explored the use of closed-loop optogenetic stimulation in response to seizure detection, which had varying effects on seizure duration depending on the type of stimulation used. These findings highlight the bidirectional role of the dorsal striatum in controlling seizure generation and propagation in different seizure models. However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]

A recent study conducted at the University of Florida has found that vagus nerve stimulation (VNS) may be effective in treating encephalopathy caused by the use of tiagabine, a gamma-aminobutyric acid reuptake inhibitor commonly used to treat epilepsy. The researchers presented a case of a patient who experienced sudden onset encephalopathy and rhythmic delta activity after VNS was turned off for a magnetic resonance imaging procedure. When VNS was turned back on, the patient's symptoms improved. This is the first reported case of VNS successfully interrupting encephalopathy caused by tiagabine. [Extracted from the article]

Researchers at the University of Sabana in Chia, Colombia have reported a case study on a 74-year-old man who developed involuntary rhythmic contractions of his left abdomen after drainage of a chronic right frontoparietal subdural hematoma. These movements were classified as clonic abdominal seizures, a rare clinical finding in patients with seizure disorders. The researchers suggest that clonic abdominal seizures should be suspected in patients with rhythmic and regular contractions of the hemiabdominal wall in the context of a contralateral cerebral structural lesion. This research has been peer-reviewed and published in Neurology. [Extracted from the article]

A recent study conducted by researchers at the Department of Anesthesiology and Intensive Care in Berlin, Germany, explored the metabolic adaptation in epilepsy. The study found that epilepsy is characterized by hypersynchronous neuronal discharges and increased cerebral metabolic rate. Uncontrolled seizure activity can lead to mitochondrial exhaustion and ATP depletion, resulting in energy mismatch and neuronal loss. The researchers discovered that acute epileptic activity boosts ATP production, while chronic epilepsy significantly reduces it. These findings provide valuable insights into the dynamic metabolic changes associated with epilepsy. [Extracted from the article]

A study conducted at Chang Gung Memorial Hospital in Taoyuan, Taiwan, evaluated the effectiveness and safety of intravenous lacosamide in critically ill children with acute repetitive seizures and convulsive status epilepticus. The study included 67 children, with 44.8% experiencing acute repetitive seizures and 55.2% experiencing convulsive status epilepticus. The results showed that early use of intravenous lacosamide was effective and safe in treating these conditions, even in young infants. The study categorized patients based on their epilepsy history and different etiologies. [Extracted from the article]

A recent study conducted at Sultan Qaboos University Hospital in Muscat, Oman, aimed to evaluate the causes, management, and outcomes of convulsive status epilepticus (CSE) in children. The study analyzed 93 children with CSE treated at the hospital's emergency department, high dependency unit, and intensive care unit. The primary causes of CSE were acute symptomatic and febrile status. Prompt and appropriate management of CSE is crucial, as a longer duration of CSE is associated with higher mortality and neurological disability. Identifying and treating the underlying cause of CSE is also important in improving patient outcomes. [Extracted from the article]

A study conducted by the All India Institute of Medical Sciences (AIIMS) compared the efficacy and safety of intravenous levetiracetam (LEV) and phenytoin (PHT) as second-line antiseizure medication (ASM) for children with status epilepticus (SE). The study found that the clinical cessation of seizures after the completion of drugs was similar in both the LEV and PHT groups, with no statistically significant difference in terms of seizure cessation, adverse events, and recurrence. The research concluded that LEV is comparable to PHT in controlling seizures as a second-line ASM in SE. [Extracted from the article]

A new report from researchers at Oregon Health & Science University (OHSU) discusses the use of responsive neurostimulation (RNS) as a therapy for epilepsy following new-onset refractory status epilepticus (NORSE). The study reviewed the outcomes of three patients who were treated with RNS after developing drug-resistant epilepsy (DRE) following NORSE. The findings suggest that RNS may be a safe and potentially effective treatment for DRE following NORSE, as it can reduce seizure burden and differentiate epileptic from non-epileptic events. The researchers also highlight the ability of RNS to distinguish between different types of events, which is a unique strength compared to other surgical options. [Extracted from the article]

