57 results on '"Ayse Kubat Uzum"'
Search Results
2. Transglutaminase 2 Expression is Associated with Increased Risk of Lymph Node Metastasis and Recurrence in Papillary Thyroid Cancer
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Yagmur Goksoy Solak, Gulcin Yegen, Semen Onder, Sakin Tekin, Ozlem Soyluk, Nurdan Gul, Refik Tanakol, Ferihan Aral, and Ayse Kubat Uzum
- Abstract
Purpose Transglutaminase 2 (TG2) is associated with mobilization, invasion, and chemoresistance of tumor cells. We aimed to determine whether the immunohistochemical staining with TG2 antibody differs between metastatic and non-metastatic papillary thyroid cancer patients. Methods We included 76 patients with papillary thyroid cancer (72% female, median age 52 (24–81) years, follow-up time 107 (60–216) months). Thirty of them with no metastasis, 30 of them with only lymph node metastasis and 16 patients with distant ± lymph node metastasis. Immunohistochemical staining of TG2 antibody was evaluated in the primary tumor and extra-tumoral tissue. We also divided subjects into two groups according to their primary tumor TG2 staining score (group A, high risk group: ≥3, n = 43; group B, low risk group
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- 2023
3. Clinical features of type 1 and type 2 diabetes patients with suspected fungal foot infections: a single-center experience
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Selda Celik, Elif Bagdemir, Sevim Purisa, Ayse Kubat Uzum, Ilhan Satman, and Gulsah Yenidunya Yalin
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Endocrinology, Diabetes and Metabolism ,Internal Medicine - Published
- 2022
4. Effect of Cabergoline Treatment on Disease Control in Acromegaly Patients
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Hulya Hacisahinogullari, Gulsah Yenidunya Yalin, Ozlem Soyluk Selcukbiricik, Nurdan Gul, Bilge Bilgic, Ayse Kubat Uzum, Refik Tanakol, and Ferihan Aral
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Cabergoline ,Human Growth Hormone ,Endocrinology, Diabetes and Metabolism ,Biochemistry (medical) ,Clinical Biochemistry ,General Medicine ,Biochemistry ,Prolactin ,Endocrinology ,Acromegaly ,Humans ,Ergolines ,Insulin-Like Growth Factor I ,Retrospective Studies - Abstract
The aim of this study was to evaluate the efficacy of cabergoline in normalizing plasma IGF-I levels in acromegaly patients with elevated IGF-I levels after surgery and/or SRL therapy. Acromegaly patients (n: 143) were evaluated retrospectively. Patients with elevated IGF-I levels after surgery and/or SRLs therapy and a fixed dose of SRLs treatment for the last six months with no history of radiotherapy in the last three years were included in the study (n: 12). Previous treatment regimens, baseline PRL and IGF-I levels (ULNR), sella MRI, and immunohistochemical findings were evaluated. Cabergoline was used as an add on (n: 11) or single medical treatment (n: 1). The median duration of treatment with SRL alone was 12 months (range 6–48 months). The mean IGF-I value before cabergoline therapy was 1.45±0.4 ULNR. The mean cabergoline dose and duration of treatment were 1.55±0.75 mg/week and 9±6.3 months, respectively. IGF-I normalization was only achieved in patients with serum IGF-I concentration
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- 2022
5. A rare cause of dilated cardiomyopathy: hypocalcemia
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Ummu Mutlu, Ramazan Cakmak, Mehmet Rasih Sonsöz, Ekrem Bilal Karaayvaz, Ayse Kubat Uzum, Refik Tanakol, and Ferihan Aral
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Endocrinology, Diabetes and Metabolism - Published
- 2022
6. Adrenal incidentaloma rate during coronavirus disease 2019 (COVID-19) pandemic
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Ozge Telci Caklili, Arzu Poyanli, Esin Duvek, Eda Canipek, Alpay Medetalibeyoglu, Hulya Hacisahinogullari, Ozlem Soyluk Selcukbiricik, Nurdan Gul, and Ayse Kubat Uzum
- Published
- 2022
7. Use of Advanced Hybrid Closed-Loop System in a Patient with Pancreas Cancer
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Hulya Hacisahinogullari, Ozge Telci Caklili, Goktug Saribeyliler, Nubar Rasulova, Ozlem Selcukbiricik, Nurdan Gul, Ayse Kubat Uzum, and Kubilay Karsidag
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Blood Glucose ,Pancreas, Artificial ,Pancreatic Neoplasms ,Medical Laboratory Technology ,Diabetes Mellitus, Type 1 ,Insulin Infusion Systems ,Endocrinology ,Blood Glucose Self-Monitoring ,Endocrinology, Diabetes and Metabolism ,Humans ,Hypoglycemic Agents ,Insulin - Published
- 2022
8. The Metabolic Effects of Pre-probiotic Supplementation After Roux-en-Y Gastric Bypass (RYGB) Surgery: a Prospective, Randomized Controlled Study
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Ilhan Satman, Ayse Kubat Uzum, Fulya Calikoglu, Umut Barbaros, and Yildiz Tutuncu
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Blood Glucose ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,media_common.quotation_subject ,Gastric Bypass ,Incretin ,030209 endocrinology & metabolism ,medicine.disease_cause ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,Glucagon-Like Peptide 1 ,law ,Weight loss ,medicine ,Humans ,Insulin ,Prospective Studies ,media_common ,Nutrition and Dietetics ,Gastric bypass surgery ,business.industry ,Probiotics ,Area under the curve ,Appetite ,Glucagon-like peptide-1 ,Obesity, Morbid ,Surgery ,030211 gastroenterology & hepatology ,medicine.symptom ,business - Abstract
Following Roux-en-Y gastric bypass (RYGB), positive alterations are observed in gut microbiota and intestinal peptides. Previous studies demonstrated similar alterations observed in cases when pre-probiotics are used without surgery. The aim of this trial was to evaluate the effectiveness of early use of pre-probiotics after RYGB. The operation and follow-up of the patients were performed at Istanbul University Medical Faculty. Thirty-two patients who had undergone RYGB were randomized to pre-probiotic group (PreProBG, n = 16; 200 g/day yogurt plus 10 g/day inulin+oligofructose) and probiotic group (ProBG, n = 16; 200 g/day yogurt only) for 6 months. Blood samples (glucose, insulin, A1c, GLP-1, PYY), anthropometric measurements, and appetite ratings have been evaluated at baseline and 3 (m3) and 6 (m6) months after RYGB. Initial anthropometric measurements and appetite ratings decreased significantly after surgery and there were no significant differences between the groups. The decrease of area under the curve(insulin) was less and has a positive correlation with the changes in anthropometric measurements in PreProBG. GLP-1 and PYY which increased dramatically after surgery in all patients were higher in PreProBG. But this increase had a negative correlation with the changes in anthropometric measurements during the study. Increased insulin, GLP-1, and PYY secretion was more enhanced by pre-probiotic use in early postoperative period. But this increase not only in anthropometric measurements but also in appetite ratings affects negatively, contrary to expectations. In summary, it should be investigated with new studies that use of pre-probiotics in the late postoperative period may be more effective in patients with weak insulin and incretin response and therefore insufficient weight loss. Trial Registration clinicaltrials.gov Identifier: NCT03517345.
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- 2020
9. A single-center experience of transsphenoidal endoscopic surgery for acromegaly in 73 patients: results and predictive factors for remission
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Esra Saka, Tugrul Cem Unal, Aydin Aydoseli, Utku Ozgen, Yavuz Aras, Nurdan Gul, Pulat Akin Sabanci, Altay Sencer, Musa Samet Ozata, Ummu Mutlu, Sema Yarman, Bilge Bilgic, Ilyas Dolas, Ayse Kubat Uzum, and Metehan Ozturk
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Endoscopic surgery ,General Medicine ,Single Center ,medicine.disease ,Surgery ,Endoscopy ,Acromegaly ,Growth hormone secreting adenoma ,Medicine ,Neurology (clinical) ,business - Abstract
Transsphenoidal endoscopic surgery is the first-line treatment for growth hormone-secreting adenomas.To analyse the results of the transsphenoidal endoscopic approach for acromegaly and to determine the predictive factors of remission.A single-centre retrospective review was performed in patients who underwent endoscopic transsphenoidal surgery for acromegaly between January 2009 and January 2019. Demographic features, clinical presentation, histopathology records, complications and pre- and postoperative radiologic and endocrinological assessments were evaluated. The factors that influenced the remission rates were investigated.A total of 73 patients underwent surgery via the transsphenoidal endoscopic approach. Cavernous sinus invasion was detected in 32 patients (43.8%); and macroadenoma, in 57 (78%). The pathology specimens of the 27 patients (36.9%) showed dual-staining adenomas with prolactin. A total of 51 patients (69.8%) attained biochemical remission 1 year after surgery. A second operation was performed in 10 patients (13.6%) with residual tumours without biochemical remission in the first year. Six (60%) of the patients attained remission at the last follow-up. Transient diabetes insipidus was observed in 18 patients (24.6%); and rhinorrhoea, which was resolved with conservative treatment, in 4 (5.4%). None of the patients developed panhypopituitarism. The presence of cavernous sinus invasion and preoperative IGF-1, immediate postoperative GH and third-month IGF-1 levels were predictive of remission.Transsphenoidal endoscopic surgery is a safe and effective treatment for acromegaly. Reoperation should be considered in patients with residual tumours without remission.
