Search

A study conducted by researchers from Tel Aviv University explores the use of mean platelet volume (MPV) as a predictive marker for late-onset sepsis in preterm infants. The study analyzed blood count data from 63 newborns with sepsis and 63 newborns in the control group. The results showed a significant elevation of MPV in septic newborns compared to non-septic controls before and after infection. The researchers suggest that high MPV in combination with a platelet count decrement may be predictive for the diagnosis of late-onset sepsis. Further research is needed to understand the underlying pathophysiology and potential clinical applications of these findings. [Extracted from the article]

A recent study conducted in Pakistan has found a relatively high prevalence of Toxoplasma gondii infection in wild rodents. The study analyzed blood samples from four species of rodents and found that 18% of the rodents tested positive for the parasite. The infection was found to affect the complete blood count and markers of oxidative stress in the rodents' vital organs. The researchers recommend further studies to determine the incidence and prevalence of this pathogen in different regions of Pakistan in order to prevent infections in humans and livestock. [Extracted from the article]

A recent preprint abstract discusses the role of LRRC8 complexes in platelet activation and arterial thrombosis. The study identifies single-nucleotide polymorphisms in LRRC8 protein subunits that are associated with altered mean platelet volume. LRRC8A, a subunit of the LRRC8 complex, is found to regulate platelet volume, adhesion, and activation. The study suggests that LRRC8A mediates ATP/ADP release in platelets, which amplifies calcium signaling and may serve as a potential target for anti-thrombotic drugs. However, it is important to note that this preprint has not yet undergone peer review. [Extracted from the article]

Researchers from Southern Medical University have conducted a study on platelet traits in patients with b-thalassemia, a type of congenital anemia. The study found that platelet count and mean platelet volume showed significant heterogeneity in b-thalassemia patients. Through whole-genome sequencing analysis, the researchers identified several genetic associations with platelet traits, including a novel gene called RNF144B associated with mean platelet volume. The findings provide potential targets for intervention in the context of b-thalassemia. [Extracted from the article]

Researchers from Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico in Milan, Italy, conducted a study on cord blood-derived platelet concentrates (CBPCs) as an alternative treatment for thrombocytopenia in preterm newborns. The study aimed to produce and evaluate the quality parameters of CBPCs during storage. The researchers found that CBPCs were of comparable quality to adult-derived platelet concentrates (PCs) during storage, but further optimization is needed for processing and storage of low volumes of PCs. Filtration of low volumes also led to significant platelet loss. The study was peer-reviewed and published in the journal Transfusion. [Extracted from the article]

A study conducted at Shandong Provincial Hospital in China explored the use of preoperative red blood cell distribution width (RDW) and platelet parameters in diagnosing patients with papillary thyroid carcinoma (PTC) or papillary thyroid microcarcinoma (PTMC). The study found that higher RDW, mean platelet volume (MPV), and platelet distribution width (PDW) values were observed in patients with PTC or PTMC compared to healthy controls. The combination of RDW and MPV improved diagnostic accuracy. Additionally, the study found associations between RDW and MPV values and certain clinicopathological characteristics. This research provides valuable insights into the diagnosis and understanding of thyroid cancer. [Extracted from the article]

A recent study conducted in Bologna, Italy, explored the relationship between blood parameters and the severity of osteoarthritis (OA). The study found that platelet-to-lymphocyte ratio (PLR) and age were significant factors in categorizing OA severity. An increase in PLR was associated with a higher likelihood of moderate/severe OA, suggesting that monitoring these biomarkers could aid in early detection and management of OA severity. Further research is needed to validate these results in larger populations. [Extracted from the article]

