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A recent report from the Chinese Academy of Sciences in Changchun, People's Republic of China, discusses the use of biomaterials-mediated biomineralization for tumor blockade therapy in nanomedicine. This innovative approach involves engineering mineralized precursor molecules to target tumor cell membranes, disrupting their biological functions and inducing cell apoptosis. The research highlights the potential of this therapy to enhance treatment precision and efficacy while reducing side effects, offering a unique strategy for tumor therapy. [Extracted from the article]

A recent study conducted at Jilin University in Changchun, People's Republic of China, focused on the effects of Deapioplatycodin D (DPD) on glioblastoma (GBM) cells. The research found that DPD inhibited the growth of GBM cells by inducing BNIP3L-mediated incomplete mitophagy. This study provides a basis for exploring new treatments for GBM, highlighting the potential of DPD in inhibiting GBM cell proliferation through mitophagy. [Extracted from the article]

A study conducted at Jilin University in Changchun, People's Republic of China, focused on the use of azithromycin-loaded Polydopamine Nanoparticles (AZM@PDA NPs) for the treatment of periodontitis. The research highlighted the high biocompatibility and low cytotoxicity of AZM@PDA NPs, which can effectively treat periodontitis and resist alveolar ridge resorption. The study concluded that the sustained release of azithromycin by AZM@PDA NPs shows promise for broad application prospects in treating periodontal diseases. [Extracted from the article]

A study from Jilin University in Changchun, People's Republic of China, explores the use of cryo-printing anisotropic scaffolds for bone regeneration. The research focuses on creating scaffolds with controllable micro-ordered morphology to enhance osteogenesis and angiogenesis. The study suggests that anisotropic mechanical stimulation signals may regulate metabolic patterns to promote osteogenic differentiation. This research offers insights into potential advancements in tissue engineering for bone regeneration. [Extracted from the article]

A study conducted at the First Hospital of Jilin University in Changchun, People's Republic of China, found that prolonged screen time is associated with increased severity of tic symptoms in children with tic disorders. The research involved 342 cases of tic disorders and 270 controls, revealing that children with tic disorders had significantly longer screen time compared to the control group. The study emphasizes the importance of monitoring and regulating screen time in children with tic disorders to manage tic symptoms effectively. [Extracted from the article]

A study conducted at Changchun University of Chinese Medicine in the People's Republic of China focused on targeting the virulence factor sortase A (SrtA) in methicillin-resistant Staphylococcus aureus (MRSA) using Tubuloside A (TnA) as a potential therapeutic strategy. TnA was found to inhibit SrtA, disrupting biofilm development and reducing MRSA pathogenicity in both cell cultures and a murine pneumonia model. The research suggests that targeting specific bacterial virulence factors like SrtA could be an effective approach against antibiotic-resistant pathogens, paving the way for innovative antivirulence therapies. [Extracted from the article]

A study conducted at Changchun Normal University in the People's Republic of China focused on developing a novel electrochemical luminescence sensor for the ultrasensitive detection of tigecycline, a third-generation tetracycline antibiotic. The sensor utilized porous graphite-phase carbon nitride and other components to achieve a low detection limit and demonstrated stability, selectivity, and reproducibility, making it suitable for detecting tigecycline in milk samples. The research was supported by the Science and Technology Development Plan Project of Jilin Province, China, and has been peer-reviewed. For more information, readers can refer to the original article published in Carbon. [Extracted from the article]

Researchers from Jilin University in Changchun, China, have explored the use of biomimetic ion channels (BICs) as a potential treatment for ion channelopathies. By mimicking natural ion channel proteins, BICs can efficiently transport ions across lipid membranes with high selectivity and responsive features. The study discusses the synthesis of BICs using different materials and highlights their potential applications in replacement therapy and antiproliferative treatment. This research, supported by the National Natural Science Foundation of China, offers insights into the promising field of biomimetics for therapeutic purposes. [Extracted from the article]

