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A recent study conducted in Telangana, India, examined the incidence, management, and outcomes of twins with major structural anomalies. The study found that the incidence of discordant twins was 1.76% in dichorionic (DC) pregnancies and 1.4% in monochorionic (MC) pregnancies. Musculoskeletal anomalies were most common in DC twins, while central nervous system anomalies were most common in MC twins. The live birth rate for anomalous twins was lower than that of normal cotwins, but surviving anomalous twins who underwent postnatal surgery or intervention had favorable outcomes. The study concluded that expectant management is a safe option for DC twins with major anomalies. [Extracted from the article]

A recent study conducted at Indraprastha Apollo Hospitals in Delhi, India, focused on the use of fetal magnetic resonance imaging (MRI) in assessing agenesis of the corpus callosum, a condition where the structure connecting the two hemispheres of the brain is absent. The study involved a 32-year-old woman who underwent fetal MRI at 22 weeks gestation after an ultrasound detected the condition. The MRI confirmed the absence of the corpus callosum and revealed other abnormalities, leading to a poor prognosis. Based on these findings, the parents decided to terminate the pregnancy. The study highlights the value of fetal MRI and tractography in guiding clinical decisions for this condition. [Extracted from the article]

Researchers from the Department of Fetal Medicine in Telangana, India, have published a case study on a rare prenatal diagnosis and management of a fetal oral cystic mass. The researchers highlight the rarity of this condition and emphasize the importance of ultrasound-based approaches for accurate diagnosis. The case involved a fetal oral cyst diagnosed at 20 weeks of gestation, which showed no changes in size or position during follow-up. The cyst was successfully excised on the first day after birth, and histopathology confirmed it to be a mucocele. This research provides valuable insights into the prenatal diagnosis and management of rare fetal oral masses. [Extracted from the article]

A recent study conducted at a fetal medicine center in South India examined the prenatal diagnosis and outcomes of trisomy 18, also known as Edwards' syndrome. Trisomy 18 is the second most common aneuploidy in humans and is characterized by major anomalies in organ systems. The study analyzed the records of 45 cases of trisomy 18 over an 11-year period and found that ultrasound findings were able to accurately detect the condition. The study emphasizes the importance of early and accurate diagnosis for appropriate genetic counseling and pregnancy decisions. [Extracted from the article]

A research study conducted at Artemis Hospitals in Haryana, India, explores the topic of heterokaryotypic monochorionic twin pregnancies. The study reveals that monozygotic twins, who are typically considered identical, can have differences in congenital defects, birth weight, and genetic makeup. The researchers report a case of a monochorionic twin pregnancy that showed signs of trisomy 18 in one twin despite a low risk on prenatal screening. They recommend twin sac amniocentesis as a prenatal diagnostic procedure to accurately identify discrepancies in monochorionic twins and provide prompt zygosity diagnosis and genetic counseling. [Extracted from the article]

A recent report discusses research on fetal medicine, specifically focusing on prenatal diagnostic invasive procedures used to determine if a fetus is at risk of a genetic disease. The more commonly performed procedures involve analyzing cells obtained from amniocentesis or chorionic villous sampling. However, in certain cases where specific molecular tests are not available, biopsy of fetal tissue during ultrasound guidance may be necessary. The report emphasizes that these procedures are rarely indicated due to the availability of molecular tests for most genetic conditions. The research was conducted by the All India Institute of Medical Sciences (AIIMS) in New Delhi, India. [Extracted from the article]

A recent report from the Amrita Institute of Medical Science in Kerala, India discusses the results of a study on fetal medicine. The study focuses on fetal lower urinary tract obstruction (LUTO) in male fetuses, which can have detrimental effects on the kidney, ureter, bladder, and lungs. The researchers found that therapeutic interventions such as in utero vesico-amniotic shunting and fetal cystoscopic laser fulguration can improve perinatal pulmonary survival and longer-term renal outcomes. However, these interventions carry significant risks and require careful patient selection and timing. The report provides guidelines for patient selection, counseling, and procedural details. [Extracted from the article]

