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664 results on '"Hagg, A."'

1. Determining Lennard-Jones Parameters Using Multiscale Target Data through Presampling-Enhanced, Surrogate-Assisted Global Optimization

Author: Max Müller, Alexander Hagg, Robin Strickstrock, Marco Hülsmann, Alexander Asteroth, Karl N. Kirschner, and Dirk Reith
Subjects: General Chemical Engineering, General Chemistry, Library and Information Sciences, Computer Science Applications
Published: 2023

2. Estimating local surface glacier mass balance from migration of the 1918 Katla eruption tephra layer on Sléttjökull, southern Iceland

Author: Wilfried Hagg, Christoph Mayer, Ulrich Münzer, Natalie Barbosa, Hans-Martin Schuler, and Matthias Staudacher
Subjects: Earth-Surface Processes
Abstract: We use the apparent horizontal shift of an englacial tephra layer outcrop to calculate local glacier mass balance on Sléttjökull, a lobe of Mýrdalsjökull in Southern Iceland. For this approach, the dipping angle of the englacial tephra layer in the glacier upstream of the outcrop and the flow velocity of the ice need to be known. An earlier investigation was expanded by the application of ground-penetrating radar, detecting the depth of the tephra along tracks with a total length of 10 km. Interpolation between the tracks enables us to derive the dipping angle of the layer along several flow lines. Together with glacier surface velocities, determined from feature tracking, we are able to estimate the local surface mass balance from the horizontal displacement of the tephra outcrop using freely available satellite imagery without additional fieldwork. The earlier local balance series was extended to the period 2014/15 to 2019/20. Although the results for the individual profiles differ slightly from each other, they show the same temporal pattern and clear variations from year to year. The results are compared to traditional mass-balance data from Hofsjökull. The two series show a good agreement in their interannual variability.
Published: 2023

3. Order Management Perspective on Fluid Manufacturing Systems

Author: Theresa-Franziska Hinrichsen, Christian Fries, Manuel Hagg, and Manuel Fechter
Subjects: General Earth and Planetary Sciences, General Environmental Science
Published: 2023

4. MLD-MPC Approach for Three-Tank Hybrid Benchmark Problem

Author: Hanen Yaakoubi, Hegazy Rezk, Mujahed Al-Dhaifallah, and Joseph Hagg鑗e
Subjects: Biomaterials, Mechanics of Materials, Modeling and Simulation, Electrical and Electronic Engineering, Computer Science Applications
Published: 2023

