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A report from the University of the Western Cape in Cape Town, South Africa, discusses the challenges in treating pediatric HIV due to the lack of clinically licensed antiretroviral drugs for children. The research highlights the need for advanced microencapsulation techniques to address issues such as poor drug adherence, therapeutic failure, and adverse reactions in pediatric HIV treatment. The study emphasizes the potential of microencapsulation strategies in developing HIV pediatric formulations to improve drug solubility, bioavailability, and taste masking. For more information, readers can refer to the article "Microencapsulation Techniques in HIV Pediatric Formulations: Advances and Future Outlook" in the Advances in Pharmacological and Pharmaceutical Sciences journal. [Extracted from the article]

A study conducted by researchers at Islamic Azad University in Tehran, Iran, focused on the use of nanocarriers containing Artemisia annua extract to target breast cancer cells. The study found that the synthesized nanocarrier had significant anticancer effects and increased the expression of apoptotic genes Caspase3 and Caspase9. The researchers concluded that further studies could lead to the use of nanocarriers as a targeted drug delivery system for anti-cancer purposes. The findings were published in Majallah-i Danishgah-i 'Ulum-i Pizishki-i Shahid Saduqi Yazd. [Extracted from the article]

The Department of Pharmacy has published new data on liposomes, highlighting their role in advanced drug delivery technology. Liposomes are lipid core nano-structured particles that improve drug solubility and toxicity profiles. The research discusses the benefits of liposomal drug delivery, ongoing challenges, and innovations in clinical applications. This study provides valuable insights into the progress, clinical outlook, and challenges of liposomal technology in drug delivery systems. [Extracted from the article]

A recent study from the South China University of Technology explores the use of nanotechnology, specifically magnetic nanoparticles, to enhance drug solubility and bioavailability in personalized medicine. The research highlights the challenges posed by biological variability and emphasizes the need for continued innovation in this field. The study calls for interdisciplinary research and the development of universal therapeutic solutions to address these challenges. For more information, the full article can be accessed for free at the publisher's website. [Extracted from the article]

A recent study conducted at the Department of Pharmacology in Telangana, India, focused on improving the dissolution properties of nateglinide, an antidiabetic agent with poor water solubility. The research utilized the liquisolid compact technique to enhance the drug's dissolution rate in acidic pH conditions. Results showed that the liquisolid compacts exhibited superior dissolution profiles and favorable flow and compressible properties compared to directly compressible tablets. This study provides valuable insights into optimizing nateglinide formulations for better therapeutic outcomes in diabetes management. [Extracted from the article]

A patent has been issued for drug delivery systems and methods by Nexgen Semi Holding Inc., focusing on nanoscale drug delivery vehicles and methods for preparing and administering them. The patent addresses the need for improved drug delivery mechanisms, emphasizing the importance of targeted delivery, controlled release, and personalized pharmacokinetics. The invention aims to provide high volumes of personalized drugs, hybrid drugs, and custom deliverable medicines, among other applications, through the use of nanoscale drug delivery vehicles. The patent outlines methods for preparing nanoscale drug delivery vehicles, including the sequential steps of providing a substrate, disposing various layers, and releasing the payload active agent for drug delivery. [Extracted from the article]

A recent study from George Emil Palade University of Medicine explores the use of beta-cyclodextrin-complexed rufinamide in modulating seizure-like activity in an in vitro model of temporal lobe epilepsy. The research aims to address the global health concern of pharmacoresistant epilepsy by investigating innovative therapeutic strategies. The study highlights the potential of beta-cyclodextrin in enhancing the efficacy of antiseizure medications by improving drug solubility and stability. For more information, readers can access the full article in Acta Marisiensis - Seria Medica. [Extracted from the article]

