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Therapy-related acute myeloid leukemia with t(8;21) in a child with previous Ewing's sarcoma
- Source :
- Medical and Pediatric Oncology. 29:132-134
- Publication Year :
- 1997
- Publisher :
- Wiley, 1997.
-
Abstract
- Cases of secondary acute myeloid leukemia (AML) occurring after treatment for an Ewing's sarcoma are uncommon. Therapy-related AML with t(8;21) translocation is an entity which has been well characterized. A case of AML-2 with t(8;21) and t(3;15) occurring 4 years after treatment for an Ewing's sarcoma with cyclophosphamide, doxorubicin, vincristine, dactinomycin, and radiotherapy, is reported. Autologous bone marrow transplantation was performed during second remission, 23 months after diagnosis. Reverse transcriptase polymerase chain reaction of the AML1/ETO fusion gene product was performed in order to monitor the quality of the remission. The patient currently remains in remission 24 months after the bone marrow transplantation.
- Subjects :
- Oncology
Cancer Research
Chemotherapy
medicine.medical_specialty
Vincristine
Pathology
Cyclophosphamide
business.industry
medicine.medical_treatment
Ewing's sarcoma
Therapy-Related Acute Myeloid Leukemia
medicine.disease
Radiation therapy
hemic and lymphatic diseases
Internal medicine
Pediatrics, Perinatology and Child Health
medicine
Secondary Acute Myeloid Leukemia
Sarcoma
business
medicine.drug
Subjects
Details
- ISSN :
- 1096911X and 00981532
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Medical and Pediatric Oncology
- Accession number :
- edsair.doi...........c416d234ca0c9db9d9051edbc66b4f00