37 results on '"Phase dynamics"'
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2. TWO-PHASE DYNAMICS OF BONE MARROW MULTIPOTENT MESENCHYMAL STROMAL CELLS (MMSC) ACTION ON LIVER AT MODELING OF FIBROTIC HEPATITIS
- Author
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N. A. Onishchenko, A. V. Lyundup, I. M. Gazizov, R. V. Deev, M. Y. Shagidulin, М. Е. Krasheninnikov, and P. V. Avramov
- Subjects
chronic fibrotic hepatitis ,bone marrow cells ,cell therapy. ,Surgery ,RD1-811 - Abstract
Under the modeling of chronic fibrousing hepatitis in rats (n = 75) the dynamics of fibrolytic effect of bone mar- row MMSC was examined after one or two-time infusion of these cells at the early stage of liver fibrosis. By dynamic measuring of liver fibrotic area and the expression of activated stellate cell markers (desmin, α-SMA) and markers of cell apoptosis (caspase-3 and caspase-9) within 90 days two phases of the development of bone marrow MMSC fibrolytic effect were found. It is shown that the development of fibrolytic effect includes the primary phase of intensification of fibrosis, which is followed by the phase of enhanced fibrolytic process in the liver. It was determined that the two-phase dynamics of liver regeneration was more intensive after two-time infusion of bone marrow MMSC.
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- 2011
- Full Text
- View/download PDF
3. [Influence of FGF2 level on the inflammation phase dynamics at the postinfarction cardiosclerosis].
- Author
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Shurygin MG and Shurygina IA
- Subjects
- Animals, Antibodies pharmacology, Female, Fibroblast Growth Factor 2 antagonists & inhibitors, Fibroblast Growth Factor 2 metabolism, Inflammation metabolism, Inflammation pathology, Inflammation physiopathology, Myocardial Infarction pathology, Myocardial Infarction physiopathology, Myocardium pathology, Rats, Rats, Wistar, Sclerosis metabolism, Sclerosis pathology, Sclerosis physiopathology, Collagen biosynthesis, Fibroblast Growth Factor 2 pharmacology, Myocardial Infarction metabolism, Myocardium metabolism
- Abstract
We modeling myocardial infarction female Wistar rats (N=126). We used morphomethry for examination of infarction zone from 2 h to 30 days after operation. The study comprised three groups of animals: "Control", "FGF" with 100 Hz FCGF2 injection into left ventricle, "anti-FGF" with 2 microg monoclonal antiFCF2 antibodies injections at period 1.5 h, 6 h and 3 day after operation. We founded that FCF2 injections leaded to enlarged of infiltrative inflammatory stage and take effect on the early collagen synthesis in infarction regions (from 3 days in group with FGF2 injection vs. 7 days in control group). Opportunity,injection of anti-FCF2 antibodies leaded to decreasing collagen volume on 30 day after infarction (19.15 +/- 1.22% in "anti-FGF" group vs. 41.71 +/- 1.30% in "Control" group, p < 0.05).
- Published
- 2010
4. [The phase dynamics of the migrating myoelectric complex following the electrical stimulation of the central nucleus area of the amygdala].
- Author
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Busygina II
- Subjects
- Animals, Dogs, Duodenum physiology, Electric Stimulation methods, Electrodes, Implanted, Electrophysiology, Muscle, Smooth physiology, Stomach physiology, Amygdala physiology, Myoelectric Complex, Migrating physiology
- Published
- 1992
5. [The phase dynamics of the migrating myoelectric complex following stimulation of the visceral field of the limbic cortex].
- Author
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Aleksandrov VG
- Subjects
- Animals, Dogs, Duodenum physiology, Electric Stimulation methods, Electrodes, Implanted, Electrophysiology, Muscle, Smooth physiology, Limbic System physiology, Myoelectric Complex, Migrating physiology
- Published
- 1992
6. [Phase dynamics of the electrical field of the heart in myocardial infarct].
- Author
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Presniakov DF and Koziatko SA
- Subjects
- Electrodes, Female, Humans, Male, Methods, Myocardial Infarction physiopathology, Electrocardiography, Heart physiopathology, Myocardial Infarction diagnosis
- Published
- 1973
7. MODEL FOR PARTICLE MOTION IN BETATRON CHAMBER UPON EXCITATION OF PARAMAGNETIC RESONANCE OF RADIAL FREE OSCILLATIONS.
- Author
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Ryzhkov, B
- Published
- 1969
8. Особенности фазовой кинетики фрагментации металлов при интенсивной пластической деформации
- Author
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Хоменко, A. В., Трощенко, Д. С., Метлов, Л. С., and Трофименко, П. Е.
- Abstract
Copyright of Nanosistemi, Nanomateriali, Nanotehnologii is the property of G.V. Kurdyumov Institute for Metal Physics, N.A.S.U and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2017
9. Strange waves in the ensemble of van der Pol oscillators
- Author
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Shabunin, Aleksej Vladimirovich
- Subjects
oscillations and waves ,multistability ,spatial structures ,Physics ,QC1-999 - Abstract
The purpose of this paper is to study the processes of spatial disorder and the development of phase multistability in a discrete medium of anharmonic oscillators. Methods. An ensemble of diffusively coupled van der Pol oscillators is used as a model of discrete anharmonic medium. The model is investigated by numerical simulation; its phase dynamics is studied. The formed spatial structures are visualized by means of phase difference distribution. Results. It is shown that the ensemble of van der Pol generators demonstrates spatially irregular wave modes when the parameter of anharmonicity exceeds certain threshold value. This phenomenon is similar to appearance of strange waves in ensemble of anharmonic phase oscillators. Regularities of evolution of these waves with parameters change are investigated. Regions of existence and stability of the waves are built. It is shown that the strange wave modes form multistability, since stability regions of waves with different numbers of phase defects overlap. Conclusion. Transition from harmonic to relaxation oscillations can be followed by a spatial disorder, because of phase failures that might take place at arbitrary points of the discrete self-oscillating medium. This effect increases with the growth of anharmonicity. As a result, the medium is divided into a lot of clusters with almost in-phase and out-of-phase behaviors. Such clusters interact, demonstrating mutual repulsion. The observed phenomena may be interesting for understanding the processes of spatial organization and formation of structures in self-oscillating media with simple temporal dynamics. Acknowledgements. The reported study was funded by RFBR and DFG according to the research project no. 20-52-12004
- Published
- 2020
- Full Text
- View/download PDF
10. Innovative development of the region's economy: methods of analysis within the recurrent approach
- Author
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Oksana Vyacheslavovna Butorina
- Subjects
Economics as a science ,HB71-74 - Abstract
Based on the application of the recurrent approach to studying cyclic processes, the article proves that modern innovative development can be considered in two ways – both as a "tool" to achieve a certain level of social development (neo-industrial, in this case,) and as a product of a particular level of development of society in general and economy in particular within the country as a whole as well as at the level of its regions. Furthermore, it is proved that the modern innovation cycle, which began in the last quarter of the 20th century, can be completed in the first third of the 21st century. Such time limits make it possible not only to distinguish indicators of the innovation cycle in regional economic systems but also to present their phase-by-phase dynamics in order to specify the phase in which the cycle is. The statistical base of the Perm region was taken as an example to perform a comprehensive analysis within three groups of indicators: the first group contains indicators that directly characterize innovative development of the economic system; the second group ("providing") includes indicators that allow one to assess the quality of creation and progressive development of the innovation component of the regional economic development; the third group consists of resulting indicators which reflect to what degree innovative transformations in the economy are completed. A conclusion is drawn that the modern innovation cycle is characterized by intertwining of progressive and regressive trends, which is seen both in the dynamics of innovative development of the economy of the Perm region as a whole and in each group of indicators. The general and differentiated conclusions have become the basis for the author's techniques for development of directions and methods of the state regulation of innovative development in the region's economy on the basis of the recurrent approach.