A recent study conducted at University Hospital in Zagreb, Croatia examined the effects of high-intensity physical activity on the health of professional water polo players. The study found that during periods of intense training, certain blood parameters such as mean corpuscular volume, platelet count, and mean platelet volume decreased, while total iron-binding capacity increased and ferritin concentrations declined. Additionally, there were slight increases in serum total and LDL cholesterol levels, a decrease in triglyceride concentrations, and positive effects on liver and kidney function biomarkers. The study concluded that water polo players may experience changes in blood parameters and lipid profiles due to intense training, but kidney function remains unchanged. [Extracted from the article]

A study conducted at Hisar Intercontinental Hospital in Istanbul, Turkey, aimed to evaluate the predictive values and relationships of serum prostate-specific antigen (PSA) levels, delta neutrophil index (DNI), neutrophil-lymphocyte ratio (NLR), and other hematological parameters in patients diagnosed with acute prostatitis. The study found that total PSA levels and C-reactive protein (CRP) levels were significantly higher in patients with acute prostatitis compared to healthy men. The NLR value was also higher in the acute prostatitis group. The study concluded that NLR, PSA, CRP, and white blood cell count (WBC) can be useful predictors of acute prostatitis. [Extracted from the article]

A recent study conducted at Nanjing Medical University in China explored the association between white matter lesions (WML) and patent foramen ovale (PFO) in young and middle-aged individuals with migraines. The study included 119 participants with a median age of 36.9 years, and brain magnetic resonance imaging showed that 56.3% of patients had WML. The researchers identified age, mean platelet volume, and fibrinogen as independent predictive factors of WML. The study concluded that the predictive nomogram developed could assist clinicians in screening for WML and developing personalized preventive and treatment strategies for migraineurs with PFO. [Extracted from the article]

A recent study conducted at Peking University Third Hospital investigated the association between platelet indices and comorbidities, all-cause mortality, and new-onset cardiovascular disease (CVD) in peritoneal dialysis (PD) patients. The study included 250 incident PD patients and found that high mean platelet volume (MPV) was independently associated with an increased risk of new-onset CVD and all-cause mortality. Additionally, patients with low mean platelet volume to platelet count ratio (MPV/PC) were more likely to experience new-onset infection events. The study suggests that platelet indices may be useful in predicting outcomes in PD patients. [Extracted from the article]

Researchers from the University Gadjah Mada in Indonesia have conducted a study to establish normal reference values for platelet count and indices in a healthy adult Indonesian population. The study included 1037 subjects and found that the reference intervals for platelet indices in the adult Indonesian population were different from previously established values, with significant differences between males and females. The researchers emphasize the importance of dedicated reference interval determination with gender consideration. This information is valuable for managing hematological disorders in the Indonesian population. [Extracted from the article]

A new report discusses research on tuberculosis conducted at Government Medical College. The study aimed to explore the use of mean platelet volume (MPV) and neutrophil-to-albumin ratio (NAR) as surrogate markers for monitoring tuberculosis treatment. The researchers recruited 150 individuals diagnosed with TB and analyzed their blood tests over the course of six months of treatment. The study found significant associations between C-reactive protein (CRP) levels and sputum grade, and MPV was identified as a potential surrogate marker for monitoring anti-tubercular therapy. The researchers concluded that personalized approaches are crucial in TB treatment monitoring and that further research should explore the mechanisms and cost-effectiveness of MPV as a treatment response marker. [Extracted from the article]

A recent study conducted at Universitas Sumatera Utara in Indonesia explored the use of platelet count and indices as prognostic factors for mortality in children with sepsis. The researchers found that platelet distribution width (PDW) was significantly higher in non-survivors compared to survivors, and PDW at admission was identified as a fast and specific tool for predicting the outcome of children with sepsis. These findings suggest that PDW could be used as a potential marker for mortality in pediatric sepsis cases. Further research is needed to validate these results and explore the clinical implications. [Extracted from the article]