- Published
- 2021
10. Gastroesophageal Reflux in Asymptomatic Patients with Diabetes: An Impedance Study Diabetes, Obesity and Gastroesophageal Reflux
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Ilhan Satman, Busra Alpaslan, Filiz Akyuz, Sabahattin Kaymakoglu, Sami Evirgen, Suut Gokturk, Fatih Besisik, Cetin Karaca, Kadir Demir, Nurdan Gul, Ayse Kubat Uzum, Bilger Cavus, Ozlem Mutluay Soyer, Serpil Arici, Asli Ormeci, and Umit Akyuz
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Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Adolescent ,Manometry ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Gastroenterology ,Asymptomatic ,Diabetes Complications ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Bolus (medicine) ,Diabetes mellitus ,Internal medicine ,Electric Impedance ,Internal Medicine ,medicine ,Humans ,Obesity ,Prospective Studies ,Prospective cohort study ,Aged ,business.industry ,Reflux ,General Medicine ,Middle Aged ,medicine.disease ,030104 developmental biology ,Gastroesophageal Reflux ,GERD ,Female ,medicine.symptom ,business ,Body mass index ,Esophagitis ,Follow-Up Studies - Abstract
Introduction Gastroesophageal reflux disease (GERD) is more frequent in patients with diabetes mellitus (DM).The aim of the present study was to evaluate gastroesophageal reflux (GER) in asymptomatic patients with DM using 24-h pH impedance. Materials and Methods 19 healthy controls and 35 patients with DM without typical GERD symptoms were enrolled in the study. A 24-h pH-impedance study, esophageal manometry and gastroscopy were performed on all patients with DM. In the control group, an impedance study was performed on all subjects, and gastroscopy and esophageal manometry were performed on those who consented to the procedures. Patients with diabetes were categorized as obese [body mass index (BMI)>30 kg/m2] or non-obese (BMI Results The mean BMI was similar in the control group (27.3±2.6 kg/m2) and the diabetic group (28.7±5 kg/m2) (p>0.05).Erosive esophagitis was found in 7.5% of the DM group. Esophageal dysmotility was higher in diabetics compared to the control group (45.5 vs. 11%, p=0.04). Neuropathy was found to be an independent risk factor for dysmotility. The mean DeMeester score (DMS) (25.6±32.5 vs. 11.2±17, p=0.01) and bolus exposure time (2.1±1.3 vs.1.3±1.3 min, p=0.009) were higher in the DM group compared with the control group.The difference was mainly observed between obese diabetics and the control group (p Conclusion Acid reflux is common in patients with diabetes.GER is associated with the existence of obesity rather than hyperglycemia.
- Published
- 2018
11. CİNSİYET HOŞNUTSUZLUĞU OLAN BİREYLERDE ENDOKRİNOLOJİK YAKLAŞIM
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Ramazan Çakmak and Ayse Kubat Uzum
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Gynecology ,medicine.medical_specialty ,business.industry ,Medicine ,business - Abstract
Cinsel kimlik, bireyin kendi bedenini ve kimligini belli bir cinsiyet icinde algilamasi, kabullenmesidir. Psikiyatri uzmanlari tarafindan yapilan degerlendirmeler sonrasinda cinsiyet hosnutsuzlugu tanisi konan bireyler endokrinolojik acidan da degerlendirilmeli ve cinsiyet hosnutsuzlugunun altinda yatabilecek bazi durumlar/ hastaliklar mutlaka dislanmalidir. Hormonal ve geri donusumsuz tedaviler baslamadan once, tercih ettigi cinsel kimlige uygun olan cinsel rolu yasamasi, tedavi oncesi gercek yasam deneyimi acisindan onemlidir. Bu sekilde, istenilen cinsiyette yasama kapasitesi ve sosyal, ekonomik, psikolojik desteklerin yeterli olup olmadigi test edilmis olur. Transbireye uc aylik gercek yasam deneyimi sonrasinda hormon tedavisine baslanabilir, tedavi bireye ozgu olmali ve oncesinde hormon tedavisinin geri donebilen ve kalici etkileri anlatilmalidir. Hormon tedavisi oncesinde fertilite korunmasi ile ilgili bilgilendirme yapilmali ve isteyen kadinlarda over prezervasyonu, erkeklerde sperm saklanmasi onerilmeli, ayrintili bilgilendirilmis onam formu imzalatilmalidir. Transkadinda feminizasyon bulgulari, serum testosteron ve estradiol duzeyleri bakilmali, ilac yan etkileri, meme, kolon, prostat kanseri acisindan rutin kanser taramasi ve osteoporoz risk faktorlerinin degerlendirilmesi yapilmalidir. Transerkek ise, virilizasyon bulgulari, serum testosteron duzeyleri, ilac yan etkileri, uterus intakt ise yillik PAP-smear, meme dokusu intakt ise mamografi ve osteoporoz risk faktorleri acisindan degerlendirilmelidir. Operasyon, en az bir yillik gercek yasam deneyimini tamamlamis olan ve bunun en az 3 ayinda hormon tedavisi kullanmis olan, 18 yasindan buyuklere onerilebilir. Ancak cerrahi tedavinin geri donulmez degisiklikler olusturacagi ve cerrahi secenege gecilmesinin sart olmadigi unutulmamalidir. Cerrahi girisim uygulanmis transbireylerin uzun donem takiplerinde intihar girisimi ve psikiyatrik morbiditelerin artabilecegi bildirilmistir.
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- 2021
12. Prevalence of papillary thyroid cancer in subacute thyroiditis patients may be higher than it is presumed: retrospective analysis of 137 patients
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Refik Tanakol, Ozlem Soyluk Selcukbiricik, Nurdan Gül, Gulcin Yegen, Ayse Kubat Uzum, and Ferihan Aral
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Adult ,Male ,endocrine system ,medicine.medical_specialty ,endocrine system diseases ,Biopsy, Fine-Needle ,R895-920 ,030209 endocrinology & metabolism ,Thyroid Function Tests ,Malignancy ,Papillary thyroid cancer ,Thyroid carcinoma ,Medical physics. Medical radiology. Nuclear medicine ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Biopsy ,Biomarkers, Tumor ,Prevalence ,thyroid cancer ,Humans ,Medicine ,Outpatient clinic ,Radiology, Nuclear Medicine and imaging ,Thyroiditis, Subacute ,subacute thyroiditis ,Thyroid cancer ,Aged ,Retrospective Studies ,Subacute thyroiditis ,medicine.diagnostic_test ,business.industry ,ultrasonography ,Middle Aged ,medicine.disease ,Fine-needle aspiration ,Oncology ,Thyroid Cancer, Papillary ,030220 oncology & carcinogenesis ,thyroid nodule ,Female ,business ,Research Article - Abstract
Background The association of subacute thyroiditis (SAT) and papillary thyroid carcinoma is a rare finding. In this study, we aimed to investigate the prevalence of differentiated thyroid cancer in a cohort of patients followed with the diagnosis of SAT. Patients and methods We retrospectively screened medical records of Endocrinology and Metabolism outpatient clinic in the past 20 years for patients with SAT. Patients with nodules and suspicious ultrasonography findings who underwent fine needle aspiration biopsy (FNAB) and operated due to malignancy risk were identified. Results We identified 137 (100 females, 37 males) patients with reliable records to confirm the diagnosis of SAT. The mean age of female patients was 41.1 ± 9.1 (range, 20–64) and of male patients was 43.0 ± 9.3 (range, 20–65). One or more FNAB was performed in 23 of the patients (16.8%) at the beginning and/or during the follow-up period when needed. Seven patients with suspicious FNAB findings were operated, and histopathological examination of the nodules confirmed the diagnosis of papillary thyroid carcinoma in 6 patients (4.4%). Conclusions Our observations suggesting a relatively higher prevalence of thyroid cancer in a small series of SAT patients warrant further studies to identify the real frequency of differentiated thyroid cancer and its association with inflammatory pathogenesis of SAT. This finding is compatible with the trend of increased thyroid cancer incidence all over the world. A repeat ultrasonography after resolution of clinical and inflammatory findings, and FNAB should be recommended to all patients with suspicious nodules.
