Search

Showing total 50 results
Start Over Topic education Publication Year Range Last 10 years
50 results

1. Systematic quantitative literature review of the dialogic pedagogy literature

Author

Paper, Original

Subjects
Dialogues -- Usage, Dialogue -- Usage, Education -- Methods, Education, Languages and linguistics
Abstract

This systematic quantitative literature review was conducted to analyse and synthesise the extant corpus of knowledge on dialogic pedagogy within school settings, and thus identify theoretical and methodological gaps in the literature, which might suggest new avenues for research. A search of eight databases (2014-2020) revealed an initial pool of 2443 papers, which was reduced to 61 after screening for eligibility. An analysis of the 61 papers was framed around the following questions: What is the dominant mode of classroom discourse (monologic or dialogic) reported in the literature? Where is dialogic pedagogy being researched? Who are the dominant voices in the field? and Which year levels and school subjects have been examined using which methodologies? A key finding of the analysis was the absence of substantial research by Australian or New Zealand authors, specifically where mathematics education is concerned. Similarly, there is little investigation focusing on the early years of schooling. While some education areas have been well researched with regard to dialogic pedagogy, further work is required that focuses on areas such as the early years of schooling; non-science contexts; and the use of qualitative research methods. Keywords Systematic quantitative literature review * Dialogic pedagogy * Dialogic practices * Dialogic teaching, 1 Introduction The purpose of this systematic quantitative literature review (SQLR) (Pickering & Byrne, 2014) is to analyse the extant literature available (2015-2020 or 2014-2019 depending on search options available) [...]

Published
2023
Full Text
View/download PDF

2. Baby Boy Jones Interactive Case-Based Learning Activity

Author

Bruce Paper, Linda Grace Solis, Bonnie Taylor, Elenice Valentim Carmona, and Lisa M. Cleveland

Subjects
E-learning (theory), education, Pilot Projects, Nursing Methodology Research, Infections, Education, User-Computer Interface, Pedagogy, Humans, Medicine, Nurse education, Education, Nursing, Internet, business.industry, Teaching, Infant, Newborn, Nurse educator, Problem-Based Learning, LPN and LVN, Pediatric Nursing, Innovative teaching, Nursing Education Research, Nursing Evaluation Research, Review and Exam Preparation, Neonatal nursing, Fundamentals and skills, Learning Management, Diffusion of Innovation, business, Limited resources, Computer-Assisted Instruction
Abstract

Faced with limited resources, nurse educators are challenged with transforming nursing education while preparing enough qualified nurses to meet future demand; therefore, innovative approaches to teaching are needed. In this article, we describe the development of an innovative teaching activity. Baby Boy Jones is a Web-delivered, case-based learning activity focused on neonatal infection. It was created using e-learning authoring software and delivered through a learning management system.

Published
2015

3. Development and Psychometric Evaluation of the Diabetes Self-Efficacy Scale

Author

Bruce Paper, Susan Grinslade, Hongjuan Jing, and Laurie Quinn

Subjects
Adult, Gerontology, Psychometrics, United Kingdom Prospective Diabetes Study, Population, Type 2 diabetes, Surveys and Questionnaires, Diabetes mellitus, medicine, Humans, education, General Nursing, Aged, Glycemic, Aged, 80 and over, Type 1 diabetes, education.field_of_study, business.industry, Reproducibility of Results, Type 2 Diabetes Mellitus, General Medicine, Middle Aged, medicine.disease, Obesity, Self Efficacy, Self Care, Diabetes Mellitus, Type 2, Female, Factor Analysis, Statistical, business
Abstract

Background and Purpose: No scales measure self-efficacy in women with Type 2 diabetes. A scale was developed and tested. Methods: Items generated, content validity index (CVI) assessed by experts, the 2-part Diabetes Self-Efficacy Scale (DSLF-I and DSLF-II) was piloted with 62 women, administered to 208 women, and then readministered to 30 women to determine initial reliability. Factor analysis was conducted for construct validity. Discriminant, convergent, and predictive validity was examined. Results: The CVI index was 98%. Cronbach's alphas were 0.88 (DSLF-I) and 0.82 (DSLF-II; pilot) and 0.87 and 0.86, respectively (main study); test-retest correlation was .60 (DSLF-I) and .69 (DSLF-II). There were 3 factors that emerged: diabetes knowledge of self-care activity, diabetes diet self-care, and diabetes medication self-care. Conclusions: The Diabetes Self-Efficacy Scale demonstrates good initial reliability and validity.Keywords: instrument development; self-efficacy; diabetes mellitus Type 2; reliability; validity; factor analysisDiabetes mellitus affects 8.3% of the population in the United States, or 25.8 million people. More than 7 million people are estimated to be undiagnosed and unaware they have the disease (Center for Disease Control and Prevention [CDC], 2011). Approximately 90%-95% of persons with diabetes have Type 2 diabetes mellitus (T2DM). The San Antonio Heart Study revealed a rising incidence of T2DM, with age, ethnicity, and neighborhood as significant predictors of T2DM (Burke et al., 1999).Although T2DM affects all ethnic and gender groups, there is a disparate effect. For example, African Americans are 1.6 times more likely to have diabetes than Whites and are more likely to go undiagnosed American Diabetes Association (ADA, 2005a). Complications from T2DM are also more prevalent in minority populations (Carter, Pugh, & Monterosa, 1996). In addition, diabetic women, compared to diabetic men, have a significantly higher prevalence of cardiovascular disease and suffer greater adverse outcomes (D'Arrigo, 1999; Gu, Cowie, & Harris, 1999; Howard et al., 1998; Smitherman & Reis, 1997). Further, Sowers (1998) reported that the gender protectiveness for coronary heart disease (CHD) declines in women between the ages of 50 and 59 years, and that the loss of gender protectiveness increases the risk ratio for CHD to 3.5 for women with diabetes compared to 2.4 for men with diabetes (p. 618). Koerbel and Korytkowski (2003) stated that women with diabetes not only have greater risk for cardiovascular disease but they also suffer greater adverse outcomes. They cite several factors, which increase this risk in women: poorer glycemic control, elevated blood pressure and lipids, central obesity, increased depression and lower socioeconomic status. These factors contribute to increased morbidity and health care costs for women with diabetes. These data support the need for more research into prevention, detection, and cost-effective methods to effectively manage T2DM and prevent its complications in women.Maintenance of health and prevention of diabetic complications require significant changes in lifestyle management and adherence to a therapeutic diabetic regimen. Behavior change and adherence are not only difficult but are also often inadequate to maintain recommended glycemic control (Anderson, Fitzgerald, & Oh, 1993; Skelly, Marshall, Haughey, Davis, & Dunford, 1995). The importance of participation in diabetic self-care behavior in achieving glycemic control has been demonstrated by the Diabetes Control and Complications Trial Research Group (1993) for individuals with Type 1 diabetes mellitus (T1DM) and by the United Kingdom Prospective Diabetes Study Group (1998) for individuals with T2DM. This goal is accomplished through a therapeutic alliance among clients, family, and health care providers to promote self-care behaviors and therapeutic modalities (ADA, 2005b). Self-care behaviors include a combination of changing or modifying eating habits, maintaining weight or achieving weight loss, participating in a physical exercise program, self-monitoring of blood glucose, and/or taking oral or injectable medication. …

Published
2015

5. The Lake Chad Basin from the water crisis to geopolitic emergency

Author

R. Fayad, A.M. Hassanein, N. Varani, S. Franzoni, B. Schlegelmisch, F. Gennari, T. Karkoszka, A. Zablocki, M. Arifin, K. Prammer, S. De Andreis, T. Erdos, D. Paper, Q. Aboagye, and M Houston

Subjects
ecosystem, education.field_of_study, Human Development Index, Population, Climate change, terrorism, Human Poverty Index, water resources, Water scarcity, basin, Water resources, water resources, basin, water crisis, ecosystem, terrorism, Human Development Index, Human Poverty Index, Global Hunger Index, Economy, Terrorism, Environmental science, Global Hunger Index, education, Environmental planning, water crisis
Abstract

The paper has the aim of reflect on the current situation of the Lake Chad Basin, characterized by the increasing Humanitarian Situation , determined not more only from the water crisis, but from the progressive presence of terrorist militias of the fundamentalist group Boko Haram. Indeed, today, environmental and social degradation of forests, increasingly advanced, the increasing salinization of soils, the proliferation of aquatic vegetation, the high concentration of population around the lake and wetlands exacerbate exploitation of resources and stir up the anarchist social conflicts. Scholars therefore speak of climate refugees, who face not only climate change, but also international terrorism . In the realization of the paper we will use the Human Development Index ( HDI ), the Human Poverty Index ( HPI ) and the Global Hunger Index referring to countries bordering Lake Chad, in order to better understand the phenomena under investigation

Published
2015

10. Fruit and vegetable consumption and sarcopenia among older adults in low- and middle-income countries

Author

Hans Oh, Louis Jacob, Ai Koyanagi, Lin Yang, Marco Solmi, Nicola Veronese, Lee Smith, Josep Maria Haro, Jae Il Shin, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), National Institute on Aging, NIA: OGHA 04034785, PI15/00862, R01‐AG034479, R21‐AG034263, Y1‐AG‐1005–01, YA1323–08‐CN‐0020 European Regional Development Fund, FEDER: ERDF?FEDER, Acknowledgments: This paper uses data from WHO’s Study on Global Ageing and Adult Health (SAGE). SAGE is supported by the U.S. National Institute on Aging through Interagency Agreements OGHA 04034785, YA1323–08‐CN‐0020, Y1‐AG‐1005–01 and through research grants R01‐AG034479 and R21‐AG034263. Ai Koyanagi’s work is supported by the PI15/00862 project, integrated into the National R + D + I and funded by the ISCIII‐General Branch Evaluation and Promotion of Health Research and the European Regional Development Fund (ERDF‐FEDER)., This paper uses data from WHO?s Study on Global Ageing and Adult Health (SAGE). SAGE is supported by the U.S. National Institute on Aging through Interagency Agreements OGHA 04034785, YA1323?08?CN?0020, Y1?AG?1005?01 and through research grants R01?AG034479 and R21?AG034263. Ai Koyanagi?s work is supported by the PI15/00862 project, integrated into the National R + D + I and funded by the ISCIII?General Branch Evaluation and Promotion of Health Research and the European Regional Development Fund (ERDF?FEDER)., Koyanagi, A., Veronese, N., Solmi, M., Oh, H., Shin, J.I., Jacob, L., Yang, L., Haro, J.M., and Smith, L.

Subjects
Male, Future studies, Logistic regression, Persones grans, older people, Eating, 0302 clinical medicine, Vegetables, vegetable, fruit, low- and middle-income countries, older people, sarcopenia, vegetable, low- and middle-income countries, 030212 general & internal medicine, Aged, 80 and over, 2. Zero hunger, education.field_of_study, Nutrition and Dietetics, Hand Strength, Smoking, Age Factors, 3. Good health, Income, Female, lcsh:Nutrition. Foods and food supply, Alcohol Drinking, Population, lcsh:TX341-641, 030209 endocrinology & metabolism, Article, Odds, sarcopenia, 03 medical and health sciences, Sex Factors, medicine, Humans, education, Developing Countries, Exercise, Poverty, Hortalisses, Adult health, Aged, Consumption (economics), business.industry, Low‐ and middle‐income countries, fruit, medicine.disease, Fruita, Cross-Sectional Studies, Low and middle income countries, Fruit, Sarcopenia, Older people, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, human activities, Food Science, Demography
Abstract

Fruit and vegetable consumption may protect against sarcopenia but there are no studies on this topic from low- and middle-income countries (LMICs). Thus, we assessed this association among older adults from six LMICs. Community-based cross-sectional data of the Study on Global Aging and Adult Health were analyzed. Sarcopenia was defined as the presence of low skeletal muscle mass based on indirect population formula, and either slow gait or low handgrip strength. Quintiles of vegetable and fruit consumption were created based on the number of servings consumed on a typical day. Multivariable logistic regression analysis was conducted. The sample consisted of 14,585 individuals aged &ge, 65 years (mean (SD) age 72.6 (11.4) years, 55% females). Adjusted analyses showed that overall, compared to the lowest quintile (Q1), the highest quintile (Q5) of fruit consumption was associated with a 40% lower odds for sarcopenia (OR = 0.60, 95% CI = 0.42-0.84) but this association was largely driven by the strong association among females (e.g., Q5 vs. Q1 OR = 0.42, 95% CI = 0.24&minus, 0.73), with no significant associations found among males. Vegetable consumption was not significantly associated with sarcopenia. Future studies of longitudinal design may shed light on whether increasing fruit consumption among older females in LMICs may reduce risk for sarcopenia.

Published
2020

13. Migration in geographic and ecological space by a large herbivore

Author

Atle Mysterud, Nicolas Morellet, Stefano Focardi, Ferdinando Urbano, Marco Heurich, Derek B. Spitz, Wibke Peters, Francesca Cagnacci, John D. C. Linnell, Mark Hebblewhite, Petter Kjellander, Department of Ecosystem and Conservation Science, Wildlife Biology Program, University of Montana, Research and Innovation Centre, Biodiversity and Molecular Ecology Department, Edmund Mach Foundation (FEM), Centre for Ecological and Evolutionary Synthesis (CEES), Department of Biosciences [Oslo], Faculty of Mathematics and Natural Sciences [Oslo], University of Oslo (UiO)-University of Oslo (UiO)-Faculty of Mathematics and Natural Sciences [Oslo], University of Oslo (UiO)-University of Oslo (UiO), Istituto Superiore per la Protezione e la Ricerca Ambientale (ISPRA), Unité de recherche Comportement et Ecologie de la Faune Sauvage (CEFS), Institut National de la Recherche Agronomique (INRA), Department of Conservation and Research, Bavarian Forest National Park, Faculty of Environment and Natural Resources, Wildlife Ecology and Management, University of Freiburg, Grimsö Wildlife Research Station, Department of Ecology, Swedish University of Agricultural Sciences (SLU)-Swedish University of Agricultural Sciences (SLU), Norwegian Institute for Nature Research (NINA), Organismic and Evolutionary Biology Department, Harvard University [Cambridge], This paper was conceived and written within the collaborative EURODEER project (paper no. 006 of the EURODEER series, Department of Ecology, Grimsö Wildlife Research Station, Swedish University of Agricultural Sciences (SLU), and Peters, Wibke

Subjects
0106 biological sciences, Range (biology), migration spatiotemporelle, Population, Niche, Zoology and botany: 480 [VDP], normalized difference vegetation index, capreolus capreolus, migration animale, 010603 evolutionary biology, 01 natural sciences, behavioral plasticity, Capreolus, Settore BIO/05 - ZOOLOGIA, biology.animal, Biologie animale, ungulates, Realized niche width, 10. No inequality, education, Zoologiske og botaniske fag: 480 [VDP], Ecology, Evolution, Behavior and Systematics, Animal biology, Ecological niche, animal migration, education.field_of_study, partial migration, biology, Ecology, 010604 marine biology & hydrobiology, [SDV.BA]Life Sciences [q-bio]/Animal biology, 15. Life on land, biology.organism_classification, spatiotemporal variation, faune sauvage, Roe deer, large herbivores, ecological distance, realized niche, niche switching, Spatial variability
Abstract

Partial migration, when only part of the population migrates seasonally while the other part remains resident on the shared range, is the most common form of migration in ungulates. Migration is often defined by spatial separation of seasonal ranges and consequently, classification of individuals as migrants or residents is usually only based on geographic criteria. However, the underlying mechanism for migration is hypothesized to be movement in response to spatiotemporal resource variability and thus, migrants are assumed to travel an “ecological distance” (ED) or shift their realized ecological niches. While ecological and geographic distances should be related, their relationship may depend on landscape heterogeneity. Here, we tested the utility of ecological niche theory to both classify migratory individuals and to understand the underlying ecological factors for migratory behavior. We developed an integrative approach combining measures in geographic and ecological niche space and used this to classify and explain migratory behavior of 71 annual roe deer (Capreolus capreolus) movement trajectories in five European study areas. First, to assess the utility of the ED concept for classifying migratory behavior, we tested whether roe deer sought the same ecological conditions year-round or moved to different ecological conditions by measuring the annual ED travelled and the seasonal niche overlap using multivariate statistics. Comparing methods to classify migrants and residents based on geographic and ecological niche space, we found that migratory roe deer switched between seasons both in geographic and in ecological dimensions. Second, we tested which seasonal ecological factors separated resident from migrant niches using discriminant analysis and which broad-scale determinants (e.g., spatiotemporal forage variation and population density) predicted migration probability using generalized linear models. Our results indicated that factors describing forage and topographic variability discriminated seasonal migrant from resident niches. Determinants for predicting migration probability included the temporal variation (seasonality) and also the spatial variability of forage patches. Last, we also found suggestive evidence for a positive relationship between population density and migration probability. By applying the ecological niche concept to the study of partial migration in ungulates, our work underlines that partial migration is a form of behavioral plasticity. Key words: behavioral plasticity; Capreolus capreolus; ecological distance; large herbivores; niche switching; Normalized Difference Vegetation Index; partial migration; realized niche; spatiotemporal variation; ungulates

