1. Frequency and prognostic value of cutaneous molecular residual disease in mycosis fungoides: a prospective multicentre trial of the Cutaneous Lymphoma French Study Group
- Author
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Nicolas Ortonne, Gaëlle Quéreux, B. Lenormand, Nathalie Franck, Stéphane Barete, P. Cornillet-Lefebvre, Liliane Laroche, Eve Maubec, C. Hurabielle, Eric Estève, Janine Wechsler, Caroline Ram-Wolff, Marie-Hélène Delfau-Larue, C. Michel, Michel d’Incan, Laurent Mortier, Saskia Ingen-Housz-Oro, Martine Bagot, Florent Grange, Pascal Joly, Laurent Machet, Sophie Dalac, Philippe Saiag, A. Merah, and Sylvie Bastuji-Garin
- Subjects
Adult ,Male ,medicine.medical_specialty ,Neoplasm, Residual ,Skin Neoplasms ,Dermatology ,Disease ,Administration, Cutaneous ,Gene Rearrangement, T-Lymphocyte ,Gastroenterology ,Cutaneous lymphoma ,Young Adult ,Mycosis Fungoides ,Adrenal Cortex Hormones ,Internal medicine ,medicine ,Humans ,Prospective Studies ,Stage (cooking) ,Aged ,Aged, 80 and over ,Mycosis fungoides ,business.industry ,Histology ,Retrospective cohort study ,Gene rearrangement ,Middle Aged ,medicine.disease ,Clone Cells ,Surgery ,Treatment Outcome ,Monoclonal ,Female ,Neoplasm Recurrence, Local ,business - Abstract
Summary Background Monoclonal T-cell receptor (TCR) rearrangement is detected in 57–75% of early-stage mycosis fungoides (MF) at diagnosis. A retrospective study showed molecular residual disease (MRD) in 31% of patients in complete clinical remission (CR) after 1 year of treatment. Objectives To confirm the frequency of MRD at 1 year and to determine its prognostic value for further relapse. Methods Patients with T1-, T2- or T4-stage MF were prospectively included in this multicentre study. At diagnosis, clinical lesions and healthy skin were biopsied. After 1 year of topical treatment, previously involved skin of patients in CR was biopsied for histology and analysis of TCR-γ gene rearrangement. The results were compared with the clinical status each year for 4 years. Results We included 214 patients, 133 at T1, 78 at T2 and three at T4 stage. At diagnosis, 126 of 204 cases (61·8%) showed TCR clonality in lesional skin. After 1 year, 83 of 178 patients (46·6%) still being followed up were in CR and 13 of 63 (21%) showed MRD. At 4 years, 55 of 109 patients (50·5%) still being followed up were in CR and 44 of 109 (40·4%) were in T1 stage. MRD did not affect clinical status at 4 years (CR vs. T1/T2, P = 1·0; positive predictive value 36·4%; negative predictive value 67·6%). Conclusions T-cell clonality at diagnosis and MRD at 1 year are not prognostic factors of clinical status at 4 years.
- Published
- 2015