5. Enhanced performance in fusion plasmas through turbulence suppression by megaelectronvolt ions

Author: Mazzi, S., Garcia, J., Zarzoso, D., Kazakov, Y., Ongena, J., Dreval, M., Nocente, M., Stancar, Z., Szepesi, G., Eriksson, J., Sahlberg, A., Benkadda, S., Abid, N., Abraham, K., Abreu, P., Adabonyan, O., Adrich, P., Afanasev, V., Afzal, M., Ahlgren, T., Aho-Mantila, L., Aiba, N., Airila, M., Akhtar, M., Albanese, R., Alderson-Martin, M., Alegre, D., Aleiferis, S., Aleksa, A., Alekseev, A., Alessi, E., Aleynikov, P., Algualcil, J., Ali, M., Allinson, M., Alper, B., Alves, E., Ambrosino, G., Ambrosino, R., Amosov, V., Andersson Sunden, E., Andrew, P., Angelini, B., Angioni, C., Antoniou, I., Appel, L., Appelbee, C., Aria, S., Ariola, M., Artaserse, G., Arter, W., Artigues, V., Asakura, N., Ash, A., Ashikawa, N., Aslanyan, V., Astrain, M., Asztalos, O., Auld, D., Auriemma, F., Austin, Y., Avotina, L., Aymerich, E., Baciero, A., Bairaktaris, F., Balbin, J., Balbinot, L., Balboa, I., Balden, M., Balshaw, C., Balshaw, N., Bandaru, V., Banks, J., Baranov, Y., Barcellona, C., Barnard, A., Barnard, M., Barnsley, R., Barth, A., Baruzzo, M., Barwell, S., Bassan, M., Batista, A., Batistoni, P., Baumane, L., Bauvir, B., Baylor, L., Beaumont, P., Beckett, D., Begolli, A., Beidler, M., Bekris, N., Beldishevski, M., Belli, E., Belli, F., Belonohy, E., Ben Yaala, M., Benayas, J., Bentley, J., Bergsaker, H., Bernardo, J., Bernert, M., Berry, M., Bertalot, L., Betar, H., Beurskens, M., Bickerton, S., Bieg, B., Bielecki, J., Bierwage, A., Biewer, T., Bilato, R., Bílkova, P., Birkenmeier, G., Bishop, H., Bizarro, J., Blackburn, J., Blanchard, P., Blatchford, P., Bobkov, V., Boboc, A., Bohm, P., Bohm, T., Bolshakova, I., Bolzonella, T., Bonanomi, N., Bonfiglio, D., Bonnin, X., Bonofiglo, P., Boocock, S., Booth, A., Booth, J., Borba, D., Borodin, D., Borodkina, I., Boulbe, C., Bourdelle, C., Bowden, M., Boyd, K., Bozicevic Mihalic, I., Bradnam, S., Braic, V., Brandt, L., Bravanec, R., Breizman, B., Brett, A., Brezinsek, S., Brix, M., Bromley, K., Brown, B., Brunetti, D., Buckingham, R., Buckley, M., Budny, R., Buermans, J., Bufferand, H., Buratti, P., Burgess, A., Buscarino, A., Busse, A., Butcher, D., Cal, E., Calabro, G., Calacci, L., Calado, R., Camenen, Y., Canal, G., Cannas, B., Cappelli, M., Carcangiu, S., Card, P., Cardinali, A., Carman, P., Carnevale, D., Carr, M., Carralero, D., Carraro, L., Carvalho, I., Carvalho, P., Casiraghi, I., Casson, F., Castaldo, C., Catalan, J., Catarino, N., Causa, F., Cavedon, M., Cecconello, M., Challis, C., Chamberlain, B., Chang, C., Chankin, A., Chapman, B., Chernyshova, M., Chiariello, A., Chmielewski, P., Chomiczewska, A., Chone, L., Ciraolo, G., Ciric, D., Citrin, J., Ciupinski, t., Clark, M., Clarkson, R., Clements, C., Cleverly, M., Coad, J., Coates, P., Cobalt, A., Coccorese, V., Coelho, R., Coenen, J., Coffey, I., Colangeli, A., Colas, L., Collins, C., Collins, J., Collins, S., Conka, D., Conroy, S., Conway, B., Conway, N., Coombs, D., Cooper, P., Cooper, S., Corradino, C., Corrigan, G., Coster, D., Cox, P., Craciunescu, T., Cramp, S., Crapper, C., Craven, D., Craven, R., Crialesi Esposito, M., Croci, G., Croft, D., Croitoru, A., Crombe, K., Cronin, T., Cruz, N., Crystal, C., Cseh, G., Cufar, A., Cullen, A., Curuia, M., Czarski, T., Dabirikhah, H., Dal Molin, A., Dale, E., Dalgliesh, P., Dalley, S., Dankowski, J., David, P., Davies, A., Davies, S., Davis, G., Dawson, K., Dawson, S., Day, I., De Bock, M., De Temmerman, G., De Tommasi, G., Deakin, K., Deane, J., Dejarnac, R., Del Sarto, D., Delabie, E., Del-Castillo-Negrete, D., Dempsey, A., Dendy, R., Devynck, P., Di Siena, A., Di Troia, C., Dickson, T., Dinca, P., Dittmar, T., Dobrashian, J., Doerner, R., Donne, A., Dorling, S., Dormido-Canto, S., Douai, D., Dowson, S., Doyle, R., Drewelow, P., Drews, P., Drummond, G., Duckworth, P., Dudding, H., Dumont, R., Dumortier, P., Dunai, D., Dunatov, T., Dunne, M., Duran, I., Durodie, F., Dux, R., Dvornova, A., Eastham, R., Edwards, J., Eich, T., Eichorn, A., Eidietis, N., Eksaeva, A., Haroun, H., Ellwood, G., Elsmore, C., Embreus, O., Emery, S., Ericsson, G., Eriksson, B., Eriksson, F., Eriksson, L., Ertmer, S., Esquembri, S., Esquisabel, A., Estrada, T., Evans, G., Evans, S., Fable, E., Fagan, D., Faitsch, M., Falessi, M., Fanni, A., Farahani, A., Farquhar, I., Fasoli, A., Faugeras, B., Fazinie, S., Felici, F., Felton, R., Fernandes, A., Fernandes, H., Ferrand, J., Ferreira, D., Ferreira, J., Ferro, G., Fessey, J., Ficker, O., Field, A., Figueiredo, A., Figueiredo, J., Fil, A., Fil, N., Finburg, P., Fiorucci, D., Fischer, U., Fishpool, G., Fittill, L., Fitzgerald, M., Flammini, D., Flanagan, J., Flinders, K., Foley, S., Fonnesu, N., Fontana, M., Fontdecaba, J., Forbes, S., Formisano, A., Fornal, T., Fortuna, L., Fortuna-Zalesna, E., Fortune, M., Fowler, C., Fransson, E., Frassinetti, L., Freisinger, M., Fresa, R., Fridstrom, R., Frigione, D., Fülop, T., Furseman, M., Fusco, V., Futatani, S., Gadariya, D., Gal, K., Galassi, D., Gafezka, K., Galeani, S., Gallart, D., Galvao, R., Gao, Y., Garcia-Munoz, M., Gardener, M., Garzotti, L., Gaspar, J., Gatto, R., Gaudio, P., Gear, D., Gebhart, T., Gee, S., Gelfusa, M., George, R., Gerasimov, S., Gervasini, G., Gethins, M., Ghani, Z., Gherendi, M., Ghezzi, F., Giacalone, J., Giacomelli, L., Giacometti, G., Gibson, C., Gibson, K., Gil, L., Gillgren, A., Gin, D., Giovannozzi, E., Giroud, C., Glen, R., Gloggler, S., Goff, J., Gohil, P., Goloborodko, V., Gomes, R., Goncalves, B., Goniche, M., Goodyear, A., Gore, S., Gorini, G., Görler, T., Gotts, N., Goulding, R., Gow, E., Graham, B., Graves, J., Greuner, H., Grierson, B., Griffiths, J., Griph, S., Grist, D., Gromelski, W., Groth, M., Grove, R., Gruca, M., Guard, D., Gupta, N., Gurl, C., Gusarov, A., Hackett, L., Hacquin, S., Hager, R., Hagg, L., Hakola, A., Halitovs, M., Hall, S., Hallworth-Cook, S., Ham, C., Hamaguchi, D., Hamed, M., Hamlyn-Harris, C., Hammond, K., Harford, E., Harrison, J., Harting, D., Hatano, Y., Hatch, D., Haupt, T., Hawes, J., Hawkes, N., Hawkins, J., Hayashi, T., Hazael, S., Hazel, S., Heesterman, P., Heidbrink, B., Helou, W., Hemming, O., Henderson, S., Henriques, R., Hepple, D., Herfindal, J., Hermon, G., Hill, J., Hillesheim, J., Hizanidis, K., Hjalmarsson, A., Ho, A., Hobirk, J., Hoenen, O., Hogben, C., Hollingsworth, A., Hollis, S., Hollmann, E., Hoelzl, M., Homan, B., Hook, M., Hopley, D., Horacek, J., Horsley, D., Horsten, N., Horton, A., Horton, L., Horvath, L., Hotchin, S., Howell, R., Hu, Z., Huber, A., Huber, V., Huddleston, T., Huijsmans, G., Huynh, P., Hynes, A., Iliasova, M., lmrie, D., lmrísek, M., lngleby, J., Innocente, P., Insulander Björk, K., Isernia, N., lvanova-Stanik, I., lvings, E., Jablonski, S., Jachmich, S., Jackson, T., Jacquet, P., Järleblad, H., Jaulmes, F., Jenaro Rodriguez, J., Jepu, I., Joffrin, E., Johnson, R., Johnson, T., Johnston, J., Jones, C., Jones, G., Jones, L., Jones, N., Jones, T., Joyce, A., Juarez, R., Juvonen, M., Kalnina, P., Kaltiaisenaho, T., Kaniewski, J., Kantor, A., Kappatou, A., Karhunen, J., Karkinsky, D., Kashchuk, Y., Kaufman, M., Kaveney, G., Kazantzidis, V., Keeling, D., Kelly, R., Kempenaars, M., Kennedy, C., Kennedy, D., Kent, J., Khan, K., Khilkevich, E., Kiefer, C., Kilpeläinen, J., Kim, C., Kim, H., Kim, S., King, D., King, R., Kinna, D., Kiptily, V., Kirjasuo, A., Kirov, K., Kirschner, A., kiviniemi, T., Kizane, G., Klas, M., Klepper, C., Klix, A., Kneale, G., Knight, M., Knight, P., Knights, R., Knipe, S., Knolker, M., Knott, S., Kocan, M., Kochl, F., Kodeli, I., Kolesnichenko, Y., Kominis, Y., Kong, M., Korovin, V., Kos, B., Kos, D., Koslowski, H., Kotschenreuther, M., Koubiti, M., Kowalska-Strzeciwilk, E., Koziol, K., Krasilnikov, A., Krasilnikov, V., Kresina, M., Krieger, K., Krishnan, N., Krivska, A., Kruezi, U., Ksiezek, I., Kukushkin, A., Kumpulainen, H., Kurki-Suonio, T., Kurotaki, H., Kwak, S., Kwon, O., Laguardia, L., Lagzdina, E., Lahtinen, A., Laing, A., Lam, N., Lambertz, H., Lane, B., Lane, C., Lascas Neto, E., Laszyriska, E., Lawson, K., Lazaros, A., Lazzaro, E., Learoyd, G., Lee, C., Lee, S., Leerink, S., Leeson, T., Lefebvre, X., Leggate, H., Lehmann, J., Lehnen, M., Leichtle, D., Leipold, F., Lengar, I., Lennholm, M., Leon Gutierrez, E., Lepiavko, B., Leppanen, J., Lerche, E., Lescinskis, A., Lewis, J., Leysen, W., Li, L., Li, Y., Likonen, J., Linsmeier, C., Lipschultz, B., Litaudon, X., Litherland-Smith, E., Liu, F., Loarer, T., Loarte, A., Lobel, R., Lomanowski, B., Lomas, P., Lopez, J., Lorenzini, R., Loreti, S., Losada, U., Loschiavo, V., Loughlin, M., Louka, Z., Lovell, J., Lowe, T., Lowry, C., Lubbad, S., Luce, T., Lucock, R., Lukin, A., Luna, C., Luna, E., Lungaroni, M., Lungu, C., Lunt, T., Lutsenko, V., Lyons, B., Lyssoivan, A., Machielsen, M., Macusova, E., Mäenpää, R., Maggi, C., Maggiora, R., Magness, M., Mahesan, S., Maier, H., Maingi, R., Malinowski, K., Manas, P., Mantica, P., Mantsinen, M., Manyer, J., Manzanares, A., Maquet, P., Marceca, G., Marcenko, N., Marchetto, C., Marchuk, O., Mariani, A., Mariano, G., Marin, M., Marinelli, M., Markovic, T., Marocco, D., Marot, L., Marsden, S., Marsh, J., Marshall, R., Martellucci, L., Martin, A., Martone, R., Maruyama, S., Maslov, M., Masuzaki, S., Matejcik, S., Mattei, M., Matthews, G., Matveev, D., Matveeva, E., Mauriya, A., Maviglia, F., Mayer, M., Mayoral, M., Mazzotta, C., McAdams, R., McCarthy, P., McClements, K., McClenaghan, J., McCullen, P., McDonald, D., McGuckin, D., McHugh, D., Mclntyre, G., McKean, R., McKehon, J., McMillan, B., McNamee, L., McShee, A., Meakins, A., Medley, S., Meekes, C., Meghani, K., Meigs, A., Meisl, G., Meitner, S., Menmuir, S., Mergia, K., Merriman, S., Mertens, P., Meshchaninov, S., Messiaen, A., Michling, R., Middleton, P., Middleton-Gear, D., Mietelski, J., Milanesio, D., Milani, E., Militello, F., Militello Asp, A., Milnes, J., Milocco, A., Miloshevsky, G., Minghao, C., Minucci, S., Miron, I., Miyamoto, M., Mlynar, J., Moiseenko, V., Monaghan, P., Monakhov, I., Moody, T., Moon, S., Mooney, R., Moradi, S., Morales, J., Morales, R., Mordijck, S., Moreira, L., Morgan, L., Moro, F., Morris, J., Morrison, K., Moser, L., Moulton, D., Mrowetz, T., Mundy, T., Muraglia, M., Murari, A., Muraro, A., Muthusonai, N., N'Konga, B., Na, Y., Nabais, F., Naden, M., Naish, J., Naish, R., Napoli, F., Nardon, E., Naulin, V., Nave, M., Nedzelskiy, I., Nemtsev, G., Nesenevich, V., Nestoras, I., Neu, R., Neverov, V., Ng, S., Nicassio, M., Nielsen, A., Nina, D., Nishijima, D., Noble, C., Nobs, C., Nodwell, D., Nordlund, K., Nordman, H., Normanton, R., Noterdaeme, J., Nowak, S., Nunn, E., Nystrom, H., Oberparleiter, M., Obryk, B., O'Callaghan, J., Odupitan, T., Oliver, H., Olney, R., O'Mullane, M., Organ, E., Orsitto, F., Orszagh, J., Osborne, T., Otin, R., Otsuka, T., Owen, A., Oya, Y., Oyaizu, M., Paccagnella, R., Pace, N., Packer, L., Paige, S., Pajuste, E., Palade, D., Pamela, S., Panadero, N., Panontin, E., Papadopoulos, A., Papp, G., Papp, P., Parail, V., Pardanaud, C., Parisi, J., Parra Diaz, F., Parsloe, A., Parsons, M., Parsons, N., Passeri, M., Patel, A., Pau, A., Pautasso, G., Pavlichenko, R., Pavone, A., Pawelec, E., Paz Soldan, C., Peacock, A., Pearce, M., Peluso, E., Penot, C., Pepperell, K., Pereira, R., Pereira, T., Perelli Cippo, E., Pereslavtsev, P., Perez von Thun, C., Pericoli, V., Perry, D., Peterka, M., Petersson, P., Petravich, G., Petrella, N., Peyman, M., Pillon, M., Pinches, S., Pintsuk, G., Pires de Sa, W., Pires dos Reis, A., Piron, C., Piron, L., Pironti, A., Pitts, R., Plassche, K., Platt, N., Plyusnin, V., Podesta, M., Pokol, G., Poli, F., Pompilian, O., Popovichev, S., Poradzinski, M., Porfiri, M., Porkolab, M., Porosnicu, C., Porton, M., Poulipoulis, G., Predebon, I., Prestopino, G., Price, C., Price, D., Price, M., Primetzhofer, D., Prior, P., Provatas, G., Pucella, G., Puglia, P., Purahoo, K., Pusztai, I., Putignano, O., Pütterich, T., Quercia, A., Rachlew, E., Radulescu, G., Radulovic, V., Rainford, M., Raj, P., Ralph, G., Ramogida, G., Rasmussen, D., Rasmussen, J., Ratta, G., Ratynskaia, S., Rebai, M., Refy, D., Reichle, R., Reinke, M., Reiser, D., Reux, C., Reynolds, S., Richiusa, M., Richyal, S., Rigamonti, D., Rimini, F., Risner, J., Riva, M., Rivero-Rodriguez, J., Roach, C., Robins, R., Robinson, S., Robson, D., Rodionov, R., Rodrigues, P., Rodriguez Ramos, M., Rodriguez-Fernandez, P., Romanelli, F., Romanelli, M., Romanelli, S., Romazanov, J., Rossi, R., Rowe, S., Rowlands, D., Rubel, M., Rubinacci, G., Rubino, G., Ruchko, L., Ruiz, M., Ruiz Ruiz, J., Ruset, C., Rzadkiewicz, J., Saarelma, S., Safi, E., Salewski, M., Salmi, A., Salmon, R., Salzedas, F., Sanders, I., Sandiford, D., Santos, B., Santucci, A., Sarkimaki, K., Sarwar, R., Sarychev, I., Sauter, O., Sauwan, P., Scapin, N., Schluck, F., Schmid, K., Schmuck, S., Schneider, M., Schneider, P., Schworer, D., Scott, G., Scott, M., Scraggs, D., Scully, S., Segato, M., Seo, J., Sergienko, G., Sertoli, M., Sharapov, S., Shaw, A., Sheikh, H., Sheikh, U., Shepherd, A., Shevelev, A., Shigin, P., Shinohara, K., Shiraiwa, S., Shiraki, D., Short, M., Sias, G., Silburn, S., Silva, A., Silva, C., Silva, J., Silvagni, D., Simfukwe, D., Simpson, J., Sinclair, D., Sipilä, S., Sips, A., Siren, P., Sirinelli, A., Sjöstrand, H., Skinner, N., Slater, J., Smith, N., Smith, P., Snell, J., Snoep, G., Snoj, L., Snyder, P., Soare, S., Solano, E., Solokha, V., Somers, A., Sommariva, C., Soni, K., Sorokovoy, E., Sos, M., Sousa, J., Sozzi, C., Spagnolo, S., Spelzini, T., Spineanu, F., Spong, D., Sprada, D., Sridhar, S., Srinivasan, C., Stables, G., Staebler, G., Stamatelatos, I., Staniec, P., Stankunas, G., Stead, M., Stefanikova, E., Stephen, A., Stephens, J., Stevenson, P., Stojanov, M., Strand, P., Strauss, H., Strikwerda, S., Ström, P., Stuart, C., Studholme, W., Subramani, M., Suchkov, E., Sumida, S., Sun, H., Susts, T., Svensson, J., Svoboda, J., Sweeney, R., Sytnykov, D., Szabolics, T., Tabia, B., Tadic, T., Tal, B., Tala, T., Tallargio, A., Tamain, P., Tan, H., Tanaka, K., Tang, W., Tardocchi, M., Taylor, D., Teimane, A., Telesca, G., Teplova, N., Teplukhina, A., Terentyev, D., Terra, A., Terranova, D., Terranova, N., Testa, D., Tholerus, E., Thomas, J., Thoren, E., Thorman, A., Tierens, W., Tinguely, R., Tipton, A., Todd, H., Tokitani, M., Tolias, P., Tomes, M., Tookey, A., Torikai, Y., Toussaint, U., Tsavalas, P., Tskhakaya, D., Turner, I., Turner, M., Turnyanskiy, M., Tvalashvili, G., Tyrrell, S., Tyshchenko, M., Uccello, A., Udintsev, V., Urbanczyk, G., Vadgama, A., Valcarcel, D., Valisa, M., Vallejos Olivares, P., Vallhagen, O., Valovic, M., Van Eester, D., Varje, J., Vartanian, S., Vasilopoulou, T., Vayakis, G., Vecsei, M., Vega, J., Ventre, S., Verdoolaege, G., Verona, C., Verona Rinati, G., Veshchev, E., Vianello, N., Viezzer, E., Vignitchouk, L., Vila, R., Villari, R., Villone, F., Vincenzi, P., Vinyar, I., Viola, B., Virtanen, A., Vitins, A., Vizvary, Z., Vlad, G., Vlad, M., Vondracek, P., de Vries, P., Wakeling, B., Walkden, N., Walker, M., Walker, R., Walsh, M., Wang, E., Wang, N., Warder, S., Warren, R., Waterhouse, J., Watts, C., Wauters, T., Weckmann, A., Wedderburn Maxwell, H., Weiland, M., Weisen, H., Weiszflog, M., Welch, P., Wendler, N., West, A., Wheatley, M., Wheeler, S., Whitehead, A., Whittaker, D., Widdowson, A., Wiesen, S., Wilkinson, J., Williams, J., Willoughby, D., Wilson, I., Wilson, J., Wilson, T., Wischmeier, M., Wise, P., Withenshaw, G., Withycombe, A., Witts, D., Wojcik-Gargula, A., Wolfrum, E., Wood, R., Woodley, C., Woodley, R., Woods, B., Wright, J., Xu, T., Yadikin, D., Yajima, M., Yakovenko, Y., Yang, Y., Yanling, W., Yanovskiy, V., Young, I., Young, R., Zabolockis, R., Zacks, J., Zagorski, R., Zaitsev, F., Zakharov, L., Zarins, A., Zarzoso Fernandez, D., Zastrow, K., Zayachuk, Y., Zerbini, M., Zhang, W., Zhou, Y., Zlobinski, M., Zocco, A., Zohar, A., Zoita, V., Zoletnik, S., Zotta, V., Zoulias, I., Zwingmann, W., Zychor, I., Physique des interactions ioniques et moléculaires (PIIM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche sur la Fusion par confinement Magnétique (IRFM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Swiss Plasma Center (SPC), Ecole Polytechnique Fédérale de Lausanne (EPFL), Laboratory for Plasma Physics (LPP), Ecole Royale Militaire / Koninklijke Militaire School (ERM KMS), Kharkiv Institute of Physics and Technology (Ukraine), V.N. Karazin Kharkiv National University (KhNU), Dipartimento di Fisica (Milano), Università degli Studi di Milano = University of Milan (UNIMI), Consiglio Nazionale delle Ricerche [Milano] (CNR), Jozef Stefan Institute [Ljubljana] (IJS), Culham Centre for Fusion Energy (CCFE), Department of Physics and Astronomy [Uppsala], Uppsala University, This work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014–2018 and 2019–2020 under Grant agreement No 633053., Mazzi, S, Garcia, J, Zarzoso, D, Kazakov, Y, Ongena, J, Dreval, M, Nocente, M, Stancar, Z, Szepesi, G, Eriksson, J, Sahlberg, A, Benkadda, S, Abid, N, Abraham, K, Abreu, P, Adabonyan, O, Adrich, P, Afzal, M, Ahlgren, T, Aho-Mantila, L, Aiba, N, Airila, M, Akhtar, M, Albanese, R, Alderson-Martin, M, Alegre, D, Aleiferis, S, Aleksa, A, Alessi, E, Aleynikov, P, Algualcil, J, Ali, M, Allinson, M, Alper, B, Alves, E, Ambrosino, G, Ambrosino, R, 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K., Zoulias, I., Zwingmann, W., Zychor, I., JET Contributors, Science and Technology of Nuclear Fusion, EIRES Eng. for Sustainable Energy Systems, Magneto-Hydro-Dynamic Stability of Fusion Plasmas, Applied Physics and Science Education, Kazakov, Yo, VTT Technical Research Centre of Finland, Culham Science Centre, Princeton Plasma Physics Laboratory, Department of Applied Physics, European Commission, Forschungszentrum Jülich, Universidade Lisboa, Fusion and Plasma Physics, University of Milan - Bicocca, Aalto University, General Atomics, ITER, University of Toyama, CEA, Oak Ridge National Laboratory, Technical University of Madrid, Swiss Federal Institute of Technology Lausanne, Dutch Institute for Fundamental Energy Research, Royal Military Academy, Seoul National University, Chalmers University of Technology, Max Planck Institute for Plasma Physics, KTH Royal Institute of Technology, and Aalto-yliopisto
Subjects: [PHYS]Physics [physics], Settore FIS/01, Settore ING-IND/18 - Fisica dei Reattori Nucleari, General Physics and Astronomy, simulation, magnetically confined plasma, nuclear fusion, tokamaks, turbulence suppression, Plasma, [PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], confinement, transport, Alpha particles, Fusion reactors, Turbulence, physics
Abstract: openaire: EC/H2020/633053/EU//EUROfusion Funding Information: We thank M. Baruzzo and F. Nave for the preparation and execution of JET experiments discussed in this paper; E. de la Luna for support in detailing the experimental diagnostics of JET; A. Ho for assistance in processing the experimental data; T. Görler for providing essential advice to ensure the correct numerical setup for the GENE modelling reported in this paper; Y. Camenen, X. Garbet and A. Bierwage for fruitful discussions about the gyrokinetic analyses; G. Giruzzi for valuable suggestions on the article strategy. The simulations were performed on the IRENE Joliot-Curie HPC system, in the framework of the PRACE projects IONFAST and AFIETC, led by J. Garcia, and on the CINECA Marconi HPC within the project GENE4EP, led by D. Zarzoso. This work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014-2018 and 2019-2020 under grant agreement no. 633053. The views and opinions express herein do not necessarily reflect those of the European Commission. Part of the work by Ye. O. Kazakov and J.Ongena was also carried out in the framework of projects done for the ITER Scientist Fellow Network (ISFN). Funding Information: We thank M. Baruzzo and F. Nave for the preparation and execution of JET experiments discussed in this paper; E. de la Luna for support in detailing the experimental diagnostics of JET; A. Ho for assistance in processing the experimental data; T. Görler for providing essential advice to ensure the correct numerical setup for the GENE modelling reported in this paper; Y. Camenen, X. Garbet and A. Bierwage for fruitful discussions about the gyrokinetic analyses; G. Giruzzi for valuable suggestions on the article strategy. The simulations were performed on the IRENE Joliot-Curie HPC system, in the framework of the PRACE projects IONFAST and AFIETC, led by J. Garcia, and on the CINECA Marconi HPC within the project GENE4EP, led by D. Zarzoso. This work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014-2018 and 2019-2020 under grant agreement no. 633053. The views and opinions express herein do not necessarily reflect those of the European Commission. Part of the work by Ye. O. Kazakov and J.Ongena was also carried out in the framework of projects done for the ITER Scientist Fellow Network (ISFN). Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Nature Limited. Alpha particles with energies on the order of megaelectronvolts will be the main source of plasma heating in future magnetic confinement fusion reactors. Instead of heating fuel ions, most of the energy of alpha particles is transferred to electrons in the plasma. Furthermore, alpha particles can also excite Alfvénic instabilities, which were previously considered to be detrimental to the performance of the fusion device. Here we report improved thermal ion confinement in the presence of megaelectronvolts ions and strong fast ion-driven Alfvénic instabilities in recent experiments on the Joint European Torus. Detailed transport analysis of these experiments reveals turbulence suppression through a complex multi-scale mechanism that generates large-scale zonal flows. This holds promise for more economical operation of fusion reactors with dominant alpha particle heating and ultimately cheaper fusion electricity.
Published: 2022