A recent study conducted at Kayseri City Training and Research Hospital in Turkey investigated the effect of nasal septoplasty on the plasma fibrinogen/high-density lipoprotein (HDL) ratio in patients with nasal septal deviation (NSD). The study included 56 patients who underwent septoplasty and 40 healthy volunteers as a control group. The researchers found that after septoplasty, fibrinogen, mean platelet volume (MPV), and the fibrinogen/HDL ratio significantly decreased, while HDL levels significantly increased in the NSD group. This study suggests that nasal septoplasty may have a therapeutic effect on the restoration of hypercoagulopathy caused by chronic hypoxia in patients with NSD. [Extracted from the article]

The article presents research from Yozgat State Hospital examining the relationship between the mean platelet volume/platelet count (MPV/PC) ratio and blood pressure patterns in hypertensive patients. Topics include the comparison of MPV/PC ratios between dipper and non-dipper hypertensive patients, the predictive value of the MPV/PC ratio for identifying non-dippers, and the implications for increased cardiovascular risk in non-dipper hypertensives.

A recent study conducted by the University of Pittsburgh examined the platelet function in trauma patients. Trauma is a leading cause of death in individuals up to 45 years of age, and platelet dysfunction plays a crucial role in trauma-induced coagulopathy (TIC). The researchers used a microfluidic model to assess the flow-dependent platelet hemostatic capacity in trauma patients. They found that trauma patients had altered platelet function and reduced hemostatic capacity compared to healthy controls. The study aims to identify key features of platelet dysfunction in bleeding trauma patients and explore their relationship with patient outcomes. [Extracted from the article]

A study conducted by researchers at Menoufia University in Shibin Al Kawm, Egypt, explored the relationship between platelet morphological parameters, lipid profile, and a specific single nucleotide polymorphism (SNP) called rs7961894 in children with type 1 diabetes mellitus (T1DM). The study found that children with T1DM had higher mean platelet volume (MPV), platelet distribution width (PDW), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) compared to healthy controls. Additionally, the rs7961894 CT genotype was associated with significant changes in MPV, PDW, and plateletcrit (PCT) values, as well as alterations in lipid parameters. These findings highlight the importance of monitoring platelet parameters and lipid profile in children with T1DM to identify potential cardiovascular risks early. [Extracted from the article]

The article discusses new research from Karaganda Medical University in Kazakhstan that explores the role of platelets and serotonin in pulmonary arterial hypertension (PAH) among children with congenital heart disease (CHD). It states that elevated platelet counts and serotonin levels were linked with PAH and surgical intervention reduced these markers, aligning more closely with control values.

A recent study conducted in Singapore investigated the effects of a specialized oral nutritional supplement (ONS) on biochemical and hematological indices in older adults at risk of malnutrition. The study involved 811 participants aged 65 and above who were randomly assigned to either the intervention group (specialized ONS and dietary counseling) or the placebo group (placebo and dietary counseling). After six months of daily consumption, the intervention group showed significant improvements in various indices, including urea, prealbumin, vitamin B12, globulin levels, reticulocyte count, mean platelet volume, total protein, and absolute monocyte count. The study concluded that the specialized ONS led to significant improvements in biochemical and hematological indices in older adults at risk of malnutrition. [Extracted from the article]

A study conducted in Nagpur, India, examined the diagnostic accuracy of mean platelet volume (MPV) and platelet distribution width (PDW) in the diagnosis of sepsis in newborns. The researchers found that MPV had a sensitivity of 94.12% and a specificity of 25.61%, while PDW had a sensitivity of 77.94% and a specificity of 37.80%. The overall diagnostic accuracy of MPV was 56.67% and PDW was 56.00%. The study suggests that platelet indices may be used as a marker to identify septic babies and could be combined with existing sepsis screening methods. [Extracted from the article]