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- 2018
13. Utility of baseline serum phosphorus levels for predicting remission in acromegaly patients
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Gulsah Yenidunya Yalin, Ayse Kubat Uzum, Ferihan Aral, Refik Tanakol, Seher Tanrikulu, and Nurdan Gul
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Adult ,Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Logistic regression ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Internal medicine ,Acromegaly ,medicine ,Humans ,Initial treatment ,In patient ,Insulin-Like Growth Factor I ,Oral glucose tolerance ,Retrospective Studies ,Human Growth Hormone ,business.industry ,Remission Induction ,Phosphorus ,Glucose Tolerance Test ,Middle Aged ,medicine.disease ,Pituitary adenoma size ,Female ,Serum phosphorus ,business ,Biomarkers ,030217 neurology & neurosurgery ,After treatment - Abstract
High GH and IGF I levels increase tubular phosphate reabsorption in patients with acromegaly. We aimed to investigate the utility of serum phosphorus levels as an indicator for predicting chance of remission in acromegaly patients. Fifty-one patients (n: 51; F: 24, M: 27) with diagnosis of acromegaly were included in the study. Plasma IGF-1, Phosphorus (P) and nadir GH levels on oral glucose tolerance test (OGTT) at the time of diagnosis were analysed retrospectively. Patients were classified into two groups according to their plasma P levels; P ≤ 4.5 mg/dl (Group-1, n: 23, 45.1%), P > 4.5 mg/dl (Group-2, n: 28, 54.9%). Two groups were compared according to remission status; remission (n: 27) and non-remission (n: 24). Remission was defined with absence of clinical symptoms, normal plasma IGF-1 (adjusted for age and gender) and GH levels (
- Published
- 2017
14. Evaluation of Glutathione Peroxidase and KCNJ11 Gene Polymorphisms in Patients with New Onset Diabetes Mellitus After Renal Transplantation
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Sevim Purisa, Sebahat Akgul, Fatma Oguz Sarvan, Gulsah Yenidunya Yalin, Mehmet Sukru Sever, Nurdan Gul, Ayse Kubat Uzum, Ilhan Satman, and Seher Tanrikulu
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Adult ,Male ,medicine.medical_specialty ,GPX1 ,Endocrinology, Diabetes and Metabolism ,030232 urology & nephrology ,030204 cardiovascular system & hematology ,Biology ,Gastroenterology ,03 medical and health sciences ,Glutathione Peroxidase GPX1 ,0302 clinical medicine ,Endocrinology ,New onset diabetes ,Internal medicine ,Diabetes Mellitus ,Internal Medicine ,medicine ,Humans ,In patient ,Potassium Channels, Inwardly Rectifying ,Allele ,Gene ,Genotyping ,chemistry.chemical_classification ,Glutathione Peroxidase ,Polymorphism, Genetic ,Glutathione peroxidase ,General Medicine ,Middle Aged ,Kidney Transplantation ,Transplantation ,chemistry ,Female - Abstract
Introduction Genetic mutations such as C599T polymorphism in glutathione peroxidase [GPX1] gene and polymorphisms in potassium channel (KCNJ11) genes have recently been proposed in the etiopathogenesis of new onset diabetes mellitus after renal transplantation (NODAT). We aimed to examine the association of GPX1 and KCNJ11 polymorphisms in NODAT. Materials and Methods This is a monocenter case-control study with a total of 118 renal transplant recipients who were divided into 2 groups; NODAT and normal glucose tolerance. Relation of GPX1 and KCNJ11 polymorphisms were investigated between these groups. PCR-RFLP method was used for genotyping of polymorphisms in the GPX1 (rs1050450) and KCNJ11 (rs1805127) genes. Two alleles were visualized for each gene (C/T for GPX1 and A/G for KCNJ11). Results NODAT was correlated with age at transplantation (p Conclusions In addition to several diabetogenic risk factors, C599T polymorphisms in GPX1 gene might also contribute to the development of NODAT. Further studies on larger patient series are necessary in order to reach definitive suggestions.
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- 2017
15. INCIDENTAL PAGET'S DISEASE DISGUISED AS BONE METASTASIS IN A PATIENT WITH ENDOMETRIUM CARCINOMA
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Bülent Canbaz, Nurdan Gul, Bilge Bilgic, Gulsah Yenidunya Yalin, Ayse Kubat Uzum, and Sema Ciftci Dogansen
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Pathology ,medicine.medical_specialty ,Bone disease ,medicine.diagnostic_test ,Endocrine and Autonomic Systems ,business.industry ,Endocrinology, Diabetes and Metabolism ,Pelvic pain ,Bone metastasis ,Case Report ,medicine.disease ,030218 nuclear medicine & medical imaging ,Bone remodeling ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Bone scintigraphy ,030220 oncology & carcinogenesis ,Carcinoma ,Medicine ,Adenocarcinoma ,Differential diagnosis ,medicine.symptom ,business - Abstract
Paget's disease is a disorder of aging bone which occurs in the setting of accelarated bone remodelling. In the presented case we discuss the difficulties in the diagnosis of Paget's disease in a 77 year old patient with coexisting endometrium carcinoma. The patient was initially diagnosed with metastatic bone disease due to endometrium adenocarcinoma when she was admitted to oncology clinic with pelvic pain. Bone scintigraphy with Tc99 and (18)F fluorodeoxyglucose positron emission tomography/CT revealed an increased uptake on the bone lesions which were reported as metastatic bone involvement. Although the (18)F-FDG uptake was much higher than the levels that would generally be anticipated in a case with Paget's disease, high levels of bone turnover markers indicated further evaluation in the differential diagnosis and the definitive diagnosis of Paget's disease was established with the pathological evaluation of bone biopsy.
- Published
- 2019
16. Radiofrequency Ablation in a Patient with Primary Hyperparathyroidism
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Arzu Poyanlı, Gulsah Yenidunya Yalin, and Ayse Kubat Uzum
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Parathyroidectomy ,Thyroid nodules ,Hyperparathyroidism ,medicine.medical_specialty ,Cinacalcet ,endocrine system diseases ,business.industry ,Radiofrequency ablation ,medicine.medical_treatment ,Urology ,medicine.disease ,law.invention ,law ,medicine ,business ,Contraindication ,Primary hyperparathyroidism ,Parathyroid adenoma ,medicine.drug - Abstract
The most common cause of hypercalcemia and high plasma PTH levels is primary hyperparathyroidism (PHPT). Clinical features are associated with recurrent urolithiasis and osteoporosis. However, most of the patients are generally asymptomatic or have nonspecific complaints. Biochemical diagnosis is based on elevated plasma calcium and parathormone levels and high 24-h urine calcium excretion. The definitive treatment of PHPT is performing parathyroidectomy after the localization of parathyroid adenoma. In patients who are ineligible for surgery (due to comorbidities or surgical risk), management of hypercalcemia can be very challenging, and several medical agents such as bisphosphonates, calcitonin, or cinacalcet are being applied periodically to control high plasma calcium levels. Radiofrequency ablation is a minimally invasive ablation method which is generally used in the management of benign thyroid nodules for volume reduction and improvement of associated symptoms. Lately, this method has also been used in the management of PHPT patients when surgery is not eligible either because of contraindication due to high surgical risk or patient refusal. We hereby present our experience with radiofrequency ablation therapy in the management of hyperparathyroidism in a 59-year-old female patient.
- Published
- 2018
17. A SOD2 Polymorphism is Associated with Abnormal Quantitative Sensory Testing in Type 2 Diabetic Patients
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A. Emre Öge, Erdem Tüzün, Cem İsmail Küçükali, Sacide Erden, Ali Isikli, Ayse Kubat-Uzum, Ilhan Satman, Elif Ozkok, Zeliha Matur, and MATUR, ZELİHA
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medicine.medical_specialty ,biology ,business.industry ,General Neuroscience ,SOD2 ,030209 endocrinology & metabolism ,Single-nucleotide polymorphism ,030204 cardiovascular system & hematology ,medicine.disease ,medicine.disease_cause ,Superoxide dismutase ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,Endocrinology ,Polymorphism (computer science) ,Internal medicine ,Sensory threshold ,Diabetes mellitus ,biology.protein ,SNP ,Medicine ,business ,Oxidative stress ,Research Article - Abstract
Introduction Diabetes mellitus (DM) affects peripheral nerves inducing diabetic polyneuropathy (DPN). Mitochondrial dysfunction and oxidative stress are potential causes of DPN. Methods Nerve conduction studies were performed in 20 type 2 DM patients (11 with DPN) and 15 healthy controls. Perception threshold values of cold, warm and vibration were measured by quantitative sensory testing. Variants of a superoxide dismutase 2 (SOD2) gene single nucleotide polymorphism (SNP) (rs5746136) were determined by polymerase chain reaction (PCR) and following NexteraXT DNA Library. Results DPN patients showed significantly increased threshold values. DM patients without DPN and healthy controls showed comparable values. TT variant of the SOD2 SNP was more prevalent in DM and DPN patients. DM patients with the TT variant displayed increased perception threshold values. Conclusions Quantitative sensory testing is not superior to standard nerve conduction studies in DPN. Carriers of SOD2 SNP manifested increased sensory threshold levels which is important in further corroborating the link between oxidative stress and DPN.