Published
2017

14. FULL PAPER

Author

Full Paper

Subjects
Education, Education (General), L7-991
Published
2019

15. FULL PAPER

Author

FULL PAPER

Subjects
Education, Education (General), L7-991
Published
2017

16. Exploração de instrumentos de avaliação de idiomas e seus princípios

Author

Claudio Díaz Larenas, Alan Jara Díaz, Yesenia Rosales Orellana, María José Sanhueza Villalón, and This paper is in the context of the research grants FONDECYT 1191021 entitled Estudio correlacional y propuesta de intervención en evaluación del aprendizaje del inglés: las dimensiones cognitiva, afectiva y social del proceso evaluativo del idioma extran

Subjects
050101 languages & linguistics, Language Assessment, Assessment Instruments, Assessment Principles, Teachers, English, Princípios de Avaliação Linguística, lcsh:Education (General), Avaliação, Education, assessment instruments, Profesorado, Principios de Evaluación del Idioma, Ferramentas de Avaliação, 0501 psychology and cognitive sciences, language assessment, Instrumentos de Evaluación, teachers, Evaluación, 05 social sciences, 050301 education, Language assessment, Professores, assessment principles, Ingleses, Inglés, lcsh:L7-991, english, 0503 education
Abstract

The instruments language teachers employ to assess student learning are rarely studied and they constitute a significant source of input of how learning and teaching are conceived. The aim of this research is to analyze 205 assessment instruments created by English teachers. This is an exploratory case study, in which the assessment principles of Authenticity, Validity, Fairness, Reliability and Practicality were analyzed within the context of the assessment instruments. The 205 assessment instruments were analyzed by using an analytic rubric, which considered the language assessment principles as criteria. Through the different analyses, it is possible to conclude that traditional assessment was favoured over authentic assessment and four different clusters reveal that language assessment principles manifest in different degrees in each type of instrument. Interestingly, although language learning is mainly about how people try to communicate with others, teachers are still stressing the assessment of grammar and vocabulary knowledge instead of helping students develop the skill of foreign language communication through key authentic assessment, self-assessment and peer-assessment techniques and procedures. Resumo Os instrumentos que os professores de línguas utilizam para avaliar a aprendizagem dos alunos raramente são estudados e são uma fonte significativa de informações sobre como a aprendizagem e o ensino são concebidos. O objetivo da pesquisa é analisar 205 instrumentos de avaliação fornecidos por professores de inglês. Este é um estudo de caso exploratório, onde os princípios de avaliação da linguagem analisados foram Autenticidade, Validade, Equidade, Confiabilidade e Praticidade. Estes 205 instrumentos de avaliação foram analisados através da utilização de uma rubrica analítica, que considerou os princípios da avaliação linguística como critérios. Por meio das diferentes análises foi possível concluir que a avaliação tradicional é favorecida sobre a avaliação autêntica e quatro agrupamentos diferentes revelam que os princípios de avaliação da linguagem manifestam-se em diferentes graus em cada tipo de instrumento. Curiosamente, embora a aprendizagem de línguas seja principalmente sobre como as pessoas tentam se comunicar com outras, os professores ainda estão enfatizando a avaliação do conhecimento de gramática e vocabulário em vez de ajudar os alunos a desenvolver a habilidade de comunicação em língua estrangeira por meio de técnicas e procedimentos autênticos de avaliação, autoavaliação e coavaliação. Resumen Los instrumentos que el profesorado de idiomas emplea para evaluar el aprendizaje son raramente estudiados, y ellos constituyen una fuente significativa de input sobre la forma como se concibe el aprendizaje y la Enseñanza. El propósito de la investigación es analizar 205 instrumentos de evaluación proporcionados por profesores de inglés. Este es un estudio de casos exploratorio, en el cual los principios de evaluación del idioma analizados fueron Autenticidad, Validez, Equidad, Confiabilidad y Practicabilidad. Estos 205 instrumentos de evaluación fueron analizados mediante el uso de una rúbrica analítica, la cual consideró los principios de evaluación del idioma como criterios. Mediante los diferentes análisis presentados en este estudio, es posible concluir que la evaluación tradicional es preferida sobre la evaluación auténtica; además, cuatro diferentes grupos revelan que los principios de evaluación del idioma se manifiestan en diferentes grados en cada tipo de instrumento de evaluación. Interesantemente, aunque el aprendizaje de la lengua consiste principalmente en cómo las personas se comunican con otros, el profesorado aún enfatiza la evaluación de la gramática y el vocabulario en vez de ayudar al estudiantado a desarrollar la habilidad de comunicación en una lengua extranjera mediante técnicas y procedimientos de evaluación auténtica, auto-evaluación y co-evaluación.

Published
2021

18. Urban environment and cognitive and motor function in children from four European birth cohorts

Author

Marina Vafeiadi, Raquel Soler-Blasco, Mariza Kampouri, Mònica Guxens, Martine Vrijheid, Johanna Lepeule, Llúcia González-Safont, Mark J. Nieuwenhuijsen, Mark Mon-Williams, John Wright, Rosie McEachan, Anne-Claire Binter, Claire Philippat, Jonathan Y. Bernard, Jordi Sunyer, Loreto Santa-Marina, Leda Chatzi, Lucia Alonso, Ainara Andiarena, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Agency for science, technology and research [Singapore] (A*STAR), University of South-Eastern Norway (USN), University of the Basque Country/Euskal Herriko Unibertsitatea (UPV/EHU), CIBER de Epidemiología y Salud Pública (CIBERESP), Universitat Jaume I, University of Crete [Heraklion] (UOC), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana [Espagne] (FISABIO), University of Bradford, University of Southern California (USC), Universitat Pompeu Fabra [Barcelona] (UPF), Erasmus University Medical Center [Rotterdam] (Erasmus MC), This work was supported by funding from the European Community’s Seventh Framework Programme [FP7/2007–206 n◦308333, the HELIX project]. This INMA cohort was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041, PI041436, PI081151 incl. FEDER funds, FIS PI06/0867, FIS-PI09/00090, FIS and FIS-PI18/01142 incl. FEDER funds, FIS-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/1213, PI07/0314, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, PI16/00118 and PI17/00663, FIS-FSE: 17/00260, Miguel Servet-FEDER CP11/00178, CP15/00025, CPII16/00051, and CPII18/00018), from UE (FP7-ENV-2011 cod 282957, HEALTH.2010.2.4.5-1, and H2020 n◦824989), Generalitat de Catalunya-CIRIT 1999SGR 00241, Fundació La marató de TV3 (090430), Generalitat Valenciana: FISABIO (UGP 15-230, UGP-15-244, and UGP-15-249), Alicia Koplowitz Foundation 2017, CIBERESP, Department of Health of the Basque Government (2013111089, 2009111069, 2013111089, 2015111065 and 2018111086), Provincial Government of Gipuzkoa (DFG06/002, DFG08/001, DFG15/221 and DFG 89/17) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain). We acknowledge support from the Spanish Ministry of Science and Innovation and the State Research Agency through the 'Centro de Excelencia Severo Ochoa 2019-2023' Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. The work was also supported by MICINN [MTM2015-68140- R] and Centro Nacional de Genotipado- CEGEN- PRB2- ISCIII (Spain). The Rhea project was financially supported by European projects, and the Greek Ministry of Health (Program of Prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece: 2011–2014, 'Rhea Plus': Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012–15). This paper presents independent research funded by the National Institute for Health Research (NIHR) under its Collaboration for Applied Health Research and Care (CLAHRC) for Yorkshire and Humber (UK). The EDEN study was supported by Foundation for medical research (FRM), National Agency for Research (ANR), National Institute for Research in Public health (IRESP: TGIR cohorte santé 2008 program), French Ministry of Health (DGS), French Ministry of Research, INSERM Bone and Joint Diseases National Research (PRO-A), and Human Nutrition National Research Programs, Paris-Sud University, Nestlé, French National Institute for Population Health Surveillance (InVS), French National Institute for Health Education (INPES), the European Union FP7 programs (ESCAPE, ENRIECO, Medall projects), Diabetes National Research Program (through a collaboration with the French Association of Diabetic Patients (AFD)), French Agency for Environmental Health Safety and French National Agency for Food Security (now ANSES), Mutuelle Générale de l’Education Nationale a complementary health insurance (MGEN), French-speaking association for the study of diabetes and metabolism (ALFEDIAM). Core support for Born in Bradford is also provided by the Wellcome Trust (WT101597MA, UK). Born in Bradford (BiB) is only possible because of the enthusiasm and commitment of the children and parents in BiB. We are grateful to all the participants, health professionals, schools and researchers who have made BiB happen. BiB receives funding from the ESRC/MRC, the Wellcome Trust (WT101597MA) and the National Institute for Health Research Yorkshire and Humber ARC (reference: NIHR20016). M. Mon-Williams was supported by a Fellowship from the Alan Turing Institute. Additional funding from the National Institute of Environmental Health Science supported Dr Chatzi (R01ES030691, R01ES029944, R01ES030364, R21ES029681, and P30ES007048). The views expressed are those of the authors, and not necessarily those of the NHS or the NIHR. None of the funders were involved in designing the study, collecting the data, analyzing or interpreting the data, deciding to submit the article for publication, or the writing of the report., HESAM Université (HESAM)-HESAM Université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Singapore Institute for Clinical Sciences [Singapour] (SICS), Bradford Institute for Health Research [Bradford, UK], Bradford Teaching Hospitals NHS Foundation Trust [Bradford, UK] (BTHFT), University of Leeds, Universitat de València (UV), Karolinska Institutet [Stockholm], Binter, Anne-Claire, Child and Adolescent Psychiatry / Psychology, Erasmus MC other, European Commission, Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA)

Subjects
Urban environment, 010501 environmental sciences, 01 natural sciences, 0302 clinical medicine, Cognition, Pregnancy, Cognició en els infants, 11. Sustainability, GE1-350, 030212 general & internal medicine, Children, Motor skill, ComputingMilieux_MISCELLANEOUS, Desenvolupament urbà, General Environmental Science, SDG 15 - Life on Land, 2. Zero hunger, education.field_of_study, Air Pollutants, 4. Education, motor function, Cohort, cohort, SDG 11 - Sustainable Cities and Communities, 3. Good health, Child, Preschool, Birth Cohort, Female, Cognitive function, Psychology, Population, Gross motor skill, 03 medical and health sciences, children, Urban planning, Air Pollution, medicine, Humans, education, Motor function, cognitive function, 0105 earth and related environmental sciences, Environmental Exposure, medicine.disease, urban environment, Confidence interval, Environmental sciences, Spain, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Particulate Matter, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Demography
Abstract

[EN]Background: The urban environment may influence neurodevelopment from conception onwards, but there is no evaluation of the impact of multiple groups of exposures simultaneously. We investigated the association between early-life urban environment and cognitive and motor function in children. Methods: We used data from 5403 mother-child pairs from four population-based birth-cohorts (UK, France, Spain, and Greece). We estimated thirteen urban home exposures during pregnancy and childhood, including: built environment, natural spaces, and air pollution. Verbal, non-verbal, gross motor, and fine motor functions were assessed using validated tests at five years old. We ran adjusted multi-exposure models using the Deletion-Substitution-Addition algorithm. Results: Higher greenness exposure within 300 m during pregnancy was associated with higher verbal abilities (1.5 points (95% confidence interval 0.4, 2.7) per 0.20 unit increase in greenness). Higher connectivity density within 100 m and land use diversity during pregnancy were related to lower verbal abilities. Childhood exposure to PM2.5 mediated 74% of the association between greenness during childhood and verbal abilities. Higher exposure to PM2.5 during pregnancy was related to lower fine motor function (-1.2 points (-2.1, -0.4) per 3.2 mu g/m3 increase in PM2.5). No associations were found with non-verbal abilities and gross motor function. Discussion: This study suggests that built environment, greenness, and air pollution may impact child cognitive and motor function at five years old. This study adds evidence that well-designed urban planning may benefit children's cognitive and motor development. Acknowledgements We are grateful to all the participating children, parents, practi-tioners and researchers in the four countries who took part in this study. This work was supported by funding from the European Community's Seventh Framework Programme [FP7/2007-206 n 308333; the HELIX project] . This INMA cohort was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds, FIS PI06/0867, FIS-PI09/00090, FIS and FIS-PI18/01142 incl. FEDER funds, FIS-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/1213, PI07/0314, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, PI16/00118 and PI17/00663; FIS-FSE: 17/00260; Miguel Servet-FEDER CP11/00178, CP15/00025, CPII16/00051, and CPII18/00018) , from UE (FP7-ENV-2011 cod 282957, HEALTH.2010.2.4.5-1, and H2020 n 824989) , Generalitat de Catalunya-CIRIT 1999SGR 00241, Fundacio La marato de TV3 (090430) , Generalitat Valenciana: FISABIO (UGP 15-230, UGP-15-244, and UGP-15-249) , Alicia Koplowitz Foundation 2017, CIBERESP, Department of Health of the Basque Government (2013111089, 2009111069, 2013111089, 2015111065 and 2018111086) , Provincial Government of Gipuzkoa (DFG06/002, DFG08/001, DFG15/221 and DFG 89/17) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain) . We acknowledge support from the Spanish Ministry of Science and Inno-vation and the State Research Agency through the "Centro de Excelencia Severo Ochoa 2019-2023" Program (CEX2018-000806-S) , and support from the Generalitat de Catalunya through the CERCA Program. The work was also supported by MICINN [MTM2015-68140-R] and Centro Nacional de Genotipado-CEGEN-PRB2-ISCIII (Spain) . The Rhea project was financially supported by European projects, and the Greek Ministry of Health (Program of Prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece: 2011-2014; "Rhea Plus": Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012-15) . This paper presents independent research funded by the National Institute for Health Research (NIHR) under its Collaboration for Applied Health Research and Care (CLAHRC) for Yorkshire and Humber (UK) . The EDEN study was supported by Foundation for medical research (FRM) , National Agency for Research (ANR) , National Institute for Research inPublic health (IRESP: TGIR cohorte sante 2008 program) , French Min-istry of Health (DGS) , French Ministry of Research, INSERM Bone and Joint Diseases National Research (PRO-A) , and Human Nutrition Na-tional Research Programs, Paris-Sud University, Nestle, French National Institute for Population Health Surveillance (InVS) , French National Institute for Health Education (INPES) , the European Union FP7 pro-grams (ESCAPE, ENRIECO, Medall projects) , Diabetes National Research Program (through a collaboration with the French Association of Diabetic Patients (AFD) ) , French Agency for Environmental Health Safety and French National Agency for Food Security (now ANSES) , Mutuelle Generale de l'Education Nationale a complementary health insurance (MGEN) , French-speaking association for the study of diabetes and metabolism (ALFEDIAM) . Core support for Born in Bradford is also provided by the Wellcome Trust (WT101597MA, UK) . Born in Bradford (BiB) is only possible because of the enthusiasm and commitment of the children and parents in BiB. We are grateful to all the participants, health professionals, schools and researchers who have made BiB happen. BiB receives funding from the ESRC/MRC, the Wellcome Trust (WT101597MA) and the National Institute for Health Research York-shire and Humber ARC (reference: NIHR20016) . M. Mon-Williams was supported by a Fellowship from the Alan Turing Institute. Additional funding from the National Institute of Environmental Health Science supported Dr Chatzi (R01ES030691, R01ES029944, R01ES030364, R21ES029681, and P30ES007048) . The views expressed are those of the authors, and not necessarily those of the NHS or the NIHR. None of the funders were involved in designing the study, collecting the data, analyzing or interpreting the data, deciding to submit the article for publication, or the writing of the report. Data sharing statement The HELIX data warehouse has been established as an accessible resource for collaborative research involving researchers external to the project. Access to HELIX data is based on approval by the HELIX Project Executive Committee and by the individual cohorts. Further details on the content of the data warehouse (data catalogue) and procedures for external access are described on the project website (http:// www.proj-ecthelix.eu/index.php/es/data-inventory) .