6. Female-specific neuroprotection after ischemic stroke by vitronectin-focal adhesion kinase inhibition

Author: Jia, Cuihong, Lovins, Chiharu, Malone, Hannah M, Keasey, Matthew P, and Hagg, Theo
Subjects: Inflammation, Integrins, Interleukin-6, Anti-Inflammatory Agents, Original Articles, Neuroprotection, Brain Ischemia, Mice, Inbred C57BL, Stroke, Mice, Neurology, Focal Adhesion Protein-Tyrosine Kinases, Animals, Humans, Female, Vitronectin, Neurology (clinical), Cardiology and Cardiovascular Medicine, Ischemic Stroke
Abstract: We found that blood vitronectin (VTN) leaks into the brain and exacerbates tissue loss after stroke by increasing pro-inflammatory IL-6 expression in female, but not male, mice. VTN signals through integrins and downstream focal adhesion kinase (FAK). Here, a two day systemic treatment with a small molecule FAK inhibitor starting 6 h after middle cerebral artery occlusion reduced ipsilateral brain injury size by ∼40–45% at 7 and 14 d, as well as inflammation and motor dysfunction in wild-type female, but not male, mice. FAK inhibition also reduced IL-6 expression in the injured female striatum at 24 h by 62%. Inducible selective gene deletion of FAK in astrocytes also reduced acute IL-6 expression by 72% only in females, and mitigated infarct size by ∼80% and inflammation at 14 d after stroke. Lastly, VTN−/− females had better outcomes, but FAK inhibitor treatment had no additional protective or anti-inflammatory effects. Altogether, this suggests that VTN is detrimental in females primarily through FAK and that FAK inhibition provides neuroprotection (cerebroprotection) by reducing VTN-induced IL-6 expression in astrocytes. Thus, VTN signaling can be targeted to mitigate harmful inflammation with relevance to treatments for women with ischemic stroke, who often have worse outcomes than men.
Published: 2022

7. Targeting activins and inhibins to treat reproductive disorders and cancer cachexia

Author: Adam Hagg, Eliza O'Shea, Craig A. Harrison, and Kelly Louise Walton
Subjects: Endocrinology, Endocrinology, Diabetes and Metabolism
Abstract: Although originally characterised as proteins involved in the control of reproductive function, activins, and to a lesser degree inhibins, are also important regulators of homeostasis in extragonadal tissues. Accordingly, disrupted inhibin/activin expression can have detrimental effects not only for fertility and fecundity, but also for the regulation of muscle, fat and bone mass. Indeed, only recently, two complementary mouse models of inhibin designed to lack bioactivity/responsiveness, revealed that inhibin A/B deficiency during pregnancy, restricts embryo and foetal survival. Conversely, hyper elevated levels of activin A/B, as are frequently observed in patients with advanced cancers, can not only promote gonadal tumour growth but also cancer-cachexia. As such, it is not surprising that inhibin/activin genetic variations or altered circulating levels have been linked to reproductive disorders and cancer. Whilst some of the detrimental health effects associated with disrupted inhibin/activin levels can be attributed to accompanied changes in circulating follicle stimulating hormone (FSH) levels, there is now abundant evidence that activins, in particular, have fundamental FSH-independent tissue homeostatic roles. Increased understanding of inhibin/activin activity, garnered over several decades, has enabled the development of targeted therapies with applications for both reproductive and extra-gonadal tissues. Inhibin- or activin-targeted technologies have been shown not just to enhance fertility and fecundity, but also to reduce disease severity in models of cancer cachexia. Excitingly, these technologies are likely to benefit human medicine and be highly valuable to animal breeding and veterinary programs.
Published: 2023

8. Supplemental Figure Legends from Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia

Author: Paul Gregorevic, Craig A. Harrison, Matthew J. Watt, Adam Hagg, Timothy D. Colgan, Hongwei Qian, Kelly L. Walton, and Justin L. Chen
Abstract: Legends
Published: 2023

9. Data from Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia

Author: Paul Gregorevic, Craig A. Harrison, Matthew J. Watt, Adam Hagg, Timothy D. Colgan, Hongwei Qian, Kelly L. Walton, and Justin L. Chen
Abstract: Cachexia is a life-threatening wasting syndrome lacking effective treatment, which arises in many cancer patients. Although ostensibly induced by multiple tumor-produced cytokines (tumorkines), their functional contribution to initiation and progression of this syndrome has proven difficult to determine. In this study, we used adeno-associated viral vectors to elevate circulating levels of the tumorkines IL6 and/or activin A in animals in the absence of tumors as a tactic to evaluate hypothesized roles in cachexia development. Mice with elevated levels of IL6 exhibited 8.1% weight loss after 9 weeks, whereas mice with elevated levels of activin A lost 11% of their body weight. Co-elevation of both tumorkines to levels approximating those observed in cancer cachexia models induced a more rapid and profound body weight loss of 15.4%. Analysis of body composition revealed that activin A primarily triggered loss of lean mass, whereas IL6 was a major mediator of fat loss. Histologic and transcriptional analysis of affected organs/tissues (skeletal muscle, fat, and liver) identified interactions between the activin A and IL6 signaling pathways. For example, IL6 exacerbated the detrimental effects of activin A in skeletal muscle, whereas activin A curbed the IL6-induced acute-phase response in liver. This study presents a useful model to deconstruct cachexia, opening a pathway to determining which tumorkines are best targeted to slow/reverse this devastating condition in cancer patients. Cancer Res; 76(18); 5372–82. ©2016 AACR.
Published: 2023

10. Supplementary figure 3 from Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia

Author: Paul Gregorevic, Craig A. Harrison, Matthew J. Watt, Adam Hagg, Timothy D. Colgan, Hongwei Qian, Kelly L. Walton, and Justin L. Chen
Abstract: Titrating rAAV6:IL-6 doses in wild type mice to elevate circulating levels of IL-6. High doses of rAAV6:IL-6 result in cachexia.
Published: 2023

11. Supplementary figure 4 from Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia

Author: Paul Gregorevic, Craig A. Harrison, Matthew J. Watt, Adam Hagg, Timothy D. Colgan, Hongwei Qian, Kelly L. Walton, and Justin L. Chen
Abstract: TA muscles of mice injected with rAAV6:TNF-α and rAAV6:Tweak exhibited muscle loss and increases in the phosphorylation of p65, but did not induce cachexia.
Published: 2023

12. Supplementary figure 8 from Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia

Author: Paul Gregorevic, Craig A. Harrison, Matthew J. Watt, Adam Hagg, Timothy D. Colgan, Hongwei Qian, Kelly L. Walton, and Justin L. Chen
Abstract: Comparing the rate of lean and fat mass loss in mice bearing colon-26 tumors and mice injected with rAAV6:activin A and/or rAAV6:IL-6.
Published: 2023

13. Supplementary Figure 7 from Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia

Author: Paul Gregorevic, Craig A. Harrison, Matthew J. Watt, Adam Hagg, Timothy D. Colgan, Hongwei Qian, Kelly L. Walton, and Justin L. Chen
Abstract: In mice injected with AAV:activin A and/or AAV:IL6, the liver was examined for expression of extracellular matrix genes and collagen deposition.
Published: 2023

14. Supplementary figure 6 from Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia

Author: Paul Gregorevic, Craig A. Harrison, Matthew J. Watt, Adam Hagg, Timothy D. Colgan, Hongwei Qian, Kelly L. Walton, and Justin L. Chen
Abstract: In mice injected with rAAV6:activin A and/or rAAV6:IL-6, the mRNA expression of E3 ubiquitin ligases was determined in quadriceps muscles. In addition, skeletal muscle, epididymal WAT and BAT depots were probed for IL-6 target genes or genes involved in lipolysis and browning.
Published: 2023

15. Supplementary figure 1 from Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia

Author: Paul Gregorevic, Craig A. Harrison, Matthew J. Watt, Adam Hagg, Timothy D. Colgan, Hongwei Qian, Kelly L. Walton, and Justin L. Chen
Abstract: Mice bearing colon-26 tumors rapidly lose lean and fat mass, together with significant wasting of muscle groups. These losses correlate with increases in the phosphorylation of the transcription factors, Stat3 and Smad3, which are activated by IL-6 and activin A, respectively. Smad3 target genes are also altered in cachectic mice.
Published: 2023

16. Supplementary figure 2 from Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia

Author: Paul Gregorevic, Craig A. Harrison, Matthew J. Watt, Adam Hagg, Timothy D. Colgan, Hongwei Qian, Kelly L. Walton, and Justin L. Chen
Abstract: mRNA expression of activin A and Il-6 in the TA muscle, heart, liver and spleen of mice bearing colon-26 tumors.
Published: 2023

17. Parsley Health: Feasibility and acceptability of a large-scale holistic telehealth program for chronic disease care

Author: Hants Williams, Sarah Steinberg, Ryan Vingum, Kendall Leon, Elena Céspedes, Robin Berzin, and Heather Hagg
Subjects: Biomedical Engineering, Medicine (miscellaneous), Health Informatics, Computer Science Applications
Abstract: BackgroundA holistic, personalized approach to medicine can be used to prevent and manage a variety of chronic diseases. However, effectively managing chronic diseases can be difficult due to barriers related to insufficient provider time, staffing, and lack of patient engagement. To address these challenges telehealth strategies are being increasingly adopted, yet few studies have explored how to evaluate the feasibility and implementation success of large-scale holistic telehealth models for chronic disease care. The aim of this study is to assess the feasibility and acceptability of a large-scale holistic telehealth program for the management of chronic diseases. Our study findings can inform the future development and assessment of chronic disease programs delivered through telehealth strategies.MethodsData was collected from participants enrolled in a Parsley Health membership from June 1, 2021 to June 1, 2022, a subscription-based holistic medicine practice designed to help people prevent or manage chronic diseases. Implementation outcome frameworks were used to understand engagement with services, participant satisfaction, and preliminary effectiveness of the program via a patient-reported symptom severity tool.ResultsData from 10,205 participants with a range of chronic diseases were included in our analysis. Participants averaged 4.8 visits with their clinical team and reported high levels of satisfaction with their care (average NPS score of 81.35%). Preliminary evidence also showed substantial reduction in patient reported symptom severity.ConclusionOur findings suggest the Parsley Health program is a feasible and acceptable large-scale holistic telehealth program for chronic disease care. Successful implementation was due, in part, to services that promoted participant engagement along with tools and interfaces that were helpful and easy to use. These findings can be used to develop future holistic-focused telehealth programs for the management and prevention of chronic diseases.
Published: 2023

18. Methodology of the brodalumab assessment of hazards:a multicentre observational safety (BRAHMS) study

Author: Mette Reilev, Peter Bjødstrup Jensen, Lise Skov Ranch, Alexander Egeberg, Kari Furu, Karin Gembert, David Hagg, Ulrike Haug, Øystein Karlstad, Johan Reutfors, Wiebke Schäfer, Sarina Schwartz, Elisabeth Smits, Emily Holthius, Ron Herings, Gianluca Trifirò, Ursula Kirchmayer, Alessandro Cesare Rosa, Valeria Belleudi, Rosa Gini, Henrik Støvring, Jesper Hallas, Epidemiology and Data Science, APH - Methodology, and APH - Quality of Care
Subjects: Adverse events, CARDIOLOGY, INFECTIOUS DISEASES, ONCOLOGY, Psoriasis, Suicide & self-harm, Suicide &amp, General Medicine, self-harm
Abstract: IntroductionSafe and effective pharmacological treatment is of paramount importance for treating severe psoriasis. Brodalumab, a monoclonal antibody against interleukin (IL) 17 receptor A, was granted marketing authorisation in the EU in 2017. The European Medicines Agency requested a postauthorisation safety study of brodalumab to address potential safety issues raised during drug development regarding major adverse cardiovascular events, suicidal conduct, cancer and serious infections.Methods and analysisBRodalumab Assessment of Hazards: A Multinational Safety is a multicentre observational safety study of brodalumab running from 2017 to 2029 using population-based healthcare databases from Denmark, Sweden, Norway, Netherlands, Germany and three different centres in Italy. A distributed database network approach is used, such that only aggregate data are exchanged between sites.Two types of designs are used: a case-time-control design to study acute effects of transient treatment and a variation of the new user active comparator design to study the effects of transient or chronic treatment. As comparators, inhibitors of TNF-α, inhibitors of IL-12 and IL-23, and other inhibitors of cytokine IL-17A are included.In the self-controlled case-time-control design, the risk of developing the outcome of interest during periods of brodalumab use is compared within individuals to the risk in periods without use.In the active comparator cohort design, new users of brodalumab are identified and matched to new users of active comparators. Potential baseline confounders are adjusted for by using propensity score modelling. For outcomes that potentially require large cumulative exposure, an adapted active comparator design has been developed.Ethics and disseminationThe study is approved by relevant authorities in Denmark, Norway, Sweden, the Netherlands, Germany and Italy in line with the relevant legislation at each site. Data confidentiality is secured by the distributed network approach. Results will be published in peer-reviewed journals.Trial registration numberEUPAS30280.
Published: 2023

19. Efficient Quality Diversity Optimization of 3D Buildings through 2D Pre-optimization

Author: Hagg, Alexander, Kliemank, Martin L., Asteroth, Alexander, Wilde, Dominik, Bedrunka, Mario C., Foysi, Holger, and Reith, Dirk
Subjects: FOS: Computer and information sciences, Computer Science - Machine Learning, Computational Mathematics, Computer Science - Neural and Evolutionary Computing, Neural and Evolutionary Computing (cs.NE), Machine Learning (cs.LG)
Abstract: Quality diversity algorithms can be used to efficiently create a diverse set of solutions to inform engineers' intuition. But quality diversity is not efficient in very expensive problems, needing 100.000s of evaluations. Even with the assistance of surrogate models, quality diversity needs 100s or even 1000s of evaluations, which can make it use infeasible. In this study we try to tackle this problem by using a pre-optimization strategy on a lower-dimensional optimization problem and then map the solutions to a higher-dimensional case. For a use case to design buildings that minimize wind nuisance, we show that we can predict flow features around 3D buildings from 2D flow features around building footprints. For a diverse set of building designs, by sampling the space of 2D footprints with a quality diversity algorithm, a predictive model can be trained that is more accurate than when trained on a set of footprints that were selected with a space-filling algorithm like the Sobol sequence. Simulating only 16 buildings in 3D, a set of 1024 building designs with low predicted wind nuisance is created. We show that we can produce better machine learning models by producing training data with quality diversity instead of using common sampling techniques. The method can bootstrap generative design in a computationally expensive 3D domain and allow engineers to sweep the design space, understanding wind nuisance in early design phases., Comment: This is the final version and has been accepted for publication in Evolutionary Computation (MIT Press)
Published: 2023
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20. On the Suitability of Representations for Quality Diversity Optimization of Shapes

Author: Scarton, Ludovico and Hagg, Alexander
Subjects: FOS: Computer and information sciences, Computer Science - Neural and Evolutionary Computing, Neural and Evolutionary Computing (cs.NE)
Abstract: The representation, or encoding, utilized in evolutionary algorithms has a substantial effect on their performance. Examination of the suitability of widely used representations for quality diversity optimization (QD) in robotic domains has yielded inconsistent results regarding the most appropriate encoding method. Given the domain-dependent nature of QD, additional evidence from other domains is necessary. This study compares the impact of several representations, including direct encoding, a dictionary-based representation, parametric encoding, compositional pattern producing networks, and cellular automata, on the generation of voxelized meshes in an architecture setting. The results reveal that some indirect encodings outperform direct encodings and can generate more diverse solution sets, especially when considering full phenotypic diversity. The paper introduces a multi-encoding QD approach that incorporates all evaluated representations in the same archive. Species of encodings compete on the basis of phenotypic features, leading to an approach that demonstrates similar performance to the best single-encoding QD approach. This is noteworthy, as it does not always require the contribution of the best-performing single encoding.
Published: 2023
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21. Cyber-Physical-Systems for Fluid Manufacturing Systems

