1. Long-Term Carriage of Medicopsis romeroi, an Agent of Black-Grain Mycetoma, Presenting as Phaeohyphomycosis in a Renal Transplant Patient.
- Author
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Lieberman JA, Fiorito J, Ichikawa D, Fang FC, Rakita RM, and Bourassa L
- Subjects
- Aged, Ascomycota classification, Ascomycota genetics, DNA, Ribosomal chemistry, DNA, Ribosomal genetics, Female, Humans, Kidney Transplantation, Sequence Analysis, DNA, Soft Tissue Infections diagnosis, Soft Tissue Infections microbiology, Ascomycota isolation & purification, Carrier State diagnosis, Carrier State microbiology, Immunocompromised Host, Phaeohyphomycosis diagnosis, Phaeohyphomycosis microbiology, Transplant Recipients
- Abstract
Medicopsis species are rare fungal pathogens that frequently resist common antifungal therapies and are difficult to identify morphologically as conidia are produced in pycnidia, a key feature of coelomycetes. Immunocompromised patients are at risk of these infections, even after remote exposure, and typically present with phaeohyphomycoses without dissemination. We present the case of a renal transplant recipient 6.5 years post-transplant who developed a slowly progressive soft tissue infection mimicking a synovial cyst. A cultured isolate was identified as Medicopsis romeroi by sequencing of multiple ribosomal loci. The patient responded well to debridement and posaconazole therapy. Solid-organ transplant patients are at risk of opportunistic fungal infection long after transplant, and molecular methods are often required for definitive identification.
- Published
- 2019
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