Published
2022

19. FULL PAPER

Author

FULL PAPER

Subjects
Education, Education (General), L7-991
Abstract

Full Paper Vol. 1 No. 2 November 2015

Published
2015
Full Text
View/download PDF

20. Mixture modeling for identifying subtypes in disease course mapping

Author

Stanley Durrleman, Pierre-Emmanuel Poulet, Algorithms, models and methods for images and signals of the human brain (ARAMIS), Sorbonne Université (SU)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), This research has received funding from the program 'Investissements d’avenir' ANR-10-IAIHU-06. This work was also funded in part by the French government under management of Agence Nationale de la Recherche as part of the 'Investissements d’avenir' program, reference ANR-19-P3IA-0001 (PRAIRIE 3IA Institute)., Aasa Feragen, Stefan Sommer, Julia Schnabel, Mads Nielsen, ANR-19-P3IA-0001,PRAIRIE,PaRis Artificial Intelligence Research InstitutE(2019), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), This paper is funded in part by grant number 678304 (ERC), 826421 (TVB-Cloud) from H2020 programme, and ANR-10-IAIHU-06 (IHU ICM), ANR-19-P3IA-0001 (PRAIRIE) and ANR-19-JPW2-000 (E-DADS) from ANR., Poulet, Pierre-Emmanuel, PaRis Artificial Intelligence Research InstitutE - - PRAIRIE2019 - ANR-19-P3IA-0001 - P3IA - VALID, Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Computer science, Population, Stochastic approximation, Machine learning, computer.software_genre, 01 natural sciences, Synthetic data, 010104 statistics & probability, 03 medical and health sciences, 0302 clinical medicine, [STAT.ML]Statistics [stat]/Machine Learning [stat.ML], Alzheimer's disease subtypes, mixed-effect models, 0101 mathematics, Cognitive decline, mixture models, education, Cluster analysis, Non-linear mixed-effect model, ComputingMilieux_MISCELLANEOUS, Mixture model, Ground truth, education.field_of_study, MCMC-SAEM, business.industry, Contrast (statistics), Disease course mapping, Disease progression modelling, [STAT.ML] Statistics [stat]/Machine Learning [stat.ML], Artificial intelligence, business, computer, [STAT.ME]Statistics [stat]/Methodology [stat.ME], 030217 neurology & neurosurgery
Abstract

International audience; Disease modeling techniques summarize the possible trajectories of progression from multimodal and longitudinal data. These techniques often assume that individuals form a homogeneous cluster, thus ignoring possible disease subtypes within the population. We extend a non-linear mixed-effect model used for disease course mapping with a mixture framework. We jointly estimate model parameters and subtypes with a tempered version of a stochastic approximation of the Expectation Maximisation algorithm. We show that our model recovers the ground truth parameters from synthetic data, in contrast to the naive solution consisting in post hoc clustering of individual parameters from a one-class model. Applications to Alzheimer's disease data allows the unsupervised identification of disease subtypes associated with distinct relationship between cognitive decline and progression of imaging and biological biomarkers.

Published
2021

21. The Fairness of Credit Scoring Models

Author

Christophe Pérignon, Christophe Hurlin, Sébastien Saurin, Université d'Orléans (UO), Ecole des Hautes Etudes Commerciales (HEC Paris), and HEC Paris Research Paper Series

Subjects
FOS: Computer and information sciences, Computer Science - Machine Learning, History, Polymers and Plastics, Computer science, media_common.quotation_subject, Population, Machine Learning (stat.ML), JEL: C - Mathematical and Quantitative Methods/C.C5 - Econometric Modeling/C.C5.C55 - Large Data Sets: Modeling and Analysis, Screening algorithm, Industrial and Manufacturing Engineering, Machine Learning (cs.LG), FOS: Economics and business, Race (biology), JEL: G - Financial Economics/G.G2 - Financial Institutions and Services/G.G2.G21 - Banks • Depository Institutions • Micro Finance Institutions • Mortgages, Statistics - Machine Learning, Rest (finance), 0502 economics and business, 050207 economics, Business and International Management, 10. No inequality, education, media_common, education.field_of_study, 050208 finance, Actuarial science, 05 social sciences, Significant difference, JEL: C - Mathematical and Quantitative Methods/C.C1 - Econometric and Statistical Methods and Methodology: General/C.C1.C10 - General, Test (assessment), Interest rate, Risk Management (q-fin.RM), [SHS.GESTION]Humanities and Social Sciences/Business administration, JEL: G - Financial Economics/G.G2 - Financial Institutions and Services/G.G2.G29 - Other, Quantitative Finance - Risk Management, JEL: C - Mathematical and Quantitative Methods/C.C3 - Multiple or Simultaneous Equation Models • Multiple Variables/C.C3.C38 - Classification Methods • Cluster Analysis • Principal Components • Factor Models
Abstract

In credit markets, screening algorithms discriminate between good-type and bad-type borrowers. This is their raison d’être. However, by doing so, they also often discriminate between individuals sharing a protected attribute (e.g. gender, age, race) and the rest of the population. In this paper, we show how to test (1) whether there exists a statistical significant difference in terms of rejection rates or interest rates, called lack of fairness, between protected and unprotected groups and (2) whether this difference is only due to credit worthiness. When condition (2) is not met, the screening algorithm does not comply with the fair-lending principle and can be qualified as illegal. Our framework provides guidance on how algorithmic fairness can be monitored by lenders, controlled by their regulators, and improved for the benefit of protected groups.

Published
2021

22. The impact of diabetes on heart failure development: the cardio-renal-metabolic connection

Author

Paul Valensi, Jean-Michel Halimi, Erwan Donal, Sara Pinto, Gaëtan Prévost, Jonchère, Laurent, Service d'endocrinologie diabétologie, nutrition (Hôpital Jean Verdier), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Jean Verdier [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Sorbonne Paris Nord, Centre de Recherche en Nutrition Humaine d'Ile-de-France (CRNH-IDF), Institut de Veille Sanitaire (INVS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Institut National Agronomique Paris-Grignon (INA P-G)-CETAF-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Sorbonne Paris Nord, CHU Rouen, Normandie Université (NU), Service de néphrologie et immunologie clinique [CHRU Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Hôpital Bretonneau-Université de Tours (UT), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], For this review paper the authors did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors., Institut de Veille Sanitaire (INVS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut National Agronomique Paris-Grignon (INA P-G)-CETAF-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Sorbonne Paris Nord, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de néphrologie et immunologie clinique [CHRU Tours] (EA4245 UT), and Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Université de Tours-Hôpital Bretonneau

Subjects
medicine.medical_specialty, GLP1-receptor agonists, Endocrinology, Diabetes and Metabolism, Population, heart failure, 030209 endocrinology & metabolism, Type 2 diabetes, urologic and male genital diseases, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Diabetes mellitus, Internal Medicine, medicine, Humans, 030212 general & internal medicine, Renal Insufficiency, Chronic, education, Intensive care medicine, Contraindication, [SDV.IB] Life Sciences [q-bio]/Bioengineering, education.field_of_study, business.industry, Diabetes, General Medicine, medicine.disease, [SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, 3. Good health, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Natural history, Diabetes Mellitus, Type 2, Heart failure, [SDV.IB]Life Sciences [q-bio]/Bioengineering, business, SGLT2 inhibitors, chronic kidney disease, coronary artery disease, Kidney disease
Abstract

Heart failure (HF) and chronic kidney disease (CKD) are often associated in type 2 diabetes (T2D), aggravate each other and exert synergistic effects to increase the risk of cardiac and renal events. The risks of renal worsening in HF patients and HF in CKD patients need to be evaluated to tailor preventive therapy. The recent CV and renal trials enriched our knowledge about the natural history of HF and CKD in T2D and provided evidence for the benefit of sodium-glucose cotransporter 2 inhibitors (SGLT2is) in HF and renal decline prevention. SGLT-2is are the best choice in patients with HFrEF to improve CV prognosis and HF-related outcomes and also to prevent kidney-related outcomes, and in CKD patients to slow down renal failure and also reduce hospitalization for HF and CV death. In both situations the number of patients to treat in order to prevent such events in one patient is lower than in the general T2D population at high CV risk. GLP1-receptor agonists could be an alternative in a patient who is intolerant or has a contraindication to SGLT-2is. A tight collaboration between diabetologists, nephrologists and cardiologists should be encouraged for a holistic and effective strategy to reduce the burden of cardio-renal-metabolic interaction.

Published
2021

23. Independent and Joint‐<scp>GWAS</scp>for growth traits inEucalyptusby assembling genome‐wide data for 3373 individuals across four breeding populations

Author

Bárbara S. F. Müller, Janeo Eustáquio de Almeida Filho, Aurélio Mendes Aguiar, Alexandre Alves Missiaggia, Orzenil B. Silva-Junior, Dario Grattapaglia, Leandro G. Neves, Elizabete Keiko Takahashi, Bruno Marco de Lima, Carla Garcia, Matias Kirst, Salvador A. Gezan, BÁRBARA S. F. MULLER, UNB, ORZENIL BONFIM DA SILVA JUNIOR, Cenargen, LEANDRO G. NEVES, RAPID GENOMICS LLC, USA, DARIO GRATTAPAGLIA, Cenargen., JANEO E. DE ALMEIDA FILHO, UENF, BRUNO M. LIMA, FIBRIA S.A. TECHNOLOGY CENTER, CARLA C. GARCIA, INTERNATIONAL PAPER OF BRAZIL, ALEXANDRE MISSIAGGIA, FIBRIA S.A. TECHNOLOGY CENTER, AURELIO M. AGUIAR, FIBRIA S.A. TECHNOLOGY CENTER, ELIZABETE TAKAHASHI, CELULOSE NIPO-BRASILEIRA (CENIBRA) S.A., MATIAS KIRST, UNIVERSITY OF FLORIDA, USA, and SALVADOR A. GEZAN, UNIVERSITY OF FLORIDA, USA

Subjects
musculoskeletal diseases, 0106 biological sciences, 0301 basic medicine, Physiology, Population, Inheritance Patterns, Single-nucleotide polymorphism, Genome-wide association study, Plant Science, Biology, Polymorphism, Single Nucleotide, 01 natural sciences, Genome, Linkage Disequilibrium, 03 medical and health sciences, Quantitative Trait, Heritable, High-throughput SNP genotyping, Joint-GWAS, Regional heritability mapping (RHM), SNP, education, Genetic association, Principal Component Analysis, Eucalyptus, education.field_of_study, Genome-wide association study (GWAS), Heritability, Plant Breeding, Meta-analysis, 030104 developmental biology, Evolutionary biology, Tree breeding, Relatedness, Genome, Plant, Genome-Wide Association Study, 010606 plant biology & botany
Abstract

Genome-wide association studies (GWAS) in plants typically suffer from limited statistical power. An alternative to the logistical and cost challenge of increasing sample sizes is to gain power by meta-analysis using information from independent studies. We carried out GWAS for growth traits with six single-marker models and regional heritability mapping (RHM) in four Eucalyptus breeding populations independently and by Joint-GWAS, using gene and segment-based models, with data for 3373 individuals genotyped with a communal EUChip60KSNP platform. While single-single nucleotide polymorphism (SNP) GWAS hardly detected significant associations at high-stringency in each population, gene-based Joint-GWAS revealed nine genes significantly associated with tree height. Associations detected using single-SNP GWAS, RHM and Joint-GWAS set-based models explained on average 3-20% of the phenotypic variance. Whole-genome regression, conversely, captured 64-89% of the pedigree-based heritability in all populations. Several associations independently detected for the same SNPs in different populations provided unprecedented GWAS validation results in forest trees. Rare and common associations were discovered in eight genes involved in cell wall biosynthesis and lignification. With the increasing adoption of genomic prediction of complex phenotypes using shared SNPs and much larger tree breeding populations, Joint-GWAS approaches should provide increasing power to pinpoint discrete associations potentially useful toward tree breeding and molecular applications.

Published
2018

24. Ranking populations in terms of inequality of health opportunity: A flexible latent type approach

Author

Caterina Francesca Guidi, Paolo Brunori, Alain Trannoy, Dipartimento di Scienze per l'Economia e l'Impresa, University of Florence, Florence, Italy, Polytechnic University of Bari, Aix-Marseille Sciences Economiques (AMSE), École des hautes études en sciences sociales (EHESS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), University of Siena, Italy, This paper benefits from the support of the Norface project IMCHILD., Università degli Studi di Firenze = University of Florence (UniFI), and Università degli Studi di Siena = University of Siena (UNISI)

Subjects
Inequality, media_common.quotation_subject, Population, latent class, Type (model theory), 03 medical and health sciences, 0502 economics and business, Econometrics, Economics, Humans, 050207 economics, 10. No inequality, education, Socioeconomic status, opportunity-inequality curve, media_common, education.field_of_study, Class (computer programming), 030503 health policy & services, Health Policy, 05 social sciences, Rank (computer programming), 1. No poverty, self-assessed health, Health Status Disparities, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, Health equity, inequality of opportunity, Europe, Ranking, Socioeconomic Factors, 8. Economic growth, health inequality, 0305 other medical science
Abstract

International audience; We offer a flexible latent type approach to rank populations according to unequal health opportunities. Building upon the latent-class method, an approch increasingly adopted to estimate health inequalities, our contribution is to let the number of socioeconomic groups considered vary to obtain an opportunity-inequality curve for a population that gives how the between-type inequality varies with the number of types. A population A is said to have less inequality of opportunity than population B if its curve is statistically below that of population B. This version of the latent class approach allows for a robust ranking of 31 European countries regarding inequality of opportunity in health.

Published
2021

25. A graph cellular automaton with relation-based neighbourhood describing the impact of peer influence on the consumption of marijuana among college-aged youths

Author

Muhammad Zaid Dauhoo, Laurent Dumas, Yusra Bibi Ruhomally, Université de Maurice, Laboratoire de Mathématiques de Versailles (LMV), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), University of Mauritius, UoM, and We would like to acknowledge the assistance of Mr Maheshsingh Mungur from the University of Mauritius in the preparation of this work. This work has been conducted under the HEC (Higher Education Commission Mauritius) MPhil/PhD scholarship. The authors would also like to thank the reviewers for their constructive and valuable comments, which led to the improvement of the paper.

Subjects
Statistics and Probability, 050402 sociology, Relation (database), media_common.quotation_subject, targeted campaigns of prevention, [SDV]Life Sciences [q-bio], Population, 02 engineering and technology, relation-based, 0504 sociology, 0202 electrical engineering, electronic engineering, information engineering, Set (psychology), education, Recreation, Neighbourhood (mathematics), media_common, Consumption (economics), education.field_of_study, peer influence, Applied Mathematics, Addiction, 05 social sciences, Marijuana, Modeling and Simulation, graph cellular automaton, Graph (abstract data type), 020201 artificial intelligence & image processing, Psychology, Social psychology
Abstract

International audience; A novel approach depicting the dynamics of marijuana usage to gauge the effects of peer influence in a school population, is the site of investigation. Consumption of drug is considered as a contagious social epidemic which is spread mainly by peer influences. A relation-based graph-CA (r-GCA) model consisting of 4 states namely, Nonusers (N), Experimental users (E), Recreational users (R) and Addicts (A), is formulated in order to represent the prevalence of the epidemic on a campus. The r-GCA model is set up by local transition rules which delineates the proliferation of marijuana use. Data available in [4] is opted to verify and validate the r-GCA. Simulations of the r-GCA system are presented and discussed. The numerical results agree quite accurately with the observed data. Using the model, the enactment of campaigns of prevention targeting N, E and R states respectively were conducted and analysed. The results indicate a significant decline in marijuana consumption on the campus when a campaign of prevention targeting the latter three states simultaneously, is enacted.

