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Researchers at the College of Pharmacy have developed a customizable self-microemulsifying drug delivery system (SMEDDS) suppository for ibuprofen using semisolid extrusion 3D printing technology. The optimal formulation consisted of 10% Triacetin, 80% Gelucire 48/16, and 10% Tetraethylene glycol, which showed improved drug absorption in the rectum. The study suggests that SMEDDS-3DPS can enhance the rectal bioavailability of ibuprofen and highlights the versatility of 3D printing in manufacturing lipid-based suppositories tailored to individual patient needs. [Extracted from the article]

Researchers at Philipps-Universitat Marburg conducted a study to explore the feasibility of using digital image processing to predict corneal penetration of curcumin formulations. Various formulation strategies were tested, with cyclodextrins showing the deepest penetration in both dermal and corneal models. The study suggests that the image analysis method developed for ex vivo skin penetration can be repurposed for studying corneal penetration of hydrophobic drugs. Financial support for the research was provided by various organizations, including Deutscher Akademischer Austauschdienst Deutschland and Health Research Council of New Zealand. [Extracted from the article]

A recent study conducted at Universiti Kebangsaan Malaysia focused on the effectiveness of lyoprotectants in protein stabilization during lyophilization, a process commonly used in the healthcare industry. The research highlighted the importance of choosing suitable lyoprotectants to protect protein conformations and increase shelf life. The study concluded that disaccharides were the most effective lyoprotectants, while other groups were best used in combination with other lyoprotectants. This research provides valuable insights for the pharmaceutical industry and healthcare professionals. [Extracted from the article]

A recent report from Poznan University of Medical Sciences discusses the use of Centella asiatica, also known as Gotu kola, in wound healing through topical applications. The study highlights the plant's active compounds that enhance collagen synthesis, modulate inflammation, and offer antioxidant protection. Clinical trials have shown that innovative delivery systems can accelerate wound healing, reduce wound size, and improve recovery times, particularly in diabetic ulcers and burns. Future research is expected to further refine these technologies and explore new applications for C. asiatica in contemporary wound care. [Extracted from the article]

A study conducted at the University of Sydney explored the potential of delivering Lacticaseibacillus rhamnosus GG (LGG) into the lungs for treating bacterial pulmonary infections through nebulization. The research compared the efficiency of a vibrating-mesh nebulizer (VMN) and a jet nebulizer (JN) in nebulizing LGG suspended in different liquid media. The study found that the nebulization efficiency of LGG depended on the nebulizer type and the liquid medium of the probiotic suspension. [Extracted from the article]

Research conducted at the Sunnybrook Research Institute in Toronto, Canada, focused on enhancing blood-brain barrier permeability for targeted drug delivery using focused ultrasound and microbubble exposure. The study explored various sonication parameters in rabbits to minimize tissue damage while increasing permeability. Findings suggest that adjusting sonication parameters can improve the efficacy and safety of clinical protocols for this drug delivery method. The full article can be accessed in the journal Pharmaceutics. [Extracted from the article]

Researchers at University Hospital Toulouse conducted a study on the potential benefits of Provinols, a red wine polyphenol extract, in reducing neointimal growth in cholesterol-fed rabbits following angioplasty. The study found that Provinols treatment led to a reduction in intimal growth, thickness, and surface area within the stented area, as well as a decrease in lipid deposition and inflammatory response. The findings suggest that plant-derived polyphenols like Provinols may have therapeutic benefits in preventing restenosis associated with stent placement. The research was supported by the Association of Cardiology of Toulouse, France, and was published in the journal Pharmaceutics. [Extracted from the article]

A recent study conducted by the University of Fort Hare in South Africa focused on developing sodium alginate-based single- and double-layer membranes loaded with Capparis sepiaria root extract for wound healing. The membranes were found to be biodegradable, non-toxic to human skin cells, and exhibited high biocompatibility and good hemocompatibility. They also showed enhanced antimicrobial activity against pathogens responsible for wound infections, making them promising wound dressings for treating infected wounds. The research was funded by the South African Medical Research Council and involved a team of researchers from various institutions. [Extracted from the article]