Author: Bozkurt, Ali, Fries, Christian, Tasci, Timur, Leberle, Urs, Kessler, Daniel, Joos, Markus, Hagg, Manuel, Neuschwander, Bernd, Hinderer, Moritz, Herberger, David, Hübner, Marco, and Stich, Volker
Subjects: Human-centered Production, Digital Twin, Dewey Decimal Classification::600 | Technik::620 | Ingenieurwissenschaften und Maschinenbau, Automotive, ddc:620, Material Flow Control, Konferenzschrift, Cyber-physical Systems, Fluid Manufacturing Systems
Abstract: Increased volatility continues to challenge the automotive manufacturer's production performance. More than a century after the start of mass production, changeable production systems that allow the flexibility for the economic mass production of customized products have arisen. Limitations on established production systems are driving the development of changeable production systems like the Fluid Manufacturing System (FLMS). In an FLMS, the individual production modules are mobile and consist of Cyber-Physical Systems (CPS) which can be combined ad-hoc to adapt to changing requirements. By connecting different CPS - e.g., Autonomous Mobile Robots (AMR) or smart load carriers - adaptable and flexible production will be achieved. This paper presents the first real-world initiation of an FLMS with the design and development of CPS and digital twins for production and logistics at the ARENA2036 research campus.
Published: 2023
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22. The Pretoria Bone Collection: A 21st Century Skeletal Collection in South Africa

Author: Ericka N. L’Abbé, Gabriele C. Krüger, Charlotte E. G. Theye, Alieske C. Hagg, and Okuhle Sapo
Subjects: skeletal collections, digital repository, legislation, whole body donation, biological anthropology, cadavers
Abstract: The Pretoria Bone Collection (PBC) began in 1942 with the opening of a medical school at the University of Pretoria (UP) in Pretoria, South Africa, where this skeletal collection is housed in the Department of Anatomy. The purpose of this paper is to provide information on the national legislation associated with obtaining, curating and researching skeletal remains in South Africa, the demographic composition of the PBC, and the inclusion of a portion of these remains into a digital repository known as Bakeng se Afrika (BsA). The PBC comprises 873 complete skeletons, 344 complete postcrania without crania, and 308 complete crania without postcrania. Skeletal contents are reflective of the population statistics of South Africa, with a smaller proportion of White (32%) than Black (65%) South Africans. Unlike the population profile, males in the PBC are greater in number (75.5%) than females (24.5%), which may be explained by the number of migrant labourers traveling into a large city such as Pretoria. From this sample, crania (206), maxillae (141), mandibulae (408), femora (137), and radii (134), as well as several other skeletal elements were micro-XCT scanned and are available on the BsA server. A researcher needs to submit an online application to the Human Research Ethics Committee (HREC) of the Faculty of Health Sciences at the University of Pretoria for access to these collections.
Published: 2021

23. Validation of the utilisation of automatic placement of anatomical and sliding landmarks on three-dimensional models for shape analysis of human pelves

Author: TM Mbonani, AC Hagg, EN L'Abbé, AC Oettlé, and AF Ridel
Subjects: Radiology, Nuclear Medicine and imaging, Pathology and Forensic Medicine
Published: 2023

24. Early downregulation of hsa-miR-144-3p in serum from drug-naïve Parkinson's disease patients

Author: Zago E., Dal Molin A., Dimitri G. M., Xumerle L., Pirazzini C., Bacalini M. G., Maturo M. G., Azevedo T., Spasov S., Gomez-Garre P., Perinan M. T., Jesus S., Baldelli L., Sambati L., Calandra Buonaura G., Garagnani P., Provini F., Cortelli P., Mir P., Trenkwalder C., Mollenhauer B., Franceschi C., Lio P., Nardini C., Adarmes-Gomez A., Bartoletti-Stella A., Bhatia K. P., Marta B. -T., Boninsegna C., Broli M., Dolores B. -R., Calandra-Buonaura G., Capellari S., Carrion-Claro M., Cilea R., Clayton R., Molin A. D., De Luca S., De Massis P., Doykov I., Escuela-Martin R., Fabbri G., Gabellini A., Giuliani C., Guaraldi P., Hagg S., Hallqvist J., Halsband C., Heywood W., Houlden H., Huertas I., Jylhava J., Labrador-Espinosa M. A., Licari C., Luchinat C., Macias D., Macri S., Magrinelli F., Rodriguez J. F. M., Massimo D., Mengozzi G., Meoni G., Mignani F., Milazzo M., Mills K., Nassetti S. A., Pedersen N. L., Perinan-Tocino M. T., Ravaioli F., Sala C., Scaglione C. L. M., Schade S., Schreglmann S., Strom S., Tejera-Parrado C., Tenori L., Turano P., Valzania F., Ortega R. V., Williams D., Apollo - University of Cambridge Repository, Zago E., Dal Molin A., Dimitri G.M., Xumerle L., Pirazzini C., Bacalini M.G., Maturo M.G., Azevedo T., Spasov S., Gomez-Garre P., Perinan M.T., Jesus S., Baldelli L., Sambati L., Calandra Buonaura G., Garagnani P., Provini F., Cortelli P., Mir P., Trenkwalder C., Mollenhauer B., Franceschi C., Lio P., Nardini C., Adarmes-Gomez A., Bartoletti-Stella A., Bhatia K.P., Marta B.-T., Boninsegna C., Broli M., Dolores B.-R., Calandra-Buonaura G., Capellari S., Carrion-Claro M., Cilea R., Clayton R., Molin A.D., De Luca S., De Massis P., Doykov I., Escuela-Martin R., Fabbri G., Gabellini A., Giuliani C., Guaraldi P., Hagg S., Hallqvist J., Halsband C., Heywood W., Houlden H., Huertas I., Jylhava J., Labrador-Espinosa M.A., Licari C., Luchinat C., Macias D., Macri S., Magrinelli F., Rodriguez J.F.M., Massimo D., Mengozzi G., Meoni G., Mignani F., Milazzo M., Mills K., Nassetti S.A., Pedersen N.L., Perinan-Tocino M.T., Ravaioli F., Sala C., Scaglione C.L.M., Schade S., Schreglmann S., Strom S., Tejera-Parrado C., Tenori L., Turano P., Valzania F., Ortega R.V., and Williams D.
Subjects: Male, Aging, Molecular biology, Science, Immunology, Article, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Medical research, Humans, Parkinson, 030304 developmental biology, Aged, 0303 health sciences, Multidisciplinary, Biological techniques, Parkinson Disease, Middle Aged, 3. Good health, nervous system diseases, Computational biology and bioinformatics, MicroRNAs, Neurology, ageing, Medicine, Female, 030217 neurology & neurosurgery, Biomarkers
Abstract: Advanced age represents one of the major risk factors for Parkinson's Disease. Recent biomedical studies posit a role for microRNAs, also known to be remodelled during ageing. However, the relationship between microRNA remodelling and ageing in Parkinson's Disease, has not been fully elucidated. Therefore, the aim of the present study is to unravel the relevance of microRNAs as biomarkers of Parkinson's Disease within the ageing framework. We employed Next Generation Sequencing to profile serum microRNAs from samples informative for Parkinson's Disease (recently diagnosed, drug-naïve) and healthy ageing (centenarians) plus healthy controls, age-matched with Parkinson's Disease patients. Potential microRNA candidates markers, emerging from the combination of differential expression and network analyses, were further validated in an independent cohort including both drug-naïve and advanced Parkinson's Disease patients, and healthy siblings of Parkinson's Disease patients at higher genetic risk for developing the disease. While we did not find evidences of microRNAs co-regulated in Parkinson's Disease and ageing, we report that hsa-miR-144-3p is consistently down-regulated in early Parkinson's Disease patients. Moreover, interestingly, functional analysis revealed that hsa-miR-144-3p is involved in the regulation of coagulation, a process known to be altered in Parkinson's Disease. Our results consistently show the down-regulation of hsa-mir144-3p in early Parkinson's Disease, robustly confirmed across a variety of analytical and experimental analyses. These promising results ask for further research to unveil the functional details of the involvement of hsa-mir144-3p in Parkinson's Disease., This work was supported by the Horizon 2020 Framework Programme (Grant number 634821, PROPAG-AGING).
Published: 2022

