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[Display omitted] • UiO-66-Cu(II) was synthesized by covalent attachment of Cu2+ to the defective site of UiO-66 using a solvothermal method. • The π complexation adsorbent UiO-66-Cu(I) was obtained by methanol vapor reduction. • The UiO-66-Cu(I) has a high adsorption of thiophene performance via π-complexation. Adsorption desulfurization is a very effective method to remove thiophenic compounds from fuels. The metal–organic frameworks (MOFs) have emerged as a new type of desulfurization adsorbents because of their porous nature and large specific surface area. In this study, Cu2+ was covalently introduced into the UiO-66 framework at the defective sites by the solvothermal method. Further, the π-complexation adsorbent UiO-66-Cu(I) containing Cu+ for adsorption desulfurization was synthesized by the methanol vapor-induced reduction. The adsorption performance was tested for the removal of thiophene from the model fuels with different sulfur concentrations. In comparison with the pristine UiO-66, the adsorbent UiO-66-Cu(I) has a higher adsorption capacity for thiophene, reaching 14.8 mg S/g. The competitive adsorption results indicated that UiO-66-Cu(I) has good selectivity for thiophene in the presence of aromatic compounds. From the recycling experiments, this adsorption still has the 86 % of the initial capacity after four cycles, indicating that the adsorbent has a good recycling performance. [ABSTRACT FROM AUTHOR]

Researchers at the University of Colorado have developed a new method for the C3-chlorination of C2-substituted benzothiophene derivatives using sodium hypochlorite. The reaction occurs in aqueous acetonitrile at 65-75 degrees Celsius, yielding C3-halogenated products in variable yields. The research, funded by various organizations including the NIH and NSF, explores the mechanism of the reaction and its potential synthetic applications. This study has been peer-reviewed and provides valuable insights into the functionalization of benzo[b]thiophene rings for drug development and materials science. [Extracted from the article]

A recent study conducted by researchers at Shenzhen University in the People's Republic of China focused on the development of novel thiophene-benzoindolium ligands targeting mitochondrial G-quadruplexes (mtG4s) for potential tumor therapy. The study identified YS-2 as a potential near-infrared fluorescent probe that selectively binds to mtG4s in triple-negative breast cancer cells, inducing mitochondrial dysfunction and inhibiting tumor cell proliferation. The research highlights the potential of these ligands in developing therapeutic strategies against tumors, particularly triple-negative breast cancer. [Extracted from the article]

A study conducted at the University of Waterloo in Canada focused on the design and synthesis of N-phenylbenzofuran-2-carboxamide and N-phenylbenzo[b]thiophene-2-carboxamide derivatives as modulators of A beta 42 aggregation. The research found that certain compounds demonstrated concentration-dependent inhibition of A beta 42 aggregation, while others accelerated fibrillogenesis. These findings suggest that these novel derivatives could serve as pharmacological tools to study the mechanisms of A beta 42 aggregation. The study was funded by various organizations including the Natural Sciences and Engineering Research Council of Canada and the Spanish Government. [Extracted from the article]

A study conducted at Mansoura University in Egypt has explored the synthesis and antimicrobial properties of thiophene-linked 1,2,4-triazoles. The researchers found that these compounds exhibited significant antimicrobial activity against both Gram-positive and Gram-negative bacteria, but were inactive against fungal strains. Additionally, some of the compounds showed potent anti-proliferative activity against cancer cell lines. The study also included a structural insight analysis and molecular docking studies. The research suggests that these compounds have potential as antimicrobial and chemotherapeutic agents. [Extracted from the article]

Researchers from the College of Science have synthesized and characterized pyrimidine-thiophene and pyrimidine-thiadiazole conjugates as potential anticancer agents. The conjugates were found to have angular configurations and reduced energy gaps compared to the parent compound. The cytotoxic effectiveness of the synthesized conjugates was evaluated against different cancer cell lines, with the acrylamide derivative showing the most potent cytotoxicity. The pharmacokinetic properties of the acrylamide compound indicated its potential as a therapeutic candidate. Further research is needed to explore the binding interactions and potential therapeutic applications of these conjugates. [Extracted from the article]