Published
2021

26. Projecting Exposure to Extreme Climate Impact Events Across Six Event Categories and Three Spatial Scales

Author

Yoshihide Wada, Fang Zhao, Yasushi Honda, Thomas Hickler, Jörg Steinkamp, Nikolay Khabarov, Tobias Stacke, Lila Warszawski, David N. Bresch, Tobias Geiger, Wim Thiery, Kazuya Nishina, Jonas Jägermeyr, Sebastian Ostberg, Hannes Müller Schmied, Manolis Grillakis, Iliusi Vega, Kerry Emanuel, Akihiko Ito, Philippe Ciais, Sonia I. Seneviratne, Stefan Lange, Naota Hanasaki, Jinfeng Chang, Jan Volkholz, Aristeidis Koutroulis, Christian Folberth, Matthias Büchner, Christopher P. O. Reyer, Minoru Yoshikawa, Sven Willner, Christoph Müller, Katja Frieler, Hong Yang, Jacob Schewe, Simon N. Gosling, Alexandra Henrot, Dieter Gerten, Marie Dury, Veronika Huber, Chao Yue, Wenfeng Liu, Ted Veldkamp, Hydrology and Hydraulic Engineering, Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Environmental Restoration and Conservation Agency, ERCA 821010 641816 SAW‐2016‐PIK‐1, 603864 Bundesministerium für Bildung und Forschung, BMBF: 01LA1829A, 01LS1201A2, 01LS1711F Ministry of Economy, Trade and Industry, METI Eidgenössische Technische Hochschule Zürich, ETH: Fel‐45 15‐1 Ministerio de Economía y Competitividad, MINECO: PCIN‐2017‐046, We thank the editor and two anonymous reviewers for constructive feedback. We thank three other anonymous reviewers for helpful comments on an earlier version of this paper submitted to a different journal. This research was supported in part by the German Federal Ministry of Education and Research (BMBF, grant numbers 01LS1201A2, 01LS1711F, and 01LA1829A) and the EU FP7 HELIX project (grant number 603864). Some authors acknowledge support from the Leibniz Competition projects SAW‐2013‐PIK‐5 (EXPACT) and SAW‐2016‐PIK‐1 (ENGAGE). Some authors acknowledge funding from the European Union's Horizon 2020 research and innovation program under grant agreement number 821010 (CASCADES). N. H., K. N., and Y. H. acknowledge support from the ERTD Funds 2RF‐1802 and S‐14 of the Environmental Restoration and Conservation Agency of Japan. W. T. was supported by an ETH Zurich postdoctoral fellowship (Fel‐45 15‐1). V. H. was supported by the Spanish Ministry of Economy, Industry and Competitiveness (MINECO, grant number PCIN‐2017‐046). P. C. acknowledges support from the CLAND ANR Convergence Institute. S. L. acknowledges funding from the European Union's Horizon 2020 research and innovation program under grant agreement number 641816 (CRESCENDO). Open access funding enabled and organized by Projekt DEAL., Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), and Water and Climate Risk

Subjects
010504 meteorology & atmospheric sciences, HYDROLOGICAL MODELS, Population, 0207 environmental engineering, FLOOD RISK, Environmental Sciences & Ecology, 02 engineering and technology, Subtropics, [SDU.STU.ME]Sciences of the Universe [physics]/Earth Sciences/Meteorology, 01 natural sciences, Population density, Latitude, Climate-related extreme events, Earth and Planetary Sciences (miscellaneous), SDG 13 - Climate Action, Meteorology & Atmospheric Sciences, BURNED AREA, GLOBAL CROP PRODUCTION, Geosciences, Multidisciplinary, 020701 environmental engineering, education, 0105 earth and related environmental sciences, General Environmental Science, Event (probability theory), education.field_of_study, Science & Technology, Land use, Global warming, VEGETATION MODEL ORCHIDEE, Geology, 15. Life on land, TERRESTRIAL CARBON BALANCE, 13. Climate action, Climatology, Physical Sciences, TROPICAL CYCLONE ACTIVITY, HURRICANE INTENSITY, Environmental science, Tropical cyclone, INTERANNUAL VARIABILITY, Life Sciences & Biomedicine, Environmental Sciences, INCORPORATING SPITFIRE
Abstract

Summarization: The extent and impact of climate‐related extreme events depend on the underlying meteorological, hydrological, or climatological drivers as well as on human factors such as land use or population density. Here we quantify the pure effect of historical and future climate change on the exposure of land and population to extreme climate impact events using an unprecedentedly large ensemble of harmonized climate impact simulations from the Inter‐Sectoral Impact Model Intercomparison Project phase 2b. Our results indicate that global warming has already more than doubled both the global land area and the global population annually exposed to all six categories of extreme events considered: river floods, tropical cyclones, crop failure, wildfires, droughts, and heatwaves. Global warming of 2°C relative to preindustrial conditions is projected to lead to a more than fivefold increase in cross‐category aggregate exposure globally. Changes in exposure are unevenly distributed, with tropical and subtropical regions facing larger increases than higher latitudes. The largest increases in overall exposure are projected for the population of South Asia. Presented on: Earth's Future

Published
2020

27. Interdisciplinary Research in Artificial Intelligence: Challenges and Opportunities

Author

Remy Kusters, Dusan Misevic, Hugues Berry, Antoine Cully, Yann Le Cunff, Loic Dandoy, Natalia Díaz-Rodríguez, Marion Ficher, Jonathan Grizou, Alice Othmani, Themis Palpanas, Matthieu Komorowski, Patrick Loiseau, Clément Moulin Frier, Santino Nanini, Daniele Quercia, Michele Sebag, Françoise Soulié Fogelman, Sofiane Taleb, Liubov Tupikina, Vaibhav Sahu, Jill-Jênn Vie, Fatima Wehbi, Centre de Recherche Interdisciplinaire / Center for Research and Interdisciplinarity [Paris, France] (CRI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Artificial Evolution and Computational Biology (BEAGLE), Laboratoire d'InfoRmatique en Image et Systèmes d'information (LIRIS), Université Lumière - Lyon 2 (UL2)-École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Lumière - Lyon 2 (UL2)-École Centrale de Lyon (ECL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Imperial College London, Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Flowing Epigenetic Robots and Systems (Flowers), Inria Bordeaux - Sud-Ouest, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), École Nationale Supérieure de Techniques Avancées (ENSTA Paris), Laboratoire Images, Signaux et Systèmes Intelligents (LISSI), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Performance analysis and optimization of LARge Infrastructures and Systems (POLARIS), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire d'Informatique de Grenoble (LIG), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Nokia Bell Labs [Cambridge], TAckling the Underspecified (TAU), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire de Recherche en Informatique (LRI), CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Hub France IA, Nokia Bell Labs [Paris-Saclay], Scool (Scool), Inria Lille - Nord Europe, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche en Informatique, Signal et Automatique de Lille - UMR 9189 (CRIStAL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Thanks to the Bettencourt Schueller Foundation long term partnership, the workshop that gave rise to this paper was partially supported by the funding from CRI Research Collaboratory, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire d'InfoRmatique en Image et Systèmes d'information (LIRIS), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-École Centrale de Lyon (ECL), Université de Lyon-Université Lumière - Lyon 2 (UL2)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Lyon (ECL), Université de Lyon-Université Lumière - Lyon 2 (UL2), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Unité d'Informatique et d'Ingénierie des Systèmes (U2IS), École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-École Nationale Supérieure de Techniques Avancées (ENSTA Paris), Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Big Data, 0301 basic medicine, [SCCO.COMP]Cognitive science/Computer science, [INFO.INFO-NE]Computer Science [cs]/Neural and Evolutionary Computing [cs.NE], [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI], 03 medical and health sciences, 0302 clinical medicine, Political science, Health care, Computer Science (miscellaneous), auditability, education, lcsh:T58.5-58.64, Ai education, business.industry, lcsh:Information technology, interdisciplinary science, Precision medicine, artificial intelligence, Transparency (behavior), ethics, Variety (cybernetics), 030104 developmental biology, [INFO.INFO-MA]Computer Science [cs]/Multiagent Systems [cs.MA], Perspective, Artificial intelligence, business, interpretability, 030217 neurology & neurosurgery, Information Systems
Abstract

The use of artificial intelligence (AI) in a variety of research fields is speeding up multiple digital revolutions, from shifting paradigms in healthcare, precision medicine and wearable sensing, to public services and education offered to the masses around the world, to future cities made optimally efficient by autonomous driving. When a revolution happens, the consequences are not obvious straight away, and to date, there is no uniformly adapted framework to guide AI research to ensure a sustainable societal transition. To answer this need, here we analyze three key challenges to interdisciplinary AI research, and deliver three broad conclusions: 1) future development of AI should not only impact other scientific domains but should also take inspiration and benefit from other fields of science, 2) AI research must be accompanied by decision explainability, dataset bias transparency as well as development of evaluation methodologies and creation of regulatory agencies to ensure responsibility, and 3) AI education should receive more attention, efforts and innovation from the educational and scientific communities. Our analysis is of interest not only to AI practitioners but also to other researchers and the general public as it offers ways to guide the emerging collaborations and interactions toward the most fruitful outcomes.

Published
2020

28. Multidimensional inequality and inframodular order

Author

Alain Chateauneuf, Zaier Aouani, Department of economics, University of Kansas, University of Kansas [Lawrence] (KU), IPAG Business School, Centre d'économie de la Sorbonne (CES), Université Paris 1 Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS), Paris School of Economics (PSE), École des Ponts ParisTech (ENPC)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris 1 Panthéon-Sorbonne (UP1)-Centre National de la Recherche Scientifique (CNRS)-École des hautes études en sciences sociales (EHESS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), This paper is part of the research project ANR ‘‘Mesure des inégalités ordinales et multidimensionnelles’’ (ORDINEQ) of the French National Research Agency (Agence Nationale de la Recherche), whose financial support is gratefully acknowledged., and ANR-16-CE41-0005,ORDINEQ,La Mesure des Inégalités Ordinales et Multidimensionnelles(2016)

Subjects
Economics and Econometrics, education.field_of_study, Multi-attribute inequality, Inequality, Applied Mathematics, media_common.quotation_subject, 05 social sciences, Population, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, Inframodular functions, Multidimensional Pigou–Dalton transfers, Order (business), 0502 economics and business, Econometrics, Inframodular order, 050207 economics, education, 050205 econometrics, media_common, Mathematics
Abstract

International audience; Motivated by the pertinence of Pigou–Dalton (PD) transfers for inequality measurement when only one attribute is involved, we show that inframodular functions are consistent with multidimensional PD transfers and that weakly inframodular functions fit more accurately with the traditional notion of PD transfers. We emphasize, for inequality rankings of allocations of multiple attributes in a population, the similarities of the inframodular order, defined using inframodular functions, with the concave order in the unidimensional framework.

Published
2020

29. Study Protocol: A Cross-Sectional Examination of Socio-Demographic and Ecological Determinants of Nutrition and Disease Across Madagascar

Author

Christopher D. Golden, Benjamin L. Rice, Hervet J. Randriamady, Arisoa Miadana Vonona, Jean Frederick Randrianasolo, Ambinintsoa Nirina Tafangy, Mamy Yves Andrianantenaina, Nicholas J. Arisco, Gauthier N. Emile, Faustin Lainandrasana, Robuste Fenoarison Faraniaina Mahonjolaza, Hermann Paratoaly Raelson, Vololoniaina Ravo Rakotoarilalao, Anjaharinony Andry Ny Aina Rakotomalala, Alex Dominique Rasamison, Rebaliha Mahery, M. Luciano Tantely, Romain Girod, Akshaya Annapragada, Amy Wesolowski, Amy Winter, Daniel L. Hartl, James Hazen, C. Jessica E. Metcalf, Harvard T.H. Chan School of Public Health, Madagascar Health and Environmental Research [Maroantsetra, Madagascar] (MAHERY), Princeton University, Unité d'Entomologie Médicale [Antananarivo, Madagascar] (IPM), Institut Pasteur de Madagascar, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Harvard University [Cambridge], Johns Hopkins Bloomberg School of Public Health [Baltimore], Johns Hopkins University (JHU), Catholic Relief Services [Antananarivo, Madagascar] (CRS), Catholic Relief Services [Baltimore] (CRS), and We are grateful for the support from the United States Agency for International Development (Grant No. AID-FFP-A-14-00008) implemented by Catholic Relief Services (CRS) in consortium with four local implementing partners in Madagascar. The views and opinions expressed in this paper are those of the authors and not necessarily the views and opinions of the United States Agency for International Development. We also thank the Wellcome Trust Our Planet, Our Health program (grant 106866/Z/15/Z) for providing funding to CM for this research.

Subjects
Environmental change, infectious disease, [SDV]Life Sciences [q-bio], Population, malaria, Distribution (economics), planetary health, Disease, migration, MESH: Madagascar, 03 medical and health sciences, 0302 clinical medicine, MESH: Cross-Sectional Studies, Environmental health, MESH: Child, disease ecology, MESH: Family Characteristics, MESH: Ecosystem, 030212 general & internal medicine, Clinical Study Protocol, education, Disease burden, 2. Zero hunger, education.field_of_study, Food security, MESH: Humans, business.industry, seasonality, 030503 health policy & services, lcsh:Public aspects of medicine, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, food security, 15. Life on land, MESH: Nutritional Status, MESH: Male, General Social Survey, Geography, 13. Climate action, micronutrient nutrition, Observational study, Public Health, 0305 other medical science, business, MESH: Female
Abstract

International audience; Madagascar has experienced significant environmental change since 1960, particularly through forest clearing for agricultural expansion. Climatic patterns are undergoing change in Madagascar as well, with increasing temperatures, droughts, and cyclonic activity. The impact of these environmental and climatic changes will pose threats to food availability, income generation, and local ecosystems, with significant potential effects on the spatial and temporal distribution of disease burden. This study seeks to describe the health status of a large sample of geographically and socially diverse Malagasy communities through multiple clinical measurements, detailed social surveys, and paired data on regional variation in local ecologies. With an increased understanding of the current patterns of variation in human health and nutrition, future studies will be better able to identify associations with climate and anticipate and mitigate the burdens expected from larger, longer-term changes. Our mixed-method approach included an observational cross-sectional study. Research subjects were men, women, and children from 1,125 households evenly distributed across 24 communities in four ecologically and socio-demographically distinct regions of Madagascar. For these 1,125 households, all persons of both sexes and all ages therein (for a total of 6,292 individuals) were recruited into the research study and a total of 5,882 individuals were enrolled. Through repeated social survey recalls and focus group meetings, we obtained social and demographic data, including broad categories of seasonal movements, and characterized the fluctuation of income generation, food production and dietary consumption. Through collection of clinical and biological samples for both point-of-care diagnoses and laboratory analyses, we obtained detailed occurrence (and importantly co-occurrence) data on micronutrient nutritional, infectious disease, and non-communicable disease status. Our research highlights the highly variable social, cultural, and environmental contexts of health conditions in Madagascar, and the tremendous inter-regional, inter-community, and intra-community variation in nutritional and disease status. More than 30% of the surveyed population was afflicted by anemia and 14% of the population had a current malaria infection. This type of rich metadata associated with a suite of biological samples and nutritional and disease outcome data should allow disentangling some of the underlying drivers of ill health across the changing landscapes of Madagascar.

Published
2020

30. Les professionnels de santé face à la pandémie de la maladie à coronavirus (COVID-19) : quels risques pour leur santé mentale ?

Author

Nefize Yalin, Frank Bellivier, Alessandro Colasanti, Bruno Étain, Tim Mantingh, Paul R. A. Stokes, Jean-Pierre Kahn, Chantal Henry, Marion Leboyer, Rashmi Patel, Allan H. Young, King‘s College London, Bethlem Royal Hospital [London], Brighton and Sussex Medical School (BSMS), Hôpitaux Universitaire Saint-Louis, Lariboisière, Fernand-Widal, Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Fondation FondaMental [Créteil], IMRB - 'Neuropsychiatrie translationnelle' [Créteil] (U955 Inserm - UPEC), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpital Henri Mondor, Perception et Mémoire / Perception and Memory, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre Psychothérapique de Nancy [Laxou] (CPN), This paper represents independent research supported by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. Authors from France acknowledge the support provided by INSERM (Research Protocol C0829), Assistance Publique des Hôpitaux de Paris (Research Protocol GAN12)., Etain, Bruno, and Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)

Subjects
MESH: United Kingdom, Identification, MESH: Protective Devices, [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, 0302 clinical medicine, MESH: Risk Factors, MESH: Bipolar Disorder, London, Medicine, MESH: Tobacco, Psychotic illness, MESH: Workload, education.field_of_study, MESH: Sleep Wake Disorders, Mania, Psychiatry and Mental health, Clinical Psychology, Characteristics, MESH: Stress Disorders, Post-Traumatic, MESH: Young Adult, Cohort, cardiovascular system, behavior and behavior mechanisms, France, medicine.symptom, MESH: Uncertainty, MESH: Occupational Diseases, medicine.medical_specialty, MESH: Pandemics, Clinical variables, MESH: Sleep, Bipolar disorder, Population, MESH: Social Support, MESH: Mania, Unipolar mania, behavioral disciplines and activities, 03 medical and health sciences, MESH: Infectious Disease Transmission, Patient-to-Professional, MESH: Severe Acute Respiratory Syndrome, mental disorders, Humans, MESH: SARS-CoV-2, education, Psychiatry, MESH: Work Schedule Tolerance, MESH: Helplessness, Learned, MESH: Humans, business.industry, MESH: Influenza Pandemic, 1918-1919, MESH: Retrospective Studies, MESH: London, medicine.disease, United Kingdom, MESH: Quantitative Trait Loci, MESH: Prospective Studies, 030227 psychiatry, MESH: France, Case register, MESH: Suicide, MESH: Pneumonia, Viral, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Matched group, RC0321, MESH: Resilience, Psychological, business, 030217 neurology & neurosurgery
Abstract

Background: Unipolar mania is a putative subtype of bipolar disorder (BD) in which individuals experience recurrent manic but not major depressive episodes. Few studies of unipolar mania have been conducted in developed countries and none in the UK. This study aimed to identify and characterise people with unipolar mania in the UK and France. \ud \ud Methods: People with unipolar mania were ascertained using a South London UK electronic case register and a French BD case series. Each unipolar mania group was compared to a matched group of people with BD who have experienced depressive episodes. \ud \ud Results: 17 people with unipolar mania were identified in South London and 13 in France. The frequency of unipolar mania as a percentage of the BD clinical population was 1.2% for the South London cohort and 3.3% for the French cohort. In both cohorts, people with unipolar mania experienced more manic episodes than people with BD, and in the French cohort were more likely to experience a psychotic illness onset and more psychiatric admissions. Treatment characteristics of people with unipolar mania were similar to people with BD except that the unipolar mania group was less likely to be treated with antidepressants. \ud \ud Limitations: The relatively small number of people with unipolar mania identified by this study limits its power to detect differences in clinical variables. \ud \ud Conclusions: People with unipolar mania can be identified in France and the UK, and they may experience a higher frequency of manic episodes but have similar treatment characteristics to people with BD.