- Published
- 2019
- Full Text
- View/download PDF
11. MULTIFREQUENCY ALGORITHMS FOR DETERMINING THE MOISTURE CONTENT OF LIQUID EMULSIONS BY THE METHOD OF RESONANCE DIELCOMETRY.
- Author
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Korobko, A. A.
- Subjects
ALGORITHMS ,LIQUID dielectrics ,MATHEMATICAL models - Abstract
Copyright of Electrical Engineering & Electromechanics is the property of National Technical University, Kharkiv Polytechnic Institute and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2017
- Full Text
- View/download PDF
12. TWO APPROACHES TO CALCULATION OF SPLIT PHASE DANCING OF OVERHEAD ELECTRICAL TRANSMISSION LINE
- Author
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I. I. Sergey and P. I. Klimkovich
- Subjects
Hydraulic engineering ,TC1-978 ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
The paper shows two approaches to mathematical modeling of split phase dancing of overhead electrical transmission line. The first approach is based on calculative method when a phase is in the shape of flexible elastic thread connected with rigid rods. The phase is represented with equivalent wire in the second approach. Principle of mechanics relations has been used to set combined boundary problem of split phase dynamics. Two packets of computer programs for calculation of split phase dancing of overhead (electric) power line have been set up and tested.
- Published
- 2005
13. Солитонная модель естественного роста древостоев леса
- Subjects
асимптотика ,Agroforestry ,Environmental science ,устойчивость ,время ,asymptotic ,structure ,phase ,stability ,фаза ,структура ,time ,Natural (archaeology) - Abstract
Проблема устойчивого управления лесами должна основываться на знании законов динамического состояния леса как проявление общей закономерности фазового развития природных пространственно-временных структур (начало, структуризация, асимптотическое состояние, деструктуризация). Линейные и нелинейные уравнения колебаний (волн), описывающие фазовую динамику различных явлений, раскрывают единство явлений природы и их универсальность (механические, электромагнитные, химические, биологические, экономические и др.). Нелинейность является неотъемлемым свойством любой системы, эволюционирующей во времени. Особое место в теории нелинейных колебаний занимают солитоны. Солитонами называются устойчивые фазовые динамические структуры, которые получаются в результате решения нелинейных уравнений колебаний (и волн). Согласно современным представлениям солитоны играют важную роль в процессе эволюции природы. Поэтому возможный анализ естественного роста древостоев лесной структуры с позиции теории нелинейных колебаний покажет их общность с множеством природных явлений. Известно, что росту насаждений как динамическому процессу соответствуют три основных момента: имеет место начало, развитие и асимптотическое значение таксационных параметров (диаметр, высота, запас биомассы). Именно такими свойствами обладают солитоны, у них есть начало, фазовое развитие и асимптотическое состояние во времени. Солитоны, получаемые в результате решения нелинейного уравнения колебаний, достаточно достоверно обобщают имеющиеся опытные таксационные параметры (высота, запас биомассы) и раскрывают фазовую картину динамики роста деревьев леса. Построенная солитонная модель фазового представления динамики роста лесных насаждений вписывает её в общую закономерную картину формирования природных структур и может стать элементом основ реализации принципа гармонии при управлении лесными ресурсами., The problem of sustainable forest management should be based on knowledge of the laws of the dynamic state of the forest, as a manifestation of the General pattern of the phase development of natural space-time structures (beginning, structuring, asymptotic state, destructuration). Linear and nonlinear equations of vibrations (waves) describing the phase dynamics of various phenomena reveal the unity of natural phenomena and their universality (mechanical, electromagnetic, chemical, biological, economic, etc.). Nonlinearity is an inherent property of any system evolving over time. A special place in the theory of nonlinear oscillations is occupied by solitons. Solitons are stable phase dynamic structures, which are obtained by solving nonlinear equations of oscillations (and waves). According to modern concepts, solitons play an important role in the evolution of nature, so a possible analysis of the natural growth of forest stands from the perspective of the theory of nonlinear oscillations will show their commonality with a variety of natural phenomena. It is known that the growth of plantations, as a dynamic process, correspond to three main points: there is a beginning, development and asymptotic value of the inventory parameters (diameter, height, biomass). These are the properties of solitons, they have a beginning, phase development and asymptotic state in time. The solitons resulting from the solution of nonlinear equations of oscillations, enough to accurately summarize the available experimental forest (diameter, height, biomass) and reveal the dynamics of phase growth of forest trees. The constructed soliton model of the phase representation of the growth dynamics of forest stands fits it into the General logical picture of the formation of natural structures and can become an element of the foundations of the principle of harmony in the management of forest resources., №225 (2018)
- Published
- 2018
- Full Text
- View/download PDF
14. Особенности фазовой кинетики фрагментации металлов при интенсивной пластической деформации
- Author
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Хоменко, A.В.