A recent study conducted at Sichuan Agricultural University in China examined the effects of meloxicam, a nonsteroidal anti-inflammatory drug, on the welfare of Holstein calves undergoing amputation dehorning (AD) procedures. The study found that AD procedures caused adverse effects such as pain, distress, anxiety, and fear in the calves. However, when meloxicam was co-administered with lidocaine, a local anesthetic, the calves showed significant improvements in response to the AD procedure, including lower respiration rates, heart rates, and rectal temperatures, as well as higher mechanical nociceptive thresholds and improved hematological conditions. These findings support the use of meloxicam in conjunction with a local anesthetic in AD procedures for calves aged 6 weeks to 6 months. [Extracted from the article]

A recent study conducted at the First Affiliated Hospital of Anhui Medical University in China explored the potential use of peripheral platelet count as a diagnostic marker for predicting the risk of rapid ejaculation. The researchers collected blood samples from different ejaculatory groups of rats and found that rapid ejaculators had significantly lower platelet counts compared to normal and sluggish ejaculators. They also observed a positive correlation between platelet count and serum serotonin levels, indicating that platelet count could indirectly reflect serotonin concentration. The study suggests that platelet count may be a useful and convenient diagnostic marker for predicting the risk of rapid ejaculation. [Extracted from the article]

Researchers from the Affiliated Hospital of Southwest Medical University have developed and validated a diagnostic prediction model for children with pertussis, also known as whooping cough. The study involved a retrospective analysis of 477 children with suspected pertussis, and the model was based on blood parameters. The model showed satisfactory discriminative ability, with a sensitivity and specificity of around 72% to 74%. The researchers concluded that the model could accurately predict the probability of pertussis in children and may be useful for clinical decisions. [Extracted from the article]

A new study from the University of Health Sciences in Ankara, Turkey, explores the levels of serum inflammatory markers in patients with alopecia areata before and after treatment. The study included 60 alopecia areata patients and 40 control patients diagnosed with tinea unguium. The results showed that the alopecia areata group had higher levels of certain inflammatory markers compared to the control group, and these markers decreased after treatment. The study suggests that the systemic immune-inflammation index (SII) can be a useful marker for assessing the severity and treatment response of alopecia areata. [Extracted from the article]

A recent study conducted at Aristotle University of Thessaloniki in Greece examined the correlation between hematological and biochemical parameters and glycated hemoglobin (HbA1c) levels in diabetic, prediabetic, and non-diabetic patients. The study found that albumin (ALB) and sodium (Na) levels were significantly lower in diabetic patients compared to non-diabetic and prediabetic patients. Additionally, red cell distribution width-standard deviation (RDW-SD) and urea levels were higher in diabetic patients compared to non-diabetic patients. The study suggests that these parameters may be useful in assessing the risk of developing diabetes and could serve as indicators for prediabetes. [Extracted from the article]

A researcher at Tehran University of Medical Sciences has presented data on fatty liver, specifically examining the clinical impact of complete blood cell inflammatory markers on body composition variations and fatty liver grading in Iranian adults undergoing bariatric surgery. The study included 237 bariatric surgery patients who met the inclusion criteria and recorded changes in CBC inflammatory biomarkers, body composition, and fatty liver grades before and after surgery. The research found that the pre-surgery red cell distribution width marker was significantly associated with changes in fat mass, and individuals with higher muscle mass at 3 and 6 months achieved a fatty liver grade of zero. The study suggests that future research should collect additional samples and examine the long-term predictive value of these markers. [Extracted from the article]

A new report discusses research on subarachnoid hemorrhage, a type of brain hemorrhage. The researchers from University Hospital Dusseldorf found that changes in certain blood cells and their sub-populations can indicate underlying systemic inflammation, which is important for predicting patient outcomes and complications. The study identified platelet count, mean platelet volume (MPV), and mean platelet volume to platelet ratio (MPR) as significant predictors of patient outcome. These findings could potentially be used as easy-to-measure biomarkers for managing subarachnoid hemorrhage. [Extracted from the article]