A study conducted at Guangdong Pharmaceutical University in Guangzhou, China, focused on the development of a nanodrug delivery system using dopamine-based functional molecules for efficient targeting of tumor cells. The research aimed to enhance the water solubility of chemotherapeutic drugs and improve their biodistribution through the use of drug-loaded nanoparticles that respond to pH changes in the tumor microenvironment. The nanoparticles achieved passive targeting and active targeting through folic acid on their surface, resulting in enhanced targeting efficiency on HepG2 cell lines. This work utilized three types of molecules to construct targeted nanoparticles that significantly improved the anti-tumor effect of the drug Cur through active and passive targeting mechanisms. [Extracted from the article]

Researchers at Annamalai University in Tamil Nadu, India, have developed a new nanohybrid delivery system using liposils to enhance the oral bioavailability of the drug ibrutinib. The study focused on utilizing silica-coated nanoliposomes as nanocarriers for the poorly water-soluble drug, resulting in improved stability and controlled release profiles. Pharmacokinetic studies in rats showed a significant increase in half-life and bioavailability of ibrutinib when delivered through liposils compared to suspensions, highlighting the potential of this approach in advancing drug delivery technologies and clinical outcomes in pharmaceutical research and development. [Extracted from the article]

A recent study conducted at NOVA University Lisbon focused on improving the bioavailability and antimicrobial properties of the antibiotic cefuroxime through the synthesis of organic salts. The research found that these cefuroxime salts demonstrated enhanced solubility and permeability compared to the original drug, with some compounds retaining antibacterial activity against specific strains. The study highlights the potential of utilizing organic salts to enhance the effectiveness of antibiotics, addressing common challenges related to drug solubility and efficacy. [Extracted from the article]

Researchers at Yonsei University in Incheon, South Korea, have developed long-acting intramuscular nanosuspensions of celecoxib for postoperative pain management. Celecoxib is a popular NSAID used for pain and arthritis treatment, with potential anticarcinogenic effects. The nanosuspensions showed sustained release over 5 days and higher efficacy compared to raw celecoxib, indicating promise for prolonged postoperative pain relief. This research, supported by the National Research Foundation of Korea, highlights the potential of intramuscular celecoxib nanosuspensions as anti-inflammatory therapeutics for postoperative pain management. [Extracted from the article]

A recent study conducted by the French National Institute of Health and Medical Research (INSERM) explores the development of a new powder self-emulsifying drug delivery system (P-SEDDS) for mitotane, a drug used in the treatment of adrenocortical cancer and Cushing's syndrome. The study aims to improve the oral bioavailability of mitotane, which is limited by its poor aqueous solubility. The results of the study demonstrate that the P-SEDDS formulation significantly enhances the bioavailability of mitotane, leading to improved dissolution velocity and absorption of the drug. This research suggests that the P-SEDDS formulation could be an effective strategy for improving the dissolution rate and bioavailability of poorly aqueous-soluble ingredients. [Extracted from the article]

Researchers from the University Gadjah Mada in Yogyakarta, Indonesia have conducted a study on angiotensin II inhibitors, specifically focusing on the drug valsartan. Valsartan has poor water solubility, which limits its bioavailability. To address this issue, the researchers prepared a solid dispersion of valsartan using the spray drying technique in a ternary system. The formulation showed a significant increase in solubility and dissolution rate compared to the pure form of valsartan. The study also analyzed the molecular interactions and physicochemical characteristics of the formulation. The findings suggest that the optimized formulation can enhance the solubility and dissolution of valsartan, potentially improving its therapeutic effectiveness. [Extracted from the article]

Researchers at Rowan University in Glassboro, New Jersey have conducted a study on the effects of impurities on the dissolution and growth of pharmaceutical solid solutions. The study found that impurities can significantly alter the properties of crystals, including solubility enhancements, changes in melting point, and growth inhibition. The researchers used dyed crystals to visually demonstrate these effects and challenge common assumptions in the study of multicomponent crystals. The findings have implications for the development of novel impurity rejection and crystal engineering strategies. [Extracted from the article]

Researchers from Texas A&M University have developed a new method for fabricating dose flexible printlets of dapsone (DDS) for pediatric patients using 3D printing. The printlets were evaluated for their physical and chemical properties, stability, and pharmacokinetics. The study found that the printlet formulations were similar to tablet formulations and could be considered clinically interchangeable. This research was supported by the National Institutes of Health (NIH) in the United States. [Extracted from the article]