A study conducted at Jilin University in Changchun, People's Republic of China, explored the anti-biofilm mechanism of reuterin against Staphylococcus aureus on milk-contact material surfaces. Reuterin was found to effectively impede biofilm formation and bacterial adhesion activity, reducing biofilm biomass and bacterial hydrophobicity. The research concluded that reuterin shows promise as an anti-biofilm agent in the food industry, with potential applications on various surfaces. [Extracted from the article]

Researchers from Northeast Normal University in Changchun, People's Republic of China, have studied the regulatory mechanism by which exogenous N-hexanoyl-L-homoserine lactone (C6-HSL) enhances the degradation of Bisphenol A (BPA) by Pseudomonas asiatica P1. The study found that C6-HSL can significantly increase the degradation rate of BPA by 12.4% compared to the control group, leading to the production of benzoic acid and succinic acid. This research sheds light on a promising new approach to enhancing bacterial BPA degradation efficiency through hierarchical regulation. [Extracted from the article]

Researchers at Northeast Normal University in Changchun, People's Republic of China, have conducted a study on metal-protein hybrid materials and their potential applications in various fields, including biomedicine. The study highlights the design strategies, properties, and biomedical uses of these materials, such as cancer therapy, drug delivery, antibacterial treatments, and tissue regeneration. The research also discusses the challenges and potential for clinical translation of these hybrid materials. This peer-reviewed study provides valuable insights into the practical implementation of metal-protein hybrid materials in biomedical applications. [Extracted from the article]

A study conducted at the First Hospital of Jilin University in Changchun, China, evaluated the Screening Tool for Autism in Toddlers (STAT) for early screening of autism in children aged 14-48 months. The research found that STAT demonstrated high sensitivity and specificity in younger age groups but had limitations in older children with less pronounced autistic traits. The study emphasizes the importance of comprehensive assessment strategies for autism diagnosis across different age groups and support needs, potentially improving early support and outcomes for autistic children. This research has been peer-reviewed and provides valuable insights into the effectiveness of autism screening tools in diverse populations. [Extracted from the article]

A study conducted at the First Hospital of Jilin University in Changchun, People's Republic of China, compared the clinical outcomes of two surgical treatments for overweight school-aged children with femoral shaft fractures. The study found that using elastic stable intramedullary nails (ESIN) combined with a temporary external fixator (EF) resulted in faster recovery and fewer complications compared to using locking compression plates (LCP). The research concluded that ESIN plus EF is a viable alternative for overweight pediatric patients with femoral shaft fractures when rigid nails are not suitable due to a narrow medullary canal. [Extracted from the article]

Jilin Normal University researchers have developed a multifunctional biosensor that can selectively identify, detect, and efficiently sterilize Salmonella typhimurium and Staphylococcus aureus. The biosensor utilizes a sandwich structure of 'capture probe/bacteria/signal probe' to achieve these functions, with a detection limit as low as 10 cfu/mL. The biosensor also offers excellent photothermal conversion efficiency for killing target bacteria in food samples, making it a promising tool for food safety. [Extracted from the article]

A study conducted by Jilin Agricultural University in Changchun, People's Republic of China, explores the role of 5-hydroxytryptamine (5-HT) in expelling Trichinella spiralis worms during the intestinal stage of infection. The research suggests that the IL-33-ST2 signaling pathway may enhance the secretion of 5-HT, thereby improving the intestine's ability to expel worms. This peer-reviewed study provides valuable insights into the mechanisms involved in combating parasitic infections like Trichinella. [Extracted from the article]

A study conducted by Jilin University in China examined the relationship between participants' satisfaction with social security and their acceptance of vulnerable groups. The research found a non-linear association between social security satisfaction and inclusion of vulnerable groups, with an inflection point at a score of 45. The study highlights the importance of social security satisfaction in enhancing individuals' acceptance of vulnerable groups, with implications for promoting social equity and justice. [Extracted from the article]

