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A SOD2 Polymorphism is Associated with Abnormal Quantitative Sensory Testing in Type 2 Diabetic Patients
- Publication Year :
- 2018
-
Abstract
- Introduction Diabetes mellitus (DM) affects peripheral nerves inducing diabetic polyneuropathy (DPN). Mitochondrial dysfunction and oxidative stress are potential causes of DPN. Methods Nerve conduction studies were performed in 20 type 2 DM patients (11 with DPN) and 15 healthy controls. Perception threshold values of cold, warm and vibration were measured by quantitative sensory testing. Variants of a superoxide dismutase 2 (SOD2) gene single nucleotide polymorphism (SNP) (rs5746136) were determined by polymerase chain reaction (PCR) and following NexteraXT DNA Library. Results DPN patients showed significantly increased threshold values. DM patients without DPN and healthy controls showed comparable values. TT variant of the SOD2 SNP was more prevalent in DM and DPN patients. DM patients with the TT variant displayed increased perception threshold values. Conclusions Quantitative sensory testing is not superior to standard nerve conduction studies in DPN. Carriers of SOD2 SNP manifested increased sensory threshold levels which is important in further corroborating the link between oxidative stress and DPN.
- Subjects :
- medicine.medical_specialty
biology
business.industry
General Neuroscience
SOD2
030209 endocrinology & metabolism
Single-nucleotide polymorphism
030204 cardiovascular system & hematology
medicine.disease
medicine.disease_cause
Superoxide dismutase
03 medical and health sciences
Psychiatry and Mental health
0302 clinical medicine
Endocrinology
Polymorphism (computer science)
Internal medicine
Sensory threshold
Diabetes mellitus
biology.protein
SNP
Medicine
business
Oxidative stress
Research Article
Subjects
Details
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....ca2cdcc481e9e9b6595f9fd506d1ae5b