Adenoviral vectors deliver genes to fetal murine muscle in utero.

The article cites a study which compares high-capacity and first-generation adenoviral vector gene delivery to murine muscle in utero. Researcher R. Bilbao and colleagues at the University of Pittsburgh, Department of Neurology wrote that in a mouse model of Duchenne muscular dystrophy, dystrophin gene transfer to muscle in utero using an high capacity adenovirus vector restored the dystrophin-associated glycoproteins. The results demonstrate that long-term transgene expression can be achieved by high-capacity adenovirus vector-mediated gene delivery to fetal muscle, although strategies of vector integration may need to be considered to accommodate muscle growth. Bilbao and colleagues published their study in the 2005 issue of the journal "Gene Therapy."