Researchers from Certara UK Ltd. have developed a physiologically based pharmacokinetic (PBPK) model to evaluate the use of 4b-hydroxycholesterol (4b-OHC) as a biomarker for hepatic CYP3A activity. The model successfully simulated plasma 4b-OHC levels in different populations and captured changes in levels due to CYP3A inducers like rifampicin. This study offers a quantitative modeling framework for assessing drug-drug interaction risks related to hepatic CYP3A induction. [Extracted from the article]

Researchers at the Institute of Gene Biology in Moscow, Russia, conducted a study on the use of modular nanotransporters to deliver an anti-Keap1 monobody into mouse hepatocytes, inhibiting the production of reactive oxygen species. The study aimed to activate the antioxidant defense of cells by releasing the transcription factor Nrf2 from a complex with Keap1. The findings suggest a new approach to modulating intracellular protein interactions, specifically targeting the Keap1-Nrf2 system. For more information, the full article can be accessed for free online. [Extracted from the article]

Researchers from the University of Kragujevac in Serbia developed an immortelle essential oil-enriched hydrogel for diabetic wound repair, aiming to address the impaired healing and infection risks associated with chronic wounds in adults with diabetes mellitus. The study involved formulating the hydrogel, conducting in vivo safety tests, and assessing its wound healing capacity on diabetic rats with excision wounds. Results showed that the immortelle essential oil-based hydrogel significantly improved wound repair, suggesting its potential as a natural, safe, and effective wound-healing dressing. The research was funded by the Ministry of Science, Technological Development And Innovation, Republic of Serbia, and the Faculty of Medical Sciences, University of Kragujevac. [Extracted from the article]

A study conducted at the University of Genova focused on developing a multilayer film for the treatment of oral mucosa lesions. The film included a soluble eggshell membrane fraction and showed promising results in promoting wound healing and releasing antimicrobial substances. The research aimed to improve patients' quality of life by accelerating the recovery process and reducing the risk of bacterial infections. The findings suggest that the formulated trilayer films have properties that make them potentially suitable for protecting oral lesions and aiding in rapid healing. [Extracted from the article]

A recent study conducted by Kyung Hee University in Seoul, South Korea, focused on developing and validating an improved HPLC-MS/MS method for quantifying total and unbound lenalidomide concentrations in human plasma. The study utilized a smaller volume of plasma sample (50 mL) with a relatively short run time (2.5 min) to measure these concentrations in multiple myeloma patients with renal impairment. The research concluded that the proposed analytical method was highly reproducible, sensitive, and efficient. For more information, readers can access the full article in Pharmaceutics, published by MDPI AG. [Extracted from the article]

A recent study conducted by researchers at the University of Genoa introduced a novel 3D hydrogel sponge scaffold for cell culture, which demonstrated high porosity, optical transparency, and mechanical resistance. The scaffold was designed to enhance cellular responses for drug evaluation in preclinical studies, potentially reducing the need for animal testing. This innovative approach in pharmaceutics was supported by Compagnia Di San Paolo and offers promising applications in pharmaceutical research and testing. [Extracted from the article]

A new report presents fresh data on pharmaceutics, specifically focusing on the development of robust human liver microsomal stability prediction models. The researchers discuss the challenges of pharmacokinetic issues in drug discovery and the need for high-throughput in vitro assays to evaluate the pharmacokinetic profiles of compounds. They describe the development of an in silico model for predicting human liver microsomal stability using experimental datasets and achieved model accuracies exceeding 80%. The best model, along with a subset of the dataset, has been made publicly accessible for the benefit of the drug discovery community. This research is the largest open-source model of its kind and the first to leverage cross-species data. [Extracted from the article]

A study conducted at the University of Pittsburgh compared the manufacturing methods of protein-based long-acting injectable formulations using conventional batch and microfluidics methods. The researchers analyzed critical quality attributes such as microparticle size, size distribution, morphology, drug encapsulation efficiency, release kinetics, and batch-to-batch variations. The results showed that the microfluidics method produced microparticles with denser surface porosity, narrower size distribution, and minimal batch-to-batch variation compared to the conventional method. This study emphasizes the importance of manufacturing methods in ensuring consistency, regulatory compliance, and quality control in drug formulation. [Extracted from the article]

