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Serum ghrelin and adiponectin levels are increased but serum leptin level is unchanged in low weight Chronic Obstructive Pulmonary Disease patients
- Source :
- European Journal of Internal Medicine. 25:364-369
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Weight loss and muscle wasting are common features reported in COPD patients and they are all related with systemic inflammation. In this study, the relationship between pulmonary functions and inflammatory and metabolic parameters in low weight COPD patients were investigated.Fifty male COPD patients were grouped according to the Global Initiative for Chronic Obstructive Lung Disease criteria. Group 1: Mild-moderate COPD patients (n=18; with a mean age of 66.4 ± 9.2 yrs; body mass index (BMI):19.7 ± 1.5 kg/m(2)), group 2: Severe-very severe COPD patients (n=32; with a mean age of 65.9 ± 10.0 yrs; BMI:19.3 ± 1.6 kg/m(2)), group 3: Control group composed of healthy nonsmoking males (n=17; with a mean age of 50.2 ± 8.4 yrs; BMI:21.85 ± 1.5 kg/m(2)). Anthropometric parameters, serum levels of adiponectin (ApN), ghrelin, leptin, hsCRP, IL-6, IL-1β, IL-8, TNF-α and pulmonary functions were compared.Adiponectin concentration was higher in group 1 (43.3 ± 28.6 ng/mL; p0.05) and group 2 (59.9 ± 31.8 ng/mL; p0.001) when compared with the control group (23.5 ± 13.6 ng/mL). Ghrelin concentrations were higher in COPD groups (1281.0 ± 1173.7 and 1840.0 ± 403.6 pg/mL; p0.05) compared to the control subjects (554.0 ± 281.9 pg/mL). When the groups were compared, no significant difference was found for leptin, IL-1β, TNF-α, and IL-8. Interleukin-6 and hsCRP levels were higher in group 1 than in the control group. ApN was negatively correlated with BMI and FEV1. In all groups, FEV1 showed positive correlation with BMI, skinfold thicknesses, insulin and triglyceride; negative correlation with age, pack/years, HDL-Chol and ApN. Increased SHBG with decreased insulin level and HOMA-IR may indicate increased insulin sensitivity in COPD groups.The anti-inflammatory effect of ApN and ghrelin is more evident in severe-very severe COPD patients.
- Subjects :
- Leptin
Male
medicine.medical_specialty
Interleukin-1beta
Adipokine
Body Mass Index
Cachexia
Pulmonary Disease, Chronic Obstructive
Thinness
Internal medicine
Internal Medicine
medicine
Humans
Aged
COPD
Adiponectin
Interleukin-6
Tumor Necrosis Factor-alpha
business.industry
Middle Aged
medicine.disease
Ghrelin
Obstructive lung disease
Respiratory Function Tests
Endocrinology
Case-Control Studies
business
Body mass index
Subjects
Details
- ISSN :
- 09536205
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- European Journal of Internal Medicine
- Accession number :
- edsair.doi.dedup.....1b8b1385b8dd5909d280f458ab63f95d