A recent study conducted at the Indian Institute of Technology Guwahati has developed a metal-organic framework (MOF) for the detection of the anti-neoplastic drug flutamide and the biomolecule hemin. The MOF demonstrated highly discriminative fluorescence sensing properties with low detection limits and a quick response time. It also showed recyclability and maintained its sensing ability across different pH levels, water samples, and biological fluids. Additionally, the MOF exhibited catalytic activity in Friedel-Crafts alkylation reactions. This research provides valuable insights into the development of effective drug monitoring techniques. [Extracted from the article]

A recent study conducted by researchers at Federal University Pernambuco in Recife, Brazil, has identified a potential alternative treatment for Candida infections that are resistant to fluconazole. The study focused on a derivative called 2-amino-5,6,7,8-tetrahydro-4 H-cyclohepta[b]thiophene-3-isopropyl carboxylate (2AT), which demonstrated antifungal and antibiofilm properties against fluconazole-resistant Candida strains. The compound showed a synergistic effect when combined with fluconazole and did not exhibit toxicity in macrophage cells. The researchers concluded that 2AT could be a promising option for invasive candidiasis therapy, particularly in cases of resistant isolates. [Extracted from the article]

Researchers at the University Pablo de Olavide in Seville, Spain have discovered new antimicrobial thiophene derivatives that show activity against drug-resistant Gram-negative bacteria, including Acinetobacter baumannii and Escherichia coli. The compounds exhibited bactericidal effects and increased membrane permeabilization, reducing bacterial adherence to host cells. Docking studies showed a strong binding affinity to specific bacterial targets. These findings suggest that thiophene derivatives could enhance the repertoire of drug treatments against drug-resistant bacteria. [Extracted from the article]

Researchers at Bharathidasan University in Tiruchirappalli, India have conducted a study on the anti-tumor properties of three new arene ruthenium(II) complexes that incorporate thiophene-based aroylhydrazone ligands. The complexes were characterized through various analyses and were found to exhibit significant cytotoxicity against several cancer cell lines. The study also revealed that one of the complexes, complex 2, demonstrated promising cytotoxicity and induced cell death through various mechanisms. The research has been peer-reviewed and published in Dalton Transactions. [Extracted from the article]

Researchers at Government College University in Faisalabad, Pakistan have synthesized a new class of thiophene-based molecules that show promising antibacterial activity against XDR Salmonella Typhi. The compound 2-ethylhexyl-5-(p-tolyl)thiophene-2-carboxylate (4F) demonstrated outstanding antibacterial action compared to ciprofloxacin and ceftriaxone. Molecular docking studies were conducted to investigate the interaction between the synthesized molecules and the bacterial enzyme. The compound 4F appears to be a promising antibacterial agent and further analysis was done to examine its electronic, structural, and spectroscopic features. [Extracted from the article]

A recent report from Ain Shams University in Cairo, Egypt discusses the design and synthesis of tetrahydrobenzo[b]thiophene derivatives as potential dual topoisomerase (Topo) I/II inhibitors for cancer treatment. Compound 14 showed the best cytotoxic potential against hepatocellular, colorectal, and breast cancer cell lines, surpassing doxorubicin in breast cancer. Compound 3 exhibited the best inhibitory potential against Topo I and II, and compound 14 displayed the best binding affinity in the DNA intercalation assay. The synthesized compounds show promise as potential anticancer candidates for future optimization. [Extracted from the article]