A recent study conducted at Maulana Azad Medical College in New Delhi, India, has provided new insights into fetal medicine. The study focused on fetal reduction, which can involve reducing the number of fetuses in multifetal pregnancies or targeting abnormal fetuses for reduction. The research found that reducing the number of fetuses in monochorionic twin pairs resulted in the most favorable pregnancy outcomes among triplets. The study also discussed various aspects of fetal reduction, including indications, consent, procedural details, risks, complications, and follow-up. The findings are published in the Journal of Fetal Medicine and can be accessed for free online. [Extracted from the article]

A new study on fetal medicine has been conducted in Haryana, India, focusing on a rare congenital anomaly called urorectal septum malformation sequence (URSMS). This condition is characterized by the absence of perineal or anal opening, external genital defects, and various urogenital and colonic abnormalities. The study presents a unique case of URSMS with prenatal diagnosis, which is challenging to identify before birth. Prenatal ultrasonography revealed the presence of intraluminal enterolithiasis in the sigmoid colon, indicating high anal atresia and a vesicocolic fistula. The research emphasizes the importance of prenatal screening for detecting rare congenital anomalies and the role of ultrasonography in distinguishing enterolithiasis from other conditions. [Extracted from the article]

Keywords: Fetal Medicine; Health and Medicine EN Fetal Medicine Health and Medicine 1561 1561 1 10/30/23 20231103 NES 231103 2023 NOV 3 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- New study results on fetal medicine have been published. Keywords for this news article include: Department of Obstetrics and Gynaecology, West Bengal, India, Asia, Fetal Medicine, Health and Medicine. [Extracted from the article]

Keywords: Fetal Medicine; Health and Medicine EN Fetal Medicine Health and Medicine 3655 3655 1 10/30/23 20231103 NES 231103 2023 NOV 3 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Imaging Week -- Researchers detail new data in fetal medicine. According to news reporting originating from Muscat, Oman, by NewsRx correspondents, research stated, "Female urogenital anomalies are often difficult to evaluate by ultrasonography, especially in late gestation. [Extracted from the article]

The news editors obtained a quote from the research from Kovai Medical Centre and Hospitals: "Cervical length and anterior uterocervical angle were measured in the mid-sagittal section. Keywords: Fetal Medicine; Health and Medicine; Risk and Prevention EN Fetal Medicine Health and Medicine Risk and Prevention 4801 4801 1 07/10/23 20230714 NES 230714 2023 JUL 14 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on fetal medicine have been published. [Extracted from the article]

Keywords: Fetal Medicine; Health and Medicine EN Fetal Medicine Health and Medicine 2198 2198 1 07/10/23 20230714 NES 230714 2023 JUL 14 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Researchers detail new data in fetal medicine. Keywords for this news article include: Fortis Hospital, New Delhi, India, Asia, Fetal Medicine, Health and Medicine. [Extracted from the article]

Keywords: Fetal Medicine; Health and Medicine; Risk and Prevention EN Fetal Medicine Health and Medicine Risk and Prevention 984 984 1 07/10/23 20230714 NES 230714 2023 JUL 14 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- New study results on fetal medicine have been published. Keywords for this news article include: All India Institute of Medical Sciences (AIIMS), Telangana, India,, Fetal Medicine, Health and Medicine, Risk and Prevention. [Extracted from the article]

Keywords: Fetal Medicine; Genetics; Health and Medicine EN Fetal Medicine Genetics Health and Medicine 1286 1286 1 07/10/23 20230714 NES 230714 2023 JUL 14 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators discuss new findings in fetal medicine. Of the 182 patients, group I (NT 95-99th centile) included 92 patients and group II 90 patients. [Extracted from the article]

Keywords for this news article include: Lokman Hekim University, Ankara, Turkey, Eurasia, Fetal Medicine, Health and Medicine. Keywords: Fetal Medicine; Health and Medicine EN Fetal Medicine Health and Medicine 1396 1396 1 06/12/23 20230617 NES 230617 2023 JUN 16 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Imaging Week -- Investigators publish new report on fetal medicine. [Extracted from the article]