A study conducted by researchers at the University of Brasilia in Brazil explores the potential of photodynamic therapy (PDT) as a treatment for melanoma, a highly aggressive form of skin cancer. PDT involves using a nanoemulsion of aluminum chloride phthalocyanine (AlPcNE) to target and destroy tumors while minimizing harm to surrounding tissues. The study found that PDT had both direct and abscopal antitumor effects, meaning that even though only one tumor was treated, effects were observed in both tumors. The research also revealed significant changes in systemic inflammation and alterations in T cell populations. These findings highlight the potential of PDT to modulate immune responses and improve targeted cancer treatments. [Extracted from the article]

A recent study conducted by researchers at Hallym University in Seoul, South Korea, explored the use of a cosmetic formulation containing arginine glutamate in patients with burn scars. The researchers aimed to evaluate the efficacy and safety of the formulation in alleviating dry skin, persistent itching, and other symptoms associated with burn scars. The study involved 10 participants who used the formula twice a day for four weeks. The results showed significant improvements in itching, skin barrier function, and hydration. The researchers concluded that the formulation has the potential to be used as a topical treatment for burn scars, pending further evaluation in follow-up studies. [Extracted from the article]

A recent study conducted by researchers at the University of Barcelona explores the use of natural polymers for the encapsulation of eugenol through spray drying. Eugenol is a compound found in clove essential oil and is known for its antiseptic, anaesthetic, and antioxidant properties. The researchers optimized the spray drying process and successfully prepared biodegradable stable polymeric microcapsules containing eugenol. This research provides valuable insights into the development of formulations to protect eugenol from degradation and enhance its stability. [Extracted from the article]

A recent study conducted in Epalinges, Switzerland, explored the use of primary progenitor cells for intervertebral disc (IVD) therapy. The study aimed to preclinically qualify these cells for potential use in IVD repair and regeneration. The research found that the investigated cellular active substance was highly sustainable and yielded positive results in terms of safety and functionality. The study also established defined processes for preparing IVD spheroids using a preclinically qualified allogeneic human cell source. Overall, the study emphasized the importance of using robust product components and optimal manufacturing processes to maximize the quality of cell-based formulations. [Extracted from the article]

A new study conducted by Lek Pharmaceuticals d.d. in Ljubljana, Slovenia, explores the use of matrixing designs in stability studies for parenteral medications. Matrixing designs offer an alternative approach to traditional stability testing by testing only a fraction of samples at each time point. The study focused on three parenteral medications and found that degradation products varied among the products and that a reduction of two time points per batch was the most appropriate approach. This research contributes to the understanding of utilizing reduced matrixing designs in stability studies, which can help reduce costs and time while maintaining precision and reliability. [Extracted from the article]

A recent study conducted at Pirogov Russian National Research Medical University in Moscow, Russia, explored the effects of curcumin and cinnamic acid on mitochondria. The researchers found that curcumin, at low concentrations, activated the opening of the calcium-dependent permeability transition pore (mPTP) and decreased calcium retention capacity. Curcumin also caused a stepwise decrease in membrane potential and activated respiration, indicating that it is a mitochondrial uncoupler. Cinnamic acid had similar effects, but at higher concentrations. The study suggests that the uncoupling action of curcumin can modulate mitochondrial functions and impact cellular processes. [Extracted from the article]

Researchers from the National and Kapodistrian University of Athens have developed a methodology to estimate population pharmacokinetic (PK) parameters from patients' reported aggregate concentration-time data. The method was applied to the data of gevokizumab, a monoclonal antibody, using a second-generation minimal physiologically based pharmacokinetic (mPBPK) model. The analysis was performed using R software and Bayesian priors were applied to the parameters. The researchers concluded that this method could be used for other drugs with different PK models and when multiple aggregate datasets need to be combined for a meta-analysis. [Extracted from the article]

A recent study conducted by researchers at the International University of Health and Welfare in Narita, Japan, explored the use of thermal analysis of frozen aqueous solutions to assess the miscibility of hyaluronic acid (HA) and polymers used for dissolving microneedles. The study found that freezing aqueous polymer solutions creates a highly concentrated polymer environment that mimics the matrix of dissolving microneedles prepared through air drying. Thermal analysis of the frozen solution can provide insights into the mixing state of condensed polymers, which can be useful for predicting the physical properties of microneedles. The findings of this study have implications for the development of dissolving microneedles in the field of pharmaceutics. [Extracted from the article]