A recent report discusses the use of nanoemulsions as a drug delivery system for the management of cancer. Nanoemulsions have been found to offer controlled drug release, increased drug solubility, and improved pharmacokinetic and pharmacodynamic profiles. They have shown stability in various cancer models and can target pathological areas with defective vasculatures. The report provides an overview of nanoemulsions, their advantages and limitations, and their role in treating various cancers such as colon, prostate, ovarian, leukemia, breast, melanoma, and lung cancer. The challenges and prospects of nanoemulsions as drug delivery systems are also discussed. This research has been peer-reviewed. [Extracted from the article]

A recent report from the Central University of Gujarat in India discusses the use of fucosylated dendrimers as a biocompatible carrier for the targeted delivery of chrysin to human lung cancer cells. The researchers found that fucosylated PAMAM dendrimers loaded with chrysin had high aqueous solubility and sustained drug release. In vitro studies showed that these dendrimers had improved cytotoxicity and increased apoptosis and cellular uptake in lung cancer cells compared to free chrysin. The researchers concluded that this biocompatible dendrimer could be used as a targeted nanomedicine for lung cancer. [Extracted from the article]

A study conducted by researchers at the University of Copenhagen in Denmark explores the use of eutectic mixtures (EMs) for dermal and transdermal drug delivery. The study specifically focuses on the impact of the composition of EMs on their permeation-enhancing effect. The researchers investigated the solubilizing potential, viscosity, and skin retention of clotrimazole (CLOT) in four terpene-based EMs. They found that the solubility of CLOT in thymol-based EMs depended on the molar ratio between the terpenes, while the solubility in EMs without thymol was independent of the molar ratio. The study concludes that the skin retention of CLOT is influenced by the content of terpenes in the EMs, viscosity of the mixtures, and drug solubility, rather than a specific ratio between them. [Extracted from the article]

Researchers from Hormozgan University of Medical Sciences in Bandar Abbas, Iran, have conducted a study on the solubility of azole-based drugs in different solvents at various temperatures. They developed mathematical models based on the Jouyban-Acree model to predict the solubility of these drugs in binary systems of solvents. The study found that the models provided accurate estimations for the solubility of the drugs and could be useful in the discovery and development of new drugs. The research also highlighted the importance of choosing the appropriate solvent for extraction and purification processes in the pharmaceutical industry. [Extracted from the article]

Researchers at Taif University have conducted a study on the solubility of the antineoplastic drug letrozole in supercritical solvents using machine learning models. Supercritical fluids have been found to be environmentally friendly alternatives to toxic organic solvents in the pharmaceutical industry. The researchers used machine learning approaches, including Passive Aggressive Regression, Random Forest, and Support Vector Machine with RBF kernel, to estimate the solubility of letrozole at different temperatures and pressures. The optimized model, RBF-SVM, demonstrated the highest accuracy in predicting letrozole solubility. This research provides valuable insights into the use of machine learning in pharmaceutical development. [Extracted from the article]

A recent report from the University of Tabriz in Iran discusses the development of chitosan/laponite nanocomposites as pH-dependent drug delivery systems for curcumin, an anticancer drug. The researchers used different techniques to confirm the structure of the synthesized samples and found that the nanocomposites had high loading capacity for curcumin. In vitro studies demonstrated the pH-sensitive release of the drug and the biocompatibility of the nanocarriers. The researchers concluded that these nanocomposites could be used as biocompatible drug delivery systems for chemotherapy applications. [Extracted from the article]

A recent study conducted by researchers from the University of Sao Paulo in Brazil explored the use of biosurfactants to stabilize nanocrystals of the drug niclosamide. Biosurfactants are stable compounds derived from biological sources that can enhance drug solubility. The study found that the biosurfactants rhamnolipid, sophorolipid, and surfactin were as effective as synthetic surfactants in stabilizing the nanocrystal suspension of niclosamide. These biosurfactants also improved the solubility of the drug and showed potential advantages over synthetic analogues in pharmaceutical development. The study was published in the Journal of Drug Delivery Science and Technology. [Extracted from the article]