- Abstract
В рамках неравновесной эволюционной термодинамики описан процесс фрагментации металлов при интенсивной пластической деформации (ИПД), который изучается в приближении двухдефектной модели с учётом плотностей границ зёрен и дислокаций. Построены фазовые портреты кинетики неравновесных переменных в процессе формирования стационарных субмикрокристаллических или нанокристаллических структур. Изучено влияние времён релаксации на фазовую динамику неравновесных переменных системы. Показано, что с приближением как к прямому, так и к обратному адиабатическому приближению система демонстрирует универсальное кинетическое поведение. Выявлено формирование особых участков, которые имеют притягивающий характер и определяются как «русло большой реки». Обнаружено, что процесс фрагментации металла или сплава во время ИПД осуществляется в два этапа, представляющие быструю релаксацию к особым участкам и медленное движение по ним. В рамках нерівноважної еволюційної термодинаміки описано процес фраґментації металів за інтенсивної пластичної деформації (ІПД), який вивчається в наближенні дводефектного моделю з урахуванням густин меж зерен і дислокацій. Побудовано фазові портрети кінетики нерівноважних змінних у процесі формування стаціонарних субмікрокристалічних або нанокристалічних структур. Вивчено вплив часів релаксації на фазову динаміку нерівноважних змінних системи. Показано, що з наближенням як до прямого, так і до зворотнього адіабатичного наближення система демонструє універсальну кінетичну поведінку. Виявлено формування особливих ділянок, які мають притягальний характер і визначаються як «русло великої річки». Виявлено, що процес фраґментації металу або стопу під час ІПД здійснюється у два етапи, що представляють швидку релаксацію до особливих ділянок і повільний рух по них. The process of metals’ fragmentation during severe plastic deformation (SPD) is described within the scope of the nonequilibrium evolutional thermodynamics. It is investigated using two-defect’ approach, which takes into account the densities of both grain boundaries and dislocations. The phase portraits, which represent the kinetics of nonequilibrium variables in the process of formation of stationary submicrocrystalline or nanocrystalline structures, are constructed. The influence of relaxation times on phase dynamics of system nonequilibrium variables is studied. As shown, with approaching the direct or inverse adiabatic approximation, the system demonstrates universal kinetic behaviour. The formation of singular sections called as ‘mainstreams’ is revealed. As found out, the process of metals’ fragmentation or alloys’ one during SPD is carried out in two stages, which represent the fast relaxation to singular sections and the slow movement over them.
- Published
- 2017
15. Частотная характеристика кольцевого лазера со знакопеременной частотной подставкой
- Subjects
КОЛЬЦЕВОЙ ЛАЗЕР,ЧАСТОТНАЯ ПОДСТАВКА,ФАЗОВОЕ УРАВНЕНИЕ,СОБСТВЕННЫЕ ЧАСТОТЫ КОЛЬЦЕВОГО РЕЗОНАТОРА,ФАЗА СИГНАЛА БИЕНИЙ,ЧАСТОТА БИЕНИЙ,ЧАСТОТНАЯ ХАРАКТЕРИСТИКА,RING LASER,FREQUENCY PEDESTAL,PHASE EQUATION,NATURAL FREQUENCIES OF A RING RESONATOR,BEAT SIGNAL PHASE,BEAT FREQUENCY,FREQUENCY RESPONSE - Abstract
Построена частотная характеристика кольцевого лазера со знакопеременной частотной подставкой. Особенность частотной подставки позволяет использовать упрощающее расчеты приближение. Такое приближение делалось и в более ранних работах, посвященных кольцевым лазерам с частотной подставкой простого вида. Однако результаты этих работ не могли быть использованы в настоящей статье, поскольку исследован принципиально другой тип сложной частотной подставки. Соответственно, потребовалось принципиально изменить подход к расчету частотной характеристики: специфическим образом преобразовать уравнение, описывающее динамику фазы сигнала биений, к системе связанных уравнений. Результатом применения этого метода стал алгоритм, по которому приближенно можно вычислить частоту биений в функции измеряемой разности собственных частот резонатора. Компьютерная реализация дала возможность построить статическую частотную характеристику кольцевого лазера с частотной подставкой сложного типа. Для контроля правильности полученных результатов построена частотная характеристика кольцевого лазера с простой частотной подставкой типа меандра, исследованной ранее другими способами, The purpose of this work was to build the frequency response (FR) of a ring laser with an alternating frequency pedestal (FP). FP characteristic feature allows us to use the approximation that simplifies calculations. We used this approximation method in earlier works devoted to ring lasers with FP of a simple type, however, the results of the previous research could not be used in this paper because this time we examined FP of a completely different type. Consequently, we had to change the approach tothe FR calculation: in a specific way we converted the equation describing the phase dynamics of the beat signal, to a system of coupled equations. The result of applying this method allowed us to obtain an algorithm for approximate calculation of the beat frequency in the function of the measured difference of the natural frequencies of the resonator. Computer implementation gave an opportunity to build the static FR ring laser with FP of a complex type. To control the accuracy of the obtained results, we built FR ring laser with simple FP of meander type, previously investigated in other ways
- Published
- 2016
16. Инновационное развитие экономики региона: методика анализа в рамках рекуррентного подхода
- Subjects
ИННОВАЦИОННОЕ РАЗВИТИЕ,РЕКУРРЕНТНЫЙ ПОДХОД,ПОКАЗАТЕЛИ ИННОВАЦИОННОГО РАЗВИТИЯ,МЕТОДИКА АНАЛИЗА ИННОВАЦИОННОГО РАЗВИТИЯ,УПРАВЛЕНИЕ ИННОВАЦИОННЫМ РАЗВИТИЕМ РЕГИОНА,RECURRENT APPROACH,INNOVATIVE DEVELOPMENT,INDICATORS OF INNOVATIVE DEVELOPMENT,METHODS OF INNOVATIVE DEVELOPMENT ANALYSIS,MANAGEMENT OF INNOVATIVE DEVELOPMENT OF THE REGION - Abstract
На основе использования рекуррентного подхода исследования циклических процессов доказано, что современное инновационное развитие может рассматриваться двояко и как «инструмент» достижения некоторого уровня общественного развития, в нашем случае неоиндустриального, и как порождение определенного уровня развития общества в целом и экономики в частности как на уровне страны в целом, так и ее регионов. Далее было доказано, что современный инновационный цикл, начавшись в последней четверти ХХ в., может завершиться в первой трети XXI в. Такие временные границы позволяют выделить не только индикаторы инновационного цикла в региональных экономических системах, но и представить их пофазовую динамику для конкретизации фазы, в которой он находится. На примере статистической базы Пермского края был осуществлен комплексный анализ по трем группам показателей: первая группа показатели, непосредственно характеризующие инновационное развитие экономической системы; вторая группа («обеспечивающая») показатели, позволяющие оценить качество создания и прогрессивного развития инновационной составляющей экономического развития региона; третья группа результирующие показатели, отражающие степень завершенности инновационных преобразований в экономике. На основании анализа был сделан общий вывод: современный инновационный цикл характеризуется тесным переплетением регрессивных и прогрессивных тенденций как по динамике инновационного развития экономики Пермского края в целом, так и дифференцированно по каждой группе показателей. Общий и дифференцированные выводы стали основой авторской методики разработки направлений и методов государственного регулирования инновационного развития в экономике края на основе рекуррентного подхода., Based on the application of the recurrent approach to studying cyclic processes, the article proves that modern innovative development can be considered in two ways both as a "tool" to achieve a certain level of social development (neo-industrial, in this case,) and as a product of a particular level of development of society in general and economy in particular within the country as a whole as well as at the level of its regions. Furthermore, it is proved that the modern innovation cycle, which began in the last quarter of the 20th century, can be completed in the first third of the 21st century. Such time limits make it possible not only to distinguish indicators of the innovation cycle in regional economic systems but also to present their phase-by-phase dynamics in order to specify the phase in which the cycle is. The statistical base of the Perm region was taken as an example to perform a comprehensive analysis within three groups of indicators: the first group contains indicators that directly characterize innovative development of the economic system; the second group ("providing") includes indicators that allow one to assess the quality of creation and progressive development of the innovation component of the regional economic development; the third group consists of resulting indicators which reflect to what degree innovative transformations in the economy are completed. A conclusion is drawn that the modern innovation cycle is characterized by intertwining of progressive and regressive trends, which is seen both in the dynamics of innovative development of the economy of the Perm region as a whole and in each group of indicators. The general and differentiated conclusions have become the basis for the author's techniques for development of directions and methods of the state regulation of innovative development in the region's economy on the basis of the recurrent approach.