Published
2020

31. Are People Willing to Pay for Reduced Inequality?

Author

Brian Hill, Thomas Lloyd, Ecole des Hautes Etudes Commerciales (HEC Paris), HEC Paris Research Paper Series, HEC Paris - Recherche - Hors Laboratoire, Centre National de la Recherche Scientifique (CNRS), Groupement de Recherche et d'Etudes en Gestion à HEC (GREGH), and Ecole des Hautes Etudes Commerciales (HEC Paris)-Centre National de la Recherche Scientifique (CNRS)

Subjects
JEL: D - Microeconomics/D.D3 - Distribution, History, Point of sale, Political spectrum, Polymers and Plastics, Inequality, media_common.quotation_subject, Population, computer.software_genre, Industrial and Manufacturing Engineering, Politics, Willingness to pay, Economic inequality, 0502 economics and business, Economics, Production (economics), inequality information provision, Income inequality, 050207 economics, Business and International Management, 10. No inequality, education, media_common, JEL: D - Microeconomics/D.D9 - Intertemporal Choice, education.field_of_study, 050208 finance, inequality attitude, 05 social sciences, [SHS.PHIL]Humanities and Social Sciences/Philosophy, 1. No poverty, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, JEL: D - Microeconomics/D.D6 - Welfare Economics/D.D6.D63 - Equity, Justice, Inequality, and Other Normative Criteria and Measurement, 8. Economic growth, inequality reporting, [SHS.GESTION]Humanities and Social Sciences/Business administration, Demographic economics, willingness to pay, computer
Abstract

In the face of rising income inequality (Acemoglu & Autor, 2011; Atkinson, Piketty, & Saez, 2011; Piketty, 2014; World Economic Forum, 2014), one recent proposal is to provide consumers with information about the income inequality across those involved in the production of each good, at the point of purchase. This has been shown to depress overall inequality (Hill, 2020), though its impact depends crucially on whether people are willing to pay more for goods whose production involves less income inequality. Here we investigate this largely unexplored empirical question through an incentivised, behavioural choice experiment on a representative sample of the English population. We find that a large majority are willing to pay significantly more for goods associated with less inequality. How much more people are willing to pay varies with political leaning and increases with the extent of the inequality reduction, but is positive across the political spectrum and for all studied inequality differences. Moreover, it is typically higher when inequality is reported in more intuitive and informa- tive formats. Our results bode well for the effectiveness of product-level inequality information provision as a tool for moderating income inequality, promising impacts even in markets where all goods involve relatively high inequality levels and potential participation across the political spectrum.

Published
2020

32. How many large camelids in the world? A synthetic analysis of the world camel demographic changes

Author

Bernard Faye, Systèmes d'élevage méditerranéens et tropicaux (UMR SELMET), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Al-Farabi Kazakh National University [Almaty] (KazNU), Département Environnements et Sociétés (Cirad-ES), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), and This paper is supported by the PRIMA programme under grant agreement No1832, project 'Boost the production, processing and consumption of camel milk in the Mediterranean basin (CAMELMILK)'. The PRIMA programme is supported by the European Union. We acknowledge also Mrs. Mohammed Bengoumi and Thomas Schultze for proofreading the English version.

Subjects
L01 - Elevage - Considérations générales, Census, 040301 veterinary sciences, [SDV]Life Sciences [q-bio], Applied ecology, Population, Dromadaire, Chameau, Distribution des populations, Dromedary, Tropical livestock unit, 0403 veterinary science, Camel population, International database, Secession, Dynamique des populations, Population animale, education, Socioeconomics, Camelidae, Demography, lcsh:SF1-1100, education.field_of_study, biology, business.industry, 0402 animal and dairy science, L60 - Taxonomie et géographie animales, 04 agricultural and veterinary sciences, Chameau d'asie, biology.organism_classification, 040201 dairy & animal science, FAO, Geography, Agriculture, Animal Science and Zoology, Livestock, lcsh:Animal culture, business, Camelid, Bactrian
Abstract

At world level, the current official number of large camelids cannot be determined exactly (it is estimated to be more than 35 million heads), and the role of camels in the livestock economy is highly variable. The only reliable statistics are provided by FAO since 1961. According to these data, five different patterns of demographic changes have been observed. In countries marked by a regular or drastic decline of their camelid population, a tendency to re-increase has been in force since the beginning of the century, except in India. Generally, countries marked by a sharp recent increase in their large camelid population have implemented a census and readjusted their data. Many inconsistencies occur in available data, most notably cases arising from changes occurring in state status (for example secession of Eritrea, Soviet Union collapse). Moreover, large camelid stocks in Australia, in countries of new camel establishment (Western countries) and those related to the expansion of camel farming, notably in Africa, are not recorded in the international database. In addition, there is no distinction between dromedary and Bactrian data. The present large camelid population in the world is probably more than 40 million and could reach 60 million after 25 years from now if the current demographic trend is maintained.

Published
2020

33. High-spatiotemporal-resolution mapping of global urban change from 1985 to 2015

Author

Zhenzhong Zeng, Xuecao Li, Xiaoping Liu, Philippe Ciais, Yimin Chen, Yinghuai Huang, Kangning Huang, Guohua Hu, Xia Li, Xiaocong Xu, Peng Gong, Qiusheng Wu, Peirong Lin, Anping Chen, Jun Chen, Kai Gong, Lyndon Estes, Alan D. Ziegler, Shaojian Wang, Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Agence Nationale de la Recherche, ANR Southern University of Science and Technology, SUSTech 2017YFA0604404, 2019YFA0607203, This research was funded by the National Key R&D Program of China (grant no. 2017YFA0604404 and grant no. 2019YFA0607203). Z.Z. was supported by the start-up fund provided by Southern University of Science and Technology (grant no. G02296001). We thank the French ANR Convergence Institute CLAND project for support. We thank many students (for example, Z. Lin) for their days and nights validating our GAUD product via high-resolution satellite image interpretation. We also thank K. C. Seto and M. Hansen for their constructive comments on this paper., ANR-16-CONV-0003,CLAND,CLAND : Changement climatique et usage des terres(2016), and Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)

Subjects
010504 meteorology & atmospheric sciences, Environmental change, Geography, Planning and Development, Population, 010501 environmental sciences, Management, Monitoring, Policy and Law, 01 natural sciences, Urban planning, Urbanization, Natural hazard, 11. Sustainability, Population growth, education, 0105 earth and related environmental sciences, Nature and Landscape Conservation, Sustainable development, Global and Planetary Change, education.field_of_study, Ecology, Flood myth, Renewable Energy, Sustainability and the Environment, business.industry, Environmental resource management, 15. Life on land, Urban Studies, Geography, 13. Climate action, [SDU]Sciences of the Universe [physics], business, Food Science
Abstract

High-resolution global maps of annual urban land coverage provide fundamental information of global environmental change and contribute to applications related to climate mitigation and urban planning for sustainable development. Here we map global annual urban dynamics from 1985 to 2015 at a 30 m resolution using numerous surface reflectance data from Landsat satellites. We find that global urban extent has expanded by 9,687 km2 per year. This rate is four times greater than previous reputable estimates from worldwide individual cities, suggesting an unprecedented rate of global urbanization. The rate of urban expansion is notably faster than that of population growth, indicating that the urban land area already exceeds what is needed to sustain population growth. Looking ahead, using these maps in conjunction with integrated assessment models can facilitate greater understanding of the complex environmental impacts of urbanization and help urban planners avoid natural hazards; for example, by limiting new development in flood risk zones. The world keeps urbanizing. This study finds that since 1985 global urban lands have expanded four times faster than previously recognized and faster than population is growing.

Published
2020

34. Otolaryngological complications of hypopharyngeal-esophageal multichannel intraluminal impedance-pH monitoring

Author

Francois Bobin, Jerome R. Lechien, Sven Saussez, Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Hôpital Foch [Suresnes], and C. Knuts (native speaker (United States)) for the proofreading of the paper. Published with written consent of the patient.

Subjects
Impedance–pH monitoring, Medicine (General), medicine.medical_specialty, Laryngology, [SDV]Life Sciences [q-bio], education, Case Report, complication, Case Reports, 030204 cardiovascular system & hematology, Ph monitoring, 03 medical and health sciences, Laryngopharyngeal reflux, R5-920, 0302 clinical medicine, medicine, otorhinolaryngologic diseases, Nose, health care economics and organizations, business.industry, pH monitoring, Reflux, General Medicine, respiratory system, medicine.disease, digestive system diseases, testing, 3. Good health, laryngopharyngeal, medicine.anatomical_structure, 030220 oncology & carcinogenesis, impedance, Medicine, lipids (amino acids, peptides, and proteins), Radiology, reflux, business
Abstract

Probe of pH study may kink in the esophagus leading to nasal symptoms during the removal.

Published
2020

35. Online Reputation and Debt Capacity

Author

Arthur Petit-Romec, Jean-Philippe Weisskopf, Alexandre Garel, François Derrien, Rotman School of Management, University of Toronto, University of Toronto, Audencia Business School, Université Paris 1 Panthéon-Sorbonne - UFR d'Économie (UP1 UFR02), Université Paris 1 Panthéon-Sorbonne (UP1), and HEC Paris Research Paper Series

Subjects
Economics and Econometrics, media_common.quotation_subject, education, Monetary economics, online reputation, Affect (psychology), Information asymmetry, Accounting, Debt, 0502 economics and business, customer ratings, 050207 economics, health care economics and organizations, media_common, 050208 finance, corporate debt, 05 social sciences, corporate investment, JEL: L - Industrial Organization/L.L1 - Market Structure, Firm Strategy, and Market Performance/L.L1.L15 - Information and Product Quality • Standardization and Compatibility, JEL: G - Financial Economics/G.G3 - Corporate Finance and Governance/G.G3.G32 - Financing Policy • Financial Risk and Risk Management • Capital and Ownership Structure • Value of Firms • Goodwill, humanities, JEL: G - Financial Economics/G.G1 - General Financial Markets/G.G1.G14 - Information and Market Efficiency • Event Studies • Insider Trading, Demand shock, Regression discontinuity design, [SHS.GESTION]Humanities and Social Sciences/Business administration, Cash flow, JEL: L - Industrial Organization/L.L8 - Industry Studies: Services/L.L8.L83 - Sports • Gambling • Restaurants • Recreation • Tourism, Psychological resilience, Business, Finance, Reputation
Abstract

This paper explores the effects of online customer ratings on debt capacity. Using a large sample of Parisian restaurants, we find a positive and economically significant relation between customer ratings and bank debt. We use the locally exogenous variation in customer ratings resulting from the rounding of scores in regression discontinuity tests to establish causality. Customer ratings affect financial policy through a reduction in cash flow risk and higher resilience to demand shocks. Restaurants with good ratings use their extra debt capacity to invest in tangible assets. Finally, favorable online ratings relax credit constraints mostly for moderately constrained restaurants.

Published
2020

36. Risk factors for bronchiolitis hospitalization in infants: A French nationwide retrospective cohort study over four consecutive seasons (2009-2013)

Author

Jean-Christophe Rozé, Jean-Michel Hascoet, Jean-François Magny, Pierre-Henri Jarreau, Brigitte Fauroux, Elie Saliba, Michaël Schwarzinger, Sommeil-Vigilance-Fatigue et Santé Publique (VIFASOM (URP_7330)), Institut de Recherche Biomédicale des Armées (IRBA)-Université Paris Cité (UPCité), Unité Pédiatrique de Ventilation Non Invasive et de Sommeil [CHU Necker Enfants-Malades], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Maternité Régionale Adolphe Pinard [Nancy], Développement, Adaptation et Handicap. Régulations cardio-respiratoires et de la motricité (DevAH), Université de Lorraine (UL), Université Paris Cité (UPCité), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre hospitalier universitaire de Nantes (CHU Nantes), Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Translational Health Economics Network [Paris] (THEN), Sorbonne Université (SU), The present study was supported by AbbVie France. Translational Health Economics (THEN) was responsible for data collection, preparation, and validation with external sources of information. THEN received payment from AbbVie for these activities. Writing charges were funded by AbbVie France, and AbbVie approved the decision to submit the paper for publication, but the corresponding author was ultimately responsible for submitting the manuscript for publication., HASCOET, JEAN-MICHEL, Service d'assistance respiratoire et sommeil de l'enfant [CHU Necker], Sommeil-Vigilance-Fatigue et Santé Publique (VIFASOM - EA 7330), Institut de Recherche Biomédicale des Armées (IRBA)-Université de Paris (UP), Regional Maternity [Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Université de Lorraine (UL), Université de Paris (UP), Department of Neonatal Medicine of Port-Royal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Cochin [AP-HP], Neonatal Intensive Care Unit of Port-Royal [Paris], Department of Neonatology [Paris], Department of Neonatology [Nantes], Department of Neonatology [Tours], Hôpital Gatien de Clocheville [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, Université Paris Diderot - Paris 7 (UPD7), Université Sorbonne Paris Cité (USPC), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, and Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS)

Subjects
Male, Pediatrics, Pulmonology, Epidemiology, Physiology, Cell Transplantation, Comorbidity, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Families, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Medicine and Health Sciences, Morphogenesis, Blood and Lymphatic System Procedures, Birth Weight, 030212 general & internal medicine, Children, education.field_of_study, Multidisciplinary, Congenital Heart Defects, Hospitals, 3. Good health, Hospitalization, Physiological Parameters, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Bronchiolitis, Medicine, Female, France, Seasons, Infants, Research Article, medicine.medical_specialty, Down syndrome, Science, Population, Cardiology, Surgical and Invasive Medical Procedures, 03 medical and health sciences, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, 030225 pediatrics, Internal medicine, Congenital Disorders, medicine, Humans, Birth Defects, education, Transplantation, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, Omphalocele, business.industry, Body Weight, Infant, Biology and Life Sciences, Retrospective cohort study, medicine.disease, Health Care, Bronchopulmonary dysplasia, Age Groups, Health Care Facilities, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Medical Risk Factors, People and Places, Respiratory Infections, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Population Groupings, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Developmental Biology, Stem Cell Transplantation
Abstract

International audience; Objectives: Large studies are needed to update risk factors of bronchiolitis hospitalization. We performed a nationwide analysis of hospitalization rates for bronchiolitis over four consecutive bronchiolitis seasons to identify underlying medical disorders at risk of bronchiolitis hospitalization and assess their frequency.Methods: Data were retrieved from the French National Hospital Discharge database. Of all infants discharged alive from maternity wards from January 2008 to December 2013 in France (N = 3,884,791), we identified four consecutive cohorts at risk of bronchiolitis during the seasons of 2009–2010 to 2012–2013. The main outcome was bronchiolitis hospitalization during a season. Individual risk factors were collected.Results: Among infants, 6.0% were preterm and 2.0% had ≥1 chronic condition including 0.2% bronchopulmonary dysplasia (BPD) and 0.2% hemodynamically significant congenital heart disease (HS-CHD). Bronchiolitis hospitalization rates varied between seasons (min: 1.26% in 2010–2011; max: 1.48% in 2012–2013; p

Published
2020

37. Web School Diary

Author

Harizanov, Krasimir, Konstantinov, Kristiyan, and The research presented in this paper is partially funded by the project of Shumen University RD-08-117/04.02.2019

Subjects
web school diary, education, learning, e-learning, ComputingMilieux_COMPUTERSANDEDUCATION, InformationSystems_MISCELLANEOUS
Abstract

The article presents the role of web school diaries in organizing and conducting training in the Bulgarian school. Some online technologies have been explored to enable the preparation and implementation of a web school diary, in keeping with modern requirements. It is proposed that the web-based electronic diary should be created in accordance with the requirements of contemporary Bulgarian education. Here are some of the web app's capabilities can be used to evaluate students, web plans and assignments, as well as a parent's announcement of changes made during the school day. Here are some screenshots visualize the main features of the application.