A recent study conducted by Jilin University in Changchun, People's Republic of China, explores the potential of cell-inspired biomaterials in cancer therapy. The research highlights the limitations of traditional cancer treatments and the advantages of using biomaterials with targeting abilities and biocompatibility. The study discusses the design strategies, applications, challenges, and prospects of cell-inspired antitumor biomaterials, aiming to provide new opportunities for the development of cancer therapies. For more information, readers can refer to the article "Tailoring Cell-inspired Biomaterials To Fuel Cancer Therapy" in Materials Today Bio. [Extracted from the article]

A study conducted at Jilin University in Changchun, People's Republic of China, focused on improving household food safety through a combination of motivational nudge strategies and knowledge-based interventions. The research involved 914 primary household food handlers and found that this approach significantly increased compliance with food safety guidelines. The study highlighted the importance of attitudes in influencing safe food-handling behaviors, offering practical intervention strategies for promoting food safety. The research has been peer-reviewed and provides valuable insights into addressing foodborne diseases and conditions. [Extracted from the article]

A recent systematic review and meta-analysis conducted by researchers at Jilin University in Changchun, People's Republic of China, focused on the clinical efficacy and safety of combining hyperbaric oxygen therapy (HBOT) with negative pressure wound therapy (NPWT) for hard-to-heal wounds. The study, which included 15 identified studies, found that the combination of HBOT and NPWT resulted in better outcomes in terms of wound healing rate, bacterial positive rate, wound healing time, wound area, hospitalization time, and hospitalization cost compared to NPWT alone. The researchers concluded that adjunctive HBOT with NPWT is a safe and effective treatment for hard-to-heal wounds, but noted that the findings should be interpreted cautiously due to study limitations. [Extracted from the article]

A study conducted by the Jilin Academy of Agricultural Sciences in Changchun, People's Republic of China, developed a multiplex PCR system for the detection and quantification of four genetically modified soybean events. This system allows for accurate and efficient detection of specific GM events in soybeans, meeting regulatory standards for GMO labeling. The research was funded by the Agricultural Quality Standards and Testing Technology Research Institute Innovation Fund and has been peer-reviewed, offering valuable technical support for regulatory compliance and GMO product monitoring. The study concluded that the multiplex approach provides a robust and efficient solution for the quantitative analysis of GM soybean components in complex sample matrices. [Extracted from the article]

Researchers at the Chinese Academy of Sciences in Changchun have developed a multifunctional polymer coating for medical catheters to address infection and inflammatory complications. The coating, which includes an ultrasonic-responsive carbon monoxide release unit, demonstrated anti-fouling, anti-inflammatory, and antibacterial properties in both in vivo and in vitro experiments. This innovative approach aims to reduce the risk of thrombosis and bacterial infection associated with catheter use, offering a potential solution for next-generation intelligent medical coatings. [Extracted from the article]

Researchers at Jilin University in Changchun, China, have developed a method using Surface-enhanced Raman Spectroscopy (SERS) and machine learning to differentiate between bladder, kidney, and prostate cancers in serum samples. This innovative approach offers rapid, label-free, and highly sensitive detection of urinary cancers, showing promise for early diagnosis and screening. The study highlights the potential application of this method in improving the efficiency of cancer detection and diagnosis. [Extracted from the article]

A recent study conducted at Jilin University in Changchun, People's Republic of China, focused on investigating the antibacterial properties of reduced graphene oxide fibers (rGOFs) fabricated using a hydrothermal method. The research utilized various techniques such as scanning electron microscopy (SEM), X-ray diffraction, and Fourier transform infrared spectroscopy to analyze the structure and composition of the rGOFs. The study concluded that the unique physicochemical properties and surface morphology of rGOFs contribute to their broad-spectrum antibacterial ability, making them potentially valuable for biomedical and nanotechnological applications. [Extracted from the article]

A recent study conducted at Jilin University in Changchun, People's Republic of China, focused on the development of highly efficient lithium-based core-shell-shell nanoprobes for temperature visualization in NIR imaging-guided drug release. By introducing Yb3+ as an energy transfer bridge and optimizing the design, the nanoprobes showed a significant enhancement in emission compared to original nanoparticles. The research aims to advance noninvasive clinical diagnostics and targeted cancer therapies through precise thermal mapping and high-resolution imaging using these nanoprobes. The study was funded by various organizations, including the National Natural Science Foundation of China and Jilin University, and has been peer-reviewed. [Extracted from the article]

