1. Therapeutic Fasting and Vitamin D Levels: A New Dimension in Type 2 Diabetes Mellitus Prevention and Management—A Brief Report.
- Author
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Nair, Pradeep M.K., Silwal, Karishma, Kodali, Prakash Babu, and Tewani, Gulab Rai
- Subjects
PREPROCEDURAL fasting ,VITAL signs ,PEARSON correlation (Statistics) ,ATTITUDES toward illness ,BODY mass index ,DATA analysis ,T-test (Statistics) ,SCIENTIFIC observation ,QUESTIONNAIRES ,VISUAL analog scale ,TREATMENT effectiveness ,VITAMIN B12 ,DESCRIPTIVE statistics ,BLOOD sugar ,WAIST circumference ,LONGITUDINAL method ,INTERMITTENT fasting ,TYPE 2 diabetes ,STATISTICS ,BLOOD pressure ,ANTHROPOMETRY ,PSYCHOLOGICAL tests ,DATA analysis software ,FASTING ,DIET therapy ,DIET in disease ,VITAMIN D - Abstract
Introduction Studies link hypovitaminosis D to be significantly associated with poor glycemic control, heightened inflammation, and risk of complications. Studies recommend fasting or calorie restriction as a useful measure to achieve diabetic reversal. The present study explores if therapeutic fasting is associated with improvement in the vitamin D levels and other clinical outcomes related to type 2 diabetes mellitus (T2DM). Methods This observational study included 26 T2DM patients exposed to a 10-day medically supervised fasting (≈ 500–1000 Kcal/day) in a complementary medicine facility. Levels of vitamin D, B12, fasting blood sugar (FBS), blood pressure, anthropometric measures, World Health Organization Quality of Life, disease perception (Brief Illness Perception Questionnaire), and self-reported vitality were measured at the baseline and the 10th day. Results Significant improvement in the levels of vitamin D (p = 0.000), B12 (p = 0.03), and reduction in FBS levels (p = 0.001), blood pressure, body mass index, waist and hip circumference (p ≤ 0.05), and improvement in quality of life, vitality, and disease perception (p < 0.001) were observed by the end of 10th day. FBS shared a negative correlation with vitamin D levels (males r = –0.1, females r = –0.48). Conclusion The present findings provide insights into the probable mechanisms by which therapeutic fasting modulates the progression of T2DM. Nevertheless, large-scale randomized controlled trials are warranted to validate the present findings. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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