- Published
- 2016
17. Особенности координации движений при выполнении удара по мячу у футболистов с заболеваниями опорно-двигательного аппарата
- Subjects
ФУТБОЛ,ПАРАЛИМПИЙСКИЙ СПОРТ,СКОЛИОЗ,ПЛОСКОСТОПИЕ,БИОМЕХАНИКА,FOOTBALL,PARALYMPIC SPORTS,SCOLIOSIS,FLAT FEET,BIOMECHANICS - Abstract
Целью исследования было изучение особенностей координации движений при выполнении удара внутренней частью стопы по мячу у футболистов с такими видами нарушений опорно-двигательного аппарата, как сколиоз III степени и плоскостопие III степени. Полученные результаты позволяют сделать выводы и определить основные отличия при ударе внутренней частью стопы у футболистов с нарушениями опорно-двигательного аппарата. Серьезные различия наблюдаются при исследовании перемещений. Несомненно, выделяются перемещения при ударе в голеностопном суставе. И это касается большинства фаз удара. Динамика изменений показателей в верхней части тела не столь выражена как в нижних конечностях, но несмотря на это разница остается заметна. И еще одним характерным и важным показателем различия двух групп являются перемещения головы по горизонтали. Значения перемещений головы основной группы существенно ниже на протяжении выполнения удара. Более яркие отличия мы можем видеть при наблюдении за скоростью. При выполнении удара у здоровых футболистов изменение показателей скорости является постепенным. В свою очередь значения скорости у футболистов с нарушениями опорно-двигательного аппарата данный показатель меняется резко. Формирование такого «патологического» динамического стереотипа у спортсменов с нарушениями ОДА является результатом трудностей с поддержанием равновесия и координацией движений. В тренировочном процессе футболистов данной группы необходимо больше внимания уделять развитию равновесия и координации, а также контролю вестибулярной чувствительности., The aim of the study was to examine the features of coordination in making a stroke the inside of the foot on the ball and the players with these types of disorders of the musculoskeletal system, as scoliosis degree III and III level flat. The results allow to draw conclusions and to identify the main differences when hitting the inside of the foot in football with disorders of the musculoskeletal system. Serious differences observed in the study of movement. Undoubtedly, the distinguished travel when struck in the ankle joint. This applies to the majority of the impact phase. Dynamics of changes in the values in the upper part of the body is not as pronounced in the lower limbs, but remains visible in spite of this difference. One more characteristic and important indicator of differences between the two groups are moving the head horizontally. The values of the core group of the head movement is significantly lower for the kick. More striking differences we can see by observing the speed. When making a stroke in healthy players the change of speed is gradual. Speed values in turn the players with disorders of the musculoskeletal system, this indicator varies dramatically. The formation of such "pathological" dynamic stereotype in athletes with locomotor impairment is a result of difficulties with balance and coordination of movements. The training process of this group of players need to pay more attention to the development of balance and coordination, as well as control of vestibular sensitivity.
- Published
- 2016
18. Исследование биоаккумуляции тяжелых металлов бактериями рода Bacillus с использованием рентгенофлуоресцентного анализа и атомно-силовой микроскопии
- Subjects
БИОАККУМУЛЯЦИЯ, СОЛИ ТЯЖЕЛЫЕ МЕТАЛЛЫ, БАКТЕРИИ BACILLUS, РЕНТГЕНОФЛУОРЕСЦЕНТНЫЙ АНАЛИЗ, АТОМНО-СИЛОВАЯ МИКРОСКОПИЯ - Abstract
Методами рентгенофлуоресцентного анализа и атомно-силовой микроскопии изучена способность бактерий рода Bacillus аккумулировать металлы Co, Pb, Cd, Zn. Установлены минимально подавляющие концентрации поглощаемых металлов Co, Pb, Cd, Zn, Mn, Fe для каждого штамма микроорганизмов. Определены фазы роста бактерий рода Bacillus без металлов и в присутствии их солей. При культивировании с металлами в некоторых случаях происходило увеличение времени выхода бактерий на стационарную фазу роста. Динамика накопления металлов клетками микроорганизмов изучена методом рентгенофлуоресцентного анализа. Для изучения изменения морфологии бактерий при накоплении тяжелых металлов использовался метод атомно-силовой микроскопии. Измерены основные морфометрические показатели клеток в присутствии солей металлов и их отсутствии. Показано, что действие солей металлов на микроорганизмы приводит к уменьшению размеров клеток, замедлению их роста и образованию спор., An ability of the Bacillus bacteria to accumulate heavy metals (Co, Pb, Cd, Zn) were studied by X-ray fluorescence analysis (XRF) and atomic force microscopy (AFM) methods. Minimal inhibitory concentrations of absorbed metals (Co, Pb, Cd, Zn, Mn, Fe) for each strain of microorganisms were established. Growth phases of Bacillus bacteria without metals and in the presence of their salts were defined. At cultivation with metals in certain cases there was an increase of time of bacteria outcome on a stationary growth phase. Dynamics of metals accumulation by microorganisms was studied by a method of the X-ray fluorescence analysis. Atomic force microscopy was used for study of bacteria morphology during heavy metals accumulation. The main morphometric parameters of cells in the presence of salts of metals and their absence were measured. It is shown that effect of salts of metals on microorganisms leads to reduction of cell sizes, deceleration of their growth and spores formation.