A recent study conducted in West Bengal, India, explored the correlation between platelet count and platelet indices in cases of acute ischemic stroke. The researchers found a significant correlation between acute ischemic stroke and platelet indices, including platelet count, mean platelet volume (MPV), platelet distribution width (PDW), and platelet to large cell ratio (P-LCR). The study suggests that larger platelets may play a role in the development of cerebral thrombosis and could be used as a cost-effective tool for predicting ischemic events, particularly in resource-poor countries like India. The findings provide valuable insights into the pathogenesis of atherosclerotic complications and thrombus formation. [Extracted from the article]

A study conducted by researchers at Dokuz Eylul University Faculty of Medicine compared the hematological parameters of patients with recurrent aphthous stomatitis (RAS) and Behcet's disease (BD). The study found that patients with newly diagnosed BD had higher levels of C-reactive protein (CRP), mean platelet volume (MPV), and lymphocyte count compared to patients with RAS. These findings suggest that elevated CRP, MPV, and lymphocyte count may be markers for distinguishing between BD and RAS. However, further large prospective studies with a healthy control group are needed to confirm these findings. [Extracted from the article]

A study conducted by researchers at Karadeniz Technical University in Turkey aimed to determine the effectiveness of laboratory parameters in predicting complicated appendicitis in patients who underwent surgery for acute appendicitis. The study included 153 patients with acute appendicitis and divided them into two groups: simple and complicated appendicitis. The researchers found that age, leukocyte count, neutrophil count, neutrophil percentage, neutrophil-lymphocyte ratio, and C-reactive protein levels were significantly higher in the complicated appendicitis group. Logistic regression analysis identified age, neutrophil count, and C-reactive protein levels as independent risk factors for the diagnosis of complicated appendicitis. These findings suggest that these parameters can be used as auxiliary tools to differentiate between simple and complicated appendicitis. [Extracted from the article]

A recent study conducted by researchers at Ben-Gurion University of the Negev in Israel investigated the hematological markers in children and adults with atopic dermatitis (AD). The study found that certain ratios of blood cells, such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), eosinophil-to-lymphocyte ratio (ELR), and eosinophil-to-neutrophil ratio (ENR), were increased in patients with moderate-to-severe AD compared to those with mild AD. Additionally, these ratios were higher in adults with AD compared to children, except for ENR. The researchers concluded that these hematological markers could be useful in managing and monitoring AD patients. [Extracted from the article]

A 54-year-old woman developed a hematoma in her anterior abdominal muscle while being treated with venlafaxine for moderate anxious depression. The woman experienced pain in her right iliac fossa five months after starting venlafaxine therapy. An abdominal ultrasound and CT scan revealed the hematoma. Various examinations were performed, and platelet aggregation tests showed abnormalities. The woman's venlafaxine therapy was discontinued, and the hematoma eventually resolved with no recurrence. The Naranjo score confirmed that the hematoma was likely caused by venlafaxine. [Extracted from the article]

A new report discusses research findings on metabolic syndrome, a collection of risk factors that can lead to various disorders. The study aimed to examine the relationship between metabolic syndrome and mean platelet volume (MPV), as well as the extent and severity of coronary artery disease (CAD). The researchers studied 151 patients who underwent coronary angiography and found that patients with metabolic syndrome had a higher incidence of multivascular disease, reduced ejection fraction, and higher Syntax Score. They also showed abnormalities in lipid values, higher blood glucose and HbA1c values, and higher values of fibrinogen and MPV. The study concluded that addressing and regulating metabolic syndrome factors is crucial for managing CAD effectively. [Extracted from the article]

A recent report discusses research findings on stroke, specifically focusing on the potential use of mean platelet volume (MPV) and red cell distribution width (RDW) as biomarkers for predicting the occurrence of stroke. The study, conducted at the Mahatma Gandhi Institute of Medical Sciences in India, aimed to investigate the relationship between platelet volume and acute ischemic stroke, as well as the association between red cell distribution width and acute ischemic stroke. The researchers found that while there were some differences in MPV and RDW between different types of stroke, these differences were not statistically significant. The study concludes that there is currently no biological substitute marker for stroke diagnosis, but MPV and RDW have the potential to be biomarkers for predicting the incidence of stroke. [Extracted from the article]