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- 2018
18. Calcitriol treatment in patients with low vitamin D levels
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Ferihan Aral, Ayse Kubat Uzum, Nurdan Gul, and Refik Tanakol
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musculoskeletal diseases ,medicine.medical_specialty ,Calcitriol ,Osteoporosis ,chemistry.chemical_element ,030209 endocrinology & metabolism ,Calcium ,vitamin D deficiency ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Bone Density ,Internal medicine ,polycyclic compounds ,Vitamin D and neurology ,medicine ,Humans ,Orthopedics and Sports Medicine ,030212 general & internal medicine ,Prospective Studies ,Vitamin D ,Cholecalciferol ,Bone mineral ,Lumbar Vertebrae ,Bone Density Conservation Agents ,business.industry ,Middle Aged ,medicine.disease ,Vitamin D Deficiency ,Clinical trial ,Endocrinology ,Treatment Outcome ,chemistry ,Dietary Supplements ,lipids (amino acids, peptides, and proteins) ,Female ,business ,medicine.drug - Abstract
The aim of the the study is to compare the effects of cholecalciferol and calcitriol on bone mineral metabolism in women with vitamin D deficiency. Calcitriol was associated with a significant increase in bone mineral density at the lumbar spine in patients with low vitamin D levels. Active vitamin D analogs may have larger impact in decreasing bone loss and fracture rate compared to cholecalciferol in osteoporosis. However, their effects in the treatment of vitamin D deficiency compared to cholecalciferol are not clear. The aim of the present study is to compare the effects of cholecalciferol and calcitriol on bone mineral metabolism and bone mineral density in pre- and postmenopausal women with vitamin D deficiency. This was a 6-month prospective, open-label, controlled clinical trial. Eligible 120 participants were pre- and postmenopausal women diagnosed with vitamin D deficiency. Forty-three subjects (group 1) received 1000 IU of cholecalciferol and 1 g of calcium daily. The other 77 subjects (group 2) received 0.5 μg calcitriol in addition to 400 IU of cholecalciferol and 1 g of calcium daily. Oral vitamin D supplementation did not increase bone mineral density after 6 months of intervention in group 1. On the other hand, bone mineral density at the lumbar spine increased from 0.809 ± 0.172 to 0.848 ± 0.161 g/cm2 in group 2 patients (p
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- 2018
19. The Experience of Transition from Childhood to Adulthood in Endocrinology
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Esin Karakilic Ozturan, Aslı Derya Kardelen, Ayse Pınar Öztürk, Ayse Kubat Uzum, Mustafa Özçetin, Firdevs Bas, Sukran Poyrazoglu, Nevin Dinccag, Refik Tanakol, Ilhan Satman, and Feyza Darendeliler
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Gynecology ,medicine.medical_specialty ,Chronic disease ,business.industry ,medicine ,business - Published
- 2018
20. Comparison of 68Ga-DOTATATE PET-CT, 18F-FDG PET-CT and 99mTc-(V)DMSA scintigraphy in the detection of recurrent or metastatic medullary thyroid carcinoma
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Işık Adalet, Zeynep Gözde Özkan, Ayse Kubat Uzum, Mehmet Fatih Gecer, Serkan Kuyumcu, Sevda Ozel, and Ferihan Aral
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Fluorodeoxyglucose ,endocrine system ,PET-CT ,medicine.diagnostic_test ,Medullary cavity ,business.industry ,Whole body imaging ,General Medicine ,medicine.disease ,Thyroid carcinoma ,Positron emission tomography ,Carcinoma ,medicine ,Radiology, Nuclear Medicine and imaging ,Technetium Tc 99m Dimercaptosuccinic Acid ,business ,Nuclear medicine ,medicine.drug - Abstract
PurposeWe aimed to compare the efficacies of gallium-68 (68Ga) DOTATATE PET-computed tomography (CT), fluorine-18 fluorodeoxyglucose (18F-FDG) PET-CT and technetium-99m (99mTc)-(V)DMSA scintigraphy in the detection of residual/metastatic medullary thyroid carcinoma (MTC).Materials and methodWe retro
- Published
- 2015
21. Management of Silent Cystic Pheochromocytomas with Benign or Malignant Histology
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Emine Yarman, Ozlem Soyluk Selcukbiricik, Nurdan Gul, Gulsah Yenidunya Yalin, Ayse Kubat Uzum, Umut Barbaros, and Gulcin Yegen
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Pathology ,medicine.medical_specialty ,Endocrinology ,Endocrine and Autonomic Systems ,business.industry ,Endocrinology, Diabetes and Metabolism ,medicine ,Histology ,business - Published
- 2015
22. Could the ENPP1 p.D85H mutation be associated with hypophosphatemic rickets?
- Author
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Ender COSKUNPINAR, Sakin TEKIN, Sukru PALANDUZ, Hakan AVCI, Kivanc CEFLE, Necip Ozan TIRYAKIOGLU, Sukru OZTURK, Ayse KUBAT UZUM, Refik TANAKOL, and Ilhan SATMAN
- Subjects
medicine.medical_specialty ,Hypophosphatemic Rickets ,Endocrinology ,business.industry ,Internal medicine ,Mutation (genetic algorithm) ,General Engineering ,Medicine ,business - Published
- 2017
23. HDL-C levels in newly diagnosed type 2 diabetes in Turkey
- Author
-
Ilhan Satman, Ayse Kubat Uzum, Ahmet Ekmekçi, Nevin Dinccag, Kubilay Karsidag, Gonca Tamer, Murat Mertoglu, and Meral Mert
- Subjects
congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Traditional medicine ,Turkish ,business.industry ,Endocrinology, Diabetes and Metabolism ,social sciences ,Newly diagnosed ,Type 2 diabetes ,medicine.disease ,eye diseases ,language.human_language ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,medicine ,language ,population characteristics ,Risk factor ,business ,geographic locations - Abstract
In this study, we aimed to investigate whether HDL-C levels of non-diabetic and type 2 diabetic Turks are as low as those of non-diabetic Turks reported in Turkish Heart Study (THS) and Turkish Adult Risk Factor Sudy (TEKHARF).
- Published
- 2014
24. Serum ghrelin and adiponectin levels are increased but serum leptin level is unchanged in low weight Chronic Obstructive Pulmonary Disease patients
- Author
-
Beyhan Omer, Munevver Mertsoylu Aydin, Esen Kiyan, Faruk Alagol, Yildiz Tutuncu, and Ayse Kubat Uzum
- Subjects
Leptin ,Male ,medicine.medical_specialty ,Interleukin-1beta ,Adipokine ,Body Mass Index ,Cachexia ,Pulmonary Disease, Chronic Obstructive ,Thinness ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Aged ,COPD ,Adiponectin ,Interleukin-6 ,Tumor Necrosis Factor-alpha ,business.industry ,Middle Aged ,medicine.disease ,Ghrelin ,Obstructive lung disease ,Respiratory Function Tests ,Endocrinology ,Case-Control Studies ,business ,Body mass index - Abstract
Weight loss and muscle wasting are common features reported in COPD patients and they are all related with systemic inflammation. In this study, the relationship between pulmonary functions and inflammatory and metabolic parameters in low weight COPD patients were investigated.Fifty male COPD patients were grouped according to the Global Initiative for Chronic Obstructive Lung Disease criteria. Group 1: Mild-moderate COPD patients (n=18; with a mean age of 66.4 ± 9.2 yrs; body mass index (BMI):19.7 ± 1.5 kg/m(2)), group 2: Severe-very severe COPD patients (n=32; with a mean age of 65.9 ± 10.0 yrs; BMI:19.3 ± 1.6 kg/m(2)), group 3: Control group composed of healthy nonsmoking males (n=17; with a mean age of 50.2 ± 8.4 yrs; BMI:21.85 ± 1.5 kg/m(2)). Anthropometric parameters, serum levels of adiponectin (ApN), ghrelin, leptin, hsCRP, IL-6, IL-1β, IL-8, TNF-α and pulmonary functions were compared.Adiponectin concentration was higher in group 1 (43.3 ± 28.6 ng/mL; p0.05) and group 2 (59.9 ± 31.8 ng/mL; p0.001) when compared with the control group (23.5 ± 13.6 ng/mL). Ghrelin concentrations were higher in COPD groups (1281.0 ± 1173.7 and 1840.0 ± 403.6 pg/mL; p0.05) compared to the control subjects (554.0 ± 281.9 pg/mL). When the groups were compared, no significant difference was found for leptin, IL-1β, TNF-α, and IL-8. Interleukin-6 and hsCRP levels were higher in group 1 than in the control group. ApN was negatively correlated with BMI and FEV1. In all groups, FEV1 showed positive correlation with BMI, skinfold thicknesses, insulin and triglyceride; negative correlation with age, pack/years, HDL-Chol and ApN. Increased SHBG with decreased insulin level and HOMA-IR may indicate increased insulin sensitivity in COPD groups.The anti-inflammatory effect of ApN and ghrelin is more evident in severe-very severe COPD patients.
