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The effect of dietary approaches to stop hypertension (DASH) diet on fatty liver and cardiovascular risk factors in subjects with metabolic syndrome: a randomized controlled trial.
- Source :
-
BMC Endocrine Disorders . 7/25/2024, Vol. 24 Issue 1, p1-10. 10p. - Publication Year :
- 2024
-
Abstract
- Background: Metabolic syndrome (MetS) as a multifactorial disorder is associated with non-communicable diseases. The dietary approaches to stop hypertension (DASH) diet is a healthy dietary pattern. We investigated the effect of the DASH diet on fatty liver and cardiovascular risk factors in subjects with MetS. Methods: 60 Subjects with MetS were assigned into the intervention group (DASH diet) or the control group (a healthy diet). Fatty liver index (FLI), hepatic steatosis index (HSI), waist circumference (WC), weight, body mass index (BMI), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c) were evaluated at the beginning and after intervention. Equations of fatty liver indices such as FLI and HSI are based on liver enzymes, anthropometric variables, sex and having diabetes. Results: 30 subjects in the intervention group and 29 subjects in the control group completed the study. We found a significant reduction in the intervention group compared to the control group in FLI (-13.06 ± 10.03 vs. -2.90 ± 6.82;P < 0.001), HSI (-2.72 ± 2.59 vs. -0.81 ± 3.80;P = 0.02), WC (-6.02 ± 4.24 vs. -2.24 ± 4.28;P = 0.001), weight (-3.39 ± 2.53 vs. -1.51 ± 2.72;P = 0.008), BMI (-1.25 ± 0.93 vs. -0.56 ± 1.01;P = 0.008), DBP (-5.16 ± 3.92 vs. -1.50 ± 7.04;P = 0.01), SBP (-6.97 ± 8.21 vs. -1.36 ± 6.83;P = 0.006), TG (-18.50 ± 14.32 vs. 0.60 ± 23.81;P < 0.001), TC (-16.10 ± 17.94 vs. -5.07 ± 23.62;P = 0.04) and LDL-c (-13.50 ± 9.58 vs. -4.90 ± 18.28;P = 0.02). These results remained significant after adjusting for confounding factors, except for TC (P = 0.25). Conclusions: The DASH diet was more effective than the control diet in managing fatty liver and cardiovascular risk factors. Trial registration: The trial was registered on 21 October 2022 at Iranian Registry of Clinical Trials (IRCT20180201038585N12, URL: https://irct.behdasht.gov.ir/trial/66161). [ABSTRACT FROM AUTHOR]
- Subjects :
- *FATTY liver prevention
*CARDIOVASCULAR disease prevention
*RISK assessment
*HDL cholesterol
*FATTY liver
*RESEARCH funding
*T-test (Statistics)
*FOOD consumption
*DIETARY patterns
*BODY mass index
*HYPERTENSION
*BODY weight
*STATISTICAL sampling
*DISEASE management
*CARDIOVASCULAR diseases risk factors
*TREATMENT effectiveness
*CHI-squared test
*ANALYSIS of covariance
*RANDOMIZED controlled trials
*DESCRIPTIVE statistics
*DASH diet
*WAIST circumference
*LOW density lipoproteins
*METABOLIC syndrome
*STATISTICS
*CHOLESTEROL
*DATA analysis software
*TRIGLYCERIDES
*ANTHROPOMETRY
*DISEASE risk factors
*DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 14726823
- Volume :
- 24
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- BMC Endocrine Disorders
- Publication Type :
- Academic Journal
- Accession number :
- 178621311
- Full Text :
- https://doi.org/10.1186/s12902-024-01661-x