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Urban environment and cognitive and motor function in children from four European birth cohorts
- Source :
- Binter, Anne Claire Bernard, Jonathan Y. Mon Williams, Mark Andiarena, Ainara González Safont, Llúcia Vafeiadi, Marina Lepeule, Johanna Soler Blasco, Raquel Alonso, Lucia Kampouri, Mariza Mceachan, Rosie Santa-Marina, Loreto Wright, John Chatzi, Leda Sunyer, Jordi Philippat, Claire Nieuwenhuijsen, Mark Vrijheid, Martine Guxens, Mònica 2022 Urban environment and cognitive and motor function in children from four European birth cohorts Environment International 158 106933, Environment International, Environment International, 2022, 158, pp.106933. ⟨10.1016/j.envint.2021.106933⟩, Environment International, Vol 158, Iss, Pp 106933-(2022), Environment International, Elsevier, 2022, 158, pp.106933. ⟨10.1016/j.envint.2021.106933⟩, Environment international, 158:106933. Elsevier Ltd., Addi. Archivo Digital para la Docencia y la Investigación, instname
- Publication Year :
- 2022
-
Abstract
- [EN]Background: The urban environment may influence neurodevelopment from conception onwards, but there is no evaluation of the impact of multiple groups of exposures simultaneously. We investigated the association between early-life urban environment and cognitive and motor function in children. Methods: We used data from 5403 mother-child pairs from four population-based birth-cohorts (UK, France, Spain, and Greece). We estimated thirteen urban home exposures during pregnancy and childhood, including: built environment, natural spaces, and air pollution. Verbal, non-verbal, gross motor, and fine motor functions were assessed using validated tests at five years old. We ran adjusted multi-exposure models using the Deletion-Substitution-Addition algorithm. Results: Higher greenness exposure within 300 m during pregnancy was associated with higher verbal abilities (1.5 points (95% confidence interval 0.4, 2.7) per 0.20 unit increase in greenness). Higher connectivity density within 100 m and land use diversity during pregnancy were related to lower verbal abilities. Childhood exposure to PM2.5 mediated 74% of the association between greenness during childhood and verbal abilities. Higher exposure to PM2.5 during pregnancy was related to lower fine motor function (-1.2 points (-2.1, -0.4) per 3.2 mu g/m3 increase in PM2.5). No associations were found with non-verbal abilities and gross motor function. Discussion: This study suggests that built environment, greenness, and air pollution may impact child cognitive and motor function at five years old. This study adds evidence that well-designed urban planning may benefit children's cognitive and motor development. Acknowledgements We are grateful to all the participating children, parents, practi-tioners and researchers in the four countries who took part in this study. This work was supported by funding from the European Community's Seventh Framework Programme [FP7/2007-206 n 308333; the HELIX project] . This INMA cohort was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds, FIS PI06/0867, FIS-PI09/00090, FIS and FIS-PI18/01142 incl. FEDER funds, FIS-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI05/1079, PI05/1052, PI06/1213, PI07/0314, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, PI16/00118 and PI17/00663; FIS-FSE: 17/00260; Miguel Servet-FEDER CP11/00178, CP15/00025, CPII16/00051, and CPII18/00018) , from UE (FP7-ENV-2011 cod 282957, HEALTH.2010.2.4.5-1, and H2020 n 824989) , Generalitat de Catalunya-CIRIT 1999SGR 00241, Fundacio La marato de TV3 (090430) , Generalitat Valenciana: FISABIO (UGP 15-230, UGP-15-244, and UGP-15-249) , Alicia Koplowitz Foundation 2017, CIBERESP, Department of Health of the Basque Government (2013111089, 2009111069, 2013111089, 2015111065 and 2018111086) , Provincial Government of Gipuzkoa (DFG06/002, DFG08/001, DFG15/221 and DFG 89/17) and annual agreements with the municipalities of the study area (Zumarraga, Urretxu , Legazpi, Azkoitia y Azpeitia y Beasain) . We acknowledge support from the Spanish Ministry of Science and Inno-vation and the State Research Agency through the "Centro de Excelencia Severo Ochoa 2019-2023" Program (CEX2018-000806-S) , and support from the Generalitat de Catalunya through the CERCA Program. The work was also supported by MICINN [MTM2015-68140-R] and Centro Nacional de Genotipado-CEGEN-PRB2-ISCIII (Spain) . The Rhea project was financially supported by European projects, and the Greek Ministry of Health (Program of Prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece: 2011-2014; "Rhea Plus": Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012-15) . This paper presents