- Published
- 2014
25. Pelvic ultrasound findings in prepubertal girls with precocious adrenarche born appropriate for gestational age
- Author
-
Rüveyde Bundak, Serdar Bozlak, Nurçin Saka, Nurdan Gul, İsmail Yildiz, Ahmet Uçar, Oğuz Bülent Erol, Ayse Kubat Uzum, Feyza Darendeliler, Sukran Poyrazoglu, Ensar Yekeler, and Firdevs Bas
- Subjects
medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Gestational Age ,Body Mass Index ,Pelvis ,Endocrinology ,Insulin resistance ,Internal medicine ,medicine ,Homeostasis ,Humans ,Insulin ,Adrenarche ,Longitudinal Studies ,Sexual Maturation ,Child ,Ultrasonography ,Gynecology ,Anthropometry ,business.industry ,Gestational age ,medicine.disease ,Polycystic ovary ,Cross-Sectional Studies ,Cohort ,Menarche ,Female ,Insulin Resistance ,business ,Body mass index ,Polycystic Ovary Syndrome - Abstract
Precocious adrenarche (PA) refers to the clinical onset of excess androgen in girls before the age of 8. It is associated with an increased risk of functional ovarian hyperandrogenism after puberty. PA may be associated with polycystic ovary syndrome (PCOS). We compared pelvic ultrasound (US) findings of girls with PA born appropriate for gestational age (AGA) to healthy body mass index (BMI)-matched peers to determine whether US findings in AGA-born PA girls are associated with PCOS antecedents.We conducted a cross-sectional study on 56 AGA-born girls with PA (6·9 ± 0·6 years) and 33 BMI-matched prepubertal AGA-born peers (7·1 ± 1·0 years). Hormonal data, homeostasis model assessment of insulin resistance (HOMA-IR), insulin sensitivity index (ISIcomp ) and pelvic US findings were compared. Associations of pelvic US findings with clinical and metabolic data were investigated.Precocious adrenarche girls had greater height and bone age-adjusted uterine length (UL; P = 0·01) and UL standard deviation score (SDS) (P = 0·02) than BMI-matched peers. Mean ovarian volume (MOV), MOV SDS, uterine volume, uterine cross-sectional area and ovarian morphology were similar between the groups (P0·05). MOV and MOV SDS correlated with ISIcomp (r = -0·683, P0·001; r = -0·760, P0·001; respectively). Correlations of pelvic US findings with other biochemical data did not reach significance (P0·05). Multivariate regression analysis revealed that in girls with PA, ISIcomp had the most significant effect on MOV SDS (R(2) = 0·731, β = -4·784, P = 0·001).Appropriate for gestational age-born PA girls have greater UL measurements than AGA-born BMI-matched peers. In AGA-born girls with PA, decreasing insulin sensitivity is strongly and independently associated with an increase in MOV. Longitudinal follow-up of our cohort after menarche will allow us to establish how many AGA-born girls with PA will ultimately develop PCOS.
- Published
- 2013
26. Cranium Metastasis: An Unusual Presentation of Differentiated Thyroid Carcinoma
- Author
-
Bülent Canbaz, Ferihan Aral, Nida Oztop, Sema Ciftci Dogansen, Abdurrahman Demir, and Ayse Kubat Uzum
- Subjects
Pathology ,medicine.medical_specialty ,lcsh:RC648-665 ,business.industry ,Endocrinology, Diabetes and Metabolism ,medicine.disease ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,Metastasis ,Thyroid carcinoma ,radioactive iodine treatment ,Differentiated thyroid carcinoma ,Internal Medicine ,Medicine ,Presentation (obstetrics) ,business ,bone metastasis - Abstract
Distant metastasis may be the initial sign of differentiated thyroid carcinoma in rare cases. In this instance, the treatment approach is usually individualized. Unlike most other cancers, local treatment of the primary tumor (total thyroidectomy) is preferred as ablative surgery; so that radioactive iodine therapy should be more effective. Repeated doses of I-131 and radiotherapy for metastatic lesions may be needed. We report a female who presented with bone metastasis with fatal progression. Turk Jem 2013; 17: 71-4
- Published
- 2013
27. Therapeutic apheresis for severe hypertriglyceridemia in pregnancy
- Author
-
Ferihan Aral, Sema Ciftci Dogansen, Bülent Canbaz, Rafet Basar, Nese Ozbey, Senem Altay-Dadin, Ayse Kubat Uzum, and Sevgi Kalayoglu-Besisik
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Gestational Age ,chemistry.chemical_compound ,Pregnancy ,Internal medicine ,Fatty Acids, Omega-3 ,medicine ,Humans ,Hypertriglyceridemia ,Triglyceride ,Cesarean Section ,Cholesterol ,business.industry ,Pregnancy Outcome ,Obstetrics and Gynecology ,Gestational age ,Plasmapheresis ,General Medicine ,medicine.disease ,Pregnancy Complications ,Endocrinology ,Pancreatitis ,chemistry ,Acute Disease ,Blood Component Removal ,Acute pancreatitis ,Female ,business ,Filtration - Abstract
During pregnancy, a progressive increase in serum triglyceride (TG) and cholesterol levels is observed whereas TG levels mostly remain300 mg/dl. In women with genetic forms of hypertriglyceridemia, pregnancy may cause extremely elevated TG levels leading to potentially life-threatening pancreatitis attacks and chylomicronemia syndrome. The only safe medical treatment option during pregnancy is ω-3 fatty acids, which have moderate TG lowering effects. Therapeutic apheresis could be used as primary treatment approach during pregnancy.We reported the effect of double filtration apheresis in one pregnant women with severe hypertriglyceridemia, therapeutic plasmapheresis and double filtration methods in the other severe hypertriglyceridemic pregnant woman; a 32-year-old pregnant woman (patient 1) with a history of hypertriglyceridemia-induced acute pancreatitis during pregnancy and a 30-year-old pregnant woman with extremely high TG levels (12,000 mg/dl) leading to chylomicronemia syndrome (patient 2). Medical nutrition therapy and ω-3 fatty acids were also provided. Double filtration apheresis (patient 1) and plasmapheresis + double filtration apheresis (patient 2) were used.When we calculated the TG levels before and after therapeutic apheresis, maximum decrease achieved with double filtration apheresis was 46.3 % for patient 1 and 37.3 % for patient 2. However, with plasmapheresis TG level declined by 72 % in patient 2. Plasmapheresis seemed to be more efficient to decrease TG levels. Iron deficiency anemia was the main complication apart from technical difficulties by lipemic obstruction of tubing system. Healthy babies were born. Delivery led to decreases in TG levels. It is concluded that during pregnancy therapeutic apheresis is an effective method to decrease extremely high TG levels and risks of its potentially life-threatening complications.
- Published
- 2013
28. Effects of Ramadan Fasting on Daily Life and Metabolic Condition in Patients with Type 2 Diabetes
- Author
-
Rukiye Pinar, Serpil Salman, S. Celik, Ayse Kubat Uzum, Çelik, S., Pinar, R., Kubat Üzüm, A., Salman, S., and Yeditepe Üniversitesi
- Subjects
Pediatrics ,medicine.medical_specialty ,Evening ,medicine.diagnostic_test ,business.industry ,Fasting ,General Medicine ,Type 2 diabetes ,Hypoglycemia ,medicine.disease ,Physical activity level ,chemistry.chemical_compound ,Diabetes mellitus ,Metabolism ,Fructosamine ,chemistry ,Metabolic control analysis ,Medicine ,business ,Lipid profile ,Type 2 ,Morning - Abstract
Objective: The objective of this study was to assess the effects of Ramadan fasting on daily life routines and metabolic conditions in diabetic patients. Material and Methods: The study sample consisted of 26 patients with Type 2 diabetes who fasted during Ramadan. Data on changes daily life routine and metabolic variables were gathered before and after Ramadan, within a 10 days period. Results: Almost all patients fasted during Ramadan although they had known that fasting had some negative effects on their health, and Islamic rules allow sick people not to fast. Most of the patients declared that they rearranged morning and evening medications according to fasting hours and skipped doses between dawn and sunset, changed diet routine and eating habits including food preference. In addition, some of them changed their sleep schedule and decreased daily physical activity level because of lack of energy caused by fasting. More than half of the patients experienced at least one episode of hypoglycemia during fasting period; all hypoglycemia experiences were mild episodes. However, there was no emergency admission due to fasting-related health problems. We found neither negative nor positive effects of Ramadan on metabolic control variables including weight, HbA1c, fructosamine, C-peptide, insulin, and lipid profile. Conclusion: Ramadan fasting has no negative effects on metabolic parameters in patients with Type 2 diabetes. © 2013 by Türkiye Klinikleri.