- Published
- 2015
19. Метод моделирования фазовой динамики для оценки запаздывающих связей между нелинейными осцилляторами при учете влияния амплитуд
- Subjects
запаздывающие связи, нелинейная динамика, моделирование фазовой динамики, система Ресслера, ЭльНиньо – Южное колебание, Северо-Атлантическое колебание - Abstract
Показано, что использование известной интервальной оценки времени запаздывания связи между осцилляторами, основанной на эмпирическом моделировании фазовой динамики и формализме максимального правдоподобия, может давать ошибочные выводы о величине запаздывания. Это имеет место, когда на фазы существенно влияет динамика амплитуд, что типично для нелинейных автоколебательных систем, находящихся под действием сильных шумов или в хаотических режимах. Предложен эмпирический критерий для диагностики таких ситуаций и модифицированная оценка запаздывания, позволяющая устранить ошибочные выводы. Оба подхода использованы для оценки связей между климатическими процессами Эль-Ниньо – Южное колебание и Северо-Атлантическое колебание по данным наблюдений., An established interval estimator of a time delay in coupling between oscillators, which is based on empirical modeling of phase dynamics and maximum likelihood formalism, is shown to give sometimes erroneous conclusions about the value of the time delay. It occurs when the dynamics of amplitudes affects phases, which is typical of nonlinear oscillatory systems under the influence of strong noises or in chaotic regimes. We suggest an empirical criterion to diagnose such situations and a modified estimator of time delay which allows one to avoid erroneous conclusions. Both approaches are applied to the estimation of couplings between climate processes El-Nino/Southern Oscillation and North Atlantic Oscillation from observational data.
- Published
- 2015
20. Состояние кардиореспираторной системы у студентов с различной степенью устойчивости к гипоксии
- Subjects
СТУДЕНТЫ, ГИПОКСИЯ, ГИПЕРКАПНИЯ, ПРОБА ШТАНГЕ, ЛЁГОЧНАЯ ВЕНТИЛЯЦИЯ, СПИРОМЕТРИЯ, ВАРИАБЕЛЬНОСТЬ СЕРДЕЧНОГО РИТМА, ЦЕНТРАЛЬНАЯ ГЕМОДИНАМИКА, РЕОГРАФИЯ, SHTANGE'S TEST - Abstract
Исследованы показатели кардиореспираторной системы у студентов с различным уровнем устойчивости к транзиторной гипоксии-гиперкапнии. Выявлены различия в параметрах внешнего дыхания, вегетативного обеспечения сердечного ритма и центральной гемодинамики у молодых людей в зависимости от результатов пробы Штанге. Установлено, что студенты с низкой устойчивостью к гипоксии обладают сниженными параметрами лёгочной вентиляции и спектральных характеристик сердечного ритма. Изучена вариабельность гемодинамических характеристик в различных фазах произвольного порогового апноэ. В результате проведённого исследования установлено, что более половины студентов в возрасте от 18 до 23 лет обладают высоким уровнем устойчивости к транзиторной гипоксии-гиперкапнии. Отмечены более низкие значения адаптивных резервов у молодых людей с низким уровнем толерантности к гипоксии. У 51% обследованных студентов наблюдаются неудовлетворительные адаптационные резервы, 3% контингента демонстрируют срыв адаптации. В ходе исследования установлены компенсаторные перестановки в системе лёгочной вентиляции у лиц с низким пороговым апноэ. Впервые изучена фазовая динамика параметров центральной гемодинамики у лиц с различным уровнем устойчивости к транзиторной гипоксии в условиях Европейского Севера России. Разрозненность и дезорганизованность факторной структуры взаимодействий исследуемых параметров у лиц с низким уровнем устойчивости к гипоксии отражает несовершенство механизмов регуляции, неспособных обеспечивать должный уровень устойчивости. У студентов с высоким пороговым апноэ ведущим компонентом является состояние модулирующей системы, звеньев гемодинамики и системы лёгочной вентиляции., The parameters of cardiorespiratory system of students with different levels of resistance to transient hypoxia-hypercapnia were studied. Differences in the lung function indices, heart rate variability and central hemodynamic in young people depending on the results of Shtange's respiratory test were identified. It was found out that students with low resistance to hypoxia had reduced ventilation indices and heart rate spectral characteristics. The variability of hemodynamic characteristics in different phases of arbitrary apnea was studied. The study found that more than a half of students aged 18 to 23 years old have a high level of resistance to transient hypoxia-hypercapnia. Lower values of adaptive reserves in young people with low tolerance to hypoxia were found. 51% of the examined students had unsatisfactory adaptation reserves, 3% demonstrated the failure of adaptation. The study established the compensatory changes in the pulmonary ventilation in patients with a low threshold of apnea. Phase dynamics of central hemodynamics parameters in patients with various degrees of resistance to transient hypoxia in the European North of Russia was studied first time. Inconsistency and disorganization of factor structure of correlations of the studied quantities in people with the low level of resistance to hypoxia reflects the imperfection of regulation mechanisms which cannot provide the necessary level of tolerance. In students with the high threshold apnea the state of modulating system, hemodynamics elements and the systems of pulmonary ventilation play the most important role.
- Published
- 2014
21. Влияние солёности воды на рост и размножение водного гиацинта в условиях биогенной нагрузки
- Subjects
ВОДНЫЙ ГИАЦИНТ, СОЛЁНОСТЬ, РОСТ, РАЗМНОЖЕНИЕ, БИОМАССА, ЧИСТАЯ ПРОДУКЦИЯ, СТРЕСС, БИОГЕННАЯ НАГРУЗКА - Abstract
В условиях лабораторного эксперимента изучено влияние 2 ‰, 4 ‰ и 6 ‰ растворов морской соли на рост и размножение накопительной культуры Eichornia crassipes (водный гиацинт) в условиях высокой стартовой биогенной нагрузки карбамида (1,0 г/л) и гидрофосфата калия (0,4 г/л). Выделены 4 фазы динамики биомассы. В начальный постстрессовый период 22 суток обнаружен стимулирующий эффект морской соли в 2 ‰ и 4 ‰ на рост. В последующие 10 суток наблюдались: угнетение, отмирание листьев и гибель растений в среде 4 ‰, 6 ‰. В период 32-45 сутки в контроле и в среде 2 ‰ происходило восстановление культуры, при этом продукция и размножение были значимо выше в контроле. Период 46–55 сутки характеризовался замедлением роста и размножения по причине исчерпания запаса биогенных элементов в среде. Динамика биомассы коррелирует с изменением активной реакции среды, отражающей увеличение скорости фотосинтеза., In laboratory experiments studied the effect of 2 ‰, 4 ‰ and 6 ‰ solutions of sea salt on the growth and reproduction of cumulative culture Eichornia crassipes (water hyacinth) in conditions of high initial nutrient loading of urea (1.0 g/l) and potassium hydrogen phosphate (0.4 g/l). Selected 4 phase dynamics of biomass. In the initial post-stress period of 22 days discovered the stimulating effect of sea salt for growth in 2 ‰ and 4 ‰. In the next 10 days were observed: depression, death of leaves and plants in the medium of 4 ‰, 6‰. During 32-45 day was a recovery culture in the control and 2‰, while the production and reproduction were significantly higher in the control. Period 46-55 day was characterized by slow growth and reproduction due to the exhaustion of the stock of nutrients in the environment. Dynamics of biomass correlates with pH variation reflecting the increase rate of photosynthesis.