A recent study conducted by researchers at Shaanxi University of Chinese Medicine explores the impact of circadian rhythms and medication timing on the progression from isolated seizures to status epilepticus (SE), a critical clinical issue. The study found that circadian rhythms significantly affect this transition, with distinct patterns observed. Timely administration of antiepileptic drugs (AEDs) during the early night-time was found to reduce conversion rates and improve survival. The researchers suggest that aligning AEDs administration with individual circadian vulnerabilities could advance epilepsy management in ICU settings, and future research should focus on personalized medication strategies that utilize circadian rhythms to optimize treatment effects. [Extracted from the article]

The article focuses on a peptide-neurotensin conjugate, VH-N412, which crosses the blood-brain barrier and induces pharmacological hypothermia and its anti-inflammatory properties,. Topics include its anticonvulsant effects, neuroprotection, and reduction of hippocampal inflammation in a mouse model of status epilepticus.

This article discusses a study that aims to understand the phenomenon of benzodiazepine resistance in status epilepticus (SE), a medical emergency characterized by seizures lasting longer than five minutes. The current first-line treatment for SE is benzodiazepines, but they are ineffective in over a third of cases. The study used a large spiking neural network model that incorporates chloride dynamics to investigate the effect of changes in intraneuronal chloride homeostasis and GABAAR physiology on benzodiazepine resistance in SE. The findings suggest that the GABAAR reversal potential (EGABA) plays a crucial role in determining the response to benzodiazepine treatment, with low EGABA being anti-seizure and high EGABA being ineffective or pro-seizure. The study also highlights the importance of pyramidal cell chloride extrusion in determining the severity of SE activity and the response to benzodiazepine application. The research provides insights that could potentially lead to improved therapeutic approaches for terminating SE in clinical settings. [Extracted from the article]

Researchers from Cairo University have conducted a study on the potential neuroprotective and autophagy-enhancing effects of the drug alogliptin on seizures induced by lithium and pilocarpine in rats. The study found that alogliptin reduced seizure severity, protected against hippocampal neurodegeneration, and increased levels of gamma-aminobutyric acid (GABA). It also activated the brain's autophagy process and showed promising results in treating status epilepticus. This research suggests that alogliptin could be a promising treatment for this condition. [Extracted from the article]

A study conducted at University Hospital in Copenhagen, Denmark, explored the levels of monoacylglycerol lipase (MAGL) in a rat model of epilepsy. The researchers used autoradiography to validate the binding properties of the MAGL radiotracer and found specific and saturable binding in both cortical grey and subcortical white matter. They observed a bilateral reduction in MAGL binding in the cerebral cortex and hippocampus after status epilepticus, suggesting that MAGL inhibitors may be effective in treating epilepsy. The study was supported by Novocure Limited and has been peer-reviewed. [Extracted from the article]

A recent study conducted in Campinas, Brazil explored the clinical characteristics and prognosis of older adults with nonconvulsive status epilepticus (NCSE)-coma. The study examined the initial EEG data, clinical variables, and hospital outcomes of 51 older adult patients. The findings revealed that the types of NCSE-coma presented different clinical aspects and patterns on initial EEG. The study also found that a history of previous seizures/epilepsy was more common in NCSE-coma with preceding seizure/SE, and this group had a more favorable prognosis. The research highlights the need for further understanding of NCSE-coma in older adults. [Extracted from the article]

A recent study conducted at Cincinnati Children's Hospital Medical Center examined the use of enteral ketamine in the treatment of convulsive and nonconvulsive status epilepticus (SE) in children with epilepsy. The study found that enteral ketamine may be an effective and well-tolerated option for treating SE in children with epilepsy, including those with genetic epilepsies. The use of ketamine may help prevent intubation and shorten hospitalization time. The study reviewed patient charts and found that seven out of nine patients experienced resolution or reduction in seizures within 48 hours of ketamine initiation. [Extracted from the article]

The article presents a case study of a 34-year-old woman who developed neurogenic pulmonary edema associated with severe hyponatremia and status epilepticus following cannabis consumption and excessive water intake. It states that this rare and potentially life-threatening condition highlights the need for awareness of neurogenic pulmonary edema in conjunction with psychogenic polydipsia and electrolyte imbalances related to cannabis use.