- Published
- 2013
29. Clinical features of thyrotropin secreting pituitary adenomas
- Author
-
Hulya Dogru, Ferihan Aral, Ayse Kubat Uzum, Nurdan Gul, Refik Tanakol, and Ozlem Soyluk Selcukbiricik
- Published
- 2016
30. How changed face of gestational diabetes mellitus within 12 years in Turkey
- Author
-
Sevda Ozel, Fulya Turker, Hulya Hacisahinoglu, Seher Tanrikulu, Nevin Dinccag, Cemile Idiz, Ayse Kubat Uzum, Selda Gedik, Sakin Tekin, and Nurdan Gul
- Subjects
Gestational diabetes ,Pediatrics ,medicine.medical_specialty ,business.industry ,medicine ,Face (sociological concept) ,medicine.disease ,business - Published
- 2016
31. Prevalence of pituitary adenomas in macroprolactinemic patients may be higher than it is presumed
- Author
-
Faruk Alagol, Meral Mert, Gonca Tamer, Ferihan Aral, Aysegul Telci, Nese Colak, Ayse Kubat Uzum, Refik Tanakol, Sema Yarman, and Harika Boztepe
- Subjects
Pituitary gland ,education.field_of_study ,medicine.medical_specialty ,Galactorrhea ,Adenoma ,business.industry ,Endocrinology, Diabetes and Metabolism ,Population ,Pituitary neoplasm ,Macroprolactin ,medicine.disease ,Gastroenterology ,Endocrinology ,medicine.anatomical_structure ,Pituitary adenoma ,Internal medicine ,medicine ,medicine.symptom ,education ,business ,Prolactinoma - Abstract
One form of prolactin (PRL) is macroprolactin with high molecular mass. Many macroprolactinemic patients have no pituitary adenomas and no clinical symptoms of hyperprolactinemia, it is controversial whether macroprolactinemia is a benign condition that does not need further investigation and treatment. In this study, we aimed to compare macroprolactinemic patients (group I) with the true hyperprolactinemic patients (group II) for the presence of pituitary adenoma. We investigated 161 patients with hyperprolactinemia, whose magnetic resonance imaging records of the pituitary were taken. All patients were questioned for irregular menses, infertility and examined for galactorrhea. Patients were screened for macroprolactinemia by polyethylene glycol precipitation, and a recovery of ≤40% and normal monomeric PRL level was taken as an indication of significant macroprolactinemia. Of 161 patients with hyperprolactinemia, 60 (37.26%) had macroprolactinemia. PRL levels of group II were lower than those of group I (P = 0.011), although monomeric PRL levels of group II were higher than those of group I (P = 0.0005). Of 60 macroprolactinemic patients, 16 (26.7%) had pituitary adenomas. The prevalence of pituitary adenomas was lower in group I, compared with group II (P = 0.0005). No significant differences were found between the prevalences of irregular menses and infertility of group I and II (P = 0.084, P = 0.361). Prevalence of galactorrhea in group I was lower than that in group II (P = 0.048). Prevalence of pituitary adenomas in macroprolactinemic patients is lower compared with the true hyperprolactinemic patients, but may be higher than that found in other recent studies and in the general population.
- Published
- 2011
32. Serum adipokines and low density lipoprotein subfraction profile in hypopituitary patients with growth hormone deficiency
- Author
-
Ayse Kubat Uzum, Nese Ozbey, Faruk Alagol, Aysegul Telci, and Serpil Salman
- Subjects
Adult ,Male ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Adipokine ,Hypopituitarism ,Growth hormone deficiency ,chemistry.chemical_compound ,Endocrinology ,Insulin resistance ,Adipokines ,Internal medicine ,medicine ,Homeostasis ,Humans ,Triglycerides ,Aged ,Triglyceride ,Adiponectin ,medicine.diagnostic_test ,Waist-Hip Ratio ,business.industry ,Leptin ,Cholesterol, LDL ,Middle Aged ,medicine.disease ,Lipoproteins, LDL ,chemistry ,Growth Hormone ,Female ,Resistin ,Insulin Resistance ,business ,Lipid profile - Abstract
The aim was to evaluate the concentrations of lipid subfractions in relation to adipokines and metabolic parameters in adult growth hormone (GH)-deficient hypopituitary patients on conventional replacement therapy. The study included 21 GH deficient-hypopituitary patients (age: 36.0 ± 15.1 years, male/female: 7/14) on conventional replacement therapy other than GH and 20 comparable controls (age: 37.3 ± 14.0 years, male/female: 6/14). Lipid subfractions (Lipoprint system), serum adipokine (leptin, adiponectin, resistin) concentrations, body composition, a surrogate marker for insulin resistance (HOMA) and conventional lipid profile were evaluated. No statistically significant difference was found with respect to HOMA, adipokine concentrations and anthropometric parameters between patients and controls except for significantly increased waist-to-hip ratio in hypopituitary group. Total and LDL cholesterol concentrations were significantly higher in the patients. LDL particle size (268.88 ± 3.16 vs. 271.31 ± 3.11 A, P = 0.151) and small-dense LDL subfraction did not differ significantly. According to logistic regression analysis, triglyceride concentrations ≥1.69 mmol/L was the sole parameter significantly and independently predicted small (
- Published
- 2011
33. Evaluation of the effect of l-thyroxin therapy on endothelial functions in patients with subclinical hypothyroidism
- Author
-
Fatma Alibaz Öner, Mecdi Ergüney, Ayse Kubat Uzum, Ender Oner, and Selen Yurdakul
- Subjects
Adult ,Male ,endocrine system ,medicine.medical_specialty ,Brachial Artery ,Turkey ,Endothelium ,Hormone Replacement Therapy ,Vasodilator Agents ,Endocrinology, Diabetes and Metabolism ,Vasodilation ,Severity of Illness Index ,Nitroglycerin ,Young Adult ,Endocrinology ,Hypothyroidism ,Risk Factors ,medicine.artery ,Internal medicine ,Diabetes mellitus ,medicine ,Hormone replacement therapy (male-to-female) ,Humans ,Longitudinal Studies ,Endothelial dysfunction ,Brachial artery ,Subclinical infection ,business.industry ,Ultrasonography, Doppler ,Middle Aged ,Atherosclerosis ,medicine.disease ,Thyroxine ,medicine.anatomical_structure ,Regional Blood Flow ,Female ,Endothelium, Vascular ,business ,Blood Flow Velocity ,Hormone - Abstract
Subclinical hypothyroidism (SH) is characterized by normal serum free T4 (FT4), free T3 (FT3) levels and increased serum thyroid-stimulating hormone (TSH) levels. Endothelial dysfunction, which is an early step of atherosclerosis, has been reported in patients with subclinical hypothyroidism. The aim of this study is to evaluate endothelial functions and the effect of L-thyroxin (L-T4) therapy on endothelial functions in SH. Twenty-seven patients with SH and 22 healthy controls were evaluated in terms of endothelial functions, using brachial artery Doppler ultrasonography. After restorating euthyroidism, measurements were repeated. Baseline and nitroglycerin induced diameter (NID) of brachial artery were similar in patients with SH and the control group. Compared to the control group, the patients with SH showed significantly reduced flow-mediated diameter (FMD). Baseline and NID values were significantly higher after LT4 therapy in SH group. FMD also significantly increased after LT4 therapy. Hypothyroidism accelerates atherogenesis through modification of atherosclerotic risk factors and direct effects on the blood vessels. In this study, we observed marked improvement in endothelial functions after L-T4 therapy in SH patients. We suggest that thyroid hormone replacement therapy may help to prevent atherosclerosis in this group of patients.
- Published
- 2011
34. Evaluation of the eff ect of L-thyroxin therapy on cardiac functions by using novel tissue Doppler-derived indices in patients with subclinical hypothyroidism
- Author
-
Selen Yurdakul, Fatma Alibaz Öner, Ayse Kubat Uzum, Ender Oner, and Mecdi Ergüney
- Subjects
Adult ,Male ,medicine.medical_specialty ,Heart Ventricles ,Diastole ,Doppler echocardiography ,Doppler imaging ,Ventricular Function, Left ,Young Adult ,symbols.namesake ,Hypothyroidism ,Internal medicine ,Humans ,Ventricular Function ,Medicine ,In patient ,Prospective Studies ,Prospective cohort study ,Isovolumetric contraction ,Subclinical infection ,medicine.diagnostic_test ,business.industry ,General Medicine ,Echocardiography, Doppler ,Thyroxine ,Ventricular Function, Right ,symbols ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Doppler effect - Abstract
Subclinical hypothyroidism (SH) is characterized by normal serum free T4 (fT4), free T3 (fT3) levels and increased serum thyroid stimulating hormone (TSH) levels.The aim of this study was to assess the validity of tissue Doppler imaging (TDI) in evaluating cardiac effects of SH and to demonstrate the improving effects of L-thyroxin(L-T4) on TDI parameters.Twenty-seven patients with SH and 22 healthy controls were evaluated by standard echocardiography and TDI. TDI-derived systolic velocities [isovolumic myocardial acceleration (IVA), peak myocardial velocity during isovolumic contraction (IW), peak systolic velocity during ejection period (Sa)] and diastolic indices (peak early (Ea) and late diastolic (Aa) velocities, Ea/Aa, E/Ea ratios and Tei index) were measured. After restoring euthyroidism, all measurements were repeated.At baseline, left ventricular (LV) systolic velocities (IW and IVA) and diastolic indices were significantly impaired in the SH group. After L-T4 therapy, left ventricular systolic and diastolic functions were improved. Right ventricular (RV) systolic velocities were similar between the study group and the healthy controls but diastolic functions were impaired in the SH group, at baseline. Tei index of the RV was improved after L-T4 therapy. RV IVA remained unchanged after hormone replacement therapy.SH is associated with biventricular systolic and diastolic dysfunction. IVA which is an accurate estimate of subclinical systolic dysfunction, was significantly impaired in the left ventricle and had improved after L-T4 therapy. We found that IVA is able to detect early effects of subclinical hypothyroidism on LV systolic functions and L-T4 therapy can improve ventricular functions.