- Published
- 2014
22. Модернизация регионов Приволжского федерального округа: пространственный анализ эволюции и фазовых состояний в 2000 – 2010 годы
- Subjects
МОДЕРНИЗАЦИЯ ЭКОНОМИКИ РЕГИОНА, ЕЕ СТАДИИ И ФАЗЫ, ХРОНОТИПОЛОГИЯ КОМПЛЕКСНЫХ СОСТОЯНИЙ МОДЕРНИЗИРОВАННОСТИ РЕГИОНОВ - Abstract
С использованием методического инструментария, разработанного Центром исследований модернизации Китайской академии наук (ЦИМ КАН), исследуются уровень и динамика модернизации ПФО в целом и его регионов, дается общая характеристика эволюции комплексных состояний модернизированности регионов (2000 – 2010 гг.), разработаны и анализируются группировки их фазовой динамики., With the use of methodological tools, developed by the Center for Modernization Studies of the Chinese Academy of Sciences (CAS CIM) examines the level and dynamics of modernization of the PFD in general and its regions, provides an overview of the evolution of complex states modernized regions (2000 – 2011 year.), developed and analyzed their group phase dynamics.
- Published
- 2013
23. Изменения электрогиппокампограммы и поведенческих реакций крыс при усилении в течение длительного стресса ГАМК-эргических механизмов мозга
- Abstract
Проанализированы изменения мощностей волн электрогиппокампограммы (ЭГпГ) крыс и ее спектральной композиции при усилении на протяжении длительного стресса активности ГАМК-эргических механизмов мозга с помощью гидазепама и пирацетама относительно значений показателей ЭГпГ при изолированном стрессовом воздействии. Установлена двухфазная динамика указанных изменений, характер которой свидетельствует об адаптогенном действии указанных препаратов. Модуляция центральных процессов при длительном стрессе и усилении на его фоне ГАМК-эргических механизмов мозга сопровождалась изменениями поведенческих реакций животных., The changes of waves’ power and spectral composition of electrohippocampogram (EHpG) were analyzed in rats which brain GABA-ergic mechanisms increased by gidazepam and pyracetam during prolonged stress comparatively to the indices of EHpG under isolated affective influence. The nature of two-phase dynamics of the changes could indicate an adaptogenic action of drugs. It’s shown that modulation of central processes during prolonged stress and amplification of brain GABA-ergic mechanisms are accompanied by the changes of the animals’ behavioral reactions.
- Published
- 2012
24. Фазовая динамика возбуждаемых квазипериодических автоколебательных осцилляторов
- Subjects
СИНХРОНИЗАЦИЯ, ФАЗОВЫЕ ОСЦИЛЛЯТОРЫ, КВАЗИПЕРИОДИЧЕСКАЯ ДИНАМИКА - Abstract
В фазовом приближении исследуется синхронизация внешней силой двух связанных фазовых осцилляторов. Рассмотрены и сравниваются режимы, когда автономные осцилляторы демонстрируют захват частот и биений с несоизмеримыми частотами. Представлены карты Ляпунова, обсуждаются возможные типы режимов возбуждаемой системы. Выявлены и классифицированы различные типы двухчастотных торов. Предложена модификация метода карт динамических режимов для определения областей существования различных резонансных двухчастотных торов., Synchronization phenomena are studied in phase dynamics approximation in the periodically driven system of two coupled oscillators. The cases are discussed when the autonomous oscillators demonstrate phase locking or beats with incommensurate frequencies. Lyapunov charts are presented, the possible regimes of dynamics of the driven system are discussed. Different types of two-dimensional tori are revealed and classified. The modification of computer generated charts of dynamical regimes method is suggested to identify the domains of existence for different two-dimensional tori.
- Published
- 2010
25. Кругооборот опекаемых благ в пофазной динамике воспроизводства
- Subjects
ОПЕКАЕМЫЕ ОБЩЕСТВЕННЫЕ БЛАГА, НЕСВОДИМЫЕ ОБЩЕСТВЕННЫЕ ИНТЕРЕСЫ, ИНСТРУМЕНТЫ МАТЕРИАЛЬНОГО ВМЕШАТЕЛЬСТВА ГОСУДАРСТВА - Abstract
В статье раскрывается специфика кругооборота опекаемых благ в пофазной динамике воспроизводства. Выявлены особенности деятельности государства, направленной на реализацию социального интереса. Определены наиболее наиболее эффективные инструменты материального вмешательства государства., The article deals with circulation of merit goods in phase-by-phase dynamics of reproduction. The author reveals characteristic features of state intervention aimed at protecting public interests. The most effective tools of state intervention in merit goods are given in the article.
- Published
- 2010
26. Хаотические режимы асимметричного кольцевого биллиарда с отражением и преломлением лучей
- Abstract
Исследована хаотическая динамика в кольцевом асимметричном биллиарде с отражением и преломлением лучей. Фазовая динамика характеризуется разнообразием динамических режимов, что связано как с проявлением традиционных механизмов хаотизации лучей, так и со сложностью допустимых законов движения. В многолистном симметричном фазовом пространстве проанализированы фазовые перестройки кольцевого биллиарда при изменении степени его асимметрии., The paper studies the chaotic dynamics in circular asymmetric billiard with beams reflection and refraction. Phase dynamics is characterized by a variety of dynamics modes, which is connected with the e-ect of traditional chaotization mechanisms as well as with the complicacy of allowable motion laws. In the multisheet symmetric phase space, the circular billiard reconstructions have been analysed its asymmetry degrees changes
- Published
- 2007
27. [Spatial distribution of lectin activity in perilesional areas of tobacco leaves inoculated with tobacco mosaic virus].