A new study conducted by researchers at Great Ormond Street Hospital for Children NHS Foundation Trust in London explores the rare and devastating condition known as new onset refractory status epilepticus (NORSE) and its subcategory febrile infection-related epilepsy syndrome (FIRES). NORSE is characterized by the sudden onset of refractory status epilepticus without an identifiable cause in individuals without a pre-existing epilepsy diagnosis. The study reviews existing clinical and treatment data and examines the underlying pathophysiology of NORSE/FIRES using pre-clinical seizure and epilepsy models. The researchers propose future directions for research to enhance our understanding of this condition. [Extracted from the article]

A retrospective, multicenter study conducted in Bologna, Italy examined the long-term outcomes of pediatric patients who developed acute central nervous system (CNS) complications after undergoing hematopoietic cell transplantation (HCT). The study found that acute symptomatic seizures, including status epilepticus (SE), were common among these patients. Nine patients (9.6%) were diagnosed with long-term focal epilepsy during follow-up, and the occurrence of acute symptomatic SE during HCT was associated with a higher risk of long-term epilepsy. The researchers concluded that further studies are needed to understand the mechanisms of epileptogenesis in pediatric patients undergoing HCT. [Extracted from the article]

New research from Marmara University School of Medicine has explored the neuroprotective effects of irisin, a hormone released during exercise, and acute strenuous exercise on epilepsy. The study found that intracerebroventricular administration of irisin or engaging in acute exhaustive exercise can alleviate oxidative brain injury, memory dysfunction, and neuroinflammation caused by seizures. The interventions were shown to correct glutamate/GABA imbalance, reduce reactive oxygen species and lipid peroxidation, replenish antioxidant levels, and improve memory function. The findings suggest that irisin and high-intensity exercise can provide neuroprotection by maintaining neurotransmitter balance and oxidant/antioxidant systems. [Extracted from the article]

A study conducted by researchers at the University libre of Bruxelles in Brussels, Belgium, aimed to understand the factors that contribute to variation in outcomes for patients with status epilepticus. The study analyzed data from Medicare beneficiaries admitted with status epilepticus between 2009 and 2019. The researchers found that hospital-to-hospital differences accounted for only a small percentage of the variation in outcomes, with patient characteristics, such as cardiac arrest, having a greater impact. The study suggests that interventions to improve outcomes should focus on individual or prehospital factors rather than inpatient systems. [Extracted from the article]

A study conducted in Bologna, Italy, explored the use of electroencephalography (EEG) as a diagnostic tool for children with acute altered mental status (AAMS) of unknown cause. The study involved 20 patients aged 1 month to 18 years who presented with AAMS. The EEG was found to be a valuable tool in diagnosing nonconvulsive status epilepticus and psychogenic events. However, it was less informative during the onset of AAMS in some cases. The study highlights the potential of EEG in identifying underlying causes of AAMS in children. [Extracted from the article]

The article discusses a study from the Catholic University of Korea on psychiatric comorbidities in children with new-onset epilepsy. Topics include the impact of psychiatric disorders on treatment outcomes and healthcare use, differences in treatment across groups with various psychiatric diagnoses, and the increased risk of status epilepticus and drug-resistant epilepsy associated with these comorbidities.

The article discusses research by Eric S. Rosenthal and colleagues from Massachusetts General Hospital, reported in the 2024 issue of Critical Care, on the utility and rationale for continuous EEG (cEEG) monitoring. Topics include the use of cEEG in detecting nonconvulsive seizures and status epilepticus, its role in neuroprognostication and monitoring neurological deterioration, and the practical considerations for intensivists in utilizing cEEG effectively in the ICU setting.