Published
2019

38. Quantitative genetic parameters for growth and wood properties in Eucalyptus 'urograndis' hybrid using near-infrared phenotyping and genome-wide SNP-based relationships

Author

Orzenil B. Silva-Junior, Bruno Marco de Lima, Shawn D. Mansfield, Carla Garcia, Dario Grattapaglia, Eduardo P. Cappa, BRUNO MARCO DE LIMA, USP, EDUARDO P. CAPPA, INSTITUTO NACIONAL DE TECNOLOGI´A AGROPECUARIA (INTA), ARGENTINA, ORZENIL BONFIM DA SILVA JUNIOR, Cenargen, CARLA GARCIA, INTERNATIONAL PAPER DO BRASIL ROD, SHAWN D. MANSFIELD, UNIVERSITY OF BRITISH COLUMBIA, CANADA, and DARIO GRATTAPAGLIA, Cenargen.

Subjects
0106 biological sciences, 0301 basic medicine, Heredity, Plant Science, 01 natural sciences, Lignin, Trees, Spectrum Analysis Techniques, NEAR-INFRARED PEHNOTYPING, Data Management, education.field_of_study, Eucalyptus, Multidisciplinary, Spectroscopy, Near-Infrared, Organic Compounds, Plant Anatomy, Eukaryota, near-Infrared Spectroscopy, Phylogenetic Analysis, Genomics, Plants, Wood, Phylogenetics, Polimorfismo de un Solo Nucleótido, Chemistry, Phenotypes, Phenotype, Genetic gain, Physical Sciences, Medicine, Brazil, Genome, Plant, Research Article, Genetic Research, Computer and Information Sciences, Genética Cuantitativa, Genotype, Science, Population, Infrared Spectroscopy, Quantitative trait locus, Biology, Research and Analysis Methods, Polymorphism, Single Nucleotide, Quantitative Genetics, 03 medical and health sciences, Quantitative Trait, Heritable, MOLECULAR RELATIONSHIP, Species Specificity, Genetic variation, Genetics, Evolutionary Systematics, PEDIGREE RELATIONSHIP, education, Cellulose, Fenotipos, Hybrid, Taxonomy, Evolutionary Biology, Models, Genetic, Directional selection, Organic Chemistry, Organisms, Chemical Compounds, Biology and Life Sciences, Heritability, purl.org/becyt/ford/4.5 [https], Plant Breeding, 030104 developmental biology, Evolutionary biology, Single Nucleotide Polymorphism, Tree breeding, Hybridization, Genetic, purl.org/becyt/ford/4 [https], 010606 plant biology & botany
Abstract

A thorough understanding of the heritability, genetic correlations and additive and non-additive variance components of tree growth and wood properties is a requisite for effective tree breeding. This knowledge is essential to maximize genetic gain, that is, the amount of increase in trait performance achieved annually through directional selection. Understanding the genetic attributes of traits targeted by breeding is also important to sustain decade-long genetic progress, that is, the progress made by increasing the average genetic value of the offspring as compared to that of the parental generation. In this study, we report quantitative genetic parameters for fifteen growth, wood chemical and physical traits for the world-famous Eucalyptus urograndis hybrid (E. grandis × E. urophylla). These traits directly impact the optimal use of wood for cellulose pulp, paper, and energy production. A population of 1,000 trees sampled in a progeny trial was phenotyped directly or following the development and use of near-infrared spectroscopy calibration models. Trees were genotyped with 33,398 SNPs and 24,001 DArT-seq genome-wide markers and genomic realized relationship matrices (GRM) were used for parameter estimation with an individual-tree additive-dominant mixed model. Wood chemical properties and wood density showed stronger genetic control than growth, cellulose and fiber traits. Additive effects are the main drivers of genetic variation for all traits, but dominance plays an equally or more important role for growth, singularly in this hybrid. GRM´s with >10,000 markers provided stable relationships estimates and more accurate parameters than pedigrees by capturing the full genetic relationships among individuals and disentangling the non-additive from the additive genetic component. Low correlations between growth and wood properties indicate that simultaneous selection for wood traits can be applied with minor effects on genetic gain for growth. Conversely, moderate to strong correlations between wood density and chemical traits exist, likely due to their interdependency on cell wall structure such that responses to selection will be connected for these traits. Our results illustrate the advantage of using genomewide marker data to inform tree breeding in general and have important consequences for operational breeding of eucalypt urograndis hybrids. Fil: de Lima, Bruno Marco. Universidade de Sao Paulo; Brasil. Ministerio da Agricultura Pecuaria e Abastecimento de Brasil. Empresa Brasileira de Pesquisa Agropecuaria; Brasil Fil: Cappa, Eduardo Pablo. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación de Recursos Naturales. Instituto de Recursos Biológicos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Silva Junior, Orzenil B.. Ministerio da Agricultura Pecuaria e Abastecimento de Brasil. Empresa Brasileira de Pesquisa Agropecuaria; Brasil. Universidade Católica de Brasília; Brasil Fil: Garcia, Carla. No especifíca; Fil: Mansfield, Shawn D.. University of British Columbia; Canadá Fil: Grattapaglia, Dario. Ministerio da Agricultura Pecuaria e Abastecimento de Brasil. Empresa Brasileira de Pesquisa Agropecuaria; Brasil. Universidade Católica de Brasília; Brasil

Published
2019

39. Cross-cultural examination of college marijuana culture in five countries: Measurement invariance of the Perceived Importance of Marijuana to the College Experience Scale

Author

Pearson, Matthew R., Bravo, Adrián J., Sotelo, Melissa, Henson, James M., Ibáñez, Manuel I, Mezquita, Laura, Ortet, Generós, Pilatti, Angelina, Prince, Mark A., Read, Jennifer P., Roozen, Hendrik G., Ruiz, Paul, Cross‐Cultural Addictions Study Team, Henson, James M., and MRP is supported by a career development grant (K01-AA023233) from the National Institute on Alcohol Abuse and Alcoholism (NIAAA). AJB is supported by a training grant (T32-AA018108) from the NIAAA. Data collection was supported, in part, by grant T32-AA018108. NIAAA had no role in the study design, collection, analysis or interpretation of the data, writing the manuscript, or the decision to submit the paper for publication. Data collection in Spain was also supported by grants UJI-A2017-18 and UJI-B2017-74 from the Universitat Jaume I and grant PSI2015-67766-R from the Spanish Ministry of Economy and Competitiveness (MINECO). Data collection in Argentina was also supported by grants from the National Secretary of Science and Technology (FONCYT, grant number #PICT 2015-849) and by grants from the Secretary of Science and Technology- National University of Córdoba (SECyT-UNC).

Subjects
Cross-Cultural Comparison, Male, Universities, education, Psychological intervention, Argentina, Medicine (miscellaneous), Bivariate analysis, Toxicology, Social norms approach, Sex Factors, cross-cultural, Surveys and Questionnaires, mental disorders, Social Norms, Cross-cultural, Humans, Measurement invariance, Students, Netherlands, college students, Reproducibility of Results, Confirmatory factor analysis, Marijuana user, United States, measurement invariance, Psychiatry and Mental health, Clinical Psychology, Level of measurement, Attitude, Spain, college norms, Uruguay, Female, Marijuana Use, Psychology, Factor Analysis, Statistical, marijuana, Clinical psychology
Abstract

This project was completed by the Cross-cultural Addictions Study Team (CAST), which includes the following investigators (in alphabetical order): Adrian J. Bravo, University of New Mexico, USA (Coordinating PI); James M. Henson, Old Dominion University, USA; Manuel I. Ibáñez, Universitat Jaume I de Castelló, Spain; Laura Mezquita, Universitat Jaume I de Castelló, Spain; Generós Ortet, Universitat Jaume I de Castelló, Spain; Matthew R. Pearson, University of New Mexico, USA; Angelina Pilatti, National University of Cordoba, Argentina; Mark A. Prince, Colorado State University, USA; Jennifer P. Read, University at Buffalo, USA; Hendrik G. Roozen, University of New Mexico, USA; Paul Ruiz, Universidad de la República, Uruguay. Marijuana internalized norms, measured by the Perceived Importance of Marijuana to the College Experience Scale (PIMCES; 8 items), has been found to be distinct from marijuana descriptive/injunctive norms and to be a unique robust predictor of marijuana-related outcomes among college students, yet the role of these beliefs has not been studied outside the U.S. Using confirmatory factor analysis, the present work examined the level of measurement invariance (i.e., configural, metric, and scalar) of the PIMCES across five different countries with distinct marijuana-related regulations (i.e., U.S., Argentina, Spain, Uruguay, and the Netherlands), sex, and marijuana user status among college students (n = 3424) recruited between September 2017 and January 2018. To make valid comparisons across groups, metric invariance is needed to compare correlations and scalar invariance is needed to compare latent means. We found strong measurement invariance (i.e., scalar invariance) for the PIMCES across countries, across males and females, and across marijuana users and non-users. College students in the U.S. reported the highest levels of marijuana internalized norms compared to college students from all other countries. As expected, males and marijuana users showed significantly higher scores on the PIMCES than females and non-users, respectively. Bivariate correlations between PIMCES scores and other marijuana-related variables were remarkably similar across males and females, though differences across countries warrant further exploration. Taken together, the degree to which college students view marijuana use to be an integral part of the college experience may be an important target for college student marijuana interventions across various countries/cultures.

Published
2019

40. Measuring educational inequality of opportunity: pupil’s effort matters

Author

Gaston Yalonetzky, Sandy Tubeuf, M. Niaz Asadullah, Alain Trannoy, University of Malaya = Universiti Malaya [Kuala Lumpur, Malaisie] (UM), Aix-Marseille Sciences Economiques (AMSE), École des hautes études en sciences sociales (EHESS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Institut de recherche santé et société [Louvain, Belgium] (IRSS), Université Catholique de Louvain = Catholic University of Louvain (UCL), Institut de recherches économiques et sociales (UCL IRES), University of Leeds, The QSSMEB survey was funded by the World Bank. We thank support from the LABEX AMSE. Alain Trannoy thanks the support of the research project IMCHILD funded by the European Union and the French National Research Agency Grants ANR-17-EURE-0020. An earlier version of the paper was presented at the 36th meeting of the ECINEQ with the support of Health Chair-a joint initiative by PSL, Universite Paris-Dauphine, ENSAE, MGEN and ISTYA under the aegis of the Fondation du Risque (FDR)., ANR-17-EURE-0020,AMSE (EUR),Aix-Marseille School of Economics(2017), University of Malaya [Kuala Lumpur, Malaisie], Leeds University Business School (The University of Leeds), UCL - SSS/IRSS - Institut de recherche santé et société, and UCL - SSH/LIDAM/IRES - Institut de recherches économiques et sociales

Subjects
JEL: C - Mathematical and Quantitative Methods/C.C0 - General/C.C0.C01 - Econometrics, Economics and Econometrics, Sociology and Political Science, Inequality, school, 050204 development studies, media_common.quotation_subject, Geography, Planning and Development, effort, Development, JEL: I - Health, Education, and Welfare/I.I2 - Education and Research Institutions/I.I2.I24 - Education and Inequality, 0502 economics and business, Production (economics), 050207 economics, media_common, Estimation, education, Actuarial science, [QFIN]Quantitative Finance [q-fin], 4. Education, 05 social sciences, Variance (accounting), [SHS.ECO]Humanities and Social Sciences/Economics and Finance, Educational inequality, inequality of opportunity, JEL: O - Economic Development, Innovation, Technological Change, and Growth/O.O1 - Economic Development/O.O1.O12 - Microeconomic Analyses of Economic Development, Social determinism, Variance decomposition of forecast errors, Normative, variance decomposition
Abstract

International audience; The distinction between effort and other factors, such as family background, matters for correcting policies and normative reasons when we appeal to inequality of opportunity. We take advantage of a purposefully designed survey on secondary schools in rural Bangladesh to offer a comprehensive view of the importance of overall effort when measuring inequalities of opportunity in education. The analysis comprises decomposition exercises of the predicted variance of student performance in mathematics and English by source (effort, circumstances, etc.) and subgroup (within- and between-schools) based on parametric estimates of educational production functions. Pupils’ effort, preferences, and talents contribute between 31% and 40% of the total predicted variances in performance scores. The contribution of overall effort falls by 10% when the correlation between effort and circumstances is taken into account. These findings are robust to the choice of estimation strategy (i.e. combined within- and between-schools variation models versus multilevel random-effect models). All in all, these results advocate that social determinism in education can be mitigated by individual effort at school.

Published
2021

41. An Integrative Model of the Influence of Parental and Peer Support on Consumer Ethical Beliefs: The Mediating Role of Self-Esteem, Power, and Materialism

Author

Elodie Gentina, Gregory M. Rose, Scott J. Vitell, Tina M. Lowrey, L. J. Shrum, Lille économie management - UMR 9221 (LEM), Université d'Artois (UA)-Université catholique de Lille (UCL)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Ecole des Hautes Etudes Commerciales (HEC Paris), and HEC Research Paper Series

Subjects
Economics and Econometrics, media_common.quotation_subject, education, Peer support, [SHS]Humanities and Social Sciences, Power (social and political), Arts and Humanities (miscellaneous), 0502 economics and business, Business and International Management, media_common, Mediation (Marxist theory and media studies), 05 social sciences, Perspective (graphical), Social change, Self-esteem, General Business, Management and Accounting, humanities, Feeling, [SHS.GESTION]Humanities and Social Sciences/Business administration, 050211 marketing, Business ethics, Materialism, Psychology, Law, Social psychology, 050203 business & management
Abstract

International audience; What causes adolescents to develop consumer’ ethical beliefs? Prior research has largely focused on the negative influence of peers and negative patterns of parent–child interactions to explain risky and unethical consumer behaviors. We take a different perspective by focusing on the positive support of parents and peers in adolescent social development. An integrative model is developed that links parental and peer support with adolescents’ self-worth motives, their materialistic tendencies, and their consumer ethical beliefs. In a study of 984 adolescents, we demonstrate support for a sequential mediation model in which peer and parental support is positively related to adolescents’ self-esteem and feelings of power, which are each associated with decreased materialism as a means of compensating for low self-worth. This reduced materialism is, in turn, associated with more ethical consumer beliefs.

Published
2018

42. Taxonomy of prokaryotic viruses: 2017 update from the ICTV Bacterial and Archaeal Viruses Subcommittee

Author

Adriaenssens, Evelien M, Wittmann, Johannes, Kuhn, Jens H, Turner, Dann, Sullivan, Matthew B., Dutilh, Bas E, Jang, Ho Bin, van Zyl, Leonardo J, Klumpp, Jochen, Lobocka, Malgorzata, Moreno Switt, Andrea I, Rumnieks, Janis, Edwards, Robert A, Uchiyama, Jumpei, Alfenas-Zerbini, Poliane, Petty, Nicola K, Kropinski, Andrew M, Barylski, Jakub, Gillis, Annika, Clokie, Martha R C, Prangishvili, David, Lavigne, Rob, Aziz, Ramy Karam, Duffy, Siobain, Krupovic, Mart, Poranen, Minna M., Knezevic, Petar, Enault, Francois, Tong, Yigang, Oksanen, Hanna M., Rodney Brister, J, Sub Bioinformatics, Theoretical Biology and Bioinformatics, University of Liverpool, Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH / Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures (DSMZ), National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), National Institutes of Health [Bethesda] (NIH), University of the West of England [Bristol] (UWE Bristol), Ohio State University [Columbus] (OSU), Utrecht University [Utrecht], Radboud University Medical Center [Nijmegen], University of the Western Cape, Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Polish Academy of Sciences (PAN), Universidad Andrés Bello - UNAB (CHILE), Latvian Biomedical Research and Study Centre [Rīga], San Diego State University (SDSU), Azabu University, Universidade Federal de Vicosa (UFV), iThree Institute, University of Technology Sydney (UTS), University of Guelph, Adam Mickiewicz University in Poznań (UAM), Université Catholique de Louvain = Catholic University of Louvain (UCL), University of Leicester, Biologie Moléculaire du Gène chez les Extrêmophiles (BMGE), Institut Pasteur [Paris], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Cairo University, University of Warwick [Coventry], University of Helsinki, University of Novi Sad, Laboratoire Microorganismes : Génome et Environnement (LMGE), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Beijing Institute of Microbiology and Epidemiology, This work was funded in part through Battelle Memorial Institute’s prime contract with the US National Institute of Allergy and Infectious Diseases (NIAID) under Contract No. HHSN272200700016I (J.H.K.). B.E.D. was supported by the Netherlands Organization for Scientific Research (NWO), Vidi Grant 864.14.004. R.A.E was supported by grant MCB-1330800 from the National Science Foundation. J.R.B. was supported by the Intramural Research Program of the National Institutes of Health, National Library of Medicine. R.L. is a member of the phagebiotics research community, supported by FWO Vlaanderen. M.M.P. was supported by the Academy of Finland (272507). A.G. was supported by the National Fund for Scientific Research (FNRS). H.M.O. was supported by University of Helsinki funding for Instruct-F1 research infrastructure., The committee would like to thank Dr. Graham Hatfull (University of Pittsburgh) for permitting us to use Actinobacteriophage Database electron micrographs in 2017’s taxonomy proposals. The authors thank Laura Bollinger (National Institutes of Health/National Institute of Allergy and Infectious Diseases, Integrated Research Facility at Fort Detrick, Frederick, MD, USA) for editing this paper., University of the Western Cape (UWC), Universidad Andrés Bello [Santiago] (UNAB), Universidade Federal de Viçosa = Federal University of Viçosa (UFV), Institut Pasteur [Paris] (IP), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), UCL - SST/ELI/ELIM - Applied Microbiology, Sub Bioinformatics, and Theoretical Biology and Bioinformatics

Subjects
0301 basic medicine, Archaeal Viruses, viruses, [SDV]Life Sciences [q-bio], 030106 microbiology, education, Coronacrisis-Taverne, Zoology, Computational biology, Biology, [SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics, Phylogenetics and taxonomy, 03 medical and health sciences, Phylogenetics, Virology, MESH: Archaeal Viruses, Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14], Bacteriophages, MESH: Bacteriophages, Virus classification, Taxonomy, General Medicine, 030104 developmental biology, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, ICTV bacterial, Classification methods, Taxonomy (biology), Bacterial virus
Abstract

International audience; The prokaryotic virus community is represented at the International Committee on Taxonomy of Viruses (ICTV) by the Bacterial and Archaeal Viruses Subcommittee. Since our last report [5], the committee composition has changed, and a large number of taxonomic proposals (TaxoProps) were submitted to the ICTV Executive Committee (EC) for approval.