independent research funded by the National Institute for Health Research (NIHR) under its Collaboration for Applied Health Research and Care (CLAHRC) for Yorkshire and Humber (UK) . The EDEN study was supported by Foundation for medical research (FRM) , National Agency for Research (ANR) , National Institute for Research inPublic health (IRESP: TGIR cohorte sante 2008 program) , French Min-istry of Health (DGS) , French Ministry of Research, INSERM Bone and Joint Diseases National Research (PRO-A) , and Human Nutrition Na-tional Research Programs, Paris-Sud University, Nestle, French National Institute for Population Health Surveillance (InVS) , French National Institute for Health Education (INPES) , the European Union FP7 pro-grams (ESCAPE, ENRIECO, Medall projects) , Diabetes National Research Program (through a collaboration with the French Association of Diabetic Patients (AFD) ) , French Agency for Environmental Health Safety and French National Agency for Food Security (now ANSES) , Mutuelle Generale de l'Education Nationale a complementary health insurance (MGEN) , French-speaking association for the study of diabetes and metabolism (ALFEDIAM) . Core support for Born in Bradford is also provided by the Wellcome Trust (WT101597MA, UK) . Born in Bradford (BiB) is only possible because of the enthusiasm and commitment of the children and parents in BiB. We are grateful to all the participants, health professionals, schools and researchers who have made BiB happen. BiB receives funding from the ESRC/MRC, the Wellcome Trust (WT101597MA) and the National Institute for Health Research York-shire and Humber ARC (reference: NIHR20016) . M. Mon-Williams was supported by a Fellowship from the Alan Turing Institute. Additional funding from the National Institute of Environmental Health Science supported Dr Chatzi (R01ES030691, R01ES029944, R01ES030364, R21ES029681, and P30ES007048) . The views expressed are those of the authors, and not necessarily those of the NHS or the NIHR. None of the funders were involved in designing the study, collecting the data, analyzing or interpreting the data, deciding to submit the article for publication, or the writing of the report. Data sharing statement The HELIX data warehouse has been established as an accessible resource for collaborative research involving researchers external to the project. Access to HELIX data is based on approval by the HELIX Project Executive Committee and by the individual cohorts. Further details on the content of the data warehouse (data catalogue) and procedures for external access are described on the project website (http:// www.proj-ecthelix.eu/index.php/es/data-inventory) .
- Subjects :
- Urban environment
010501 environmental sciences
01 natural sciences
0302 clinical medicine
Cognition
Pregnancy
Cognició en els infants
11. Sustainability
GE1-350
030212 general & internal medicine
Children
Motor skill
ComputingMilieux_MISCELLANEOUS
Desenvolupament urbà
General Environmental Science
SDG 15 - Life on Land
2. Zero hunger
education.field_of_study
Air Pollutants
4. Education
motor function
Cohort
cohort
SDG 11 - Sustainable Cities and Communities
3. Good health
Child, Preschool
Birth Cohort
Female
Cognitive function
Psychology
Population
Gross motor skill
03 medical and health sciences
children
Urban planning
Air Pollution
medicine
Humans
education
Motor function
cognitive function
0105 earth and related environmental sciences
Environmental Exposure
medicine.disease
urban environment
Confidence interval
Environmental sciences
Spain
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Particulate Matter
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Demography
Subjects
Details
- Language :
- English
- ISSN :
- 01604120
- Database :
- OpenAIRE
- Journal :
- Binter, Anne Claire Bernard, Jonathan Y. Mon Williams, Mark Andiarena, Ainara González Safont, Llúcia Vafeiadi, Marina Lepeule, Johanna Soler Blasco, Raquel Alonso, Lucia Kampouri, Mariza Mceachan, Rosie Santa-Marina, Loreto Wright, John Chatzi, Leda Sunyer, Jordi Philippat, Claire Nieuwenhuijsen, Mark Vrijheid, Martine Guxens, Mònica 2022 Urban environment and cognitive and motor function in children from four European birth cohorts Environment International 158 106933, Environment International, Environment International, 2022, 158, pp.106933. ⟨10.1016/j.envint.2021.106933⟩, Environment International, Vol 158, Iss, Pp 106933-(2022), Environment International, Elsevier, 2022, 158, pp.106933. ⟨10.1016/j.envint.2021.106933⟩, Environment international, 158:106933. Elsevier Ltd., Addi. Archivo Digital para la Docencia y la Investigación, instname
- Accession number :
- edsair.doi.dedup.....0bdd82d0a7f4eaf37c49090f622e778c