- Published
- 2011
35. Meningeal Irritation Signs in Patients With Acromegaly
- Author
-
Sema Yarman and Ayse Kubat Uzum
- Subjects
medicine.medical_specialty ,business.industry ,Infectious Meningitis ,Pituitary apoplexy ,medicine.disease ,Meningeal irritation ,Dermatology ,medicine.anatomical_structure ,Endocrinology ,Internal medicine ,Acromegaly ,medicine ,Surgery ,In patient ,Neurology (clinical) ,Subarachnoid space ,business - Abstract
Pituitary apoplexy may cause meningeal irritation signs because of blood and necrotic cells passed to subarachnoid space. Meningeal irritation signs, clinically indistinguishable from infectious meningitis, are considered rare and reviewed as presenting signs in a few cases of acromegaly. We reporte
- Published
- 2009
36. RET/PTC Oncogene Expression in Papillary Thyroid Carcinoma and Its Correlation With Clinicopathologic Findings
- Author
-
Nese Ozbey, Dilek Arpaci, Ayse Kubat Uzum, and Yersu Kapran
- Subjects
Thyroid carcinoma ,business.industry ,Endocrinology, Diabetes and Metabolism ,PTC Oncogene ,Cancer research ,Medicine ,business - Published
- 2008
37. Transient gestational diabetes insipidus diagnosed in successive pregnancies: review of pathophysiology, diagnosis, treatment, and management of delivery
- Author
-
Alkan Yildirim, Ayse Kubat Uzum, Recep Has, Tülay Özkan, Ibrahim Kalelioglu, and Funda Gungor
- Subjects
Adult ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,urologic and male genital diseases ,Preeclampsia ,Acute fatty liver of pregnancy ,Endocrinology ,Polyuria ,Pregnancy ,medicine ,Humans ,Deamino Arginine Vasopressin ,Cesarean Section, Repeat ,Desmopressin ,Fetus ,business.industry ,Obstetrics ,medicine.disease ,Magnetic Resonance Imaging ,female genital diseases and pregnancy complications ,Diabetes, Gestational ,Diabetes insipidus ,Etiology ,Female ,medicine.symptom ,business ,Diabetes Insipidus ,hormones, hormone substitutes, and hormone antagonists ,medicine.drug - Abstract
Gestational diabetes insipidus (GDI) is a rare disorder characterised by polyuria, polydypsia, and excessive thirst usually manifesting in the third trimester of pregnancy. The etiology is thought to depend on excessive vasopressinase activity, a placental enzyme that degrades arginine-vasopressin (AVP), but not 1-deamino-8-D: -arginine vasopressin (dDAVP), which is a synthetic form. This is a transient syndrome and may be associated with acute fatty liver of pregnancy and preeclampsia. The use of dDAVP in symptomatic cases has been proven as a safe method for both the mother and the fetus during the pregnancy. We report a case of recurrent gestational diabetes insipidus in successive pregnancies, which responded to dDAVP and subsided after delivery.
- Published
- 2007
38. Crossed renal ectopia with fusion: Report of two patients
- Author
-
Neslihan Boyan, Huseyin Kubat, Ayse Kubat Uzum, and Çukurova Üniversitesi
- Subjects
Adult ,Male ,Embryology ,medicine.medical_specialty ,Histology ,Urinary system ,government.form_of_government ,Autopsy ,Kidney ,urologic and male genital diseases ,Asymptomatic ,Urinary system anomalies ,Ureter ,medicine ,Humans ,Crossed renal ectopia ,Renal ectopia ,Crossed fused renal ectopia ,business.industry ,General Medicine ,Perioperative ,medicine.disease ,Abdominal Pain ,Nephroptosis ,Surgery ,Radiography ,medicine.anatomical_structure ,Urogenital Abnormalities ,government ,Anatomy ,medicine.symptom ,business - Abstract
Crossed renal ectopia is one of the rarest urinary system anomalies. It is more often seen at autopsy than in clinical practice. Most cases of renal ectopia remain asymptomatic during life and are diagnosed incidentally. Renal ultrasonography, intravenous pyelography, computerized tomography, and renal scintigraphy (technetium-based tests) are the imaging methods used for diagnosis. Demonstration of crossed renal ectopia is important because it is a predisposing factor for obstruction, infection, and neoplasia of the urinary system. We report two male patients who had unremarkable clinical findings. Both had left-to-right inferior crossed renal ectopia with fusion. Additionally, the first patient had a history of surgery for a recurrent inguinal hernia, whereas the second had crossed fused renal ectopia associated with nephroptosis. Surgeons should be aware of ectopic and fused kidneys to minimize perioperative complications because of the uncertain anatomy. Clin. Anat. 20:699–702, 2007. © 2007 Wiley-Liss, Inc.
- Published
- 2007
39. Management of urgent surgical intervention due to coexistence of phaeochromocytoma and hydrocephalus in a patient presenting with Von Hippel Lindau syndrome
- Author
-
Gulsah Yenidunya Yalin, Mehmet Barbur, Gulcin Yegen, Ayse Kubat Uzum, Refik Tanakol, Ferihan Aral, and Seher Tanrikulu
- Subjects
Pediatrics ,medicine.medical_specialty ,business.industry ,Intervention (counseling) ,medicine ,business ,medicine.disease ,Von Hippel-Lindau syndrome ,Hydrocephalus ,Surgery - Published
- 2015
40. Glycaemic variability in pregnant women with gestational diabetes
- Author
-
Ilhan Satman, Yildiz Tutuncu, Selda Celik, Nida Oztop, Cemile Idiz, Ayse Kubat Uzum, Nevin Dinccag, and Elif Bagdemir
- Subjects
Gestational diabetes ,medicine.medical_specialty ,business.industry ,Obstetrics ,medicine ,medicine.disease ,business - Published
- 2015
41. Fatigue as the presenting symptom of multiple endocrine neoplasia of type 2A
- Author
-
Ferihan Aral, Gulsah Yenidunya-Yalin, Refik Tanakol, Ayse Kubat-Uzum, and Nurdan Gul
- Subjects
Oncology ,medicine.medical_specialty ,business.industry ,Internal medicine ,Medicine ,business ,Multiple endocrine neoplasia ,medicine.disease - Published
- 2015
42. Risks of having gestational diabetes in the future for mothers and their offspring
- Author
-
Sevda Ozel Yildiz, Bülent Canbaz, Selda Gedik, Firdevs Bas, Cemile Idiz, Nevin Dinccag, Sabin Goktas Aydin, Ayse Kubat Uzum, Rüveyde Bundak, and Banu Kucukemre Aydin
- Subjects
Gestational diabetes ,medicine.medical_specialty ,business.industry ,Obstetrics ,Offspring ,medicine ,medicine.disease ,business - Published
- 2015
43. Oncogenic osteomalacia misdiagnosed as ankylosing spondylitis
- Author
-
Samet Vasfi Kuvat, Burak Ince, Nurdan Gul, Refik Tanakol, Ayse Kubat Uzum, Seher Tanrikulu, and Ferihan Aral
- Subjects
medicine.medical_specialty ,Ankylosing spondylitis ,business.industry ,medicine ,medicine.disease ,business ,Dermatology ,Oncogenic osteomalacia - Published
- 2015
44. Comparison of ⁶⁸Ga-DOTATATE PET-CT, ¹⁸F-FDG PET-CT and 99mTc-(V)DMSA scintigraphy in the detection of recurrent or metastatic medullary thyroid carcinoma
- Author
-
Zeynep G, Ozkan, Serkan, Kuyumcu, Ayse Kubat, Uzum, Mehmet F, Gecer, Sevda, Ozel, Ferihan, Aral, and Isik, Adalet
- Subjects
Adult ,Male ,Neoplasm, Residual ,Middle Aged ,Multimodal Imaging ,Carcinoma, Neuroendocrine ,Young Adult ,Fluorodeoxyglucose F18 ,Positron-Emission Tomography ,Technetium Tc 99m Dimercaptosuccinic Acid ,Biomarkers, Tumor ,Organometallic Compounds ,Humans ,Female ,Whole Body Imaging ,Thyroid Neoplasms ,Neoplasm Metastasis ,Tomography, X-Ray Computed ,Aged ,Retrospective Studies - Abstract
We aimed to compare the efficacies of gallium-68 (68Ga) DOTATATE PET-computed tomography (CT), fluorine-18 fluorodeoxyglucose (18F-FDG) PET-CT and technetium-99m (99mTc)-(V)DMSA scintigraphy in the detection of residual/metastatic medullary thyroid carcinoma (MTC).We retrospectively evaluated DOTATATE PET-CT, 18F-FDG PET-CT and (V)DMSA scintigraphy of 22 MTC patients, all taken within a 6-month period in each patient, because of high levels of calcitonin (Ct) and carcinoembryonic antigen (CEA). We investigated the relationships between the results of the imaging modalities and tumour marker levels and the sporadic versus hereditary nature of the disease, as well as the effect of imaging results on patient management.The ages of the patients at diagnosis were between 20 and 69 years. The median levels of Ct and CEA were 871.5 pg/ml and 11.2 ng/ml, respectively. In the patient-based analysis, we observed at least one focus of abnormal uptake in 15 of 22 DOTATATE PET-CT (68.2% sensitivity), eight of 18 18F-FDG PET-CT (44.4% sensitivity) and five of 15 (V)DMSA scans (33.3% sensitivity). These data showed a significant difference between DOTATATE PET-CT and (V)DMSA scintigraphy (P=0.016), whereas the relationships between DOTATATE PET-CT and 18F-FDG PET-CT and between 18F-FDG PET-CT and (V)DMSA scintigraphy showed no significant differences (P0.05). In the lesion-based analysis, 134 lesions were detected with DOTATATE PET-CT, 76 lesions with 18F-FDG PET-CT and nine lesions with (V)DMSA scintigraphy.DOTATATE PET-CT is an efficient imaging modality in MTC patients with increased Ct and CEA (especially1000 pg/ml and 50 ng/ml, respectively) for localizing recurrent or metastatic disease. 18F-FDG PET-CT can be performed if DOTATATE PET-CT is not available, but (V)DMSA scintigraphy is not recommended.