Researchers from the University of Western Ontario have developed a drug delivery system using nanofibers. The system, called GAP Gel, is composed of ascorbyl palmitate (AP) nanofibers and gelatin methacryloyl polymer. The AP nanofibers enhance the viscoelasticity of the gel and allow it to interact with other hydrophilic molecules. The GAP Gel has shown in vitro biocompatibility, sustained drug delivery efficacy, and cell viability in a 3D environment, making it a promising platform for the delivery of biotherapeutics. [Extracted from the article]

A study conducted by the Russian Academy of Sciences in Ivanovo, Russia, explored the use of cyclodextrins to improve the solubility of the anti-arrhythmia drug dofetilide (DFT). The researchers used phase solubility diagrams and solid dispersions technique to study the complexation of DFT with cyclodextrins. The results showed that cyclodextrins, particularly sulfobutylether-13-cyclodextrin (SBE-13-CD), significantly improved the solubility of DFT. The study concluded that SBE-beta-CD had the best solubilization potential for DFT in both solution and solid dispersion forms. This research has been peer-reviewed and provides valuable insights for the development of improved drug therapies. [Extracted from the article]

Researchers at the SRM Institute of Science and Technology in Kattankulathur, India have discovered new solid forms of the anti-tumor drug Ripretinib that improve its solubility and chemical stability. Ripretinib is used to treat gastrointestinal stromal tumors but has poor aqueous solubility and is prone to degradation in sunlight. The researchers performed salt screening and identified hydrochloride, acetate, 2,6-dihydroxybenzoate, and ferulate salts, as well as a solvate with formic acid and an unexpected methanol solvate. The new multicomponent solids were characterized and found to have improved solubility and chemical stability compared to the native drug. [Extracted from the article]

A study conducted by the Department of Chemical Engineering in Pondicherry, India, focused on developing new solubility models for drugs in supercritical carbon dioxide (SC-CO2). The researchers aimed to predict solubility data at desired experimental conditions, which is crucial for micronizing drug particles with SC-CO2. The study compared the proposed models with existing density models and also calculated thermodynamic quantities of the compounds. The research concluded with a statistical comparison of the models. For more information, readers can contact Chandrasekhar Garlapati at Puducherry Technol Univ, Dept. of Chemical Engineering in Pondicherry, India. [Extracted from the article]

Researchers from the University of Technology in Iraq have published a review on the use of mesoporous silica nanoparticles (MSNs) as a drug delivery system. The researchers highlight the advantages of MSNs, such as their tunable surface area and pore size, which make them suitable for loading various molecules, including drugs. The review also discusses drug loading methods, mechanisms of drug release, and release kinetic models using mesoporous carriers. The researchers emphasize the importance of particle stability and cytotoxicity in designing MSNs. This information is valuable for those interested in drug delivery systems and emerging technologies. [Extracted from the article]

A study conducted by Merck & Company in Rahway, New Jersey, has found that traditional methods of testing drug dissolution in the gastrointestinal (GI) tract may not accurately represent the complex physiologies of the GI tract. The study utilized a biorelevant transfer method called the gastrointestinal simulator alpha (GIS-alpha) to study the dissolution profiles of commercially available BCS Class II drugs. The GIS-alpha with biorelevant buffers yielded superior dissolution profiles compared to the compendial methods. This research provides valuable insight into drug dissolution behavior and absorption patterns, which can be crucial for formulation development and enhancing drug delivery systems. [Extracted from the article]

A recent study conducted by Hovione in East Windsor, United States, compared the dissolution rates of different brands of enzalutamide capsules available in the Indian market. Enzalutamide is a medication used in the treatment of certain conditions. The study found that three out of four generic products were interchangeable with the reference product, while one generic brand did not meet the acceptance criteria. The research suggests that generic brand 4 is the preferred generic substitution for enzalutamide capsules in India. This study has been peer-reviewed and provides valuable information for those interested in dissolution technologies and pharmaceutical research. [Extracted from the article]