Researchers at Ain Shams University in Cairo, Egypt have conducted a study on the synthesis of tetrahydrobenzo[b]thiophene candidates using the beta-enaminonitrile scaffold. The study involved in vitro antiproliferative assessment and molecular docking to explore the potential binding modes of interaction with the tubulin protein. The results showed that certain candidates exhibited high potency against cancer cell lines and displayed good binding affinity towards tubulin. The researchers also conducted pharmacokinetics analyses, which indicated desirable drug-likeness and bioavailability properties. For more information, readers can refer to the article "B-enaminonitrile In the Synthesis of Tetrahydrobenzo[b]Thiophene Candidates With Dft Simulation, in Vitro Antiproliferative Assessment, Molecular Docking, and Modeling Pharmacokinetics" published in RSC Advances. [Extracted from the article]

A recent study conducted by the Department of Chemistry in Bengaluru, India, explores the properties of a potential anti-cancer thiophene derivative. The study utilizes computational tools to investigate the molecule's properties, including density functional theory calculations and topological analyses. The molecule's potency against brain cancer was evaluated through molecular docking with positive results. This research provides valuable insights into the potential of thiophene derivatives as anti-cancer agents. [Extracted from the article]

Researchers at Mustansiriyah University in Baghdad, Iraq have conducted a study on new 3-furan-1-thiophene-based chalcones as antibacterial and anticancer agents. The compounds were synthesized, characterized, and evaluated for their pharmacological properties. The results showed that the chalcones exhibited antibacterial activity against both Gram-positive and Gram-negative bacterial species. Additionally, one of the compounds demonstrated potent anticancer activity against breast cancer cells. Molecular docking studies supported the in vitro findings, suggesting that these chalcones could be potential candidates for the development of novel antibacterial and anticancer drugs. [Extracted from the article]

A patent application has been filed for a method of preparing a poly(thioctic acid)-copper coating on the surface of cardiovascular stent material. The current coatings used on drug-eluting stents have limitations, such as inhibiting the growth of endothelial cells and being costly. The new method aims to address these issues by providing a cost-effective and simple process for creating a poly(thioctic acid)-copper coating that enhances endothelial cell proliferation, accelerates endothelialization, and provides anti-thrombotic effects. The method involves grinding the stent material, treating it with a precursor solution, and drying it to form the coating. [Extracted from the article]

A recent study conducted at Shenyang Pharmaceutical University in China has discovered a series of novel thiophene-3-carboxamide derivatives that have potential as VEGFR-2 inhibitors with anti-angiogenic properties. Compound 14d, in particular, showed excellent anti-proliferative activity against various cancer cell lines and effective VEGFR-2 inhibitory activity. The compound also demonstrated the ability to inhibit colony formation, cell migration, and tube formation in a dose-dependent manner. These findings suggest that compound 14d could be a promising lead compound for anti-angiogenesis. The research was supported by various funding sources and has been peer-reviewed. [Extracted from the article]

A recent report from Fujian Normal University in China discusses new findings in tissue engineering. The researchers have developed a biodegradable underwater tissue adhesive called acid-induced adhesive (AIA), which is composed of poly(thioctic acid) (polyTA). The AIA exhibits strong adhesion to wet tissue and has self-hardening capabilities. It also demonstrates good biocompatibility and has potential applications in biomedical fields. The research was supported by various funding sources and has been peer-reviewed. [Extracted from the article]

Researchers from Huanghe Science and Technology College in China have synthesized a novel thiophene derivative, compound 1312, and investigated its potential as a therapeutic agent for gastrointestinal cancers. The compound demonstrated significant efficacy in suppressing colony formation of cancer cells and inducing cell cycle arrest. It also exhibited inhibitory effects on cell migration and invasion, as well as apoptotic cell death. Furthermore, compound 1312 effectively suppressed both the b-tubulin cytoskeletal network and the Wnt/b-catenin signaling pathway. The study suggests that compound 1312 shows promise as a prospective candidate for gastrointestinal cancer treatment, but further research is needed to explore its therapeutic efficacy in greater detail. [Extracted from the article]