According to the news editors, the research concluded: "With advances in MRI technology and cumulative experience, MRI can be used as a valuable complementary tool to ultrasound in detecting and better evaluating fetal anomalies. Keywords: Diagnostics and Screening; Fetal Medicine; Health and Medicine; Magnetic Resonance Imaging; Ultrasound EN Diagnostics and Screening Fetal Medicine Health and Medicine Magnetic Resonance Imaging Ultrasound 4936 4936 1 06/12/23 20230617 NES 230617 2023 JUN 16 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Imaging Week -- New research on fetal medicine is the subject of a new report. [Extracted from the article]

Health and Medicine, Kidney, Nephrology, Fetal Medicine Keywords: Fetal Medicine; Health and Medicine; Kidney; Nephrology EN Fetal Medicine Health and Medicine Kidney Nephrology 5472 5472 1 06/12/23 20230616 NES 230616 2023 JUN 16 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on fetal medicine. [Extracted from the article]

Keywords for this news article include: University of Health Sciences, Istanbul, Turkey, Eurasia, Cardiology, Fetal Medicine, Health and Medicine. Keywords: Cardiology; Fetal Medicine; Health and Medicine EN Cardiology Fetal Medicine Health and Medicine 1521 1521 1 06/12/23 20230612 NES 230612 2023 JUN 12 (NewsRx) -- By a News Reporter-Staff News Editor at Cardiovascular Week -- Research findings on fetal medicine are discussed in a new report. [Extracted from the article]

The news correspondents obtained a quote from the research from Department of Genomics: "Trisomy 13 is often associated with major and minor fetal malformations and can be screened by antenatal fetal scan and first- and second-trimester biochemical screening. Keywords: Fetal Medicine; Genetics; Health and Medicine; Risk and Prevention EN Fetal Medicine Genetics Health and Medicine Risk and Prevention 1590 1590 1 06/05/23 20230609 NES 230609 2023 JUN 9 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Week -- Fresh data on fetal medicine are presented in a new report. [Extracted from the article]

The article cites a research study conducted by researcher James D. Reynolds and published in the "Journal of Cerebral Blood Flow and Metabolism," which states that an anesthetic regimen commonly used during surgery on pregnant mothers appears to have no negative effects on the developing brain of the fetus. Furthermore, the researchers found, the use of this regimen to produce general anesthesia appears to improve the oxygenation of the fetal brain, according to their novel system for measuring cerebral oxygenation in the developing fetus.

The article presents information about obstetrics research advances. According to one study conducted by researcher G. Romero-Gutierrez and colleagues, published in a 2004 issue of the "American Journal of Perinatology," the association between insulin resistance and hypertension during pregnancy with the homeostatic model assessment was investigated. A longitudinal prospective study was carried out. One hundred sixty normotensive pregnant women were followed from the first trimester until delivery. HOMA-IR levels were determined each trimester. Statistical analysis included one-way analysis of variance and multivariate logistic regression.

Reports on findings of studies of obstetrics. "Advanced paternal age and risk of fetal death: A cohort study," by A.M.N. Anderson and colleagues at Denmark's National Institute of Public Health, and published in the "American Journal of Epidemiology"; "Unselected women with elevated levels of factor VIII:C or homocysteine are not at increased risk for obstetric complications," by S. Middledorp and colleagues, University of Amsterdam, and published in the "Thromobis and Haemostasis".

Summarizes findings of research in the field of cardiology. Effect of the drug tedisamil on fetal transformation of myosin; Expression of cardiac troponin; Effects of norepinephrine and cardiotrophin on phospholipase D activity.

Provides updates on obstetrics research. Appearance of maternal killer immunoglobulin receptors and fetal HLA-C to influence the risk of preeclampsia; Disclosure on hypertensive pregnancy disorders as leading cause of perinatal and maternal morbidity and mortality; Increase the mother's plasma lead levels in bone resorption that occurs during pregnancy.