Researchers from COMSATS University in Islamabad, Pakistan have developed pH-responsive nanoparticles that could enhance the cytotoxic properties of the anticancer drug paclitaxel (PTX) for the treatment of breast cancer. The researchers prepared an inclusion complex between PTX and hydroxypropyl-(3-cyclodextrin (HP(3CD) to improve the drug's solubility. The inclusion complex was then encapsulated in poly-3-hydroxybutyrate (PHB) to create drug-loaded nanoparticles. The nanoparticles demonstrated a pH-dependent release profile and showed improved cytotoxic and apoptotic effects compared to free PTX. This research has been peer-reviewed and could have potential applications in breast cancer treatment. [Extracted from the article]

A study conducted at St. John's University in Queens, New York, explored the application of the acid-base supersolubilization (ABS) principle to weakly acidic drugs. The researchers used flurbiprofen as a model weakly acidic drug and tested different bases to determine which would result in supersolubilization. They found that lysine and meglumine produced supersolubilization, with meglumine maintaining its supersolubilization without crystallization. The study concluded that the ABS principle can also be applied to acidic drugs depending on the weak base used. This research has been peer-reviewed and published in the International Journal of Pharmaceutics. [Extracted from the article]

A patent has been issued to Hitachi Zosen Corporation for a device that tests the solubility of drugs in the gastrointestinal tract. The device includes multiple vessels that correspond to different parts of the gastrointestinal tract, a digestive-juice supply device, a liquid delivery path, a delivery driving source, a control device, and a suction nozzle. The device aims to accurately simulate the conditions of the gastrointestinal tract in order to test the solubility of drugs more effectively. This patent provides a potential solution to the problem of accurately testing drug solubility in the gastrointestinal tract. [Extracted from the article]

A recent report discusses research conducted at Shanghai Jiao Tong University in China on the potential use of a marine alkaloid called AP-427 for the treatment of hepatocellular carcinoma (HCC), a type of liver cancer. The researchers aimed to improve the clinical suitability of AP-427 by investigating its physicochemical properties and developing liposomal formulations. They found that AP-427 had low solubility and high toxicity, but the liposomal formulation showed promise in reducing cytotoxicity and enhancing antitumor efficacy. This study provides insights into the challenges of drug solubility and offers a potential solution for HCC treatment. [Extracted from the article]

A recent report from researchers at the Beijing Institute of Technology discusses the findings of a study on combination therapy for tumors. The researchers focused on the use of a water-soluble perylene diimide (PDI) cyclophane called "Gemini Box" (GBox-14+), which acts as both a hypoxia-responsive photothermal agent and a drug capsule. The study found that this combination therapy showed more effective inhibition of tumor growth compared to single treatments. The research expands the application of host-guest cyclophane systems and offers potential for improved specificity in treating hypoxic tumors. [Extracted from the article]

The article discusses the global pharmaceutical excipients market and provides insights into the current and forecasted market analysis, key players, challenges, drivers, and trends. It highlights that North America is expected to dominate the market, with the binders category being a significant revenue contributor. The article also mentions notable pharmaceutical excipients companies and their collaborations and product launches. It explains the role of excipients in drug formulations and their impact on drug stability, solubility, and bioavailability. The market dynamics are influenced by factors such as regulatory standards, technological advancements, personalized medicine, and the global nature of the pharmaceutical industry. [Extracted from the article]

A patent application titled "Method Of Enhancing The Efficacy And Stability Of Ingredients In Suspensions" has been published online. The application discusses the challenges faced by manufacturers in formulating solutions that contain both active and inactive ingredients, particularly when these ingredients have poor solubility in liquid delivery vehicles. The invention described in the application involves a composition and method for preparing a suspension that includes a low-solubility ingredient with a particle size of at most 10 mm dispersed in a solvent. The composition passes the freeze-thaw cycling test and has potential applications in various products such as medications, cosmetics, and nutritional supplements. [Extracted from the article]

