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Chromoblastomycosis due to Fonsecaea pedrosoi and F. monophora in Cuba.
- Source :
-
Mycopathologia [Mycopathologia] 2013 Jun; Vol. 175 (5-6), pp. 439-44. Date of Electronic Publication: 2013 Mar 08. - Publication Year :
- 2013
-
Abstract
- We report two cases of chromoblastomycosis due to Fonsecaea pedrosoi and F. monophora in otherwise healthy Cuban males. Direct microscopic examination of biopsies revealed muriform cells, the hallmark of chromoblastomycosis. The suspected agents were recovered in culture, identified on the basis of morphological criteria and confirmed by sequencing of the internal transcribed spacer regions of rDNA. Final treatment consisted of surgical excision. The patients were successfully cured since there was no relapse after a follow-up of more than a year. In vitro antifungal susceptibility testing of both isolates showed that itraconazole and posaconazole had potent activity. High MICs of amphotericin B (2 μg/ml), fluconazole (>64 μg/ml), anidulafungin (8 μg/ml) and caspofungin (8 μg/ml) were found.
- Subjects :
- Aged
Antifungal Agents pharmacology
Ascomycota drug effects
Ascomycota genetics
Biopsy
Chromoblastomycosis pathology
Cuba
DNA, Fungal chemistry
DNA, Fungal genetics
DNA, Ribosomal Spacer chemistry
DNA, Ribosomal Spacer genetics
Histocytochemistry
Humans
Male
Microbial Sensitivity Tests
Microscopy
Middle Aged
Sequence Analysis, DNA
Skin microbiology
Skin pathology
Ascomycota classification
Ascomycota isolation & purification
Chromoblastomycosis diagnosis
Chromoblastomycosis microbiology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-0832
- Volume :
- 175
- Issue :
- 5-6
- Database :
- MEDLINE
- Journal :
- Mycopathologia
- Publication Type :
- Academic Journal
- Accession number :
- 23471535
- Full Text :
- https://doi.org/10.1007/s11046-013-9634-3