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[Anti-tumor activity of the polysaccharide mannan, and its effect on the dynamics of cyclic nucleotides in tissue].
- Source :
-
Voprosy onkologii [Vopr Onkol] 1983; Vol. 29 (4), pp. 67-70. - Publication Year :
- 1983
-
Abstract
- Mice with transplantable Harding-Passey melanoma were treated with polysaccharide mannan (50 mg/kg), cyclophosphamide (20 and 100 mg/kg) and their combinations. Mannan proved to possess considerable antitumor properties. It potentiated the therapeutic effect of cyclophosphamide and diminished its toxicity. Mannan treatment resulted in two-phase dynamics of cyclic nucleotide system in mouse liver and melanoma.
- Subjects :
- Animals
Cyclic AMP metabolism
Cyclic GMP metabolism
Cyclophosphamide administration & dosage
Drug Therapy, Combination
Liver metabolism
Mannans administration & dosage
Mice
Neoplasm Transplantation
Neoplasms, Experimental drug therapy
Phosphoric Diester Hydrolases metabolism
Antineoplastic Agents
Mannans pharmacology
Melanoma drug therapy
Nucleotides, Cyclic metabolism
Polysaccharides pharmacology
Subjects
Details
- Language :
- Russian
- ISSN :
- 0507-3758
- Volume :
- 29
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Voprosy onkologii
- Publication Type :
- Academic Journal
- Accession number :
- 6305032