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Transient gestational diabetes insipidus diagnosed in successive pregnancies: review of pathophysiology, diagnosis, treatment, and management of delivery
- Source :
- Pituitary. 10:87-93
- Publication Year :
- 2007
- Publisher :
- Springer Science and Business Media LLC, 2007.
-
Abstract
- Gestational diabetes insipidus (GDI) is a rare disorder characterised by polyuria, polydypsia, and excessive thirst usually manifesting in the third trimester of pregnancy. The etiology is thought to depend on excessive vasopressinase activity, a placental enzyme that degrades arginine-vasopressin (AVP), but not 1-deamino-8-D: -arginine vasopressin (dDAVP), which is a synthetic form. This is a transient syndrome and may be associated with acute fatty liver of pregnancy and preeclampsia. The use of dDAVP in symptomatic cases has been proven as a safe method for both the mother and the fetus during the pregnancy. We report a case of recurrent gestational diabetes insipidus in successive pregnancies, which responded to dDAVP and subsided after delivery.
- Subjects :
- Adult
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
urologic and male genital diseases
Preeclampsia
Acute fatty liver of pregnancy
Endocrinology
Polyuria
Pregnancy
medicine
Humans
Deamino Arginine Vasopressin
Cesarean Section, Repeat
Desmopressin
Fetus
business.industry
Obstetrics
medicine.disease
Magnetic Resonance Imaging
female genital diseases and pregnancy complications
Diabetes, Gestational
Diabetes insipidus
Etiology
Female
medicine.symptom
business
Diabetes Insipidus
hormones, hormone substitutes, and hormone antagonists
medicine.drug
Subjects
Details
- ISSN :
- 15737403 and 1386341X
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Pituitary
- Accession number :
- edsair.doi.dedup.....01c9b418b6244ea57db4c8a37c4a2b17