25. Disruption prediction with artificial intelligence techniques in tokamak plasmas

Author: Vega, J., Murari, A., Dormido-Canto, S., Rattá, G. A., Gelfusa, M., Mailloux, J., Abid, N., Abraham, K., Abreu, P., Adabonyan, O., Adrich, P., Afanasev, V., Afzal, M., Ahlgren, T., Aho-Mantila, L., Aiba, N., Airila, M., Akhtar, M., Albanese, R., Alderson-Martin, M., Alegre, D., Aleiferis, S., Aleksa, A., Alekseev, A. G., Alessi, E., Aleynikov, P., Algualcil, J., Ali, M., Allinson, M., Alper, B., Alves, E., Ambrosino, G., Ambrosino, R., Amosov, V., Andersson Sundén, E., Andrew, P., Angelini, B. M., Angioni, C., Antoniou, I., Appel, L. C., Appelbee, C., Aria, S., Ariola, M., Artaserse, G., Arter, W., Artigues, V., Asakura, N., Ash, A., Ashikawa, N., Aslanyan, V., Astrain, M., Asztalos, O., Auld, D., Auriemma, F., Austin, Y., Avotina, L., Aymerich, E., Baciero, A., Bairaktaris, F., Balbin, J., Balbinot, L., Balboa, I., Balden, M., Balshaw, C., Balshaw, N., Bandaru, V. K., Banks, J., Baranov, Yu. F., Barcellona, C., Barnard, A., Barnard, M., Barnsley, R., Barth, A., Baruzzo, M., Barwell, S., Bassan, M., Batista, A., Batistoni, P., Baumane, L., Bauvir, B., Baylor, L., Beaumont, P. S., Beckett, D., Begolli, A., Beidler, M., Bekris, N., Beldishevski, M., Belli, E., Belli, F., Belonohy, É., Ben Yaala, M., Benayas, J., Bentley, J., Bergsaker, H., Bernardo, J., Bernert, M., Berry, M., Bertalot, L., Betar, H., Beurskens, M., Bickerton, S., Bieg, B., Bielecki, J., Bierwage, A., Biewer, T., Bilato, R., Bílková, P., Birkenmeier, G., Bishop, H., Bizarro, J. P. S., Blackburn, J., Blanchard, P., Blatchford, P., Bobkov, V., Boboc, A., Bohm, P., Bohm, T., Bolshakova, I., Bolzonella, T., Bonanomi, N., Bonfiglio, D., Bonnin, X., Bonofiglo, P., Boocock, S., Booth, A., Booth, J., Borba, D., Borodin, D., Borodkina, I., Boulbe, C., Bourdelle, C., Bowden, M., Boyd, K., Božičević Mihalić, I., Bradnam, S. C., Braic, V., Brandt, L., Bravanec, R., Breizman, B., Brett, A., Brezinsek, S., Brix, M., Bromley, K., Brown, B., Brunetti, D., Buckingham, R., Buckley, M., Budny, R., Buermans, J., Bufferand, H., Buratti, P., Burgess, A., Buscarino, A., Busse, A., Butcher, D., de la Cal, E., Calabro, G., Calacci, L., Calado, R., Camenen, Y., Canal, G., Cannas, B., Cappelli, M., Carcangiu, S., Card, P., Cardinali, A., Carman, P., Carnevale, D., Carr, M., Carralero, D., Carraro, L., Carvalho, I. S., Carvalho, P., Casiraghi, I., Casson, F. J., Castaldo, C., Catalan, J. P., Catarino, N., Causa, F., Cavedon, M., Cecconello, M., Challis, C. D., Chamberlain, B., Chang, C. S., Chankin, A., Chapman, B., Chernyshova, M., Chiariello, A., Chmielewski, P., Chomiczewska, A., Chone, L., Ciraolo, G., Ciric, D., Citrin, J., Ciupinski, T., Clark, M., Clarkson, R., Clements, C., Cleverly, M., Coad, J. P., Coates, P., Cobalt, A., Coccorese, V., Coelho, R., Coenen, J. W., Coffey, I. H., Colangeli, A., Colas, L., Collins, C., Collins, J., Collins, S., Conka, D., Conroy, S., Conway, B., Conway, N. J., Coombs, D., Cooper, P., Cooper, S., Corradino, C., Corrigan, G., Coster, D., Cox, P., Craciunescu, T., Cramp, S., Crapper, C., Craven, D., Craven, R., Crialesi Esposito, M., Croci, G., Croft, D., Croitoru, A., Crombé, K., Cronin, T., Cruz, N., Crystal, C., Cseh, G., Cufar, A., Cullen, A., Curuia, M., Czarski, T., Dabirikhah, H., Dal Molin, A., Dale, E., Dalgliesh, P., Dalley, S., Dankowski, J., David, P., Davies, A., Davies, S., Davis, G., Dawson, K., Dawson, S., Day, I. E., De Bock, M., De Temmerman, G., De Tommasi, G., Deakin, K., Deane, J., Dejarnac, R., Del Sarto, D., Delabie, E., Del-Castillo-Negrete, D., Dempsey, A., Dendy, R. O., Devynck, P., Di Siena, A., Di Troia, C., Dickson, T., Dinca, P., Dittmar, T., Dobrashian, J., Doerner, R. P., Donné, A. J. H., Dorling, S., Douai, D., Dowson, S., Doyle, R., Dreval, M., Drewelow, P., Drews, P., Drummond, G., Duckworth, Ph., Dudding, H., Dumont, R., Dumortier, P., Dunai, D., Dunatov, T., Dunne, M., Duran, I., Durodié, F., Dux, R., Dvornova, A., Eastham, R., Edwards, J., Eich, Th., Eichorn, A., Eidietis, N., Eksaeva, A., El Haroun, H., Ellwood, G., Elsmore, C., Embreus, O., Emery, S., Ericsson, G., Eriksson, B., Eriksson, F., Eriksson, J., Eriksson, L. G., Ertmer, S., Esquembri, S., Esquisabel, A. L., Estrada, T., Evans, G., Evans, S., Fable, E., Fagan, D., Faitsch, M., Falessi, M., Fanni, A., Farahani, A., Farquhar, I., Fasoli, A., Faugeras, B., Fazinié, S., Felici, F., Felton, R., Fernandes, A., Fernandes, H., Ferrand, J., Ferreira, D. R., Ferreira, J., Ferro, G., Fessey, J., Ficker, O., Field, A. R., Figueiredo, A., Figueiredo, J., Fil, A., Fil, N., Finburg, P., Fiorucci, D., Fischer, U., Fishpool, G., Fittill, L., Fitzgerald, M., Flammini, D., Flanagan, J., Flinders, K., Foley, S., Fonnesu, N., Fontana, M., Fontdecaba, J. M., Forbes, S., Formisano, A., Fornal, T., Fortuna, L., Fortuna-Zalesna, E., Fortune, M., Fowler, C., Fransson, E., Frassinetti, L., Freisinger, M., Fresa, R., Fridstrom, R., Frigione, D., Fülop, T., Furseman, M., Fusco, V., Futatani, S., Gadariya, D., Gál, K., Galassi, D., Gafézka, K., Galeani, S., Gallart, D., Galvao, R., Gao, Y., Garcia, J., García-Muñoz, M., Gardener, M., Garzotti, L., Gaspar, J., Gatto, R., Gaudio, P., Gear, D., Gebhart, T., Gee, S., George, R., Gerasimov, S. N., Gervasini, G., Gethins, M., Ghani, Z., Gherendi, M., Ghezzi, F., Giacalone, J. C., Giacomelli, L., Giacometti, G., Gibson, C., Gibson, K. J., Gil, L., Gillgren, A., Gin, D., Giovannozzi, E., Giroud, C., Glen, R., Gloggler, S., Goff, J., Gohil, P., Goloborodko, V., Gomes, R., Gonçalves, B., Goniche, M., Goodyear, A., Gore, S., Gorini, G., Gorler, T., Gotts, N., Goulding, R., Gow, E., Graham, B., Graves, J. P., Greuner, H., Grierson, B., Griffiths, J., Griph, S., Grist, D., Gromelski, W., Groth, M., Grove, R., Gruca, M., Guard, D., Gupta, N., Gurl, C., Gusarov, A., Hackett, L., Hacquin, S., Hager, R., Hagg, L., Hakola, A., Halitovs, M., Hall, S., Hall, S. A., Hallworth-Cook, S., Ham, C. J., Hamaguchi, D., Hamed, M., Hamlyn-Harris, C., Hammond, K., Harford, E., Harrison, J. R., Harting, D., Hatano, Y., Hatch, D. R., Haupt, T., Hawes, J., Hawkes, N. C., Hawkins, J., Hayashi, T., Hazael, S., Hazel, S., Heesterman, P., Heidbrink, B., Helou, W., Hemming, O., Henderson, S. S., Henriques, R. B., Hepple, D., Herfindal, J., Hermon, G., Hill, J., Hillesheim, J. C., Hizanidis, K., Hjalmarsson, A., Ho, A., Hobirk, J., Hoenen, O., Hogben, C., Hollingsworth, A., Hollis, S., Hollmann, E., Holzl, M., Homan, B., Hook, M., Hopley, D., Horá:ek, J., Horsley, D., Horsten, N., Horton, A., Horton, L. D., Horvath, L., Hotchin, S., Howell, R., Hu, Z., Huber, A., Huber, V., Huddleston, T., Huijsmans, G. T. A., Huynh, P., Hynes, A., Iliasova, M., Lmrie, D., Lmrísek, M., Lngleby, J., Innocente, P., Insulander Björk, K., Isernia, N., lvanova-Stanik, I., Lvings, E., Jablonski, S., Jachmich, S., Jackson, T., Jacquet, P., Järleblad, H., Jaulmes, F., Jenaro Rodriguez, J., Jepu, I., Joffrin, E., Johnson, R., Johnson, T., Johnston, J., Jones, C., Jones, G., Jones, L., Jones, N., Jones, T., Joyce, A., Juarez, R., Juvonen, M., Kalnina, P., Kaltiaisenaho, T., Kaniewski, J., Kantor, A., Kappatou, A., Karhunen, J., Karkinsky, D., Kashchuk, Yu, Kaufman, M., Kaveney, G., Kazakov, Y. E. O., Kazantzidis, V., Keeling, D. L., Kelly, R., Kempenaars, M., Kennedy, C., Kennedy, D., Kent, J., Khan, K., Khilkevich, E., Kiefer, C., Kilpeläinen, J., Kim, C., Hyun-Tae, Kim, Kim, S. H., King, D. B., King, R., Kinna, D., Kiptily, V. G., Kirjasuo, A., Kirov, K. K., Kirschner, A., Kiviniemi, T., Kizane, G., Klas, M., Klepper, C., Klix, A., Kneale, G., Knight, M., Knight, P., Knights, R., Knipe, S., Knolker, M., Knott, S., Kocan, M., Kochl, F., Kodeli, I., Kolesnichenko, Y., Kominis, Y., Kong, M., Korovin, V., Kos, B., Kos, D., Koslowski, H. R., Kotschenreuther, M., Koubiti, M., Kowalska-Strzęciwilk, E., Koziol, K., Krasilnikov, A., Krasilnikov, V., Kresina, M., Krieger, K., Krishnan, N., Krivska, A., Kruezi, U., Ksiézek, I., Kukushkin, A. B., Kumpulainen, H., Kurki-Suonio, T., Kurotaki, H., Kwak, S., Kwon, O. J., Laguardia, L., Lagzdina, E., Lahtinen, A., Laing, A., Lam, N., Lambertz, H. T., Lane, B., Lane, C., Lascas Neto, E., Łaszyríska, E., Lawson, K. D., Lazaros, A., Lazzaro, E., Learoyd, G., Chanyoung, Lee, Lee, S. E., Leerink, S., Leeson, T., Lefebvre, X., Leggate, H. J., Lehmann, J., Lehnen, M., Leichtle, D., Leipold, F., Lengar, I., Lennholm, M., Leon Gutierrez, E., Lepiavko, B., Leppanen, J., Lerche, E., Lescinskis, A., Lewis, J., Leysen, W., Li, L., Li, Y., Likonen, J., Linsmeier, Ch., Lipschultz, B., Litaudon, X., Litherland-Smith, E., Liu, F., Loarer, T., Loarte, A., Lobel, R., Lomanowski, B., Lomas, P. J., López, J. M., Lorenzini, R., Loreti, S., Losada, U., Loschiavo, V. P., Loughlin, M., Louka, Z., Lovell, J., Lowe, T., Lowry, C., Lubbad, S., Luce, T., Lucock, R., Lukin, A., Luna, C., de la Luna, E., Lungaroni, M., Lungu, C. P., Lunt, T., Lutsenko, V., Lyons, B., Lyssoivan, A., Machielsen, M., Macusova, E., Mäenpää, R., Maggi, C. F., Maggiora, R., Magness, M., Mahesan, S., Maier, H., Maingi, R., Malinowski, K., Manas, P., Mantica, P., Mantsinen, M. J., Manyer, J., Manzanares, A., Maquet, Ph., Marceca, G., Marcenko, N., Marchetto, C., Marchuk, O., Mariani, A., Mariano, G., Marin, M., Marinelli, M., Markovič, T., Marocco, D., Marot, L., Marsden, S., Marsh, J., Marshall, R., Martellucci, L., Martin, A., Martin, A. J., Martone, R., Maruyama, S., Maslov, M., Masuzaki, S., Matejcik, S., Mattei, M., Matthews, G. F., Matveev, D., Matveeva, E., Mauriya, A., Maviglia, F., Mayer, M., Mayoral, M-L., Mazzi, S., Mazzotta, C., Mcadams, R., Mccarthy, P. J., Mcclements, K. G., Mcclenaghan, J., Mccullen, P., Mcdonald, D. C., Mcguckin, D., Mchugh, D., Mclntyre, G., Mckean, R., Mckehon, J., Mcmillan, B., Mcnamee, L., Mcshee, A., Meakins, A., Medley, S., Meekes, C. J., Meghani, K., Meigs, A. G., Meisl, G., Meitner, S., Menmuir, S., Mergia, K., Merriman, S., Mertens, Ph., Meshchaninov, S., Messiaen, A., Michling, R., Middleton, P., Middleton-Gear, D., Mietelski, J., Milanesio, D., Milani, E., Militello, F., Militello Asp, A., Milnes, J., Milocco, A., Miloshevsky, G., Minghao, C., Minucci, S., Miron, I., Miyamoto, M., Mlynář, J., Moiseenko, V., Monaghan, P., Monakhov, I., Moody, T., Moon, S., Mooney, R., Moradi, S., Morales, J., Morales, R. B., Mordijck, S., Moreira, L., Morgan, L., Moro, F., Morris, J., Morrison, K-M., Moser, L., Moulton, D., Mrowetz, T., Mundy, T., Muraglia, M., Muraro, A., Muthusonai, N., N’Konga, B., Yong-Su, Na, Nabais, F., Naden, M., Naish, J., Naish, R., Napoli, F., Nardon, E., Naulin, V., Nave, M. F. F., Nedzelskiy, I., Nemtsev, G., Nesenevich, V., Nestoras, I., Neu, R., Neverov, V. S., Ng, S., Nicassio, M., Nielsen, A. H., Nina, D., Nishijima, D., Noble, C., Nobs, C. R., Nocente, M., Nodwell, D., Nordlund, K., Nordman, H., Normanton, R., Noterdaeme, J. M., Nowak, S., Nunn, E., Nystrom, H., Oberparleiter, M., Obryk, B., O’Callaghan, J., Odupitan, T., Oliver, H. J. C., Olney, R., O’Mullane, M., Ongena, J., Organ, E., Orsitto, F., Orszagh, J., Osborne, T., Otin, R., Otsuka, T., Owen, A., Oya, Y., Oyaizu, M., Paccagnella, R., Pace, N., Packer, L. W., Paige, S., Pajuste, E., Palade, D., Pamela, S. J. P., Panadero, N., Panontin, E., Papadopoulos, A., Papp, G., Papp, P., Parail, V. 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K., Sips, A. C. C., Sirén, P., Sirinelli, A., Sjöstrand, H., Skinner, N., Slater, J., Smith, N., Smith, P., Snell, J., Snoep, G., Snoj, L., Snyder, P., Soare, S., Solano, E. R., Solokha, V., Somers, A., Sommariva, C., Soni, K., Sorokovoy, E., Sos, M., Sousa, J., Sozzi, C., Spagnolo, S., Spelzini, T., Spineanu, F., Spong, D., Sprada, D., Sridhar, S., Srinivasan, C., Stables, G., Staebler, G., Stamatelatos, I., Stancar, Z., Staniec, P., Stankūnas, G., Stead, M., Stefanikova, E., Stephen, A., Stephens, J., Stevenson, P., Stojanov, M., Strand, P., Strauss, H. R., Strikwerda, S., Ström, P., Stuart, C. I., Studholme, W., Subramani, M., Suchkov, E., Sumida, S., Sun, H. J., Susts, T. E., Svensson, J., Svoboda, J., Sweeney, R., Sytnykov, D., Szabolics, T., Szepesi, G., Tabia, B., Tadić, T., Tál, B., Tala, T., Tallargio, A., Tamain, P., Tan, H., Tanaka, K., Tang, W., Tardocchi, M., Taylor, D., Teimane, A. 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K., Zoulias, I., Zwingmann &amp, Zychor, I., Vega, J, Murari, A, Dormido-Canto, S, Ratta, Ga, Gelfusa, M, Chiariello, A, JET Contributors, VTT Technical Research Centre of Finland, Culham Science Centre, Princeton Plasma Physics Laboratory, Department of Applied Physics, Uppsala University, European Commission, Forschungszentrum Jülich, Universidade Lisboa, Fusion and Plasma Physics, University of Milan - Bicocca, University of Helsinki, General Atomics, ITER, University of Toyama, CEA, Oak Ridge National Laboratory, Technical University of Madrid, Swiss Federal Institute of Technology Lausanne, Dutch Institute for Fundamental Energy Research, Royal Military Academy, Seoul National University, Chalmers University of Technology, Max Planck Institute for Plasma Physics, KTH Royal Institute of Technology, Aalto-yliopisto, Aalto University, Science and Technology of Nuclear Fusion, EIRES Eng. for Sustainable Energy Systems, Magneto-Hydro-Dynamic Stability of Fusion Plasmas, Vega, J., Murari, A., Dormido-Canto, S., Ratta, G. A., Gelfusa, M., Mailloux, J., Abid, N., Abraham, K., Abreu, P., Adabonyan, O., Adrich, P., Afanasev, V., Afzal, M., Ahlgren, T., Aho-Mantila, L., Aiba, N., Airila, M., Akhtar, M., Albanese, R., Alderson-Martin, M., Alegre, D., Aleiferis, S., Aleksa, A., Alekseev, A. G., Alessi, E., Aleynikov, P., Algualcil, J., Ali, M., Allinson, M., Alper, B., Alves, E., Ambrosino, G., Ambrosino, R., Amosov, V., Sunden, E. A., Andrew, P., Angelini, B. M., Angioni, C., Antoniou, I., Appel, L. C., Appelbee, C., Aria, S., Ariola, M., Artaserse, G., Arter, W., Artigues, V., Asakura, N., Ash, A., Ashikawa, N., Aslanyan, V., Astrain, M., Asztalos, O., Auld, D., Auriemma, F., Austin, Y., Avotina, L., Aymerich, E., Baciero, A., Bairaktaris, F., Balbin, J., Balbinot, L., Balboa, I., Balden, M., Balshaw, C., Balshaw, N., Bandaru, V. K., Banks, J., Baranov, Y. 