The article informs that obstetricians face a similar problem with ultrasound monitors used during labor to track fetal heart rate, considered the best available indicator of an unborn baby's well-being. The sonar-like system must find the baby's heartbeat in a jumble of sounds from the mother's body, and the results can be inadequate or even misleading, University of Florida physicians and a private engineering firm are developing what could be the first commercial monitoring system to noninvasively detect electrical activity in the baby's heart, producing a fetal electrocardiogram, or EKG, said Tammy Euliano, MD, a UF associate professor of anesthesiology, and obstetrics and gynecology.

This article presents information on fetal alcohol syndrome (FAS). Numerous studies have documented intelligence quotient (IQ) deficits in children with FAS. Little research, however, has found IQ deficits in children with alcohol-related neurodevelopmental disorder (ARND), who generally exhibit less severe neurobehavioral deficits than children with FAS. FAS is characterized by growth retardation, central nervous system impairment, and a distinctive pattern of craniofacial anomalies. ARND refers to nonsyndromal individuals with confirmed heavy prenatal alcohol exposure who exhibit measurable, but generally subtler neurobehavioral deficits than those seen with FAS.

This article presents information on children with fetal alcohol syndrome (FAS). Numerous studies have documented IQ deficits in children with FAS. Little research, however, has found IQ deficits in children with alcohol-related neurodevelopmental disorder, who generally exhibit less severe neurobehavioral deficits than children with FAS. A study in "Alcoholism: Clinical & Experimental Research" examined the relationship between selected variables and prenatal alcohol exposure on subsequent IQ. Results indicate that maternal age and first-trimester drinking by mothers with a history of drinking problems can have substantial effects on IQ.

The lack of a gene called LBP-1a in the mouse embryo prevents normal growth of blood vessels in the placenta. This finding suggests that a similar defect in humans could play a role in fetal growth retardation, infant mortality, and spontaneous abortion. These results, by investigators at St. Jude Children's Research Hospital in Tennessee, were published in the August 2004 issue of "Molecular and Cellular Biology." The finding could one day help scientists develop a test to identify women who have this mutation and are at risk for these problems, as well as guide development of new prevention treatments.

Growing older carries more risks, among them the risk for vitamin B-12 deficiency. For most people, B-12 deficiency is more commonly associated with anemia than with its more subtle but potentially grave complications. Emerging evidence points to B-12 deficiency as an increasingly common reason behind high levels of homocysteine in the blood. A presentation "Vitamin B-12: deficiency, evolution in diagnosis, and at-risk populations" was given by Ralph Green, MD, professor and chair of the department of pathology at the University of California-Davis Health System, and pathologist-in-chief at the University of California-Davis Medical Center, Sacramento. Green offered his remarks during the 55th Annual Meeting of the American Association for Clinical Chemistry (AACC) in Philadelphia. Research is evolving to better ways to identify true B-12 deficiency. The key to preventing B-12 deficiency is a balanced diet, particularly among the elderly. But some individuals, despite following a nutritious diet plan, may not be able to absorb a food's vitamins due to gastrointestinal problems. Therefore, to rule out (or in) B-12 deficiency, screening is recommended.

The article presents information on the effects of cigarette smoke on lung fibroblasts. Lysyl oxidase (LO), a copper-dependent enzyme, plays a critical role in the formation and repair of the extracellular matrix by catalyzing the crosslinking of elastin and collagen. To better understand mechanisms of cigarette smoke-induced emphysema, researchers examined changes in LO and its substrates, i.e, elastin and collagen type 1, the major components of cellular thiols, i.e, metallothionein and glutathione (GSH), and gammaglutamylcysteine synthetase, a key enzyme for GSH biosynthesis, in cigarette smoke condensate-treated rat fetal lung fibroblasts.

The article describes fetal magnetocardiographic mapping using independent component analysis. According to the report from Italy, fetal magnetocardiography (fMCG) is the only noninvasive technique allowing effective assessment of fetal cardiac electrical activity during the prenatal period. The reconstruction of reliable magnetic field mapping associated with fetal heart activity would allow three-dimensional source localization. The efficiency of independent component analysis in restoring reliable fetal traces from multichannel fMCG has already been demonstrated.

