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The impact of diabetes on heart failure development: the cardio-renal-metabolic connection
- Source :
- Diabetes Research and Clinical Practice, Diabetes Research and Clinical Practice, 2021, 175, pp.108831. ⟨10.1016/j.diabres.2021.108831⟩, Diabetes Research and Clinical Practice, Elsevier, 2021, 175, pp.108831. ⟨10.1016/j.diabres.2021.108831⟩
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Heart failure (HF) and chronic kidney disease (CKD) are often associated in type 2 diabetes (T2D), aggravate each other and exert synergistic effects to increase the risk of cardiac and renal events. The risks of renal worsening in HF patients and HF in CKD patients need to be evaluated to tailor preventive therapy. The recent CV and renal trials enriched our knowledge about the natural history of HF and CKD in T2D and provided evidence for the benefit of sodium-glucose cotransporter 2 inhibitors (SGLT2is) in HF and renal decline prevention. SGLT-2is are the best choice in patients with HFrEF to improve CV prognosis and HF-related outcomes and also to prevent kidney-related outcomes, and in CKD patients to slow down renal failure and also reduce hospitalization for HF and CV death. In both situations the number of patients to treat in order to prevent such events in one patient is lower than in the general T2D population at high CV risk. GLP1-receptor agonists could be an alternative in a patient who is intolerant or has a contraindication to SGLT-2is. A tight collaboration between diabetologists, nephrologists and cardiologists should be encouraged for a holistic and effective strategy to reduce the burden of cardio-renal-metabolic interaction.
- Subjects :
- medicine.medical_specialty
GLP1-receptor agonists
Endocrinology, Diabetes and Metabolism
Population
heart failure
030209 endocrinology & metabolism
Type 2 diabetes
urologic and male genital diseases
[SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology
Coronary artery disease
03 medical and health sciences
0302 clinical medicine
Endocrinology
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Diabetes mellitus
Internal Medicine
medicine
Humans
030212 general & internal medicine
Renal Insufficiency, Chronic
education
Intensive care medicine
Contraindication
[SDV.IB] Life Sciences [q-bio]/Bioengineering
education.field_of_study
business.industry
Diabetes
General Medicine
medicine.disease
[SDV.MHEP.UN] Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology
3. Good health
[SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Natural history
Diabetes Mellitus, Type 2
Heart failure
[SDV.IB]Life Sciences [q-bio]/Bioengineering
business
SGLT2 inhibitors
chronic kidney disease
coronary artery disease
Kidney disease
Subjects
Details
- Language :
- English
- ISSN :
- 01688227
- Database :
- OpenAIRE
- Journal :
- Diabetes Research and Clinical Practice, Diabetes Research and Clinical Practice, 2021, 175, pp.108831. ⟨10.1016/j.diabres.2021.108831⟩, Diabetes Research and Clinical Practice, Elsevier, 2021, 175, pp.108831. ⟨10.1016/j.diabres.2021.108831⟩
- Accession number :
- edsair.doi.dedup.....61eec668f912b2bd5306b44a49d21e94