A recent report from researchers at the University of Salamanca in Spain explores the challenges of treating strongyloidiasis, a parasitic infection prevalent in tropical regions. The study focused on identifying chemical rules for drug penetration into the parasite Strongyloides venezuelensis. The researchers found that certain dyes were effective in reducing parasite viability, with some showing activity against adult parasites as well. Structural analysis revealed that positive charges facilitated compound access to the parasite tissue. These findings provide valuable insights for future drug screening and development campaigns, and may have implications for related parasites. [Extracted from the article]

A new report discusses research findings on pharmaceutics from the Technical University Munich (TU Munich) in Germany. The study focused on the influence of the drying process on the crystallization of thin sucrose films. The researchers found that the growth rate of the crystals was dependent on temperature, but not on air humidity. They also observed differences in nucleation behavior based on air humidity levels. The research provides insights into the formation of the physical state during convective drying. [Extracted from the article]

A recent study conducted by researchers at the Federal University of Para in Belem, Brazil, explores the use of acai oil-based organogels containing hyaluronic acid for topical cosmetic applications. The study found that the organogel formulation exhibited high levels of hydration, thermal protection, and release of hyaluronic acid. The acai oil used in the formulation met quality standards and demonstrated antioxidant capacity. The researchers concluded that the organogel formulation has potential for use in the cosmetic industry. [Extracted from the article]

Researchers from Shanghai Jiao Tong University School of Medicine have conducted a study on the pharmacokinetics and pharmacodynamics of remimazolam, a benzodiazepine used for sedation and anesthesia. The study aimed to establish a population model to optimize dosing regimens for sedation therapy. Data was collected from a clinical pharmacology study involving healthy Chinese volunteers, and a population PK/PD model was developed. The researchers also created a web-based dashboard to provide individualized dosing regimens. The study concluded that the established model could be used to optimize individual dosing regimens for remimazolam. [Extracted from the article]

Researchers from Peking University in Beijing, China have conducted a study on radiodynamic therapy (RDT) as a potential treatment for deep-seated tumors. RDT utilizes low-dose, high-energy radiation to activate photosensitizers and generate reactive oxygen species, which can kill cancer cells. The study explores recent advancements in the development of RDT systems, including the use of nanomaterials with high-Z metal elements, which have shown promise in inhibiting deep-seated tumors and enhancing the immune response. The researchers hope that their findings will provide valuable insights for oncology researchers and practitioners and guide future directions in RDT research. [Extracted from the article]

Researchers at the Medical University Innsbruck in Austria have conducted a study on the automated production of [68Ga]Ga-desferrioxamine B, a radiolabelled siderophore used for PET imaging of bacterial infection. The study utilized two different synthesis platforms and commercially obtainable cassettes, and the quality control was established through RP-HPLC analysis. The researchers found that both synthesis methods were able to produce [68Ga]Ga-desferrioxamine B with high reproducibility and stability, making it suitable for clinical application. This study has led to the initiation of an academic clinical trial for imaging bacterial infection. [Extracted from the article]

A recent study conducted at Hannover Medical School in Germany explored the use of a molded round window niche implant (RNI) as a delivery system for dexamethasone (DEX) in cochlear implant (CI) surgery. The researchers found that the RNI containing 10% DEX had anti-inflammatory properties and beneficial effects on hearing preservation at high frequencies. The study involved guinea pigs as a CI-trauma model and evaluated the drug release, auditory response, impedance measurement, micro-computed tomography imaging, and histology. The findings suggest that the RNI could be a promising approach for preserving residual hearing after CI surgery. [Extracted from the article]

Researchers from Universidade Estadual do Centro-Oeste in Guarapuava, Brazil have developed and characterized hydrogels and films based on cationic guar gum (CGG) for wound healing. The hydrogels showed adequate viscosity and spreadability for wound coverage, but their bioadhesive strength was reduced on injured skin. In contrast, the films maintained consistent bioadhesive strength regardless of skin condition and demonstrated superior antioxidant potential compared to the hydrogels. The films also showed biocompatibility, cell proliferation, and potential wound healing, making them promising for advanced wound treatment. [Extracted from the article]