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H., Dorling, S., Douai, D., Dowson, S., Doyle, R., Dreval, M., Drewelow, P., Drews, P., Drummond, G., Duckworth, P., Dudding, H., Dumont, R., Dumortier, P., Dunai, D., Dunatov, T., Dunne, M., Duran, I., Durodie, F., Dux, R., Dvornova, A., Eastham, R., Edwards, J., Eich, T., Eichorn, A., Eidietis, N., Eksaeva, A., El Haroun, H., Ellwood, G., Elsmore, C., Embreus, O., Emery, S., Ericsson, G., Eriksson, B., Eriksson, F., Eriksson, J., Eriksson, L. G., Ertmer, S., Esquembri, S., Esquisabel, A. L., Estrada, T., Evans, G., Evans, S., Fable, E., Fagan, D., Faitsch, M., Falessi, M., Fanni, A., Farahani, A., Farquhar, I., Fasoli, A., Faugeras, B., Fazinie, S., Felici, F., Felton, R., Fernandes, A., Fernandes, H., Ferrand, J., Ferreira, D. R., Ferreira, J., Ferro, G., Fessey, J., Ficker, O., Field, A. R., Figueiredo, A., Figueiredo, J., Fil, A., Fil, N., Finburg, P., Fiorucci, D., Fischer, U., Fishpool, G., Fittill, L., Fitzgerald, M., Flammini, D., Flanagan, J., Flinders, K., Foley, S., Fonnesu, N., Fontana, M., Fontdecaba, J. M., Forbes, S., Formisano, A., Fornal, T., Fortuna, L., Fortuna-Zalesna, E., Fortune, M., Fowler, C., Fransson, E., Frassinetti, L., Freisinger, M., Fresa, R., Fridstrom, R., Frigione, D., Fulop, T., Furseman, M., Fusco, V., Futatani, S., Gadariya, D., Gal, K., Galassi, D., Gafezka, K., Galeani, S., Gallart, D., Galvao, R., Gao, Y., Garcia, J., Garcia-Munoz, M., Gardener, M., Garzotti, L., Gaspar, J., Gatto, R., Gaudio, P., Gear, D., Gebhart, T., Gee, S., George, R., Gerasimov, S. N., Gervasini, G., Gethins, M., Ghani, Z., Gherendi, M., Ghezzi, F., Giacalone, J. C., Giacomelli, L., Giacometti, G., Gibson, C., Gibson, K. J., Gil, L., Gillgren, A., Gin, D., Giovannozzi, E., Giroud, C., Glen, R., Gloggler, S., Goff, J., Gohil, P., Goloborodko, V., Gomes, R., Goncalves, B., Goniche, M., Goodyear, A., Gore, S., Gorini, G., Gorler, T., Gotts, N., Goulding, R., Gow, E., Graham, B., Graves, J. P., Greuner, H., Grierson, B., Griffiths, J., Griph, S., Grist, D., Gromelski, W., Groth, M., Grove, R., Gruca, M., Guard, D., Gupta, N., Gurl, C., Gusarov, A., Hackett, L., Hacquin, S., Hager, R., Hagg, L., Hakola, A., Halitovs, M., Hall, S., Hall, S. A., Hallworth-Cook, S., Ham, C. J., Hamaguchi, D., Hamed, M., Hamlyn-Harris, C., Hammond, K., Harford, E., Harrison, J. R., Harting, D., Hatano, Y., Hatch, D. R., Haupt, T., Hawes, J., Hawkes, N. C., Hawkins, J., Hayashi, T., Hazael, S., Hazel, S., Heesterman, P., Heidbrink, B., Helou, W., Hemming, O., Henderson, S. S., Henriques, R. B., Hepple, D., Herfindal, J., Hermon, G., Hill, J., Hillesheim, J. C., Hizanidis, K., Hjalmarsson, A., Ho, A., Hobirk, J., Hoenen, O., Hogben, C., Hollingsworth, A., Hollis, S., Hollmann, E., Holzl, M., Homan, B., Hook, M., Hopley, D., Hora:ek, J., Horsley, D., Horsten, N., Horton, A., Horton, L. D., Horvath, L., Hotchin, S., Howell, R., Hu, Z., Huber, A., Huber, V., Huddleston, T., Huijsmans, G. T. A., Huynh, P., Hynes, A., Iliasova, M., Lmrie, D., Lmrisek, M., Lngleby, J., Innocente, P., Bjork, K. I., Isernia, N., lvanova-Stanik, I., Lvings, E., Jablonski, S., Jachmich, S., Jackson, T., Jacquet, P., Jarleblad, H., Jaulmes, F., Rodriguez, J. J., Jepu, I., Joffrin, E., Johnson, R., Johnson, T., Johnston, J., Jones, C., Jones, G., Jones, L., Jones, N., Jones, T., Joyce, A., Juarez, R., Juvonen, M., Kalnina, P., Kaltiaisenaho, T., Kaniewski, J., Kantor, A., Kappatou, A., Karhunen, J., Karkinsky, D., Kashchuk, Y., Kaufman, M., Kaveney, G., Kazakov, Y. E. O., Kazantzidis, V., Keeling, D. L., Kelly, R., Kempenaars, M., Kennedy, C., Kennedy, D., Kent, J., Khan, K., Khilkevich, E., Kiefer, C., Kilpelainen, J., Kim, C., Kim, H. -T., Kim, S. H., King, D. B., King, R., Kinna, D., Kiptily, V. G., Kirjasuo, A., Kirov, K. K., Kirschner, A., Kiviniemi, T., Kizane, G., Klas, M., Klepper, C., Klix, A., Kneale, G., Knight, M., Knight, P., Knights, R., Knipe, S., Knolker, M., Knott, S., Kocan, M., Kochl, F., Kodeli, I., Kolesnichenko, Y., Kominis, Y., Kong, M., Korovin, V., Kos, B., Kos, D., Koslowski, H. R., Kotschenreuther, M., Koubiti, M., Kowalska-Strzeciwilk, E., Koziol, K., Krasilnikov, A., Krasilnikov, V., Kresina, M., Krieger, K., Krishnan, N., Krivska, A., Kruezi, U., Ksiezek, I., Kukushkin, A. B., Kumpulainen, H., Kurki-Suonio, T., Kurotaki, H., Kwak, S., Kwon, O. J., Laguardia, L., Lagzdina, E., Lahtinen, A., Laing, A., Lam, N., Lambertz, H. T., Lane, B., Lane, C., Neto, E. L., Laszyriska, E., Lawson, K. D., Lazaros, A., Lazzaro, E., Learoyd, G., Lee, C., Lee, S. E., Leerink, S., Leeson, T., Lefebvre, X., Leggate, H. J., Lehmann, J., Lehnen, M., Leichtle, D., Leipold, F., Lengar, I., Lennholm, M., Gutierrez, E. L., Lepiavko, B., Leppanen, J., Lerche, E., Lescinskis, A., Lewis, J., Leysen, W., Li, L., Li, Y., Likonen, J., Linsmeier, C., Lipschultz, B., Litaudon, X., Litherland-Smith, E., Liu, F., Loarer, T., Loarte, A., Lobel, R., Lomanowski, B., Lomas, P. J., Lopez, J. M., Lorenzini, R., Loreti, S., Losada, U., Loschiavo, V. P., Loughlin, M., Louka, Z., Lovell, J., Lowe, T., Lowry, C., Lubbad, S., Luce, T., Lucock, R., Lukin, A., Luna, C., de la Luna, E., Lungaroni, M., Lungu, C. P., Lunt, T., Lutsenko, V., Lyons, B., Lyssoivan, A., Machielsen, M., Macusova, E., Maenpaa, R., Maggi, C. F., Maggiora, R., Magness, M., Mahesan, S., Maier, H., Maingi, R., Malinowski, K., Manas, P., Mantica, P., Mantsinen, M. J., Manyer, J., Manzanares, A., Maquet, P., Marceca, G., Marcenko, N., Marchetto, C., Marchuk, O., Mariani, A., Mariano, G., Marin, M., Marinelli, M., Markovic, T., Marocco, D., Marot, L., Marsden, S., Marsh, J., Marshall, R., Martellucci, L., Martin, A., Martin, A. J., Martone, R., Maruyama, S., Maslov, M., Masuzaki, S., Matejcik, S., Mattei, M., Matthews, G. F., Matveev, D., Matveeva, E., Mauriya, A., Maviglia, F., Mayer, M., Mayoral, M. -L., Mazzi, S., Mazzotta, C., Mcadams, R., Mccarthy, P. J., Mcclements, K. G., Mcclenaghan, J., Mccullen, P., Mcdonald, D. C., Mcguckin, D., Mchugh, D., Mclntyre, G., Mckean, R., Mckehon, J., Mcmillan, B., Mcnamee, L., Mcshee, A., Meakins, A., Medley, S., Meekes, C. J., Meghani, K., Meigs, A. G., Meisl, G., Meitner, S., Menmuir, S., Mergia, K., Merriman, S., Mertens, P., Meshchaninov, S., Messiaen, A., Michling, R., Middleton, P., Middleton-Gear, D., Mietelski, J., Milanesio, D., Milani, E., Militello, F., Asp, A. M., Milnes, J., Milocco, A., Miloshevsky, G., Minghao, C., Minucci, S., Miron, I., Miyamoto, M., Mlynar, J., Moiseenko, V., Monaghan, P., Monakhov, I., Moody, T., Moon, S., Mooney, R., Moradi, S., Morales, J., Morales, R. B., Mordijck, S., Moreira, L., Morgan, L., Moro, F., Morris, J., Morrison, K. -M., Moser, L., Moulton, D., Mrowetz, T., Mundy, T., Muraglia, M., Muraro, A., Muthusonai, N., N'Konga, B., Na, Y. -S., Nabais, F., Naden, M., Naish, J., Naish, R., Napoli, F., Nardon, E., Naulin, V., Nave, M. F. F., Nedzelskiy, I., Nemtsev, G., Nesenevich, V., Nestoras, I., Neu, R., Neverov, V. S., Ng, S., Nicassio, M., Nielsen, A. H., Nina, D., Nishijima, D., Noble, C., Nobs, C. R., Nocente, M., Nodwell, D., Nordlund, K., Nordman, H., Normanton, R., Noterdaeme, J. M., Nowak, S., Nunn, E., Nystrom, H., Oberparleiter, M., Obryk, B., O'Callaghan, J., Odupitan, T., Oliver, H. J. C., Olney, R., O'Mullane, M., Ongena, J., Organ, E., Orsitto, F., Orszagh, J., Osborne, T., Otin, R., Otsuka, T., Owen, A., Oya, Y., Oyaizu, M., Paccagnella, R., Pace, N., Packer, L. W., Paige, S., Pajuste, E., Palade, D., Pamela, S. J. P., Panadero, N., Panontin, E., Papadopoulos, A., Papp, G., Papp, P., Parail, V. V., Pardanaud, C., Parisi, J., Diaz, F. P., Parsloe, A., Parsons, M., Parsons, N., Passeri, M., Patel, A., Pau, A., Pautasso, G., Pavlichenko, R., Pavone, A., Pawelec, E., Soldan, C. P., Peacock, A., Pearce, M., Peluso, E., Penot, C., Pepperell, K., Pereira, R., Pereira, T., Cippo, E. P., Pereslavtsev, P., Perez von Thun, C., Pericoli, V., Perry, D., Peterka, M., Petersson, P., Petravich, G., Petrella, N., Peyman, M., Pillon, M., Pinches, S., Pintsuk, G., Pires de Sa, W., Pires dos Reis, A., Piron, C., Piron, L., Pironti, A., Pitts, R., van de Plassche, K. L., Platt, N., Plyusnin, V., Podesta, M., Pokol, G., Poli, F. M., Pompilian, O. G., Popovichev, S., Poradzinski, M., Porfiri, M. T., Porkolab, M., Porosnicu, C., Porton, M., Poulipoulis, G., Predebon, I., Prestopino, G., Price, C., Price, D., Price, M., Primetzhofer, D., Prior, P., Provatas, G., Pucella, G., Puglia, P., Purahoo, K., Pusztai, I., Putignano, O., Putterich, T., Quercia, A., Rachlew, E., Radulescu, G., Radulovic, V., Rainford, M., Raj, P., Ralph, G., Ramogida, G., Rasmussen, D., Rasmussen, J. J., Ratta, G., Ratynskaia, S., Rebai, M., Refy, D., Reichle, R., Reinke, M., Reiser, D., Reux, C., Reynolds, S., Richiusa, M. L., Richyal, S., Rigamonti, D., Rimini, F. G., Risner, J., Riva, M., Rivero-Rodriguez, J., Roach, C. M., Robins, R., Robinson, S., Robson, D., Rodionov, R., Rodrigues, P., Ramos, M. R., Rodriguez-Fernandez, P., Romanelli, F., Romanelli, M., Romanelli, S., Romazanov, J., Rossi, R., Rowe, S., Rowlands, D., Rubel, M., Rubinacci, G., Rubino, G., Ruchko, L., Ruiz, M., Ruiz, J. R., Ruset, C., Rzadkiewicz, J., Saarelma, S., Safi, E., Sahlberg, A., Salewski, M., Salmi, A., Salmon, R., Salzedas, F., Sanders, I., Sandiford, D., Santos, B., Santucci, A., Sarkimaki, K., Sarwar, R., Sarychev, I., Sauter, O., Sauwan, P., Scapin, N., Schluck, F., Schmid, K., Schmuck, S., Schneider, M., Schneider, P. A., Schworer, D., Scott, G., Scott, M., Scraggs, D., Scully, S., Segato, M., Seo, J., Sergienko, G., Sertoli, M., Sharapov, S. E., Shaw, A., Sheikh, H., Sheikh, U., Shepherd, A., Shevelev, A., Shigin, P., Shinohara, K., Shiraiwa, S., Shiraki, D., Short, M., Sias, G., Silburn, S. A., Silva, A., Silva, C., Silva, J., Silvagni, D., Simfukwe, D., Simpson, J., Sinclair, D., Sipila, S. K., Sips, A. C. C., Siren, P., Sirinelli, A., Sjostrand, H., Skinner, N., Slater, J., Smith, N., Smith, P., Snell, J., Snoep, G., Snoj, L., Snyder, P., Soare, S., Solano, E. R., Solokha, V., Somers, A., Sommariva, C., Soni, K., Sorokovoy, E., Sos, M., Sousa, J., Sozzi, C., Spagnolo, S., Spelzini, T., Spineanu, F., Spong, D., Sprada, D., Sridhar, S., Srinivasan, C., Stables, G., Staebler, G., Stamatelatos, I., Stancar, Z., Staniec, P., Stankunas, G., Stead, M., Stefanikova, E., Stephen, A., Stephens, J., Stevenson, P., Stojanov, M., Strand, P., Strauss, H. R., Strikwerda, S., Strom, P., Stuart, C. I., Studholme, W., Subramani, M., Suchkov, E., Sumida, S., Sun, H. J., Susts, T. E., Svensson, J., Svoboda, J., Sweeney, R., Sytnykov, D., Szabolics, T., Szepesi, G., Tabia, B., Tadic, T., Tal, B., Tala, T., Tallargio, A., Tamain, P., Tan, H., Tanaka, K., Tang, W., Tardocchi, M., Taylor, D., Teimane, A. S., Telesca, G., Teplova, N., Teplukhina, A., Terentyev, D., Terra, A., Terranova, D., Terranova, N., Testa, D., Tholerus, E., Thomas, J., Thoren, E., Thorman, A., Tierens, W., Tinguely, R. A., Tipton, A., Todd, H., Tokitani, M., Tolias, P., Tomes, M., Tookey, A., Torikai, Y., von Toussaint, U., Tsavalas, P., Tskhakaya, D., Turner, I., Turner, M., Turner, M. M., Turnyanskiy, M., Tvalashvili, G., Tyrrell, S., Tyshchenko, M., Uccello, A., Udintsev, V., Urbanczyk, G., Vadgama, A., Valcarcel, D., Valisa, M., Olivares, P. V., Vallhagen, O., Valovic, M., Eester, D. V., Varje, J., Vartanian, S., Vasilopoulou, T., Vayakis, G., Vecsei, M., Ventre, S., Verdoolaege, G., Verona, C., Rinati, G. V., Veshchev, E., Vianello, N., Viezzer, E., Vignitchouk, L., Vila, R., Villari, R., Villone, F., Vincenzi, P., Vinyar, I., Viola, B., Virtanen, A. J., Vitins, A., Vizvary, Z., Vlad, G., Vlad, M., Vondracek, P., de Vries, P., Wakeling, B., Walkden, N. R., Walker, M., Walker, R., Walsh, M., Wang, E., Wang, N., Warder, S., Warren, R., Waterhouse, J., Watts, C., Wauters, T., Weckmann, A., Maxwell, H. W., Weiland, M., Weisen, H., Weiszflog, M., Welch, P., Wendler, N., West, A., Wheatley, M., Wheeler, S., Whitehead, A., Whittaker, D., Widdowson, A., Wiesen, S., Wilkinson, J., Williams, J. C., Willoughby, D., Wilson, I., Wilson, J., Wilson, T., Wischmeier, M., Wise, P., Withenshaw, G., Withycombe, A., Witts, D., Wojcik-Gargula, A., Wolfrum, E., Wood, R., Woodley, C., Woodley, R., Woods, B., Wright, J., Wright, J. C., Xu, T., Yadikin, D., Yajima, M., Yakovenko, Y., Yang, Y., Yanling, W., Yanovskiy, V., Young, I., Young, R., Zabolockis, R. J., Zacks, J., Zagorski, R., Zaitsev, F. S., Zakharov, L., Zarins, A., Fernandez, D. Z., Zastrow, K. -D., Zayachuk, Y., Zerbini, M., Zhang, W., Zhou, Y., Zlobinski, M., Zocco, A., Zohar, A., Zoita, V., Zoletnik, S., Zotta, V. K., Zoulias, I., Zwingmann, W., and Zychor, I.
Subjects: JET, Settore ING-IND/18 - Fisica dei Reattori Nucleari, General Physics and Astronomy, artificial intellingence, tokamaks, magnetically confined plasma, disruption predictions, tokamak plasmas, nuclear fusion
Abstract: openaire: EC/H2020/633053/EU//EUROfusion Funding Information: This work was partially funded by the Spanish Ministry of Science and Innovation under projects nos. PID2019-108377RB-C31 and PID2019-108377RB-C32. This work has been carried out within the framework of the EUROfusion Consortium, funded by the European Union via the Euratom Research and Training Programme (grant agreement no. 101052200 — EUROfusion). Views and opinions expressed are however those of the authors only and do not necessarily reflect those of the European Union or the European Commission. Neither the European Union nor the European Commission can be held responsible for them. Publisher Copyright: © 2022, Springer Nature Limited. In nuclear fusion reactors, plasmas are heated to very high temperatures of more than 100 million kelvin and, in so-called tokamaks, they are confined by magnetic fields in the shape of a torus. Light nuclei, such as deuterium and tritium, undergo a fusion reaction that releases energy, making fusion a promising option for a sustainable and clean energy source. Tokamak plasmas, however, are prone to disruptions as a result of a sudden collapse of the system terminating the fusion reactions. As disruptions lead to an abrupt loss of confinement, they can cause irreversible damage to present-day fusion devices and are expected to have a more devastating effect in future devices. Disruptions expected in the next-generation tokamak, ITER, for example, could cause electromagnetic forces larger than the weight of an Airbus A380. Furthermore, the thermal loads in such an event could exceed the melting threshold of the most resistant state-of-the-art materials by more than an order of magnitude. To prevent disruptionsor at least mitigate their detrimental effects, empirical models obtained with artificial intelligence methods, of which an overview is given here, are commonly employed to predict their occurrence—and ideally give enough time to introduce counteracting measures.
Published: 2022