- Author
-
Babosha AV
- Subjects
- Detergents chemistry, Plant Leaves virology, Nicotiana virology, Peroxidase metabolism, Plant Leaves metabolism, Plant Lectins metabolism, Nicotiana metabolism, Tobacco Mosaic Virus
- Abstract
The activities of lectins and peroxidase and lignin content were studied in the perilesional area of leaves in two tobacco species (Nicotiana tabacum L., cultivar Samsun NN, and N. glutinosa L.) inoculated with tobacco mosaic virus. The development of hypersensitivity response proved to be accompanied by a complex spatial and temporal distribution of lectin activity. The area 5-9 mm away from the lesion center was characterized by the highest activity of loosely bound membrane lectins eluted with 0.05% Triton X-100. In the fraction of tightly bound membrane lectins (eluted with 0.5% detergent), lectin activity decreased during the first two days but increased on day 4 after inoculation. The activity of loosely bound membrane lectins increased in the leaf areas distant from the lesion. Two-phase dynamics in the interlesional area were also observed for lectin activity in the tightly bound membrane fraction (decrease on day 2 days and increase on day 4 after inoculation) and for peroxidase activity (increase on day 2 days and decrease on day 4). The relationship between the dynamics and spatial distribution of lectins in the perilesional area and the possible involvement of these proteins in pathogen-induced changes in photosynthesis are discussed.
- Published
- 2004
28. [Affective phases in dynamics of personality disorders (on a model of borderline personality disorder)].
- Author
-
Smulevich AB, Dubnitskaia EB, and Koliutskaia EV
- Subjects
- Adolescent, Adult, Borderline Personality Disorder classification, Borderline Personality Disorder diagnosis, Cyclothymic Disorder diagnosis, Emotions, Female, Humans, Male, Marital Status, Multicenter Studies as Topic, Occupations, Personality Disorders diagnosis, Personality Disorders psychology, Time Factors, Borderline Personality Disorder psychology, Cyclothymic Disorder psychology, Personality Disorders classification
- Abstract
Affective phases developing in personality disorder (index-sample--98 patients) were compared to those in cyclothymia (85 patients--control group). A preference of phase dynamics in the group of abnormalities relating to ICD-10 item "Borderline personality disorder" was confirmed. In line with a concept considering personality disorders as clinical syndromes, patients of the index-group have personality disorders with the signs of psychopathological diathesis determined by vulnerability to affective disorders. Affective phases are interpreted not only as an expression of a specific type of personality disorders dynamics but as an emergence of affective pathology, which is alternative to endogenous one both by modus of constitutional predisposition and clinical parameters (egosyntonic moderating of the phase, domination of negative affectivity in its structure, amphitymic duality of pathologically altered affect).
- Published
- 2004
29. [Clinical and nosological approach to diagnosis of schizoaffective psychosis].
- Author
-
Panteleeva GP and Bologov PV
- Subjects
- Acute Disease, Adult, Diagnosis, Differential, Humans, Prognosis, Psychotic Disorders classification, Psychotic Disorders psychology, Time Factors, Psychotic Disorders diagnosis
- Abstract
Using clinical and psychopathological method, 134 patients who met the ICD-10 criteria of diagnosis of schizoaffective psychosis (F25), were examined. Relatively small prognostic informative value of standard schizoaffective psychosis differentiation into affective- and schizo-dominant types was found. Subtyping of schizoaffective psychosis according to peculiarities of delusion formation in the picture of the disease attacks proved to be more significant. Given clinico-psychopathological features of circular affective and delusional disorders and their pathokinesis, as well as dynamics types and disease outcome, a schizoaffective psychosis systematization has been elaborated. That includes 3 nosologic types: "nuclear" type with non-progressive phase dynamics; "marginal" (intermediate) type and schizoaffective type of attack-like progressive schizophrenia. The concept of nosologic independence of schizoaffective psychosis ("nuclear" type) is discussed.
- Published
- 2002
30. [The elastase-like activity of the blood serum in patients with acute pneumonia].
- Author
-
Bratchik AM and Smuglov EP
- Subjects
- Acute Disease, Humans, Lung Abscess diagnosis, Pneumonia complications, Pneumonia, Pneumococcal diagnosis, Prognosis, Time Factors, Clinical Enzyme Tests, Pancreatic Elastase blood, Pneumonia diagnosis
- Abstract
A total of 168 patients were examined presenting with different clinical and roentgenological forms of acute pneumonia, such as focal one with an acute course, focal protracted, croupous with an acute course, croupous protracted, abscessing ones. Blood serum elastinase-like activity was studied. The complicated forms of pneumonia were found to be accompanied by two-phase dynamics of elastinase-like activity, such that it soars by day 10-15 of the disease process and declines by day 20-15, unlike the prognostically favourable forms of the condition where the initial reduction of this parameter turns to its gradual normalization.
- Published
- 1996
31. [The temporal characteristics of "winter" paradoxical sleep in the hibernating suslik Citellus major].
- Author
-
Pastukhov IuF, Afanas'ev SV, Fedorova NV, and Chepkasov IE
- Subjects
- Animals, Body Temperature physiology, Female, Male, Polysomnography, Time Factors, Wakefulness physiology, Hibernation physiology, Sciuridae physiology, Seasons, Sleep, REM physiology
- Abstract
It has been shown that paradoxical sleep (PS) total time (TT) in euthermia phase of hibernation cycle (winter sleep) can be compared with its mean values in euthermia season. Ultradian fluctuations of PS episodes duration, TT and phase number as well as bradycardia microintervals are revealed in euthermia phase dynamics. Amplitude of these fluctuations increases before hibernation entry; in transitional "start" period PSTT increases up to maximum critical values. In hibernation cycle PSTT rapidly decreases at the first stage owing to reduction of PS phase number and their duration. These data support and supplement earlier suggested hypothesis about endogenous "swinging up" of ultradian rhythms of sleep and thermoregulation promoting stage-to-stage expansion of homeostasis temperature limits in various critical periods of preparation and entry of homeotherms into natural hypometabolic states (torpor, hibernation and others).
- Published
- 1995
32. [Dynamics of absorption of C-14-biotin by blood cells and plasma protein binding in ontogenesis].
- Author
-
El'kina VA and Rozanov AIa
- Subjects
- Absorption, Age Factors, Animals, Biotin pharmacokinetics, Carbon Radioisotopes, In Vitro Techniques, Male, Protein Binding, Rats, Rats, Inbred Strains, Biotin blood, Blood Proteins metabolism, Erythrocytes metabolism, Leukocytes metabolism
- Abstract
Age peculiarities of absorption of 14C-biotin by the blood cells and plasma proteins in vitro are studied. The phase dynamics of 14C-biotin absorption by the blood cells and binding by plasma proteins is found. The reliable ontogenetic differences in absorption of 14C-biotin by the blood cells and plasma proteins are determined. The biotin-binding in vitro by the blood cells and plasma proteins decreases and becomes slower in old rats as compared with young ones.
- Published
- 1990
33. [Importance of catecholamines and various subtypes of beta-adrenoreceptors for resistance of mice to acute, intensive cooling].