The article reports that IVMD Inc. has recently announced the results of recent clinical trials conducted in connection with its labor prediction device. According to the company, when used in home environments by healthy pregnant women, the device provided an overall prediction of the onset of normal labor between 14 and 7 days in advance. Independent studies show the uterus spends time before the actual birth date getting ready for the labor process. IVMD's predictive technology interprets this established physiology with a small electrode system that is placed on the abdomen and an electronic recording device.

The article reports that Serologicals Corp. has said that Celliance Corp., its wholly-owned subsidiary, announced the introduction of Hybri- CYTE, a serum-free cell culture supplement designed and optimized for use in hybridoma cell culture that has been proven to work with mouse, rat and rabbit derived cell-lines. Hybri-CYTE is the first of Celliance's new line of serum-free cell culture supplements, each designed and optimized for the most commonly used cell lines in research and bioprocessing. Additional products designed for use with CHO and HEK293 cell lines are in development. Serologicals has a patent pending on the formulation of Hybri-CYTE.

This article presents the findings of a research previously published in the medical journal "Journal of the American Medical Association," conducted by researcher Rosa Ana de la Chica. Maternal smoking during pregnancy has many consequences during and after pregnancy, such as infertility, coagulation problems, obstetric complications such as extrauterine pregnancy and placenta previa, and intrauterine growth retardation. However, only indirect data have been published on a possible genotoxic effect on pregnancy in humans.

The article presents information on a study from England, according to which animal models support human epidemiological studies in demonstrating a relationship between impaired fetal growth and risk of adult hypertension. Undernutrition during pregnancy exerts programming effects on the developing kidney, and modulation of angiotensin receptor (ATR) expression has been observed persisting into adult life. Fetal overexposure to glucocorticoids is thought to be central to the nutritional programming of blood pressure and may act through an interaction with ATR expression. The study was conducted by researcher S. McMullen and colleagues, and published in the "American Journal of Physiology--Regulatory Integrative and Comparative Physiology."

The article reports that scientists at the University of Pavia, Italy, have developed a one-step procedure that uses non-physiologic conditions to isolate fetal cells from maternal blood for prenatal genetic testing. Fetal cells were always present in maternal blood starting in the first trimester of pregnancy. However, a rapid, simple and consistent procedure for their isolation for prenatal non-invasive genetic investigation is still lacking, said G. Sitar and colleagues. Sitar and coauthors published their study in the journal of "Experimental Cell Research."

The article cites a study which reports on the downregulation of lysyl oxidase (LO) and upregulation of cellular thiols in rat fetal lung fibroblasts treated with cigarette smoke condensate. Researchers L.J. Chen and colleagues said that to better understand mechanisms of cigarette smoke-induced emphysema, they examined changes in LO and its substrates, that is, elastin and collagen type 1, the major components of cellular thiols, that is, metallothionein and glutathione and gammaglutamylcysteine synthetase, a key enzyme for GSH biosynthesis, in cigarette smoke condensate-treated rat fetal lung fibroblasts. Chen and colleagues published their study in the journal "Toxicological Sciences."

Discusses a study indicating that antisense blockade of ICAM-1 does not harm fetal development in study models. Evaluation of the potential for reproductive toxicity of an antisense oligonucleotide designed to inhibit ICAM-1 as part of the safety assessment for this compound; Tests conducted; Implications for biotechnology.

Reports that mesenchymal stem cells isolated from the bone marrow and fetal liver can form a hematopoietic microenvironment. Properties of cells forming fibroblast colonies from the bone marrow and fetal liver of mouse and rat.

Cites key research findings in 2005 indicating that adenoviral vectors deliver genes to fetal murine muscle in utero. Details of research findings; Research applications; Implications on biotechnology.