Researchers from Changchun University of Chinese Medicine have developed a new dual-responsive fluorescent probe, DSM-NO2, for detecting Nitroreductase (NTR) activity in tumor cells under hypoxic conditions. The probe showed high sensitivity to NTR, with a 50-fold fluorescence enhancement and a detection limit of 1 ng/mL. In high-viscosity environments, the fluorescence enhancement could reach up to 220-fold, with a detection limit of 55 pg/mL. The probe was successfully used for real-time monitoring of NTR in Escherichia coli growth and cancer cells, as well as in in situ fluorescent imaging studies in a murine model of lung cancer. [Extracted from the article]

Researchers from Jilin University conducted a study on Asiaticoside, a compound derived from Centella asiatica, and its effects on Non-Alcoholic Fatty Liver Disease (NAFLD). The study found that Asiaticoside activated the Nrf2 pathway to alleviate oxidative stress, inhibited the NF-kappa B pathway to reduce inflammation, and decreased lipid droplets in experimental models. The research suggests that Asiaticoside has the potential to alleviate NAFLD by activating Nrf2 and inhibiting the NF-kappa B pathway. [Extracted from the article]

A study conducted at Jilin University in Changchun, People's Republic of China, focused on developing a black phosphorus nanosheet-composited hydrogel for the treatment of dentin hypersensitivity. The hydrogel, named GelMA/BP, demonstrated a significant reduction in dentinal tubule diameter and achieved high rates of tubule occlusion, acid resistance, friction resistance, and long-term stability. The research highlighted the potential of this hydrogel as an effective dentinal tubule sealant for treating dentin hypersensitivity, offering promising clinical benefits. [Extracted from the article]

A recent study conducted at the First Hospital of Jilin University in Changchun, People's Republic of China, focused on the effectiveness of isoferulic acid (IFA) in targeting the capsule of hypervirulent Klebsiella pneumoniae (hvKP). The research found that IFA, a natural phenolic acid compound, inhibited capsule polysaccharide synthesis in K. pneumoniae, leading to reduced capsule thickness and improved bacterial clearance. This study suggests that IFA could be a potential alternative therapeutic strategy to combat hvKP infections, especially in cases of drug resistance. The findings highlight the importance of innovative treatments in addressing the challenges posed by highly pathogenic bacteria like hvKP. [Extracted from the article]

A study conducted at Jilin University in Changchun, People's Republic of China, explored the potential of ginsenoside Ro in improving salmonella Typhimurium-induced colitis by inhibiting virulence factors SopB and SopE2 through the Rac1/cdc42/arp2/3 pathway. The research found that ginsenoside Ro reduced mortality rates in infected mice, reversed colon damage, and decreased inflammatory markers while increasing protective genes. This study suggests that ginsenoside Ro could be a promising therapeutic agent against salmonella infections, paving the way for further development in this area. [Extracted from the article]

A study conducted by the Chinese Academy of Agricultural Sciences in Changchun, People's Republic of China, focused on the H5N6 avian influenza virus and its potential threat to human health. The research found that two different recombinant H5N6 viruses exhibited varying levels of pathogenicity and transmissibility in mice, with one strain showing enhanced capabilities for transmission through aerosols. The study concluded that continuous monitoring of these viruses in poultry is necessary to prevent potential transmission to humans. [Extracted from the article]

A study conducted by the Chinese Academy of Sciences in Changchun, People's Republic of China, introduced a drug-free nanomaterial called sodium succinate to enhance cancer immunotherapy by activating cell pyroptosis and enhancing MHC-I expression. The nanomaterial triggers the pyroptosis pathway, leading to increased immune responses and inhibiting tumor immune escape. This research offers a novel approach to tumor treatment that shows potential for clinical application in cancer immunotherapy. [Extracted from the article]