26. Investigating the complementarity of qualitative and quantitative approaches to textual data

Author: Hagg, Lauryn, Youssef, George, Westrupp, Elizabeth, Klas, Anna, Fuller-Tyszkiewicz, Matthew, Evans, Subhadra, and Merkouris, Stephanie
Subjects: Medicine and Health Sciences, Psychiatry and Psychology
Abstract: This project aims to investigate how qualitative methodologies complement, differ, or detract from Natural Language Processing (NLP) topic modelling methods (specifically Latent Dirichlet Allocation – LDA) when used on a large textual data set derived from scientific journal articles on exploratory behaviour in children.
Published: 2022
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27. Cognitive Dissonance in Parenting

Author: Hagg, Lauryn, Ling, Mathew, Klas, Anna, Kothe, Emily, Westrupp, Elizabeth, and Benstead, Michelle
Published: 2022
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28. Lipidomic analysis of surfactant and plasma from horses with asthma and age-matched healthy horses

Author: Undine Christmann, Allen E. Page, David W. Horohov, Amanda A. Adams, Seth E. Chapman, Courtney L. Hancock, Audrey L. Emery, Jesse R. Poovey, Casey Hagg, Saira M. Ortega Morales, Ashley R. Duncan, Joey Morgan, Laurent L. Couetil, Peter Morresey, and Paul L. Wood
Subjects: Inflammation, General Veterinary, Phosphatidylglycerols, Pulmonary Surfactants, General Medicine, Ceramides, Pulmonary Surfactant-Associated Protein D, Asthma, Surface-Active Agents, Lipidomics, Animals, Horse Diseases, Horses, Bronchoalveolar Lavage Fluid, Phospholipids
Abstract: OBJECTIVE To perform lipidomic analysis of surfactant and plasma from asthmatic and healthy horses. ANIMALS 30 horses with clinical signs of asthma and 30 age-matched control horses. PROCEDURES Detailed history, physical examination, CBC, and bronchoalveolar lavage fluid (BALF) cytologies were obtained. Asthmatic horses were grouped based on their BALF inflammatory profile: severe equine asthma (SEA), mild equine asthma with neutrophilic airway inflammation (MEA-N), or mild equine asthma with eosinophilic airway inflammation (MEA-E). Each asthma group was assigned its own age-matched control group. Lipidomic analysis was completed on surfactant and plasma. Surfactant protein D (SP-D) concentrations were measured in serum and BALF. RESULTS SEA surfactant was characterized by a phospholipid deficit and altered composition (increased ceramides, decreased phosphatidylglycerol, and increased cyclic phosphatidic acid [cPA]). In comparison, MEA-N surfactant only had a decrease in select phosphatidylglycerol species and increased cPA levels. The plasma lipidomic profile was significantly different in all asthma groups compared to controls. Specifically, all groups had increased plasma phytoceramide. SEA horses had increased plasma cPA and diacylglycerol whereas MEA-N horses only had increased cPA. MEA-E horses had increases in select ceramides and dihydrocermides. Only SEA horses had significantly increased serum SP-D concentrations. CLINICAL RELEVANCE The most significant surfactant alterations were present in SEA (altered phospholipid content and composition); only mild changes were observed in MEA-N horses. The plasma lipidomic profile was significantly altered in all groups of asthmatic horses and differed among groups. Data from a larger population of asthmatic horses are needed to assess implications for diagnosis, prognosis, and treatment.
Published: 2022

29. Assessment of the bi-directional relationship between blood mitochondrial DNA copy number and type 2 diabetes mellitus

Author: Wang, W.Y., Luo, J., Dijk, K.W. van, Hagg, S., Grassmann, F., Hart, L.M. 't, Heemst, D. van, and Noordam, R.
Subjects: Cross-Sectional Studies, DNA Copy Number Variations, Diabetes Mellitus, Type 2, Endocrinology, Diabetes and Metabolism, Type 2 diabetes mellitus, Internal Medicine, Humans, Prospective Studies, Mendelian randomisation, DNA, Mitochondrial, Prospective analyses, Mitochondria, Mitochondrial DNA copy number
Abstract: Aims/hypothesis Mitochondrial dysfunction, which can be approximated by blood mitochondrial DNA copy number (mtDNA-CN), has been implicated in the pathogenesis of type 2 diabetes mellitus. Thus far, however, insights from prospective cohort studies and Mendelian randomisation (MR) analyses on this relationship are limited. We assessed the association between blood mtDNA-CN and incident type 2 diabetes using multivariable-adjusted regression analyses, and the associations between blood mtDNA-CN and type 2 diabetes and BMI using bi-directional MR. Methods Multivariable-adjusted Cox proportional hazard models were used to estimate the association between blood mtDNA-CN and incident type 2 diabetes in 285,967 unrelated European individuals from UK Biobank free of type 2 diabetes at baseline. Additionally, a cross-sectional analysis was performed to investigate the association between blood mtDNA-CN and BMI. We also assessed the potentially causal relationship between blood mtDNA-CN and type 2 diabetes (N=898,130 from DIAGRAM, N=215,654 from FinnGen) and BMI (N=681,275 from GIANT) using bi-directional two-sample MR. Results During a median follow-up of 11.87 years, 15,111 participants developed type 2 diabetes. Participants with a higher level of blood mtDNA-CN are at lower risk of developing type 2 diabetes (HR 0.90 [95% CI 0.89, 0.92]). After additional adjustment for BMI and other confounders, these results attenuated moderately and remained present. The multivariable-adjusted cross-sectional analyses showed that higher blood mtDNA-CN was associated with lower BMI (−0.12 [95% CI −0.14, −0.10]) kg/m2. In the bi-directional MR analyses, we found no evidence for causal associations between blood mtDNA-CN and type 2 diabetes, and blood mtDNA-CN and BMI in either direction. Conclusions/interpretation The results from the present study indicate that the observed association between low blood mtDNA-CN and higher risk of type 2 diabetes is likely not causal. Graphical abstract
Published: 2022

30. Artificial Intelligence in Elite Sports-A Narrative Review of Success Stories and Challenges

Author: Fabian Hammes, Alexander Hagg, Alexander Asteroth, and Daniel Link
Subjects: Sports and Active Living, artificial intelligence, elite sports, SMPA loop, explainable AI, AI usage in sports, Physiology, Tourism, Leisure and Hospitality Management, Anthropology, Public Health, Environmental and Occupational Health, Orthopedics and Sports Medicine, Physical Therapy, Sports Therapy and Rehabilitation, ddc:006, ddc
Abstract: This paper explores the role of artificial intelligence (AI) in elite sports. We approach the topic from two perspectives. Firstly, we provide a literature based overview of AI success stories in areas other than sports. We identified multiple approaches in the area of Machine Perception, Machine Learning and Modeling, Planning and Optimization as well as Interaction and Intervention, holding a potential for improving training and competition. Secondly, we discover the present status of AI use in elite sports. Therefore, in addition to another literature review, we interviewed leading sports scientist, which are closely connected to the main national service institute for elite sports in their countries. The analysis of this literature review and the interviews show that the most activity is carried out in the methodical categories of signal and image processing. However, projects in the field of modeling & planning have become increasingly popular within the last years. Based on these two perspectives, we extract deficits, issues and opportunities and summarize them in six key challenges faced by the sports analytics community. These challenges include data collection, controllability of an AI by the practitioners and explainability of AI results.
Published: 2022

31. The Validity of the Parsley Symptom Index: an e-PROM designed for Telehealth (Preprint)

Author: Hants Williams, Sarah Steinberg, Kendall Leon, Catherine O’Shea, Robin Berzin, and Heather Hagg
Abstract: BACKGROUND The Parsley Symptom Index (PSI) is a recently developed symptom assessment for adults with chronic disease in telehealth settings. OBJECTIVE The purpose of this study was to validate the PSI against the Self-Rated Health (SRH) item. METHODS This prospective cohort study took place from January 15, 2021 to December 15, 2021 among a sample of 10,519 adult patients at Parsley Health, a subscription based holistic medical practice. The PSI and the SRH were completed by patients via an online portal. The association between the PSI and SRH was assessed via polyserial and polychoric correlations, while weighted kappa scores provided information related to agreement between the PSI and SRH. RESULTS From 22,748 responses, there were moderate levels of association (polyserial r=0.51; polychoric r=0.52) and agreement (weighted ???? = 0.46) between the PSI and SRH. In total 74.2% (16865) of responses between the PSI and SRH were relatively congruent while 36.2% (8229) were literally congruent. CONCLUSIONS The PSI demonstrates validity with the SRH for adults with chronic disease in a telehealth setting.
Published: 2022

32. Die bayerischen Gletscher, die verbliebenen Eisreserven Deutschlands

Author: Markus Weber, Anja Wendt, Wilfried Hagg, and Christoph Mayer
Subjects: Environmental sciences, 05 social sciences, 0507 social and economic geography, GE1-350, Oceanography, 050703 geography
Abstract: Gletscher gibt es in Deutschland nur in dem sehr kleinen Alpenanteil und dort nur an wenigen, für die Eismassen günstigen Stellen. Diese Gletscher sind vermutlich keine Relikte der letzten Eiszeit, sondern Reste der kühleren Phasen der letzten Jahrhunderte. Trotzdem ging von diesen verbliebenen Eisreserven seit dem Beginn der touristischen Erschließung der Alpen eine große Faszination aus, da sie teilweise vom Tal aus zu sehen, oder verhältnismäßig leicht zu erreichen waren. Selbst heute noch kann man auf dem nördlichen Schneeferner den einzigen Gletscherskilift in Deutschland erleben, wenngleich auch dort die Gletscherflächen erheblich zurückgegangen sind. Die frühe Aufmerksamkeit führte auch dazu, dass es viele historische Dokumente über diese Gletscher gibt und so zumindest ihre Veränderung seit dem Ende der kleinen Eiszeit gut dokumentiert ist. Heute sind fast alle der bayerischen Gletscher am Rande ihrer Existenz und es ist nur eine Frage der Zeit, bis der deutsche Alpenraum eisfrei wird. Wir versuchen mit diesem Beitrag die Entwicklung der Gletscher seit den ersten Untersuchungen zu dokumentieren.
Published: 2021

33. O papel do enfermeiro no setor de pronto atendimento: um relato de experiência

Author: Silvia Silva de Souza, Alessandra Paiz, Tatiana Gafurri da Silva, Fabiana Brum Hagg, Rozana Bellaver, Denise Consuelo Moser Aguiar, Suellen Rodrigues de Oliveira Maier, Maraisa Manorov, Carime Bueno, and Gelson Aguiar da Silva Moser
Subjects: Service (business), education.field_of_study, 030504 nursing, Undergraduate nursing, Population, emergãªncias, Context (language use), educaã§ã£o continuada, lcsh:A, Emergency department, Unit (housing), 03 medical and health sciences, 0302 clinical medicine, Nursing, papel do profissional de enfermagem, 030212 general & internal medicine, Good prognosis, lcsh:General Works, 0305 other medical science, Psychology, education, Diversity (business)
Abstract: Demonstrar as experiências acerca do papel do enfermeiro no setor de pronto socorro de um Hospital referência do Oeste de Santa Catarina, por acadêmicas do curso de enfermagem. Relato de experiência embasado na vivência de acadêmicas do curso de graduação em Enfermagem pela UFFS em unidade de pronto socorro. Tornou-se possível identificar que o profissional de enfermagem possui um papel de extrema importância neste setor de urgência e emergência, onde exige responsabilidade, conhecimento e organização, tanto na assistência quanto na gestão. Tendo em vista de que a demanda por este serviço cresce a cada dia e que inúmeras situações surgem neste contexto, ter uma equipe qualificada contribui para o bom andamento da unidade e bom prognóstico para aos pacientes. Ainda, para atingir bons resultados, tornam-se necessárias a realização de capacitações e educações permanentes para a equipe, a fim de aperfeiçoar e atualizar seus conhecimentos para melhor atender a população que necessita deste serviço. A extrema diversidade e complexidade da demanda desse setor exige que o enfermeiro assuma diversos papéis, de gestor, articulador, comunicador e líder, para que em conjunto de sua equipe desenvolva todas as dimensões do cuidado.
Published: 2021

34. La enseñanza de habilidades transdisciplinarias en la licenciatura en Psicología: Retos y Posibilidades

Author: Carime Hagg, Alejandra Cruz Cruz, Ligia Colmenares Vázquez, and Alejandra Valencia Cruz
Subjects: General Medicine
Published: 2021

35. Integrating behavioral health services at employer-sponsored health clinics: A descriptive analysis

Author: Heather K. Hagg, Katie Taylor, Ross S. Nelson, Joanna Morgan Keller, John R. Wright, Dena M. Bravata, and Sharon A. Watts
Subjects: Adult, Male, medicine.medical_specialty, Occupational Health Services, PsycINFO, Ambulatory Care Facilities, Cohort Studies, Patient satisfaction, Surveys and Questionnaires, Health care, medicine, Humans, Applied Psychology, Depression (differential diagnoses), Retrospective Studies, Descriptive statistics, Delivery of Health Care, Integrated, business.industry, Retrospective cohort study, Middle Aged, Triage, Psychiatry and Mental health, Patient Satisfaction, Family medicine, Anxiety, Female, medicine.symptom, business
Abstract: INTRODUCTION Approximately, 20% of adults in the United States have a behavioral health concern, resulting in $732M in direct medical spending and over 5 million lost workdays annually. Employers bear a substantial share of these costs. The objective of this study was to describe the integration of behavioral health services at employer-sponsored health clinics. METHOD Retrospective cohort analysis of patients seen for individual behavioral health services from 1/1/2018 to 12/31/2018 in employer-sponsored clinics. RESULTS Among the 2,954 patients cared for by a behavioral health provider, 49% met criteria for moderate or severe depression and/or anxiety. The median duration between appointment scheduling and a behavioral health triage visit was 2 days (SD = 7.2 days), and median interval to an initial psychotherapy visit was 10 days (SD = 14 days). The mean number of visits with a behavioral health provider within the initial 3 months after presenting for care was 5.3 visits (SD = 2.8 visits). During the course of treatment, anxiety (Generalized Anxiety Disorder-7 [GAD-7] scores) decreased by 31% and depression (Patient Health Questionnaire-9 [PHQ-9] scores) decreased by 24%. Patient satisfaction with their behavioral health care was excellent. DISCUSSION Integrating behavioral health services into employer-sponsored clinics can result in timely access to psychotherapy, improvements in clinical symptoms, and excellent patient satisfaction. Employers interested in providing greater access to behavioral health care should evaluate integrating such services into onsite or near-site health clinics. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
Published: 2020

36. Effect of gamma radiation on the structure and thermal properties of polyaniline-cobalt/polycarbonate nanocomposite

Author: A. A. Al-Hagg, Tarek M. Hegazy, Mohamed El-Feky, Rania Mohamed Samy, and Sayed hassan
Subjects: Thermogravimetric analysis, Nanocomposite, Materials science, Scanning electron microscope, General Medicine, chemistry.chemical_compound, chemistry, Differential thermal analysis, visual_art, Polyaniline, visual_art.visual_art_medium, Irradiation, Polycarbonate, Fourier transform infrared spectroscopy, Nuclear chemistry
Abstract: The induced alterations in the structure and thermal properties of polyaniline-cobalt/polycarbonate, PANI-Co/PC, nanocomposite (NCP) owing to  irradiation have been investigated. The chemical composition and morphology of the prepared NCP samples were studied using scanning electron microscopy and energy dispersive spectrometry technique. Additionally, X-ray diffraction (XRD), FTIR spectroscopy, thermogravimetric analysis (TGA) and differential thermal analysis (DTA) were performed to investigate the resulted effect of  radiation. The  radiation with doses 50-350 kGy leads to the prevalence of intermolecular crosslinking which enhances the disordered phase and increases the bonds between the hydrogen of the PANI amine groups and carbonyl groups of PC. This is reflected in a rise in the degradation temperature values from 400 to 475oC indicating an improvement in the thermostability of the NCP samples. Additionally, the melting temperature increased from 350 to 361 oC indicating a more compact structure of the NCP samples.
Published: 2020