Published
2018

43. The association between the incidence of postmenopausal breast cancer and concentrations at street-level of nitrogen dioxide and ultrafine particles

Author

Mark S. Goldberg, France Labrèche, Scott Weichenthal, Eric Lavigne, Marie-France Valois, Marianne Hatzopoulou, Keith Van Ryswyk, Maryam Shekarrizfard, Paul J. Villeneuve, Daniel Crouse, Marie-Élise Parent, Research Institute of the McGill University Hospital Centre, Department of Medecine [Montréal], McGill University = Université McGill [Montréal, Canada], Department of Environmental and Occupational Health, School of Public Health, Université de Montréal (UdeM), Department of Epidemiology, Biostatistics and Occupational Health [Montréal], Health Canada, Air Health Science Division, Health Canada, Department of Epidemiology, Public Health and Preventive Medicine, University of Ottawa [Ottawa], Department of Civil Engineering, University of Toronto, Department of Health Sciences, School of Mathematics and Statistics, Carleton University, Department of Sociology, and New Brunswick Institute for Research, Data, and Training, University of New Brunswick (UNB), Institut Armand Frappier (INRS-IAF), Réseau International des Instituts Pasteur (RIIP)-Institut National de la Recherche Scientifique [Québec] (INRS), and The data collection for the breast cancer study was funded by the Quebec Breast Cancer Foundation and analyses for this paper were funded by Health Canada. Dr. Weichenthal also received support from a GRePEC salary award funded by the Cancer Research Society, the Quebec Ministry of Economy, Science and Innovation, and les Fonds de Recherche du Québec- Santé (FRQS). Marie-Élise Parent held a career award from the FRQS

Subjects
Postmenopausal breast cancer, [SDV]Life Sciences [q-bio], 010501 environmental sciences, 01 natural sciences, Biochemistry, 0302 clinical medicine, Interquartile range, Ultrafine particle, Medicine, General Environmental Science, education.field_of_study, Air Pollutants, Incidence (epidemiology), Incidence, Quebec, Case-control study, Environmental exposure, Middle Aged, 3. Good health, Postmenopause, 030220 oncology & carcinogenesis, Female, Environmental Monitoring, Diesel exhaust, Population, Nitrogen Dioxide, [SDV.CAN]Life Sciences [q-bio]/Cancer, Breast Neoplasms, 03 medical and health sciences, Breast cancer, Traffic-related air pollution, Occupational Exposure, Humans, Particle Size, education, 0105 earth and related environmental sciences, Aged, business.industry, Odds ratio, Environmental Exposure, medicine.disease, [SDE.ES]Environmental Sciences/Environmental and Society, Logistic Models, Ultrafine particles, [SHS.ENVIR]Humanities and Social Sciences/Environmental studies, Case-Control Studies, Particulate Matter, business, Demography
Abstract

International audience; There is scant information as to whether traffic-related air pollution is associated with the incidence of breast cancer. Nitrogen dioxide (NO2) and ultrafine particles (UFPs

Published
2017

44. The harlequin ladybird, Harmonia axyridis: global perspectives on invasion history and ecology

Author

Alexandra Magro, Artur Gil, A.J.M. Loomans, Cang Hui, Katie M. Murray, Sandra Viglášová, Paul S. van Wielink, Axel Vandereycken, Arnaud Estoup, Susana Clusella-Trullas, Benoit Facon, Annette Herz, May-Guri Saethre, Zdenka Martinkova, Richard Comont, Isabel Borges, Dirk Maes, Sergey K. Ryndevich, Thomas Guillemaud, Helen E. Roy, António O. Soares, Marina J. Orlova-Bienkowskaja, Mary M. Gardiner, Alexander Ok Lukashuk, Tim Adriaens, William D. Hutchison, Ingrid A. Minnaar, Patrick De Clercq, John J. Sloggett, Peter M. J. Brown, Alois Honek, Marc Kenis, Audrey A. Grez, Hans Peter Ravn, Tania Zaviezo, Nick Berkvens, Wolfgang Rabitsch, Danny Haelewaters, Riaan Stals, Zihua Zhao, Ján Kulfan, John E. Losey, Peter Zach, Andy G. Howe, Eric Lombaert, I. A. Zakharov, Lori Lawson Handley, Oldrich Nedved, Robert L. Koch, Steph L. Rorke, Matthew C. Tinsley, Gabriele Rondoni, René Eschen, Naoya Osawa, Edward W. Evans, Gilles San Martin, Centre for Ecology and Hydrology [Wallingford] (CEH), Natural Environment Research Council (NERC), Anglia Ruskin University (ARU), Research Institute for Nature and Forest (INBO), Research Institute for Agricultural, Fisheries and Food (ILVO), University of the Azores, Centre for Ecology, Evolution and Environmental Changes (cE3c) / Azorean Biodiversity Group and Universidade dos Açores, Departamento de Ciências e Engenharia do Ambiente, Açores, Stellenbosch University, Centre for Invasion Biology, Department of Botany and Zoology, Bumblebee Conservation Trust, Universiteit Gent = Ghent University [Belgium] (UGENT), Department of Crop Protection, Centre for Agricultural and Biosciences International Europe - Switzerland (CABI Europe - Switzerland), Centre de Biologie pour la Gestion des Populations (UMR CBGP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Utah State University (USU), Ohio State University [Columbus] (OSU), Ohio Agricultural Research and Development Center, Universidad de Chile = University of Chile [Santiago] (UCHILE), Institut Sophia Agrobiotech (ISA), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Recherche Agronomique (INRA), Department of Organismic and Evolutionary Biology [Cambridge] (OEB), Harvard University [Cambridge], Julius Kühn-Institut - Federal Research Centre for Cultivated Plants (JKI), Crop Res Inst, Div Crop Genet & Breeding, Prague, Czech Republic, Partenaires INRAE, Department of Geosciences and Natural Resource Management [Copenhagen] (IGN), Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Centre for Invasion Biology, Department of Mathematical Sciences, Stellenbosch University, University of Minnesota System, Institute of Forest Ecology - SAS, University of Hull [United Kingdom], National Plant Protection Organization (NPPO), Cornell University [New York], Berezinskiy Biosphere Reserve, Belarus, Evolution et Diversité Biologique (EDB), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, University of Stirling, Department of Biological and Environmental Sciences, University of Stirling, Walloon Agricultural Research Centre, Department of Botany and Zoology, Centre of Excellence for Invasion Biology, University of South Bohemia, Institute of Entomology [České Budějovice] (BIOLOGY CENTRE CAS), Biology Centre of the Czech Academy of Sciences (BIOLOGY CENTRE CAS), Czech Academy of Sciences [Prague] (CAS)-Czech Academy of Sciences [Prague] (CAS), A.N. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences [Moscow] (RAS), Kyoto University [Kyoto], Laboratory of Insect Ecology, Graduate School of Agriculture, Kyoto University, Environment Agency Austria, Department of Agricultural, Food and Environmental Sciences, University of Perugia (DSA3), Università degli Studi di Perugia (UNIPG), The paper had its origin at a workshop on 'Drivers, impacts, mechanisms and adaptation in insect invasions' hosted by the DST-NRF Centre of Excellence for Invasion Biology in Stellenbosch, South Africa, in November 2014. Additional financial support was provided by HortGro, the National Research Foundation of South Africa, Stellenbosch University, and SubTrop. We thank all our collaborators, and particularly the volunteer community, who have contributed to research around the world on H. axyridis. The number of references included reflects the range of inspiring studies on H. axyridis from so many people-we look forward to new and continued collaborations in the future. We are grateful to the editors of this special issue for inviting this review and providing an opportunity to explore ideas through the 'Invasive Insects Workshop funding (NRF South Africa, CIB)'. We also thank the anonymous reviewers for all their useful comments and reflections. The UK Ladybird Survey and associated coauthors are supported by the Biological Records Centre (part of the Centre for Ecology & Hydrology), which receives support from both the Natural Environment Research Council and the Joint Nature Conservation Committee. The IOBC WPRS and Global Working Groups 'Benefits and Risks of Exotic Biological Control Agents' and the COST Action TD1209 'Alien Challenge' have facilitated discussions and collaborations on H. axyridis. This study was supported by the French Agropolis Fondation (Labex Agro-Montpellier, BIOFIS Project Number 1001-001) and by a grant from the ERA-Net BiodivERsA, with the national funders ANR (France), DFG (Germany) and BELSPO (Belgium), as part of the 2012-2013 BiodivERsA call for research proposals. Support has been also received from FONDECYT 1140662 (Chile). The study of M.J. Orlova-Bienkowskaja and I. A. Zakharov was supported by Russian Science Foundation, Project No. 16-16-00079. Gabriele Rondoni acknowledges financial support from Fondazione Cassa di Risparmio di Perugia. Riaan Stals acknowledges funding from the Department of Science and Technology, South Africa. The research of Peter Zach and colleagues was funded by the project VEGA 2/0035/13 and VEGA 2/0052/15. A. Honek and Z. Martinkova were supported by grants GACR 14-26561S and COST CZ LD14084. Research in Switzerland is funded by the Swiss Federal Office for the Environment. Hans Peter Ravn was supported by the Villum Foundation. Danny Haelewaters acknowledges funding from the David Rockefeller Center for Latin American Studies at Harvard University and from the Mycological Society of America., Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Research Institute for Nature and Forest, Institut Sophia Agrobiotech [Sophia Antipolis] (ISA), Institut National de la Recherche Agronomique (INRA)-Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Julius Kühn Institute (JKI), CABI Europe Switzerland, Universität der Bundeswehr München [Neubiberg], Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Grad Sch Agr, Lab Forest Ecol, Department of Biodiversity and Nature Conservation, NEMOD Biotherapeutics GmbH & Co. KG, Facultad de Agronomía e Ingeniería Forestal, Pontificia Universidad Católica de Chile (UC), RS: FSE MSP, and Maastricht Science Programme

Subjects
0106 biological sciences, Range (biology), Ecology (disciplines), ADALIA-BIPUNCTATA, Population, Biodiversity, INTRAGUILD PREDATION, Generalist and specialist species, NATURAL ENEMIES, 010603 evolutionary biology, 01 natural sciences, Ecology and Environment, 1ST RECORD, Competitive interactions, MYZUS-PERSICAE HOMOPTERA, education, Ecology, Evolution, Behavior and Systematics, ComputingMilieux_MISCELLANEOUS, Apex predator, education.field_of_study, APHIS-GLYCINES, Ecology, biology, PALLAS COLEOPTERA-COCCINELLIDAE, Biocontrol, 15. Life on land, biology.organism_classification, Harmonia axyridis, 010602 entomology, MULTICOLORED ASIAN LADYBIRD, Coccinellidae, Invasion history, Species traits, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, BEETLE COLEOPTERA, BIOLOGICAL-CONTROL, Intraguild predation
Abstract

International audience; The harlequin ladybird, Harmonia axyridis (Pallas) (Coleoptera: Coccinellidae), is native to Asia but has been intentionally introduced to many countries as a biological control agent of pest insects. In numerous countries, however, it has been introduced unintentionally. The dramatic spread of H. axyridis within many countries has been met with considerable trepidation. It is a generalist top predator, able to thrive in many habitats and across wide climatic conditions. It poses a threat to biodiversity, particularly aphidophagous insects, through competition and predation, and in many countries adverse effects have been reported on other species, particularly coccinellids. However, the patterns are not consistent around the world and seem to be affected by many factors including landscape and climate. Research on H. axyridis has provided detailed insights into invasion biology from broad patterns and processes to approaches in surveillance and monitoring. An impressive number of studies on this alien species have provided mechanistic evidence alongside models explaining large-scale patterns and processes. The involvement of citizens in monitoring this species in a number of countries around the world is inspiring and has provided data on scales that would be otherwise unachievable. Harmonia axyridis has successfully been used as a model invasive alien species and has been the inspiration for global collaborations at various scales. There is considerable scope to expand the research and associated collaborations, particularly to increase the breadth of parallel studies conducted in the native and invaded regions. Indeed a qualitative comparison of biological traits across the native and invaded range suggests that there are differences which ultimately could influence the population dynamics of this invader. Here we provide an overview of the invasion history and ecology of H. axyridis globally with consideration of future research perspectives. We reflect broadly on the contributions of such research to our understanding of invasion biology while also informing policy and people.

Published
2016

45. Impact of early complications on outcomes in patients with implantable cardioverter-defibrillator for primary prevention

Author

Maria Soledad Ascoeta, Marie-Cécile Perier, Olivier Piot, Daniel Gras, Laurent Fauchier, Nicolas Sadoul, Pascal Defaye, Didier Klug, Frankie Beganton, Eloi Marijon, Serge Boveda, Vincent Algalarrondo, Dominique Babuty, Christophe Leclercq, Jean-Claude Deharo, Pierre Bordachar, Centre cardiologique du Nord (CCN), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Centre Hospitalier Universitaire [Grenoble] (CHU), Hôpital cardiologique, Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Nouvelles Cliniques Nantaises, Hôpital Antoine Béclère, Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de cardiologie, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes], CHU Pontchaillou [Rennes], Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Hôpital Haut-Lévêque, Université Sciences et Technologies - Bordeaux 1-CHU Bordeaux [Bordeaux], Service de Cardiologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Clinique Pasteur et Groupe Rythmologie Stimulation Cardiaque/SFC, Clinique Pasteur [Toulouse], Editorial support on the final version of the paper was provided by MedLink Healthcare Communications Ltd and was funded by the authors. ADREC (Association Dyonisienne de Recherche et Enseignement de Cardiologie) provided secretarial assistance., Centre cardiologique du Nord, Hôpital Européen Georges Pompidou [APHP] ( HEGP ), Centre Hospitalier Universitaire [Grenoble] ( CHU ), Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille ), Paris-Centre de Recherche Cardiovasculaire ( PARCC - U970 ), Hôpital Européen Georges Pompidou [APHP] ( HEGP ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP), Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille ( APHM ) - Hôpital de la Timone [CHU - APHM] ( TIMONE ), Laboratoire Traitement du Signal et de l'Image ( LTSI ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de cardiologie et maladies vasculaires, Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Hôpital Pontchaillou-CHU Pontchaillou [Rennes], CHU de Tours, Centre Hospitalier Régional Universitaire de Nancy ( CHRU Nancy ), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Université Sciences et Technologies - Bordeaux 1 (UB)-CHU Bordeaux [Bordeaux], Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Université Paris Descartes - Paris 5 (UPD5)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], and CHU Bordeaux [Bordeaux]-Université Sciences et Technologies - Bordeaux 1

Subjects
Male, Pediatrics, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Coronary Artery Disease, 030204 cardiovascular system & hematology, Coronary artery disease, 0302 clinical medicine, Postoperative Complications, Risk Factors, Medicine, 030212 general & internal medicine, Registries, education.field_of_study, Hematoma, Primary prevention, Sudden death, Incidence (epidemiology), Incidence, Middle Aged, Implantable cardioverter-defibrillator, 3. Good health, Defibrillators, Implantable, Female, France, Cardiology and Cardiovascular Medicine, Cardiomyopathy, Dilated, medicine.medical_specialty, Population, Cardiac resynchronization therapy, Electric Countershock, Risk Assessment, 03 medical and health sciences, Physiology (medical), Humans, Mortality, education, Aged, [ SDV ] Life Sciences [q-bio], business.industry, Implantable cardiac-defibrillator, Odds ratio, medicine.disease, Survival Analysis, Equipment Failure Analysis, Death, Sudden, Cardiac, Tachycardia, Ventricular, Morbidity, Complication, business
Abstract

International audience; Background - The lifesaving benefit of implantable cardioverter-defibrillators (ICDs) has been demonstrated. Their use has increased considerably in the past decade, but related complications have become a major concern. Objective - The purpose of this study was to assess the incidence and effect on outcomes of early (≤30 days) complications after ICD implantation for primary prevention in a large French population. Methods - We analyzed data from 5539 patients from the multicenter French DAI-PP (Défibrillateur Automatique Implantable-Prévention Primaire) registry (2002-2012) who had coronary artery disease or dilated cardiomyopathy and were implanted with an ICD for primary prevention. Results - Overall, early complications occurred in 707 patients (13.5%), mainly related to lead dislodgment or hematoma (57%). Independent factors associated with occurrence of early complications were severe renal impairment (odds ratio [OR] 1.66, 95% confidence interval [CI] 1.17-2.37, P = .02), age ≥75 years (OR 1.01, 95% CI 1.00-1.02, P = .03), cardiac resynchronization therapy (OR 1.58, 95% CI 1.16-2.17, P = .01), and anticoagulant therapy (OR 1.28, 95% CI 1.02-1.61, P = .03). During a mean ± SD follow-up of 3.1 ± 2.3 years, 824 (15.8%) patients experienced ≥1 late complication (>30 days), and 782 (14.9%) patients died. After adjustment, early complications remained associated with occurrence of late complications (OR 2.15, 95% CI 1.73-2.66, P < .0001) and mortality (OR 1.70, 95% CI 1.34-2.17, P = .003). Conclusion - Early complications are common after ICD implantation for primary prevention, occurring in 1 in 7 patients, and are associated with an increased risk of late complications and overall mortality. Further studies are needed to investigate the underlying mechanisms of such associations.