A recent study conducted at the Second Affiliated Hospital of Wenzhou Medical University in China explored the relationship between coagulative function and preeclampsia, a pregnancy complication associated with maternal and perinatal mortality and morbidity. The study aimed to identify specific hematologic parameters in preeclamptic and normotensive pregnant women and determine their significance in the development of preeclampsia. The researchers found that mild and severe preeclampsia were associated with lower hemoglobin levels, higher mean platelet volume and fibrinogen levels, and shorter prothrombin and activated partial thromboplastin times. These findings provide evidence of the hematologic coagulative factors involved in the pathogenesis and severity of preeclampsia. [Extracted from the article]

A recent study conducted by researchers at the University of Ottawa explored the use of biomarkers in predicting the risk of venous thromboembolism (VTE) in cancer patients. The study reviewed 114 studies and identified nine candidate blood biomarkers that may help optimize VTE prediction in cancer patients. These biomarkers include factors such as factor VIII, d-dimer, fibrinogen, mean platelet volume, platelet count, hemoglobin levels, and white blood cell count. The findings suggest that further research is needed to fully understand the potential of these biomarkers in predicting VTE risk in cancer patients. [Extracted from the article]

A recent study conducted at the Mahatma Gandhi Institute of Medical Sciences in Maharashtra, India, explored the role of inflammatory and immunological changes in schizophrenia (SZ) and bipolar disorder (BD). The study compared blood parameters in 141 SZ patients, 164 BD patients, and 93 nonpsychiatric hospital admissions. The results showed elevated levels of mean platelet volume (MPV) and platelet distribution width (PDW) in both SZ and BD patients, suggesting neuroinflammatory origins of these illnesses. Additionally, there was a significant difference in these parameter levels between SZ and BD, indicating biological distinctness between the two conditions. [Extracted from the article]

A recent study conducted by researchers at the Chinese Academy of Medical Sciences examined the clinical significance of hematological parameters in patients with palmoplantar pustulosis (PPP), a chronic inflammatory disease. The study found that certain hematological parameters, such as monocyte count, plateletcrit (PCT), and pan-immune-inflammation value (PIV), were significantly higher in PPP patients compared to healthy controls. These parameters were also found to be correlated with disease severity and treatment response. The researchers concluded that PCT and PIV could serve as simple and inexpensive biomarkers for systemic inflammation in PPP patients. [Extracted from the article]

A recent report from the University of Health Sciences Turkiye discusses new research on thrombocytopenic purpura, a blood disorder. The study aimed to evaluate the mean platelet volume (MPV) and platelet distribution width (PDW) as markers of treatment response in immune thrombotic thrombocytopenic purpura (iTTP). The study found that MPV and PDW correlated with lactate dehydrogenase (LDH) and platelet count, which are currently used to evaluate treatment response. Changes in MPV and PDW may serve as indicators of response to plasmapheresis in iTTP patients. [Extracted from the article]

A recent study conducted by researchers at Benha University in Egypt focused on the relationship between hematological indices and psoriatic enthesopathy, a condition associated with psoriatic arthritis (PsA). The study found that red cell distribution width (RDW) and mean platelet volume (MPV) were higher in PsA patients compared to control subjects, while there was no significant difference in neutrophil/lymphocyte ratio (NLR) between the two groups. The researchers concluded that monitoring PsA disease activity can be improved by considering RDW and MPV as reliable indicators and using them to screen for psoriatic enthesopathy with musculoskeletal ultrasound (MSUS) indices. This research has been peer-reviewed. [Extracted from the article]