A report from the University of Miami discusses research findings on status epilepticus, a condition characterized by prolonged seizures. The report focuses on a complex case involving a patient who experienced posterior reversible encephalopathy syndrome (PRES) and super-refractory status epilepticus after a combined heart and kidney transplant. The patient did not receive calcineurin inhibitors and ultimately had a fatal outcome. The research highlights the delicate balance between immunosuppression and the risk of PRES, as well as the potential interactions between antiseizure medications and immunosuppressive drugs. The report suggests that multifocal necrotizing leukoencephalopathy (MNL) should be considered in the differential diagnosis for refractory seizures in patients with established risk factors. [Extracted from the article]

A recent study conducted by researchers at the State University of New York (SUNY) in Brooklyn focused on improving the quality of care for status epilepticus (SE), a prolonged seizure condition. The study found that there are often gaps between recommended and implemented care for SE, and identified several interventions that could optimize treatment. These interventions include seizure action plans, rescue medications, noninvasive wearables with seizure detection capabilities, standardized EMS protocols, EMS education, screening tools, provider education, SE order sets and alerts, and rapid EEG technologies. The researchers concluded that a multipronged approach, tailored to local contexts and incorporating pre-hospital intervention and SE databases, has the potential to transform SE treatment and outcomes. [Extracted from the article]

A study conducted at Auckland City Hospital in New Zealand aimed to determine the two-year mortality and seizure recurrence rates in patients with status epilepticus (SE). The study followed 335 patients with SE over a two-year period and found that the two-year all-cause mortality rate was 14.9%, or 18.4% when febrile SE was excluded. The two-year seizure recurrence rate was 58.8%. Factors associated with lower mortality included younger age, Asian ethnicity, SE duration less than 30 minutes, and acute (febrile) causes. Factors associated with higher mortality included older age and progressive causes. The study suggests that future research should focus on functional measures of outcome and long-term quality of life. [Extracted from the article]

A study conducted in Warsaw, Poland, suggests that between 14% and 20% of cases of drug-resistant epilepsy may be linked to an impaired immune response. The study aimed to assess the impact of immune response disorders on the course of the disease and factors indicating an autoimmune cause. The researchers analyzed 30 patients with drug-resistant epilepsy, dividing them into two groups based on whether they had experienced status epilepticus or not. The study collected and analyzed various medical data and tests, including blood tests, neuropsychological evaluations, EEGs, CSF examinations, and MRI scans. The study found no significant difference in age, gender, onset, or disease duration between the two groups. None of the patients showed the presence of tested antibodies against neuronal surface antigens and oligoclonal bands in the CSF. The researchers concluded that the absence of antibodies against neuronal antigens does not necessarily rule out autoimmune epilepsy, and a history of status epilepticus increases the risk of autoimmune epilepsy. [Extracted from the article]

A study conducted by researchers at Chongqing Medical University in China investigated the effectiveness and safety of miR-23b-3p in anti-seizure activity and its relationship with Cx43 in the nervous system. The study used a rat model of status epilepticus and found that overexpression of miR-23b-3p reduced the severity of seizures and brain damage. The researchers concluded that miR-23b-3p targets and blocks the expression of hippocampal Cx43, which reduces the formation of pathological high-frequency oscillations and improves seizure-induced brain damage. This research has been peer-reviewed and published in ACS Chemical Neuroscience. [Extracted from the article]

Researchers at Texas Children's Hospital have presented data on infantile spasms in infants with tuberous sclerosis complex (TSC). The case study involved a newborn with a prenatally discovered cardiac rhabdomyoma, which led to an early genetic diagnosis of TSC. The researchers found that early diagnosis and presymptomatic electroencephalography (EEG) revealed subclinical seizures meeting the definition for status epilepticus on the first day of life. The study suggests that early consideration for neonatal EEG monitoring can help identify and treat neonatal seizures, reduce the risk of infantile spasms, and potentially improve neurodevelopmental outcomes. [Extracted from the article]

Researchers at Gyeongsang National University in JinJu, South Korea have reported new data on the therapeutic effect of vagus nerve stimulation (VNS) on super-refractory nonconvulsive status epilepticus (NCSE). Super refractory status epilepticus (SRSE) is a condition where status epilepticus persists despite 48 hours of anesthetic treatment, while NCSE is characterized by seizures lasting more than 30 minutes on an electroencephalogram without convulsions. Prompt treatment of NCSE is crucial to prevent additional brain damage and progression to convulsive status epilepticus. VNS has been approved as an adjunct treatment for drug-resistant epilepsy, but it is rarely used for refractory status epilepticus. This research reports a successful case of a patient with posttraumatic epilepsy who was treated with VNS for super refractory-NCSE after convulsive status epilepticus. The study has been peer-reviewed and published in Neurology Asia. [Extracted from the article]