A report from King Saud University in Riyadh, Saudi Arabia discusses research findings on cancer treatment. The study focuses on enhancing the dissolution and therapeutic capabilities of gefitinib, an inhibitor of epidermal growth factor receptor (EGFR) used to treat metastatic non-small cell lung cancer. The researchers prepared gefitinib complexes using cyclodextrins and solid dispersions using various ratios of polymers. The formulations showed improved dissolution, cytotoxicity, and tablet formulation compared to untreated gefitinib. The study provides valuable insights for optimizing the effectiveness of gefitinib in cancer treatment. [Extracted from the article]

Celator Pharmaceuticals Inc. has been issued a patent (USPTO 12070471) for the remote loading of sparingly water-soluble drugs into lipid vesicles. The patent describes a method of utilizing liposomes for drug delivery, specifically loading liposomes with high concentrations of therapeutic agents to reduce the amount of liposomes needed for treatment. The invention also includes pharmaceutical formulations comprising the liposomes and methods of making them. The patent provides detailed information on the composition and characteristics of the liposomes, as well as their potential applications in treating various diseases. [Extracted from the article]

A recent study conducted by researchers at the University of Arkansas has explored the use of a multicomponent microneedle patch for the delivery of meloxicam in veterinary applications. The study found that the patch successfully encapsulated the drug and maintained its structural integrity and chemical stability even after sterilization. Mechanical testing demonstrated that the patch had the necessary properties for effective skin penetration and drug delivery. The research concluded that microneedle patches have the potential for controlled drug release in veterinary applications. [Extracted from the article]

A recent study conducted at the University of Zagreb in Croatia explored the use of cyclodextrins to increase the solubility of loratadine, a drug with low aqueous solubility. The researchers found that the addition of cyclodextrins, particularly randomly methylated (3-CD, significantly increased the solubility of loratadine. The study also examined the thermodynamic and energetic properties of the loratadine-cyclodextrin complexes using various spectroscopic and computational methods. The research concluded that protonation had a minimal effect on the stability of the complexes. This study provides valuable insights into the potential use of cyclodextrins to enhance the solubility of loratadine and improve its therapeutic efficacy. [Extracted from the article]

Researchers at Air University Multan Campus have conducted a study on cyclodextrin, a medication used in cancer treatments, to address challenges such as poor solubility and potential side effects. By investigating the topological indices of cyclodextrin using algebraic polynomials, the researchers aimed to understand its structural characteristics and physicochemical behavior. The computed indices can serve as predictive tools for assessing the health benefits and therapeutic efficacy of cyclodextrin-based formulations. The study also explored the relationship between the computed indices and the physicochemical characteristics of antiviral drugs. The findings can aid in designing novel drug delivery systems with improved pharmacological properties. [Extracted from the article]

A recent study conducted by researchers from the University of Modena and Reggio Emilia in Italy focuses on optimizing the formulation conditions of poly(lactic-co-glycolic acid) (PLGA) microparticles for the delivery of Indomethacin (IND), a non-steroidal anti-inflammatory drug used to treat osteoarthritis and arthritis. The study aims to address the issue of high doses of IND required to reach therapeutic plasma levels, which can lead to significant systemic side effects. By adjusting the pH of the formulation process, the researchers were able to enhance the encapsulation efficiency of IND in PLGA microparticles, leading to prolonged drug release and effective encapsulation for potential clinical use. This research provides a foundational framework for the development of drug delivery systems for IND. [Extracted from the article]

A recent study conducted at Oriental University focused on the development of an analytical method for the simultaneous estimation of Candesartan and Simvastatin using UV-spectrophotometry. The researchers used ethanol as a solvent and validated the analytical method according to ICH guidelines. The study found that the method had a high correlation coefficient (r2) value and good percentage recovery for both drugs. The method also demonstrated robustness and stability when tested under different conditions. For more information, readers can refer to the original article published in the Research Journal of Pharmacy and Technology. [Extracted from the article]