A recent study conducted at the University of Guanajuato in Mexico evaluated the antinociceptive and anti-inflammatory effects of a patent-pending ointment containing extracts from five different plants: Eucalyptus globulus, Curcuma longa, Hamamelis virginiana, Echinacea purpurea, and Zingiber officinale. The ointment demonstrated similar antinociceptive and anti-inflammatory effects to diclofenac gel and ketoprofen gel. The antinociceptive actions of the ointment may be mediated by the opiodergic system and the nitric oxide pathway, while the anti-inflammatory response is characterized by a decrease in pro-inflammatory mediators. The study provides valuable insights into the potential therapeutic applications of this ointment. [Extracted from the article]

A recent report from the Hebrew University of Jerusalem discusses the effects of simulated microgravity on the cellular uptake of small molecules. The study found that exposure to simulated microgravity led to an increase in the cellular uptake of efflux transporter substrates, while a glucose transporter substrate showed a decrease. Additionally, the study found that the cellular emission of molecules larger than ~3000 g/mol was reduced in simulated microgravity. The researchers suggest that short-term exposure to simulated microgravity could have differential effects on drug distribution across membranes, and longer exposure during spaceflight may have distinct effects on the cellular uptake of small molecules. [Extracted from the article]

A recent article published in Pharmaceutics discusses the applications of amphiphilic copolymers (ACs) in drug release systems for skin treatment. ACs are versatile systems that can form nanomaterials such as micelles, vesicles, nanocapsules, and nanogels. These materials have been extensively studied for their ability to enhance the solubility and permeation of poorly water-soluble drugs into skin tissue, making them useful for treating skin diseases, including cancer and infections caused by bacteria, fungi, and viruses. The article provides a comprehensive analysis of the effects of ACs on various skin diseases and highlights their potential as alternative treatments. [Extracted from the article]

A recent report from Altinbas University discusses the applications of chitosan in the prevention and treatment of infectious diseases. Chitosan, a cationic biopolymer, has gained attention in the medical field due to its biocompatibility, biodegradability, and bioadhesivity. The research highlights the potential of chitosan-based systems for drug and vaccine delivery, as well as their antimicrobial, antiviral, and immunostimulatory effects. The report also discusses the technical and regulatory aspects of utilizing chitosan as a biomaterial and provides future perspectives on its utilization. For more information, readers can refer to the original article published in Pharmaceutics. [Extracted from the article]

A study conducted by the Institute of Advanced Chemistry of Catalonia in Barcelona, Spain, explored the use of lipid-based gels for the delivery of 3-O-ethyl L-ascorbic acid (ETVC) in topical applications. The study compared two lipid gel systems: a hydrogel consisting of lipids and water, and a bigel combining the hydrogel with an oleogel made from olive oil and beeswax. The results showed that the bigel exhibited slower ETVC release compared to the hydrogel, and the presence of lipids in the formulations enhanced ETVC retention in the skin. The study also found that the ETVC gels exhibited antioxidant activity. These findings provide valuable insights into the potential of lipid-based gels for topical applications. [Extracted from the article]

A recent study conducted by researchers at the State University of New York (SUNY) Buffalo has explored the distribution of drugs within different organelles of mammalian cells. The study highlights the importance of understanding how drugs are distributed within these cellular structures, as it directly impacts their efficacy and potential toxicity. The researchers discuss the unique biological features of various organelles and how they selectively accumulate or exclude drugs based on their physicochemical attributes. They also explore strategies for modulating subcellular drug distribution to enhance therapeutic efficacy and propose the use of physiologically based computational models to simulate and predict drug distribution at the subcellular level. [Extracted from the article]

Researchers from Cardinal Stefan Wyszynski University in Warsaw, Poland have conducted a study on the complexation of folic acid (FA) and its structural analog methotrexate (MTX) with cyclodextrins. The researchers found that the addition of simple sugars, such as D-glucose, D-galactose, and D-mannose, to cyclodextrins can enhance the complexation of FA and MTX. The study utilized experimental and theoretical methods to prove the complexation, and the results showed that the addition of a glucose subunit significantly increased the association constant for both FA and MTX. The research provides new insights into the field of pharmaceutics and may have implications for drug development. [Extracted from the article]