The article cites a study which compares high-capacity and first-generation adenoviral vector gene delivery to murine muscle in utero. Researcher R. Bilbao and colleagues at the University of Pittsburgh, Department of Neurology wrote that in a mouse model of Duchenne muscular dystrophy, dystrophin gene transfer to muscle in utero using an high capacity adenovirus vector restored the dystrophin-associated glycoproteins. The results demonstrate that long-term transgene expression can be achieved by high-capacity adenovirus vector-mediated gene delivery to fetal muscle, although strategies of vector integration may need to be considered to accommodate muscle growth. Bilbao and colleagues published their study in the 2005 issue of the journal "Gene Therapy."

Investigates the potential use of fetal bone cells for engineered regeneration of adult skeletal tissue. Increase of the proliferation of fetal and adult bone cells by dexamethasone; Detection of the presence of calcium deposits in the extracellular matrix of fetal bone cells; Improvement of the nodule formation and calcification by the differentiation treatment.

Discusses a study conducted by researchers from Switzerland, which concludes that fetal bone cells have potential use for tissue engineering. Authors of the study; Implications of the findings for fetal stem cell research; Periodical where the study was published.

The article presents findings of a recent report that focused on echocardiographic evaluation of cardiac function in the fetus. According to the report, the development of high-resolution ultrasound has allowed detailed examination of the fetal heart. The accuracy of fetal echocardiography in the diagnosis of malformations of the fetal heart has been established in the second trimester and, more recently, at a much earlier stage in gestation. Researcher J. Simpson said that confirmation of structural abnormalities has usually been by autopsy or by postnatal investigation. This is certainly sufficient for confirmation of structural malformations, but functional evaluation of the fetal heart is far more difficult to validate. Simpson published the report in the journal "Prenatal Diagnosis."

The article focuses on the recent article published in the journal "Prenatal Diagnosis," which found that in many countries, ultrasound examination is used in the second trimester of pregnancy to look for congenital malformations as part of routine prenatal care. While tertiary centers scanning high-risk pregnancies have reported a high degree of accuracy in the detection of congenital heart disease, many studies have shown that cardiac abnormalities are commonly overlooked during routine obstetric evaluation and there still remains a huge variation between centers, said Guerleen Sharland. It is feasible to achieve widespread screening for fetal congenital heart disease in low-risk groups, but this does need commitment and effort from those performing the scans and those teaching them how to examine the heart, Sharland said.

The article cites a study conducted by researcher R. Ridsdale and colleagues, published in the "Journal of Biological Chemistry," which found that researchers from Canada have documented an increased phosphatidylcholine (PtdCho) production but disrupted glycogen metabolism in fetal type II cells that overexpress CTP:phosphocholine cytidylyltransferase (CCT). CCT is a rate-determining enzyme in the de novo synthesis of PtdCho. Alveolar type II cells synthesize large quantities of disaturated PtdCho, the surface-active agent of pulmonary surfactant, particularly at late gestation when the lung prepares itself for postnatal air breathing. To determine which domain contributes to the glycogen phenotype, two additional transgenes were created overexpressing either CCTalpha(1-239) or CCTalpha(239-367).

The article cites a study which describes that fetal stem cells are advantageous for developing ex vivo gene therapy. According to scientist K. O'Donoghue and colleagues in England, fetal stem cells can be isolated from fetal blood and bone marrow as well as from other fetal tissues, including liver and kidney. Fetal blood is a rich source of hemopoietic stem cells, which proliferate more rapidly than those in cord blood or adult bone marrow. O'Donoghue and colleagues published their report in the 2004 issue of the journal "Best Practice & Research in Clinical Obstetrics & Gynaecology."

The article cites a study which reports a six-fold increase in women who have undergone amniocentesis and who carry a fetus diagnosed with Down syndrome. Researcher E. Falcidia and colleagues said that fetal nucleated red blood cells circulate in the maternal blood throughout pregnancy. Even if the frequency of fetal cells in the maternal circulation remains to be ascertained, complications of pregnancy such as fetal cells aneuploidies, preeclampsia, abnormal Doppler of the uterine artery without symptoms of preeclampsia, fetal growth restriction and polyhydramnios are associated with an increased feto-maternal trafficking. Falcidia and coauthors published the results of their research in the journal "Neuropediatrics."