- Published
- 2014
45. Management and follow-up results of an incidental thyroid carcinoma in a young woman with ovarian teratoma
- Author
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Nihat Aksakal, Nese Colak Ozbey, Ayse Kubat Uzum, Ferihan Aral, Cem Iyibozkurt, Sema Dogansen Ciftci, Yersu Kapran, and Bülent Canbaz
- Subjects
Adult ,endocrine system ,Pathology ,medicine.medical_specialty ,endocrine system diseases ,Ovariectomy ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Levothyroxine ,Thyroid carcinoma ,Endocrinology ,Carcinoma ,Humans ,Medicine ,Thyroid Neoplasms ,Radical surgery ,Thyroid cancer ,Ovarian Neoplasms ,Incidental Findings ,business.industry ,Thyroid ,Teratoma ,Thyroidectomy ,Fertility Preservation ,Obstetrics and Gynecology ,medicine.disease ,Carcinoma, Papillary ,medicine.anatomical_structure ,Female ,Radiology ,business ,Follow-Up Studies ,medicine.drug - Abstract
Thyroid cancer in ovarian teratoma is reported to be rare and experiences are limited. A 26-year-old woman had undergone bilateral cystectomy and omentectomy for bilateral cystic adnexial masses. Pathological examination showed 1.5 cm follicular variant papillary thyroid carcinoma on the basis of unilateral mature cystic teratoma. Increased CA-125 and CA19-9 levels decreased to normal reference ranges after surgery, but postoperative magnetic resonance imaging indicated multiple abdominal cystic loci. After total thyroidectomy, high dose I-131 was administered to ablate thyroid tissue. Thereafter, levothyroxine was started to achieve subclinical hyperthyroidism. No iodine uptake was detected in post-therapeutic whole body scan (WBS) other than thyroid bed. This finding supported that tumor did not show dissemination to abdomen. No uptake on the first-year evaluation with low-dose I-131 WBS suggested the complete ablation of the thyroid gland. It is recommended that thyroid carcinoma arising from ectopic thyroid tissue in a teratoma should be managed as thyroid carcinoma in thyroid. However, direct dissemination to contiguous regions in abdomen and hematogenous dissemination to distant organs should be in mind. Radical surgery including total abdominal hysterectomy, bilateral salphingo-oopherectomy, pelvic and paraaortic lymph node excision and thyroidectomy is recommended. Fertility preserving surgery may be the surgical procedure as in the present case.
- Published
- 2013
46. Radiation Dose to Hippocampus With Increasing Planning Target Volume in Patients With Pituitary Adenoma Treated With Hypofractionated Radiation Therapy
- Author
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E. Hatipoglu, Aysel Ahmedova, Musa Altun, Rasim Meral, Gonul Kemikler, Murat Okutan, N. Gurdal, Altay Sencer, Ayse Kubat Uzum, and Dilek Sahin
- Subjects
Cancer Research ,medicine.medical_specialty ,Radiation ,Hypofractionated Radiation Therapy ,business.industry ,Radiation dose ,Planning target volume ,Hippocampus ,medicine.disease ,Oncology ,Pituitary adenoma ,medicine ,Radiology, Nuclear Medicine and imaging ,In patient ,Radiology ,Nuclear medicine ,business - Published
- 2015
47. Pituitary Apoplexy
- Author
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Nese Ozbey, Altay Sencer, Ferihan Aral, Burcu Göker, Faruk Kutluturk, Ayse Kubat Uzum, and Meral Mert
- Subjects
medicine.medical_specialty ,business.industry ,Acromegaly ,medicine ,Pituitary apoplexy ,Surgery ,Neurology (clinical) ,medicine.disease ,business - Published
- 2006
48. Presence of Paget's disease in a patient with endometrium carcinoma
- Author
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Bülent Canbaz, Nese Ozbey, Sema Ciftci Dogansen, Nurdan Gul, Bilge Bilgic, Gulsah Yenidunya Yalin, and Ayse Kubat Uzum
- Subjects
Paget s disease ,Oncology ,medicine.medical_specialty ,medicine.anatomical_structure ,business.industry ,Internal medicine ,medicine ,Carcinoma ,Endometrium ,business ,medicine.disease - Published
- 2013
49. Unchanged serum adipokine concentrations in the setting of short-term thyroidectomy-induced hypothyroidism
- Author
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Ayse Kubat Uzum, Ozlem Kaplan, Nese Ozbey, Gungor Uzum, Kezban Nur Planci, Hale Aral, Vahit Tunali, Ozgu Kesmezacar, and Ozlem Demir
- Subjects
Adult ,Leptin ,endocrine system ,medicine.medical_specialty ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Adipokine ,Body Mass Index ,Endocrinology ,Adipokines ,Hypothyroidism ,Internal medicine ,medicine ,Humans ,Euthyroid ,Resistin ,medicine.diagnostic_test ,Adiponectin ,business.industry ,Body Weight ,Thyroidectomy ,nutritional and metabolic diseases ,General Medicine ,Middle Aged ,Lipids ,Female ,business ,Lipid profile ,Body mass index ,hormones, hormone substitutes, and hormone antagonists ,Follow-Up Studies ,Goiter, Nodular - Abstract
To investigate short-term effects of thyroidectomy-induced hypothyroidism on leptin, adiponectin, and resistin concentrations in association with anthropometric data.Thirty premenopausal women with euthyroid nodular goiter-mean age, 44.0 ± 11.6 years; mean body mass index (BMI), 28.6 ± 5.9 kg/m2; 13 obese, 7 overweight, and 10 normal weight subjects-scheduled for total thyroidectomy were included in the study. Serum leptin, adiponectin, resistin, free triiodothyronine, free thyroxine, thyroid-stimulating hormone, glucose, insulin, and C-reactive protein concentrations, lipid profile, and anthropometric variables were determined in the euthyroid state (preoperatively) and the hypothyroid state (postoperatively, with a thyroid-stimulating hormone concentration30 mIU/L).Body weight, BMI, waist and hip circumferences, body fat mass, and serum lipid concentrations increased significantly after thyroidectomy. No significant difference was found between preoperative and postoperative serum leptin, adiponectin, and resistin concentrations. Fat tissue mass-corrected leptin, adiponectin, and resistin concentrations did not differ significantly between euthyroid and hypothyroid periods. Thyroid hormone concentrations showed no significant correlations with adipokine levels.Serum adipokine concentrations seem not to change significantly during short-term thyroidectomy-induced hypothyroidism despite significant increases in body weight, BMI, fat mass, and lipid concentrations.
- Published
- 2012
50. Overt and mild subclinical hypothyroidism do not influence mean platelet volume in premenopausal women having low cardiac risk
- Author
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Ayse Nur Torun, Ayse Kubat Uzum, and Nurten Aksoy
- Subjects
Adult ,Blood Platelets ,medicine.medical_specialty ,endocrine system diseases ,Adolescent ,Heart Diseases ,chemistry.chemical_compound ,Hypothyroidism ,Risk Factors ,Internal medicine ,medicine ,Humans ,Euthyroid ,In patient ,Mean platelet volume ,Patient group ,Cardiac risk ,Subclinical infection ,Cholesterol ,business.industry ,Hematology ,General Medicine ,Cholesterol, LDL ,Endocrinology ,C-Reactive Protein ,chemistry ,Premenopause ,Female ,business ,Hormone - Abstract
Mean platelet volume (MPV) was studied in subclinical hypothyroidism (SH) and the results are conflicting. The aim of this study is to assess how MPV is affected in overt hypothyroidism (OH) and mild SH, the 2 end points of hypothyroidism, in patients having low cardiac risk. Premenopausal women without any cardiac risk, 18 with OH, 30 with mild SH, and 37 euthyroid controls were enrolled. Overt hypothyroidism group had higher low-density lipoprotein cholesterol (LDL-C) and total cholesterol levels than the control group ( P < .001 and P < .05, respectively). Increase in MPV was insignificant in OH group when compared with SH and control groups. No correlation was observed between MPV and metabolic and hormonal parameters. Both OH and SH did not influence MPV and high-sensitivity C-reactive protein (hs-CRP) in patients with low cardiovascular risk, but these findings need to be further evaluated in this patient group.
- Published
- 2011
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