A study conducted by Northeast Normal University in Changchun, People's Republic of China, explored the impact of parental phubbing on social withdrawal in preschool children. The research found that parental phubbing had a significant positive effect on social withdrawal in young children, with parent-child conflict and negative emotions mediating this relationship. The study highlights the importance of understanding how parental behavior can influence social withdrawal in preschool children and suggests interventions to address this issue in China. [Extracted from the article]

Researchers at Jilin University in Changchun, China, have developed a novel method for delivering circular RNA (circRNA) using virus-like nanoparticles (VLNPs) derived from the human papillomavirus (HPV). By functionalizing the VLNPs with a transmembrane peptide, they were able to enhance the delivery and escape of circRNA, resulting in improved target protein expression in various cell types. This study highlights the potential of HPV-VLNPs as carriers for circRNA delivery, offering promising prospects for RNA therapy applications in the future. The research was supported by various funding sources and has been peer-reviewed, providing valuable insights into the field of nanotechnology and vaccine development. [Extracted from the article]

A study conducted by the Chinese Academy of Sciences in Changchun focused on tissue engineering for bone regeneration. The research involved the development of a biphasic scaffold loaded with icariin and quercetin to promote antioxidant activity and osteogenesis. Results showed that the scaffold successfully scavenged reactive oxygen species and enhanced bone repair, making it a promising solution for bone defects and regeneration. The study was funded by various organizations and has been peer-reviewed for publication in Biotechnology and Bioengineering. [Extracted from the article]

A recent study conducted at Jilin University in Changchun, People's Republic of China, explored the effects of pimpinellin on ulcerative colitis (UC) in mice. The research found that pimpinellin reduced inflammation, maintained intestinal barrier integrity, and modulated gut microbiota, ultimately alleviating UC symptoms. This study sheds light on the potential pharmaceutical applications of pimpinellin in treating UC. [Extracted from the article]

A recent study conducted at Changchun University of Technology in China focused on the use of nanofibers to promote wound healing in diabetic patients. The research highlighted the challenges of healing diabetic wounds due to bacterial infections caused by elevated blood glucose levels. The study found that nanofiber membranes with a radially oriented structure showed promising results in promoting cell proliferation, adhesion, and wound healing, indicating potential applications in chronic diabetic wound care. The research has been peer-reviewed and offers valuable insights into the use of nanotechnology in healthcare. [Extracted from the article]

Researchers at Jilin Agricultural University in Changchun, China, have developed Zeolitic Imidazolate Framework-8 (ZIF-8) nanocomposite hydrogels loaded with dihydroquercetin (DHQ) for diabetic wound healing. The hydrogel showed promising in vitro antioxidant activity, inhibition of bacteria, and promotion of cell growth and migration. In vivo experiments demonstrated that the hydrogel promotes wound healing by inhibiting specific pathways and stimulating skin neovascularization. This research suggests that ZIF-8 nanocomposite hydrogels could be effective for diabetic wound dressings and long-term tissue repair applications. [Extracted from the article]

A study conducted at Northeast Normal University in Changchun, People's Republic of China, focused on enhancing the efficacy of photodynamic therapy (PDT) using iridium(iii) complexes as photosensitizers. By cationization engineering, researchers developed two iridium complexes that showed improved reactive oxygen species (ROS) generation and antitumor effects in vivo. This research provides new insights into designing effective photosensitizers for advanced PDT, offering potential advancements in cancer treatment. The study was supported by various funding sources and has been peer-reviewed for publication in Inorganic Chemistry Frontiers. [Extracted from the article]

Researchers at Jilin University in Changchun, People's Republic of China, have developed a stable and lead-free perovskite hemispherical photodetector for filterless single-pixel color imaging. By reducing trap density in the perovskite film, the device demonstrates exceptional stability and low light response capability, outperforming commercial silicon photomultiplier tubes in imaging quality. This advancement in filterless color imaging technology opens new possibilities for high-resolution color imaging applications. The research was funded by the National Natural Science Foundation of China and the Fundamental Research Funds for the Central Universities. [Extracted from the article]