A recent study from Linkoping University in Sweden explores the development of ligands that can selectively detect pathological hallmarks associated with Alzheimer's disease (AD). The researchers synthesized thiophene-based optical ligands and investigated their ability to distinguish between tau deposits and aggregated amyloid-beta (Aβ) pathology. The study found that specific molecular interactions between the ligands and the aggregates are necessary for selective detection of tau deposits. These findings provide chemical insights for the development of ligands that can distinguish between different proteinaceous species and may contribute to the creation of novel agents for clinical imaging of tau pathology in AD. [Extracted from the article]

Researchers from Kinnaird College for Women in Lahore, Pakistan have made advances in the treatment of ureolytic bacterial infections by targeting the urease enzyme. They designed and synthesized morpholine-thiophene hybrid thiosemicarbazone derivatives and evaluated their potential to inhibit urease enzyme in vitro. The majority of the synthesized compounds were more potent than the conventional inhibitor, thiourea. The lead inhibitor, 2-(1-(5-chlorothiophen-2-yl)ethylidene)-N-(2-morpholinoethyl)hydrazinecarbothioamide, showed strong affinity for the urease active site and displayed druglikeness behavior. This research provides insights into potential treatments for bacterial infections. [Extracted from the article]

A study conducted at Mansoura University in Egypt focuses on the synthesis and biological evaluation of a new series of thiophene derivatives as potential anticancer agents. The researchers synthesized various compounds based on 3-oxobutanamidothiophene and tested their anticancer properties against hepatocellular carcinoma and breast cancer cells. The results showed that certain compounds exhibited strong anticancer activity. The study provides valuable insights into the development of novel therapeutic agents for cancer treatment. [Extracted from the article]

A recent report from Shanghai Normal University in China discusses the development of a visual Raman nano-delivery system (NS) based on a thiophene polymer for microtumor detection. The researchers introduce a donor-acceptor (D-A)-structured thiophene-based polymer called PBDB-T, which exhibits strong pre-resonant Raman enhancement and avoids fluorescence interference. The PBDB-T NS enables the diagnosis of microtumor regions and deeper tumor tissues, with potential applications in visual drug delivery systems. This research opens up possibilities for targeted drug delivery methods tailored to specific regions. [Extracted from the article]

Researchers from the University of Dschang in Cameroon have synthesized two new Cobalt(II) complexes using a novel ligand. The compounds were characterized using various techniques and their antibacterial activity was tested. The ligand displayed moderate antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae, while one of the complexes showed moderate activity against Pseudomonas aeruginosa and Klebsiella pneumoniae, and the other complex showed moderate activity only against Klebsiella pneumoniae. This research provides valuable insights into the synthesis and antibacterial properties of these compounds. [Extracted from the article]

Researchers at Cairo University in Giza, Egypt have conducted a study on the synthesis and antibacterial evaluation of novel scaffolds based on bis-thiazole or bis-1,3,4-thiadiazole linked to thieno[2,3-b]thiophene as new hybrid molecules. The researchers used various chemical reactions to create these compounds and determined their structures through elemental analyses and spectral data. The antibacterial activity of the compounds was evaluated, and their pharmacokinetic properties were assessed through in silico ADMET analysis. This research has been peer-reviewed and provides valuable insights into the development of new antibiotics. [Extracted from the article]

A recent study conducted at the University of Tsukuba in Japan explored the polymerization of furan-thiophene-based monomers in chiral liquid crystals. The researchers were able to produce electro-optically active polymers with characteristics of liquid crystal molecular order and organic semiconductors. The study found that the electrical properties and chirality of the polymers could be controlled by selecting suitable monomer units. The research concluded that the optical activity of the furan-thiophene-based polymers could be achieved through electrical control. [Extracted from the article]

Researchers from Northwest Normal University in Lanzhou, China have synthesized three different variants of thiophene-zinc porphyrins for use as photosensitizers in photodynamic therapy for cancer treatment. Among the synthesized compounds, Zn-P1 showed the highest activity and demonstrated superior singlet oxygen generation capability. Cytotoxicity assays revealed that Zn-P1 exhibited remarkable phototoxicity and selectivity for HepG2 cells. The study highlights the potential utility of cationic porphyrin photosensitizer complexes in photodynamic therapy and provides new insights for the development of innovative photosensitizers in cancer treatment. [Extracted from the article]