Published
2016

46. The Unintended Consequences of Government Regulations in Emerging Financial Markets: Evidence from the Chinese IPO Market

Author

Xiaohui Wu, François Derrien, Yan Zhang, Qi Zeng, Huazhong University of Science and Technology [Wuhan] (HUST), Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Qiongzhou University, HEC Paris Research Paper Series, and Haldemann, Antoine

Subjects
JEL: G - Financial Economics/G.G3 - Corporate Finance and Governance/G.G3.G30 - General, education.field_of_study, Government, Unintended consequences, media_common.quotation_subject, Emerging markets, Population, Financial market, Financial system, JEL: G - Financial Economics/G.G3 - Corporate Finance and Governance/G.G3.G38 - Government Policy and Regulation, Initial Public Offerings, Cash, [SHS.GESTION]Humanities and Social Sciences/Business administration, Dividend, JEL: G - Financial Economics/G.G2 - Financial Institutions and Services/G.G2.G28 - Government Policy and Regulation, Business, [SHS.GESTION] Humanities and Social Sciences/Business administration, education, Initial public offering, Regulation, media_common
Abstract

This paper explores the impact of regulations imposed by the Chinese government on the development of the Chinese IPO market between 2000 and 2011. Some of these regulations have affected the population of Chinese firms that went public domestically, some firms being excluding from the domestic IPO markets, others being induced to list abroad. We also provide evidence that, because of limits on prices and proceeds, the Chinese IPO market does not attract companies that need cash the most. Some IPO firms that raise large amounts of cash decide to pay large dividends shortly after going public, which investors interpret as evidence that their growth options were overestimated at the time of their IPO.

Published
2016

47. Interventions and decision-making at the end of life: the effect of establishing the terminal illness situation

Author

Rafael Montoya-Juárez, María Paz García-Caro, E. Hernández-López, César Hueso-Montoro, F. Ojeda-Virto, C. Campos-Calderón, [Campos-Calderón,C] Foundation of Progress and Health, Andalusian Health Service, Granada, Spain. [Montoya-Juárez,R, Hueso-Montoro,C, García-Caro,MP] Nursing Department, University of Granada, Granada, Spain. [Hernández-López,E] General Hospital of the Virgen de las Nieves of Granada, Andalusian Health Service, Granada, Spain. [Ojeda-Virto,F] Hospital Santa Ana, Andalusian Health Service, Motril, Spain., and This work is part of an investigative project financed by the Department of Health of the Board of Andalucía in its 2010 call for papers, titled ‘Variability of Clinical Practice and Conditional Factors in the Implementation of the Processes of Attention at End of Life’.Ref: PI-0670-2010.

Subjects
Palliative care, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies [Medical Subject Headings], medicine.medical_treatment, España, Psychological intervention, Chemicals and Drugs::Inorganic Chemicals::Elements::Chalcogens::Oxygen [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, Oxygen therapy, Medicine, Analgésicos opioides, Oxígeno, 030212 general & internal medicine, Patient Comfort, Practice Patterns, Physicians', Resuscitation Orders, Health Care::Health Care Facilities, Manpower, and Services::Health Facilities::Hospitals [Medical Subject Headings], Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings], Medicine(all), Terminal Care, Palliative Care, Do not resuscitate, Symptom management, General Medicine, Prognosis, Hospitals, Humanos, End-of-life care, Teaching/learning strategies, 030220 oncology & carcinogenesis, Peripheral venous catheter, Hospitales, Research Article, medicine.medical_specialty, Clinical Decision-Making, education, M-learning, Prescripciones, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Peripheral Nervous System Agents::Sensory System Agents::Analgesics::Analgesics, Opioid [Medical Subject Headings], Advance Care Planning, Estudios retrospectivos, 03 medical and health sciences, Humans, Terminally Ill, Medical prescription, Órdenes de resucitación, Intensive care medicine, Retrospective Studies, Delivery of care, Hospital care, business.industry, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Emergency Treatment::Resuscitation::Resuscitation Orders [Medical Subject Headings], Andalucía, Retrospective cohort study, Spain, business, Decision making, Physical therapy, Health Care::Health Care Facilities, Manpower, and Services::Health Services::Pharmaceutical Services::Prescriptions [Medical Subject Headings]
Abstract

Background: Mobile learning (m-learning) has becoming very popular in education due to the rapidly advancing technology in our society. The potentials of the mobile applications should be used to enhance the education process. Few mobile applications have been designed to complement the study of physical therapy skills for physiotherapy students. The aim of this study was to investigate whether a mobile application, as a supplement to traditional learning, is useful for physiotherapy students in the acquisition of palpation and ultrasound skills in the shoulder area. Methods: Forty-nine students participated in this single-blinded, randomized controlled study. They were randomly distributed into two groups: experimental, with free access to the mobile application; and control, with access to traditional learning materials on the topic. Objective structured clinical evaluation (OSCE) and multiple-choice questionnaire (MCQ) were used to assess the educational intervention. Then, we also assessed the time taken to get a reliable ultrasound image and to localize a specific shoulder structure by palpation. Results: There was no significant intergroup difference in the acquisition of theoretical knowledge (p = .089). Scores were significantly higher in the experimental group than in the control group for the majority items in the ultrasound assessment; positioning of patient (p < .001), positioning of ultrasound probe (p = 0.007), handling of ultrasound probe (p = .013) and global OSCE (p < .001) and skills in palpation of the shoulder; position of patient (p = .009), direction of palpation contact (p = .021) and global OSCE (p = .034). There were no significant differences in the time required to perform the examination between groups in ultrasound (p = .944) and palpation (p = .393). The results from the post-program survey assessing the global satisfaction with the mobile application were high (8.200 ± .767), on an 11 numeric point rating scale. Conclusion: These results suggest the effectiveness of an m-learning program as a complement to traditional education for developing skills in ultrasound and palpation of the shoulder region in undergraduate physiotherapy students., The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded by a grant from the Educational Innovation Unit of the University of Granada, Spain (PID 13–86).

Published
2016

48. Historical summer distribution of the endangered North Atlantic right whale (Eubalaena glacialis): a hypothesis based on environmental preferences of a congeneric species

Author

Tim D. Smith, Maria Grazia Pennino, David M. Kaplan, Sophie Monsarrat, Ana S. L. Rodrigues, Randall R. Reeves, Christine N. Meynard, Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université Paul-Valéry - Montpellier 3 (UPVM), UMR 212 EME 'écosystèmes marins exploités' (EME), Université de Montpellier (UM)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Institut de Recherche pour le Développement (IRD), World Whaling History, Okapi Wildlife Associates, Centre de Biologie pour la Gestion des Populations (UMR CBGP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Virginia Institute of Marine Science (VIMS), College of William and Mary [Williamsburg] (WM), The MORSE project funded this project (Agence Nationale de la Recherche, CEP&S 2011 – Project ANR-11-CEPL-006). This paper benefited from discussions with members of the CESAB (Center for Synthesis and Analysis of Biodiversity) PELAGIC project, financed by the 'Fondation pour la diversité' (FRB) and the Fondation TOTAL., ANR-11-CEPL-0006,MORSE,Gestion de ressources marines sous des attendus changeants : amener la perspective historique dans la conservation de mammifères marins(2011), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Université Paul-Valéry - Montpellier 3 (UPVM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut de Recherche pour le Développement (IRD [France-Sud])

Subjects
Range (biology), [SDV]Life Sciences [q-bio], Species distribution, Population, Endangered species, Distribution (economics), historical distribution, Latitude, Whaling, Boosted regression trees, 14. Life underwater, education, species distribution models, Ecology, Evolution, Behavior and Systematics, education.field_of_study, biology, Ecology, business.industry, whaling, right whale, biology.organism_classification, Geography, 13. Climate action, Right whale, business, Eubalaena
Abstract

International audience; Aim To obtain a plausible hypothesis for the historical distribution of North Atlantic right whales (NARWs) (Eubalaena glacialis) in their summer feeding grounds. Previously widespread in the North Atlantic, after centuries of hunting, these whales survive as a small population off eastern North America. Because their exploitation began before formal records started, information about their historical distribution is fragmentary. Location North Atlantic and North Pacific oceans. Methods We linked historical records of North Pacific right whales (E.japonica; from 19th-century American whaling logbooks) with oceanographic data to generate a species distribution model. Assuming that the two species have similar environmental preferences, the model was projected into the North Atlantic to predict environmental suitability for NARWs. The reliability of these predictions was assessed by comparing the model results with historical and recent records in the North Atlantic. Results The model predicts suitable environmental conditions over a wide, mostly offshore band across the North Atlantic. Predictions are well supported by historical and recent records, but discrepancies in some areas indicate lower discriminative ability in coastal, shallow-depth areas, suggesting that this model mainly describes the summer offshore distribution of right whales. Main conclusions Our results suggest that the summer range of the NARW consisted of a relatively narrow band (width c.10 degrees in latitude), extending from the eastern coast of North America to northern Norway, over the Grand Banks of Newfoundland, south of Greenland and Iceland, north of the British Isles and in the Norwegian Sea. These results highlight possibilities for additional research both on the history of exploitation and on the current summer distribution of this species. In particular, better survey coverage of historical whaling grounds could help inform conservation efforts for this endangered species. More generally, this study illustrates the challenges and opportunities in using historical data to understand the original distribution of highly depleted species.

Published
2015

49. Accounting Quality and Debt Concentration: Evidence from Internal Control Weakness Disclosures

Author

Ningzhong Li, Yun Lou, Clemens A. Otto, Regina Wittenberg Moerman, Groupement de Recherche et d'Etudes en Gestion à HEC (GREGH), Ecole des Hautes Etudes Commerciales (HEC Paris)-Centre National de la Recherche Scientifique (CNRS), Singapore Management University (SIS), Singapore Management University, and HEC Paris Research Paper Series

Subjects
Weakness, business.industry, Creditor, media_common.quotation_subject, Control (management), education, Accounting, humanities, Empirical research, Capital (economics), Debt, medicine, [SHS.GESTION]Humanities and Social Sciences/Business administration, Quality (business), medicine.symptom, business, health care economics and organizations, media_common, Credit risk
Abstract

This paper examines how accounting quality affects the degree of debt concentration in corporate capital structures (i.e., a firm’s tendency to predominantly rely on only a few types of debt). Motivated by theoretical and empirical research that supports a strong link between creditors’ coordination costs and debt concentration and the importance of accounting quality in reducing these coordination costs, we hypothesize that firms with low accounting quality have a more concentrated debt structure. Measuring financial reporting quality by the disclosure of material internal control weaknesses over financial reporting (ICWs), we find that ICWs lead to a significantly more concentrated debt structure. We also show that the effect of ICWs on the degree of debt concentration is stronger for more severe ICW disclosures and for firms with a higher credit risk, further reinforcing the importance of financial reporting quality in determining debt concentration.

Published
2014

50. Multiple vulnerabilities and maternal healthcare in Vietnam: findings from the Multiple Indicator Cluster Surveys, 2000, 2006, and 2011

Author

Chul Ou Lee, Hoang Van Minh, Vu Duy Kien, Tran Thi Huong, Luu Ngoc Hoat, Juhwan Oh, Kim Bao Giang, You Seon Nam, and This paper was written as part of collaborative project on strengthening health system in Viet Nam which is being implemented by Hanoi Medical University, University of Medicine and Pharmacy of Ho Chi Minh City, Viet Nam and LEE Jong-wook Center for Globa

Subjects
Rural Population, Program evaluation, inequality, Ethnic group, 0302 clinical medicine, Pregnancy, Surveys and Questionnaires, Health care, Ethnicity, Medicine, 030212 general & internal medicine, Socioeconomics, media_common, education.field_of_study, Multiple Indicator Cluster Surveys, lcsh:Public aspects of medicine, Health Policy, healthcare, Public Health, Global Health, Social Medicine and Epidemiology, multiple socioeconomic vulnerabilities, Vietnam, Female, Original Article, Public Health, 0305 other medical science, Adult, Inequality, media_common.quotation_subject, Population, Developing country, 03 medical and health sciences, Environmental health, Humans, Maternal Health Services, Healthcare Disparities, education, Socioeconomic status, 030505 public health, skilled antenatal care, business.industry, Public Health, Environmental and Occupational Health, skilled delivery, inequity, lcsh:RA1-1270, Patient Acceptance of Health Care, Delivery, Obstetric, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Cross-Sectional Studies, Socioeconomic Factors, Special Issue: Millennium Development Goals in Vietnam: the Progress and Social Determinants, business
Abstract

Background: Knowledge of the aggregate effects of multiple socioeconomic vulnerabilities is important for shedding light on the determinants of growing health inequalities and inequities in maternal healthcare.Objective: This paper describes patterns of inequity in maternal healthcare utilization and analyzes associations between inequity and multiple socioeconomic vulnerabilities among women in Vietnam.Design: This is a repeated cross-sectional study using data from the Vietnam Multiple Indicator Cluster Surveys 2000, 2006, and 2011. Two maternal healthcare indicators were selected: (1) skilled antenatal care and (2) skilled delivery care. Four types of socioeconomic vulnerabilities – low education, ethnic minority, poverty, and rural location – were assessed both as separate explanatory variables and as composite indicators (combinations of three and four vulnerabilities). Pairwise comparisons and adjusted odds ratios were used to assess socioeconomic inequities in maternal healthcare.Results: In all three surveys, there were increases across the survey years in both the proportions of women who received antenatal care by skilled staff (68.6% in 2000, 90.8% in 2006, and 93.7% in 2011) and the proportions of women who gave birth with assistance from skilled staff (69.9% in 2000, 87.7% in 2006, and 92.9% in 2011). The receipt of antenatal care by skilled staff and birth assistance from skilled health personnel were less common among vulnerable women, especially those with multiple vulnerabilities.Conclusions: Even though Vietnam has improved its coverage of maternal healthcare on average, policies should target maternal healthcare utilization among women with multiple socioeconomic vulnerabilities. Both multisectoral social policies and health policies are needed to tackle multiple vulnerabilities more effectively by identifying those who are poor, less educated, live in rural areas, and belong to ethnic minority groups.Keywords: healthcare; skilled antenatal care; skilled delivery; multiple socioeconomic vulnerabilities; inequity; inequality(Published: 29 February 2016)Citation: Glob Health Action 2016, 9: 29386 - http://dx.doi.org/10.3402/gha.v9.29386This paper is part of the Special Issue: Millennium Development Goals in Vietnam: the Progress and Social Determinants. More papers from this issue can be found at www.globalhealthaction.net

Published
2016