A recent study conducted at the University of Blida 1 in Algeria has explored the development of inclusion complexes of niflumic acid (NA) with 2-hydroxypropyl-b-cyclodextrin (2HP-b-CD) to address the drug's poor solubility and low bioavailability. The study investigated the effect of converting NA to its sodium salt (NAs) and adding hydroxypropyl methylcellulose (HPMC) on complex formation. The results showed that the NAs-2HP-b-CD-HPMC complex exhibited the highest drug-cyclodextrin interactions, improved solubility, and dissolution profiles. This complex has the potential to enhance the therapeutic effectiveness of NA and minimize side effects. [Extracted from the article]

A recent report from the University of Greifswald in Germany discusses the use of fiber-based technologies in pharmaceuticals. While fiber-based technologies are commonly used in various industries, their use in pharmaceuticals is limited. The researchers aimed to develop processes for the production and processing of pharmaceutical fibers for targeted drug delivery. They successfully prepared fibers loaded with a model drug using a continuous melt extrusion process and directly spun them. These fibers exhibited uniform surface smoothness and consistent tensile strength, and were further processed into tubular dosage forms that demonstrated rapid drug release. [Extracted from the article]

Researchers at the University of Bonn in Germany have developed a method for analyzing the penetration depth and kinetics of drugs in the cornea. The study used a semiquantitative imaging method and a quantitative corneal depth-cut technique to assess the penetration of fluorescein sodium in sheep corneas. The researchers found that both methods effectively demonstrated the concentration- and time-dependent depth of penetration. The study also validated the traceability of kinetic processes using polysorbate 80 as a penetration enhancer and detected the retention of larger structures in the lacrimal layer. [Extracted from the article]

A recent study conducted by researchers at Hoseo University in South Korea explored the potential wound healing and anti-melanogenic activities of Aralia elata (Miq.) Seem. flower essential oil (AESFEO) on skin cells. The study found that AESFEO promoted proliferation and collagen production in human-derived keratinocytes, while also inhibiting melanin synthesis and tyrosinase activity in melanocytes. The researchers identified 18 compounds in AESFEO through gas chromatography/mass spectrometry analysis. These findings suggest that AESFEO could be a natural substance with beneficial effects on skin wound healing and inhibition of skin pigmentation. [Extracted from the article]

A recent report from Cidade University in Recife, Brazil, discusses the development of a therapeutic dressing using papain immobilized in wet oxidized bacterial cellulose (OxBC-Papain). The study found that the OxBC-Papain membrane demonstrated enzyme stability, absorption capacity, water vapor transmission, hemocompatibility, cytotoxicity, and cell adhesion. The membrane showed potential as a natural biomolecule-based therapeutic dressing for wound care, offering efficient debridement, moisture maintenance, exudate absorption, gas exchange, and hemostasis without cytotoxic effects or cell adhesion. Further research is needed to assess its efficacy in inducing epithelialization. [Extracted from the article]

A recent study conducted by researchers at the University of Kragujevac in Serbia explored the potential anti-inflammatory effects of Melilotus officinalis, a plant traditionally used for its anti-inflammatory properties. The researchers developed gel and cream formulations containing the extract of Melilotus officinalis and evaluated their stability, safety, and anti-inflammatory activity. The formulations showed stable physical characteristics and did not cause any adverse skin reactions. The gel formulation exhibited a significant reduction in inflammation, comparable to hydrocortisone. The study suggests that these formulations have the potential to be effective and safe dermal products for treating inflammatory skin conditions. [Extracted from the article]

A recent study conducted by researchers at Washington State University (WSU) has provided new insights into the biotransformation pathways of a potential oral male contraceptive called 11b-Methyl-19-nortestosterone (11b-MNT) and its prodrugs. The study found that the oral administration of 11b-MNTDC, a prodrug of 11b-MNT, resulted in poor bioavailability of 11b-MNT due to its lower serum concentration. The researchers identified ten biotransformation products of 11b-MNT, with glucuronidation metabolites being the major ones. The study suggests that the poor and variable bioavailability of the drug may be attributed to the rapid metabolism of 11b-MNT and its prodrugs by the intestinal UGT2B17 enzyme. [Extracted from the article]