A recent study conducted by researchers at Maharshi Dayanand University in Rohtak, India, focused on the synthesis and analysis of novel tellurium (IV) complexes derived from thiophene. The compounds were investigated using various analytical techniques and spectral analyses. The study found that the complexes exhibited significant antimicrobial and antioxidant properties, particularly complexes 3c and 3d. Computational analyses further supported the efficacy of these complexes as therapeutic agents. The research provides valuable insights into drug design and potential applications in pharmaceuticals. [Extracted from the article]

Researchers at Oregon State University have identified and evaluated ionizable lipids containing a thiophene moiety (Thio-lipids) for efficient mRNA encapsulation and delivery. Through the rational design of ionizable lipid structure, they prepared 47 Thio-lipids and identified structural criteria required for efficient mRNA delivery. Two top lipids, 20b and 29d, were found to be effective in biodistribution and mRNA delivery to various tissues, including the liver, spleen, lung, and retina. Lipid 20b was particularly potent in delivering mRNA to the retina without acute toxicity in non-human primates. This research provides valuable insights into the development of lipid nanoparticles for gene delivery. [Extracted from the article]

Researchers at Karnatak University in Dharwad, India have developed a new series of compounds called thiophene-1,3,4-oxadiazole-thiazolidine-2,4-dione hybrids. These compounds were found to have potential anticancer activity against breast cancer cells (MCF-7) in laboratory tests. One compound in particular, TOT-14, showed a strong inhibitory effect on cancer cell growth and exhibited selective activity. The researchers also found that TOT-14 had moderate interaction with DNA. The designed molecules met the requirements for drug-likeness and ADME. [Extracted from the article]

A research study conducted at AMITY University Uttar Pradesh in India has investigated the synthesis of new thiophene hybridized thiadiazolyl Schiff bases as potential antibacterial agents. The compounds were found to have optimal binding affinity with beta-lactamase and demonstrated antibacterial activity against gram-positive and gram-negative bacterial strains. The study suggests that these compounds could be developed as alternatives to beta-lactamase inhibitors for the treatment of bacterial infections. The research has been peer-reviewed and published in the Indian Journal of Heterocyclic Chemistry. [Extracted from the article]

Researchers from the University of Desarrollo in Santiago, Chile have developed a mathematical model to predict the reactivity of thiophene-containing photosensitizers in photodynamic therapy (PDT). The model, which combines advanced computational methods and experimental data, can classify photosensitizers based on their efficiency and safety. The study also provides insights into the impact of electronic effects on thiophene reactivity and advances the design of thiophene-based photosensitizers for PDT. This research has the potential to contribute to the development of therapeutic agents that achieve a balance between efficiency and safety in PDT. [Extracted from the article]

A recent study conducted at Umm Al-Qura University focused on the synthesis of tetrazole-based derivatives and their antimicrobial activity. The researchers used computational methods to calculate the electronic properties of these derivatives and investigated their effectiveness against bacterial and fungal strains. The study found that certain derivatives exhibited antibacterial activity against Gram-positive and Gram-negative bacterial strains, while others showed effectiveness against fungal strains. The researchers concluded that these tetrazole hybrids have potential as lead molecules for drug development and suggested further research on their electrical characteristics and applications. [Extracted from the article]

A recent study conducted at Ain Shams University in Cairo, Egypt, focused on the synthesis and evaluation of antiproliferative activity of thiophene-based compounds. The researchers used thiophene-2-carbohydrazide to produce derivatives of oxadiazole, triazole, and thiazolidinone. The compounds were tested against breast adenocarcinoma and colon cancer cell lines, and the hydrazones and spiro-indolin-oxadiazole derivatives showed the most potent antiproliferative activity. Molecular docking studies were also conducted to assess the binding energies of the compounds to human carbonic anhydrase IX protein. The study concluded that the synthesized compounds exhibited promising antiproliferative activity and were supported by computational studies. [Extracted from the article]