A recent study conducted by researchers at the University of Duhok focused on improving the solubility of gliclazide, a medication used to treat type II diabetes mellitus. Gliclazide is classified as a drug with high permeability and poor aqueous solubility. The study compared different solid dispersion methods and drug to carrier ratios to determine the most effective approach. The researchers found that the solvent evaporation method with a ratio of 1:5 of gliclazide to polyvinyl pyrrolidone K30 (PVP K30) resulted in the highest solubility improvement and dissolution rate. The findings suggest that this method could enhance the effectiveness of gliclazide therapy. [Extracted from the article]

Researchers in Himachal Pradesh, India have published a new report on drug research. The study focuses on Rebamipide, a drug used to prevent and treat ulcers, but which has low solubility and poor bioavailability. The researchers aimed to enhance the drug's solubility and sustain its release in the stomach by creating solid dispersion-loaded floating beads. The study found that this approach could be effective in preventing and treating stomach ulcers by increasing drug concentration in gastric fluid and providing sustained release. The research has been peer-reviewed and published in the Indian Journal of Pharmaceutical Education and Research. [Extracted from the article]

Researchers at Krupanidhi College of Pharmacy in Karnataka, India, conducted a study to improve the dissolution profiles of Oxcarbazepine (OXC) tablets. They formulated liquisolid tablets using different liquid vehicles and conducted in vitro drug dissolution testing. The study found that the dissolution rate of oxcarbazepine was highest from liquisolid tablets formulated using Polyethylene glycol 200. The research concluded that the best formulation (F2) showed no incompatibility between the drug and excipients used. This research has been peer-reviewed and published in the Indian Journal of Pharmaceutical Education and Research. [Extracted from the article]

A study conducted by researchers from Omdurman Islamic University in Sudan has found that the dissolution of paracetamol (APAP) tablets can be enhanced by incorporating croscarmellose sodium (CCS) instead of microcrystalline cellulose (MCC) as an excipient. The study used a wet granulation method to prepare APAP tablets with various CCS concentrations and compared their disintegration time and dissolution rate with commercial APAP tablets available in Sudan. The results showed that the APAP tablets with CCS had a faster disintegration time and dissolution rate compared to the commercial tablets. This simple approach could potentially provide faster pain relief using APAP. [Extracted from the article]

A recent report discusses research conducted at the University Pharmacy Department of Pharmacy Administration in Budapest, Hungary, on the treatment of bacterial conjunctivitis. The study focused on the development of a novel ophthalmic delivery system using levofloxacin-loaded, preservative-free, nanofiber-based inserts. The researchers found that the nanofibrous formulation showed promise as an alternative to traditional eye drops, offering advantages in solubility, stability, and patient compliance for the treatment of ocular infections. The study was supported by the National Research, Development, and Innovation Fund. [Extracted from the article]

A recent study conducted in Maharashtra, India, explored the use of deep eutectic solvents (DES) to enhance the solubility and bioavailability of zileuton, an anti-inflammatory drug used to treat chronic bronchial asthma. The researchers developed stable DESs and assessed their properties, including viscosity, pH, and solubility. They found that a DES comprising ChCl: EG (1:3) exhibited excellent zileuton solubility. To overcome the drawbacks of liquid DES, a wet impregnation approach using inert carriers was performed to solidify the DES-ZLT. The solidified DES-ZLT showed a significant increase in dissolution studies, leading to a 2.91-fold rise in oral bioavailability. The study demonstrates the potential of DES systems to improve the solubility and stability of drugs with limited therapeutic effectiveness due to solubility issues. [Extracted from the article]

A recent report from investigators at Princeton University explores the potential of using amorphous solid dispersions (ASDs) to enhance the solubility of cannabidiol (CBD), a promising therapeutic agent. The researchers investigated the interactions between CBD and various polymers, such as poly(vinylpyrrolidone) and poly(methyl methacrylate), and found that the mixing behavior varied among the polymers. The study suggests that stable polymer-CBD hydrogen bonds can positively affect dissolution rates, while disruptions to the polymer-polymer hydrogen bond network can have negative effects. These findings have implications for the development of ASD formulations for CBD and other small-molecule therapeutic agents. [Extracted from the article]