- Author
-
Plotnikov NIu and Kulinskiĭ VI
- Subjects
- Animals, Female, Male, Methoxamine analogs & derivatives, Methoxamine pharmacology, Mice, Mice, Inbred Strains, Practolol pharmacology, Receptors, Adrenergic, beta drug effects, Acclimatization, Body Temperature Regulation drug effects, Catecholamines physiology, Cold Temperature, Receptors, Adrenergic, beta physiology
- Abstract
A phase dynamics in body temperature and thermoproduction was shown in the course of cooling of mice. 3 periods of various intensity were noted in thermocompensatory reactions. Within the first period content of noradrenaline was maintained in the vitally important tissues (brain, heart and brown adipose tissues); later on the content of noradrenaline was distinctly decreased. The blockade of ganglions and beta-adrenoreceptors inhibited markedly the thermoproduction and resistance to cooling. The main thermocompensatory reactions were realized via beta 1-adrenoreceptors; blocking of beta 1-adrenoreceptors by means of practolol was more effective as compared with the influence of N-isopropylmethoxamine--inhibitor of beta 2-adrenoreceptors. Importance of beta 1-adrenoreceptors in thermoregulation is discussed.
- Published
- 1983
34. [Anti-tumor activity of the polysaccharide mannan, and its effect on the dynamics of cyclic nucleotides in tissue].
- Author
-
Gavrilenko IS, Sokolova IP, Saiapin AV, and Ivnitskiĭ IuIu
- Subjects
- Animals, Cyclic AMP metabolism, Cyclic GMP metabolism, Cyclophosphamide administration & dosage, Drug Therapy, Combination, Liver metabolism, Mannans administration & dosage, Mice, Neoplasm Transplantation, Neoplasms, Experimental drug therapy, Phosphoric Diester Hydrolases metabolism, Antineoplastic Agents, Mannans pharmacology, Melanoma drug therapy, Nucleotides, Cyclic metabolism, Polysaccharides pharmacology
- Abstract
Mice with transplantable Harding-Passey melanoma were treated with polysaccharide mannan (50 mg/kg), cyclophosphamide (20 and 100 mg/kg) and their combinations. Mannan proved to possess considerable antitumor properties. It potentiated the therapeutic effect of cyclophosphamide and diminished its toxicity. Mannan treatment resulted in two-phase dynamics of cyclic nucleotide system in mouse liver and melanoma.
- Published
- 1983
35. [Interaction of functionally coupled vitamins in the distribution and metabolism of [14C]nicotinic acid in tissues and blood cells].
- Author
-
Rozanov AIa and Iakubik EIu
- Subjects
- Animals, Coenzymes metabolism, Coenzymes pharmacology, Erythrocytes metabolism, Leukocytes metabolism, Male, Niacin administration & dosage, Niacin blood, Rats, Rats, Inbred Strains, Tissue Distribution, Vitamins metabolism, Niacin metabolism, Vitamins pharmacology
- Abstract
Leucocytes adsorb by two orders of magnitude more labeled nicotinic acid ([14C]Na) than erythrocytes (as calculated on a per cell basis). The dynamics of binding of labeled vitamin by leucocytes is biphasic with the formation of predominantly [14C]nicotinic coenzymes already at very short time intervals after their injection to rats. Simultaneous injections of thiamine, riboflavin, lipoate and pantotenate increased the level of total labeled nicotinate metabolites in the blood and leucocytes 2.1- and 4.1-fold, respectively. The metabolism of subcutaneously injected [14C]NA was predominantly localized in the digestive system with a markedly pronounced two-phase dynamics of changes of the level of total labeled metabolites in the liver and small intestine concomitant with their secretion together with digestive juices. The functionally coupled vitamins injected simultaneously sharply increased the incorporation of the total label into liver tissues (up to 45% of the injected dose against 33% in the control) and the increase in the level of [14C]pyridine nucleotides. Similar effects were observed upon accumulation of labeled metabolites of [14C]NA in small intestine membranes. The increase in the maximal accumulation of nicotinate under effects of other group B vitamins in brain, heart and spleen tissues correlated with the dynamics, of their accumulation in the blood. In the postmaximal period in cardiac muscle and brain tissues, the second increase in the [14C]NA binding correlated with the dynamics of its accumulation in the digestive system.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1985
36. [Pantothenate metabolism in the rat liver and its regulation].
- Author
-
Rozanov AIa, Kirilenko OA, Savchenko SN, Stepanova LN, and Agafonova NE
- Subjects
- Animals, Calcium, Coenzyme A metabolism, Digestive System metabolism, Intestinal Mucosa metabolism, Pantothenic Acid pharmacology, Rats, Time Factors, Liver metabolism, Pantothenic Acid metabolism
- Abstract
Pantothenate, penetrating the liver tissue after intraperitoneal administration into young rats at a dose 100 mumole/kg was metabolized to unidentified substances within 15-30 min without accumulation of 4-phosphopantothenate. Within subsequent 2-4 hrs period pantothenate, 4-phosphopantothenate, CoA and considerably higher amounts of the unidentified metabolites (apparently symmetric and mixed (disulphides) were simultaneously accumulated in liver tissue; the latter substances determined the subsequent prolonged and essential elevation in content of CoA in the liver tissue. The phase dynamics of accumulation in liver tissue of the administered pantothenate is due to its recirculation from intestine and to alteration in the activity of pantothenate metabolizing enzymes, particularly those, which catalyze the reactions of thiodisulphide metabolism.
- Published
- 1977
37. Serotonin metabolism in duodenal tissue in acute renal ischemia in rabbits.
- Author
-
Ermolaev MV and Semenova MV
- Subjects
- Acute Disease, Animals, Dopa Decarboxylase metabolism, Enzyme Activation, Hydroxyindoleacetic Acid metabolism, Monoamine Oxidase metabolism, Rabbits, Duodenum metabolism, Ischemia metabolism, Kidney blood supply, Serotonin metabolism
- Abstract
Metabolism of serotonin was studied in duodenum of rabbits in acute kidney ischemia (from 15 min to 1 hr). Estimations of serotonin and 5-hydroxy indolacetic acid content and the activities of 5-hydroxytryptophane decarboxylase (5-HTD) and monoamine oxidase (MAO) using serotonin as a substrate were carried out. A complicated phase dynamics in the intestine of main patterns of serotonin metabolism was observed in acute kidney ischemia. Within the ischemic period content of serotonin and the MAO activity correlated with the activity of 5-HTD in the duodenal tissue. The alterations in the activity of MAO from intestine suggest that this enzyme was especially important in the serotonin metabolic conversions studied.
- Published
- 1977
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