A research report from Harbor-UCLA Medical Center in Torrance, California discusses the findings on Staphylococcus aureus, specifically methicillin-resistant strains (MRSA). The report highlights the challenge that MRSA strains pose to clinicians due to their resistance to beta-lactams, the first-line treatment for methicillin-susceptible S. aureus. The researchers discovered a phenomenon called "NaHCO3-responsiveness," where MRSA isolates become susceptible to beta-lactams in the presence of physiologically relevant concentrations of NaHCO3. They also found that NaHCO3 exposure represses the synthesis of wall teichoic acid (WTA), which is similar to the effect of WTA synthesis inhibitors. The study suggests that WTA synthesis inhibitors, in combination with specific beta-lactam agents, could be used to treat certain MRSA strains. [Extracted from the article]

• The 2-(Trifluoroacetyl) thiophene (TFPN) has been developed as a functional electrolyte additive. • Introduction of 0.5 wt% TFPN into the electrolyte can greatly enhance the cycling performance of high-voltage LiCoO 2 cathode. • Addition of 0.5 wt% TFPN can effectively suppress the decomposition of both electrolyte solvent and lithium salt. The development of high voltage electrolytes plays a critical role to achieve advanced lithium ion batteries with high energy density. Application of suitable electrolyte additives is a facile and effective way to achieve enhanced electrochemical performance at high voltage operation. In this work, 2-(trifluoroacetyl) thiophene (TFPN) was investigated as a functional electrolyte additive for high performance lithium ion batteries using high-voltage LiCoO 2 cathode. When cycled between 3.0 V and 4.4 V at 0.5 C, the capacity retention of the LiCoO 2 cathode significantly increases from 33.2 %–90.6 % by the addition of 0.5 wt% TFPN into the baseline electrolyte. Based on the measurements on impedance spectra and X-ray photoelectron spectra, the improved cycling performance is attributed to the preferential oxidation of TFPN on the cathode surface and thus form a protective layer to suppress the decomposition of both electrolyte solvent and lithium salt. This work presents that TFPN has great potential as functional additive for the development of high-voltage and high-energy-density lithium ion batteries. [ABSTRACT FROM AUTHOR]

• Quinoxaline-based polymers were synthesized for polymer solar cells. • The electron-donating indacenodithiophene and indacenodithieno[3,2-b]thiophene were linked to the electron-accepting 2,3-diphenylquinoxaline. • The incorporation of CN substituent in DPQ unit can efficiently improve the photovoltaic performances. Three donor-acceptor type quinoxaline-based conjugated polymers, in which electron-donating indacenodithiophene (IDT) and indacenodithieno[3,2-b]thiophene (IDTT) were connected to the electron-accepting 2,3-diphenylquinoxaline (DPQ) derivatives, were synthesized using the Stille coupling reaction. To investigate the effects of the strong electron-withdrawing cyano (CN) substituent on the photovoltaic properties of polymers, it was selectively introduced in the DPQ unit on the polymer backbone. The combination of IDT and the standard DPQ produced the reference polymer IDT-Qx, while the coupling of IDT and IDTT with mono-CN substituted DPQ provided the target polymers IDT-QxCN and IDTT-QxCN, respectively. Owing to the significant contributions of the CN substituent, IDT-QxCN and IDTT-QxCN exhibited better photovoltaic performances than IDT-Qx reference. Furthermore, the presence of more planar two thieno[3,2-b] thiophenes in IDTT than the two thiophenes in IDT allowed IDTT-QxCN to display the highest power conversion efficiency (5.47%) with an open circuit voltage of 0.95 V, short-circuit current density of 15.30 mA cm−2, and fill factor of 56.95%. [ABSTRACT FROM AUTHOR]