New research from Amrita Vishwa Vidyapeetham in Kerala, India, explores the association between mean platelet volume (MPV) and grades of hypertensive retinopathy (HR). The study found that MPV increases with the severity of HR, suggesting that MPV may play a role in the development of retinopathy. Testing MPV levels could help determine the need for preventative treatments to reduce the risk of cardiovascular and cerebrovascular events. The research provides valuable insights into the understanding and management of hypertensive retinopathy. [Extracted from the article]

A new study conducted at a tertiary care hospital in India has found that immature platelet fraction (IPF), mean platelet volume (MPV), and interleukin-6 (IL-6) are important indicators in the assessment of acute coronary syndrome (ACS). The study included 70 ACS patients and 70 healthy controls, and the levels of IPF, MPV, and IL-6 were analyzed. The findings suggest that elevated MPV and IPF can be used as ancillary indicators in the evaluation of ACS. This research provides valuable insights into the pathophysiology of ACS and may contribute to improved diagnosis and treatment of the condition. [Extracted from the article]

A recent study conducted by Anhui Medical University investigated the factors associated with the upgrading of cervical biopsy results from cervical intraepithelial neoplasia (CIN)3 to cervical cancer (CC) after conical resection. The study found that age, menopausal status, contact bleeding, and mean platelet volume were independently associated with pathological upgrading. These findings can help identify high-risk patients who are susceptible to pathological upgrading to CC. The study provides valuable insights into the risk factors for cervical cancer progression and may contribute to improved prevention and treatment strategies. [Extracted from the article]

A recent study conducted in Andhra Pradesh, India, examined the role of platelet indices in premenopausal females with metabolic syndrome (MetS) and their association with individual risk factors of MetS. The study found that there was a high prevalence of components associated with MetS, such as hyperglycemia, hypertension, and obesity. Additionally, the study highlighted the impact of diabetes mellitus, hypertension, and hyperlipidemia on platelet indices. These findings contribute to the understanding of cardiovascular risk assessment in premenopausal females with MetS. [Extracted from the article]

A study conducted at University Hospital Canarias in Tenerife, Spain, has found that mean platelet volume (MPV) is lower in patients with systemic lupus erythematosus (SLE) compared to healthy controls. The research analyzed the relationship between MPV and disease characteristics in 179 SLE patients and 181 healthy controls. The study concluded that MPV may serve as a biomarker for disease damage in SLE, particularly in relation to renal, peripheral vascular, and musculoskeletal manifestations of the disease. This information may be useful for researchers and healthcare professionals studying and treating SLE. [Extracted from the article]

A systematic review with meta-analyses examined the prognostic value of mean platelet volume (MPV) in patients with coronary artery disease (CAD). The review analyzed 52 studies with 47,066 patients and found that an increase in MPV values was associated with a 29% rise in the risk of long-term mortality in CAD patients. The results were consistent in patients treated with percutaneous coronary intervention (PCI) and those presented with acute coronary syndrome (ACS). However, it is important to note that this preprint has not been peer-reviewed. [Extracted from the article]

A study conducted at Lagos State University Teaching Hospital in Nigeria explored the potential of mean platelet volume (MPV) and platelet distribution width (PDW) as predictive markers for early-onset pre-eclampsia. The study involved 648 healthy pregnant women and found that women who later developed pre-eclampsia had higher median MPV and PDW levels compared to normotensive women. The study concluded that evaluating MPV and PDW between 14 and 18 weeks of gestation could be a reliable predictor of severe early-onset pre-eclampsia. [Extracted from the article]

A recent study conducted by the Faculty of Medical Laboratory Sciences in Sudan aimed to evaluate platelet count and platelet indices among Sudanese patients with chronic kidney disease (CKD). The study involved 75 CKD patients and 75 healthy individuals as a control group. The results showed no significant difference in platelet count and platelet indices between CKD patients and the control group, as well as between CKD patients on hemodialysis and those not on hemodialysis. This study provides new insights into platelet function in CKD patients and suggests that platelet function may not be significantly affected in this population. [Extracted from the article]