Researchers at Jilin University in Changchun, China, have developed a method for 4D printing self-folding Shape Memory Polymers (SMPs) by pre-stretching extruded filaments during 3D printing. The SMPs can automatically perform shape memory processes under stimulation without manual programming. This innovative technology has potential applications in tissue engineering scaffolds, self-folding robots, and self-assembly systems. The research was funded by the National Natural Science Foundation of China and the Science and Technology Development Plan Project of Jilin Province. [Extracted from the article]

Researchers at Changchun University of Technology in China have developed a novel ratiometric fluorescence sensor using chiral europium-doped carbon dots for the specific and portable detection of tetracycline. The sensor can detect tetracycline with high sensitivity and specificity, with detection limits as low as 2.82 nM. This research not only advances the field of biomedical sensing but also offers a new approach to enhancing the sensitivity of resistant bacteria to drugs. The study was supported by the Jilin Province Natural Science Foundation and has been peer-reviewed. [Extracted from the article]

Researchers from Jilin University in Changchun, People's Republic of China, have developed an advanced microneedle patch that integrates temperature monitoring, wireless communication, and responsive drug release for treating wound infections. The patch, named SP-CSMN, uses chitosan and poly(N-isopropylacrylamide) to encapsulate and release the antibiotic rifampicin, enabling real-time feedback and automatic drug release when infection is detected. This innovative system has shown enhanced antibacterial activities against Staphylococcus aureus and Escherichia coli, accelerating wound healing in infected mice. The research offers a promising solution for efficient management of bacterial wound infections, demonstrating the potential of intelligent microneedle technology in healthcare. [Extracted from the article]

A recent study conducted at Changchun University of Science and Technology in the People's Republic of China introduced a new method for detecting lung cancer using a Symmetrical Single LCVR Polarization Imaging System (SSLPIS). This innovative approach aims to improve the accuracy and efficiency of cancer detection by leveraging the stability of Liquid Crystal Variable Retarders (LCVRs). The research, supported by the National Natural Science Foundation of China, highlights the potential of polarization imaging technology in distinguishing between cancerous and normal tissues, offering a faster and more precise detection method with an accuracy rate of over 90%. [Extracted from the article]

A study conducted at Jilin University in Changchun, People's Republic of China, focused on identifying cancer biomarkers for pancreatic cancer using a novel deep learning framework called HATZFS. The framework combines hierarchical deep Q-network, graph attention network, and zero-forcing set to analyze RNA transcription data and identify driver biomarkers. The research concluded that the proposed model outperformed other methods in identifying important RNA molecules and driver nodes in the pancreatic cancer RNA regulatory network. The study has been peer-reviewed and the source code is available for further exploration. [Extracted from the article]

Researchers at Jilin University in Changchun, China, have developed a nanomedicine using shikonin (SHK) that shows promise in treating breast cancer. The SHK-SS-PEG conjugate has high water solubility and can self-assemble into micelles, allowing for targeted delivery to tumor tissues. The release of SHK from the conjugate is triggered by reduced Glutathione (GSH) levels in tumor cells, resulting in a higher cell killing rate for breast cancer cells compared to normal cells. This research has been peer-reviewed and offers a potential treatment option for various types of cancers. [Extracted from the article]

A study from the Second Hospital of Jilin University in Changchun, People's Republic of China, explores the connection between tumor sex differences and cancer therapy. Researchers highlight the importance of understanding gender variations in cancer at the molecular level, beyond just sex hormones, to improve personalized treatment approaches. The study emphasizes the need to consider gender differences in cancer development across various pathways, such as sex hormones, genetics, and epigenetics, to enhance clinical treatment strategies for both men and women. This research aims to advance sex-based cancer personalized medicine models and promote future scientific and clinical studies that incorporate sex-specific considerations. [Extracted from the article]

A study conducted at Changchun University of Science and Technology in China developed a SIRV epidemic model for influenza transmission, incorporating vaccination dynamics and data memory effects. The research focused on the impact of vaccination on controlling influenza, highlighting the influence of individual perceptions on strategic vaccination decisions. The study emphasized the importance of understanding the benefits and costs of vaccination in managing the spread of the disease. [Extracted from the article]