Serotonin metabolism in duodenal tissue in acute renal ischemia in rabbits.

Metabolism of serotonin was studied in duodenum of rabbits in acute kidney ischemia (from 15 min to 1 hr). Estimations of serotonin and 5-hydroxy indolacetic acid content and the activities of 5-hydroxytryptophane decarboxylase (5-HTD) and monoamine oxidase (MAO) using serotonin as a substrate were carried out. A complicated phase dynamics in the intestine of main patterns of serotonin metabolism was observed in acute kidney ischemia. Within the ischemic period content of serotonin and the MAO activity correlated with the activity of 5-HTD in the duodenal tissue. The alterations in the activity of MAO from intestine suggest that this enzyme was especially important in the serotonin metabolic conversions studied.