A recent study conducted by researchers at the University of Khartoum in Sudan has found a rare occurrence of sagittal sinus thrombosis and haemorrhagic infarction with dengue fever. The study highlights the growing recognition of neurological symptoms associated with dengue virus (DENV) infection, some of which can be lethal if left untreated. The researchers presented a case of an elderly Sudanese patient who developed sagittal sinus thrombosis, which was later complicated by ischemic stroke with haemorrhagic transformation and status epilepticus. This study emphasizes the need for further research to validate dengue as a pathogenic mechanism of ischemic stroke. [Extracted from the article]

A recent study conducted at Yokohama City University in Japan has reported new findings on adolescent-onset epilepsy and its association with CAD deficiency. CAD is a gene that encodes a protein involved in the biosynthesis of pyrimidine, and pathogenic variants in this gene can lead to developmental and epileptic encephalopathy. The study highlights the importance of considering CAD deficiency as a potential cause of epilepsy in older patients and in cases of status epilepticus with no clear underlying cause. The research was supported by the Japan Agency for Medical Research and Development and the Takeda Science Foundation. [Extracted from the article]

A report from Kumamoto University Hospital discusses the use of thiamylal as a treatment for refractory status epilepticus (RSE), a condition characterized by prolonged seizures. Thiamylal is effective in treating RSE, but it can also reduce the concentration of other antiepileptic drugs (AEDs) administered prior to thiamylal. The report highlights the need for clinicians to closely monitor the concentrations of concurrent AEDs, particularly carbamazepine, during thiamylal therapy. This information is valuable for researchers and healthcare professionals studying and treating epilepsy. [Extracted from the article]

A clinical trial, NCT06498362, is currently underway to investigate the use of LEVETIRACETAM in the management of status epilepticus in children. Status epilepticus is a neurological emergency in children, with high mortality and morbidity rates. The trial aims to determine if LEVETIRACETAM is as effective as PHENYTOIN in stopping and preventing the recurrence of status epilepticus, with better clinical tolerance. The trial is recruiting participants aged 3 months to 17 years and is expected to be completed by May 2025. [Extracted from the article]

A preprint abstract discusses the potential of a peptide-neurotensin conjugate, VH-N412, to induce pharmacological hypothermia and provide anticonvulsant, neuroprotective, and anti-inflammatory effects in mice with status epilepticus. The study explores the use of neurotensin, a neuropeptide that regulates body temperature, and its conjugation with peptides that enhance blood-brain barrier permeability. VH-N412 demonstrated improved stability, binding potential, and brain distribution, leading to rapid hypothermia, reduced inflammation, and preserved cognitive function in mice. The research suggests that vectorized neurotensin may offer neuroprotection through hypothermia and intrinsic properties. However, it is important to note that this preprint has not undergone peer review. [Extracted from the article]

A recent study conducted by researchers at the University of California Irvine explores the mechanisms by which brain insults, such as trauma, stroke, infections, and long seizures, lead to epilepsy. The study focuses on the neuron-restrictive silencing factor (NRSF/REST), which plays a role in disrupting the expression of key neuronal genes and potentially contributing to epileptogenesis. The researchers found that transient interference with REST/NRSF chromatin binding after an epilepsy-provoking seizure delayed the onset of spontaneous seizures in adult male rats. However, it did not completely prevent or abolish epilepsy. This research provides insight into the multifactorial mechanisms that contribute to epilepsy in the adult brain. [Extracted from the article]

A report from Cincinnati Children's Hospital discusses the short-term impact of seizures and potential ways to mitigate their burdens. The study conducted a systematic review of articles published between 2017 and 2023 to explore the effects of seizures and the benefits of acute treatments. The research found that seizure emergencies negatively affect the quality of life and daily activities of patients and caregivers, and are associated with physical and financial burdens. Acute treatments were found to not only reduce seizure activity but also to alleviate the short-term burdens of seizures. The study suggests that seizure action plans and acute treatments can improve the well-being of patients and caregivers. [Extracted from the article]