37. Liver vitronectin release into the bloodstream increases due to reduced vagal muscarinic signaling after cerebral stroke in female mice

Author: Matthew P. Keasey, Chiharu Lovins, Cuihong Jia, and Theo Hagg
Subjects: Integrins, Physiology, Cholinergic Agents, Infarction, Middle Cerebral Artery, Vagus Nerve, Bethanechol, Stroke, Mice, Liver, Physiology (medical), Animals, Female, RNA, Messenger, Vitronectin
Abstract: Vitronectin (VTN) is a glycoprotein enriched in the blood and activates integrin receptors. VTN blood levels increase only in female mice 24 h after an ischemic stroke and exacerbate brain injury through IL-6-driven inflammation, but the VTN induction mechanism is unknown. Here, a 30 min middle cerebral artery occlusion (MCAO) in female mice induced VTN protein in the liver (normally the main source) in concert with plasma VTN. Male mice were excluded as VTN is not induced after stroke. MCAO also increased plasma VTN levels after de novo expression of VTN in the liver of VTN
Published: 2022

38. Eye-Movements During Navigation in a Virtual Environment: Sex Differences and Relationship to Sex Hormones

Author: TiAnni, Harris, Johanna, Hagg, and Belinda, Pletzer
Subjects: General Neuroscience
Abstract: Sex differences in spatial navigation have been related to different navigation strategies. For example, women are more likely to utilize local landmark-information in the environment compared to men. Furthermore, sex differences appear to be more pronounced when distances need to be judged in Euclidian terms and an allocentric representation of the environment is necessary. This suggests differential attentional processes during spatial navigation in men and women. However, eye-tracking studies on spatial navigation exploring these attentional processes are rare. The present study (39 men and 36 women) set out to investigate sex differences in eye-movements during spatial navigation in a 3D environment using virtual reality goggles. While we observed the expected sex differences in overall navigation performance, women did not benefit from the landmark-based instructions. Gaze fixations were in accordance with the preferred Euclidian strategy in men, but did not confirm the expected landmark-based strategy in women. However, high estradiol levels where related to an increased focus on landmark information. Surprisingly, women showed longer gaze distances than men, although the utilization of distal landmarks has been related to allocentric representations preferred by men. In fact, larger gaze distances related to slower navigation, even though previous studies suggest that the utilization of distal landmarks is beneficial for navigation. The findings are discussed with respect to the utility of virtual reality presentation for studies on sex differences in navigation. While virtual reality allows a full first-person immersion in the environment, proprioceptive and vestibular information is lacking.
Published: 2022

39. The Validity of the Parsley Symptom Index: an e-PROM designed for Telehealth

Author: Hants Williams, Sarah Steinberg, Kendall Leon, Catherine O’Shea, Robin Berzin, and Heather Hagg
Abstract: Background / PurposeThe Parsley Symptom Index (PSI) is a recently developed symptom assessment for adults with chronic disease in telehealth settings. The purpose of this study was to validate the PSI against the Self-Rated Health (SRH) item.Materials and MethodsThis prospective cohort study took place from January 15, 2021 to December 15, 2021 among a sample of 10,519 adult patients at Parsley Health, a subscription based holistic medical practice. The PSI and the SRH were completed by patients via an online portal. The association between the PSI and SRH was assessed via polyserial and polychoric correlations, while weighted kappa scores provided information related to agreement between the PSI and SRH.ResultsFrom 22,748 responses, there were moderate levels of association (polyserial r=0.51; polychoric r=0.52) and agreement (weighted □ = 0.46) between the PSI and SRH. In total 74.2% (16865) of responses between the PSI and SRH were relatively congruent while 36.2% (8229) were literally congruent.ConclusionsThe PSI demonstrates validity with the SRH for adults with chronic disease in a telehealth setting.
Published: 2022

40. Female-specific role of ciliary neurotrophic factor in the medial amygdala in promoting stress responses

Author: Cuihong Jia, W. Drew Gill, Chiharu Lovins, Russell W. Brown, and Theo Hagg
Subjects: Neurophysiology and neuropsychology, Anhedonia, Endocrine and Autonomic Systems, Physiology, QP351-495, Passive stress-coping, Neurosciences. Biological psychiatry. Neuropsychiatry, Neutralizing antibody, Biochemistry, Neuroendocrine response, Cellular and Molecular Neuroscience, Endocrinology, Stereotaxic injection, Chronic unpredictable stress, Neurology. Diseases of the nervous system, RC346-429, Molecular Biology, RC321-571
Abstract: Ciliary neurotrophic factor (CNTF) is produced by astrocytes which have been implicated in regulating stress responses. We found that CNTF in the medial amygdala (MeA) promotes despair or passive coping, i.e., immobility in an acute forced swim stress, in female mice, while having no effect in males. Neutralizing CNTF antibody injected into the MeA of wildtype females reduced activation of downstream STAT3 (Y705) 24 and 48 h later. In concert, the antibody reduced immobility in the swim test in females and only after MeA injection, but not when injected in the central or basolateral amygdala. Antibody injected into the male MeA did not affect immobility. These data reveal a unique role of CNTF in female MeA in promoting despair or passive coping behavior. Moreover, 4 weeks of chronic unpredictable stress (CUS) increased immobility in the swim test and reduced sucrose preference in wildtype CNTF+/+, but not CNTF-/- littermate, females. Following CUS, 10 min of restraint stress increased plasma corticosterone levels only in CNTF+/+ females. In males, the CUS effects were present in both genotypes. Further, CUS increased CNTF expression in the MeA of female, but not male, mice. CUS did not alter CNTF in the female hippocampus, hypothalamus and bed nucleus of stria terminalis. This suggests that MeA CNTF has a female-specific role in promoting CUS-induced despair or passive coping, behavioral anhedonia and neuroendocrine responses. Compared to CNTF+/+ mice, CNTF-/- mice did not show differences in CUS-induced anxiety-like behavior and sensorimotor gating function as measured by elevated T-Maze, open field and pre-pulse inhibition of the acoustic startle response. Together, this study reveals a novel CNTF-mediated female-specific mechanism in stress responses and points to opportunities for developing treatments for stress-related disorders in women.
Published: 2022

41. An Employer-Sponsored Musculoskeletal Care Coordination Service Can Improve Clinical Outcomes and Self-Reported Productivity

Author: Heather K. Hagg, Allison R. Schoeneck, Daniel Pizzarello, Divya K. Madhusudhan, Sujith Thokala, and Dena M. Bravata
Subjects: Musculoskeletal care, medicine.medical_specialty, Referral, Eighty Nine, 03 medical and health sciences, 0302 clinical medicine, Clinical pathway, musculoskeletal care, Humans, Medicine, Prospective Studies, Referral and Consultation, Productivity, Physical Therapy Modalities, Service (business), business.industry, Public Health, Environmental and Occupational Health, Original Articles, 030210 environmental & occupational health, Low back pain, care coordination, physical medicine, Mood, occupational health, Physical therapy, Self Report, medicine.symptom, business, Low Back Pain
Abstract: Objective: To evaluate the effects of participation with a novel musculoskeletal care coordination service on clinical outcomes, self-reported productivity, and satisfaction. Methods: Prospective analysis of participants using the service from January 1, 2019 to December 31, 2019. Results: One hundred eighty nine participants were enrolled; 54 participants completed their recommended clinical pathway. Low back pain was the most common musculoskeletal issue (N = 86, 46%). 88 participants (47%) were triaged to home exercise and 59 (31%) to physical therapy. Behavioral health issues were common: 47 participants (25%) were referred to their EAP. Only 30 participants (16%) required a medical referral. Engagement was associated with improvements in pain, physical function, mood, and self-reported productivity (P
Published: 2020

42. Blood Vitronectin Induces Detrimental Brain Interleukin-6 and Correlates With Outcomes After Stroke Only in Female Mice

Author: Hannah M. Malone, Matthew P. Keasey, Theo Hagg, Chiharu Lovins, Jacob Elam, and Cuihong Jia
Subjects: Male, medicine.medical_specialty, Ischemia, Leukemia Inhibitory Factor, Article, Mice, 03 medical and health sciences, chemistry.chemical_compound, Sex Factors, 0302 clinical medicine, Internal medicine, Animals, Medicine, Ciliary Neurotrophic Factor, RNA, Messenger, Vitronectin, Stroke, 030304 developmental biology, Inflammation, Mice, Knockout, Advanced and Specialized Nursing, 0303 health sciences, biology, Interleukin-6, business.industry, Macrophages, Penumbra, Interleukin, Infarction, Middle Cerebral Artery, medicine.disease, Castration, Endocrinology, chemistry, Blood-Brain Barrier, Knockout mouse, biology.protein, Female, Microglia, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery, Hormone
Abstract: Background and Purpose— Women have worse stroke outcomes than men, especially after menopause. Few studies have focused on female-specific mechanisms, other than hormones. We investigated the role of the blood protein VTN (vitronectin) after ischemic stroke in mice. Methods— Adult male and female VTN knockout and wild-type littermates and C57BL/6 mice received a middle cerebral artery occlusion and the injured brain tissue analyzed 24 hours to 3 weeks later for cell loss and inflammation, as well as neurological function. Blood VTN levels were measured before and after stroke. Results— Intravenously injected VTN leaked extensively from bloodstream into brain infarct and penumbra by 24 hours after stroke. Strikingly, VTN was detrimental in female, but not male, mice, as shown by reduced brain injury (26.2±2.6% versus 13.4±3.8%; P =0.018; n=6 and 5) and forelimb dysfunction in female VTN knockout mice. Stroke increased plasma VTN 2- to 8-fold at 24 hours in females (36±4 versus 145±24 μg/mL; P P >0.99; n=10 and 7), and returned to control levels by 7 days. Individually variable VTN levels at 24 hours correlated with stroke-induced brain injury at 7 days only in females. VTN promoted stroke-induced microglia/macrophage activation and leukocyte infiltration in females. Proinflammatory IL (interleukin)-6 greatly increased in the striatum at 24 hours in wild-type mice but was increased ≈60% less in female (739±159 versus 268±111; P =0.02; n=7 and 6), but not male (889±178 versus 1179±295; P =0.73; n=10 and 11), knockout mice. In individual wild-type females, plasma VTN levels correlated with striatal IL-6 expression at 24 hours. The female-specific effect of VTN-induced IL-6 expression following stroke was not due to gonadal hormones, as shown by ovariectomy and castration. Lastly, intrastriatal injection of IL-6 in female mice immediately before stroke reversed the VTN knockout phenotypes of reduced brain injury and microglia/macrophage activation. Conclusions— VTN plays a novel sexually dimorphic detrimental pathophysiological role in females and might ultimately be a therapeutic target to improve stroke outcomes in women.
Published: 2020

43. Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes

Author: Mark A. Febbraio, Darren C. Henstridge, Paul Gregorevic, Jonathan R. Davey, Hongwei Qian, Helen Ludlow, Mark P. Hedger, Martin Whitham, Melinda T. Coughlan, Sean L. McGee, Adam Hagg, Rachel E. Thomson, Emma Estevez, and Kevin I. Watt
Subjects: 0301 basic medicine, Follistatin, endocrine system, medicine.medical_specialty, medicine.medical_treatment, Glucose uptake, Glycemic Control, Type 2 diabetes, Biochemistry, Diabetes Mellitus, Experimental, Mice, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Internal medicine, Diabetes mellitus, Genetics, medicine, Animals, Molecular Biology, Glycemic, biology, business.industry, Insulin, Gene Transfer Techniques, Skeletal muscle, Genetic Therapy, medicine.disease, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, Diabetes Mellitus, Type 2, Hyperglycemia, biology.protein, Administration, Intravenous, Insulin Resistance, business, hormones, hormone substitutes, and hormone antagonists, 030217 neurology & neurosurgery, Biotechnology
Abstract: Type 2 diabetes (T2D) manifests from inadequate glucose control due to insulin resistance, hypoinsulinemia, and deteriorating pancreatic β-cell function. The pro-inflammatory factor Activin has been implicated as a positive correlate of severity in T2D patients, and as a negative regulator of glucose uptake by skeletal muscle, and of pancreatic β-cell phenotype in mice. Accordingly, we sought to determine whether intervention with the Activin antagonist Follistatin can ameliorate the diabetic pathology. Here, we report that an intravenous Follistatin gene delivery intervention with tropism for striated muscle reduced the serum concentrations of Activin B and improved glycemic control in the db/db mouse model of T2D. Treatment reversed the hyperglycemic progression with a corresponding reduction in the percentage of glycated-hemoglobin to levels similar to lean, healthy mice. Follistatin gene delivery promoted insulinemia and abundance of insulin-positive pancreatic β-cells, even when treatment was administered to mice with advanced diabetes, supporting a mechanism for improved glycemic control associated with maintenance of functional β-cells. Our data demonstrate that single-dose intravascular Follistatin gene delivery can ameliorate the diabetic progression and improve prognostic markers of disease. These findings are consistent with other observations of Activin-mediated mechanisms exerting deleterious effects in models of obesity and diabetes, and suggest that interventions that attenuate Activin signaling could help further understanding of T2D and the development of novel T2D therapeutics.
Published: 2020

44. Text mining of Reddit posts: Using latent Dirichlet allocation to identify common parenting issues

Author: Lauryn J Hagg, George J. Youssef, Matthew Fuller-Tyszkiewicz, Tomer S. Berkowitz, Elizabeth M. Westrupp, and Christopher J Greenwood
Subjects: Parents, Computer science, Emotions, PsyArXiv|Social and Behavioral Sciences|Developmental Psychology, 170199 Psychology not elsewhere classified, Social Sciences, FOS: Health sciences, PsyArXiv|Social and Behavioral Sciences|Developmental Psychology|Toddlerhood/Preschool Period, PsyArXiv|Social and Behavioral Sciences|Developmental Psychology|Middle & Late Childhood, Families, Fathers, Psychology, Data Mining, bepress|Social and Behavioral Sciences|Psychology|Child Psychology, Computer Networks, bepress|Social and Behavioral Sciences|Psychology|Developmental Psychology, Child, PsyArXiv|Social and Behavioral Sciences|Developmental Psychology|Early Childhood, Children, Multidisciplinary, Parenting, Semantics, FOS: Psychology, Child, Preschool, symbols, Medicine, Infants, Research Article, Computer and Information Sciences, Adolescent, Science, Parenting Behavior, 111799 Public Health and Health Services not elsewhere classified, 111714 Mental Health, Latent Dirichlet allocation, symbols.namesake, Text mining, Humans, Toddlers, Behavior, Internet, Information retrieval, PsyArXiv|Social and Behavioral Sciences|Developmental Psychology|Social Development, business.industry, Infant, Newborn, Biology and Life Sciences, Infant, Linguistics, PsyArXiv|Social and Behavioral Sciences, Age Groups, People and Places, bepress|Social and Behavioral Sciences, Population Groupings, business, Social Media
Abstract: Background: Parenting interventions offer an evidence-based method for the prevention and early intervention of child mental health problems, but to-date their population-level effectiveness has been limited by poor reach and engagement, particularly for fathers, working mothers, and disadvantaged families. Internationally, there has been a call for more sensitive intervention frameworks that better recognize parents’ differences and match support accordingly. Tailoring intervention content to parents’ context (i.e., to common parenting situations) offers potential to enhance parent engagement and learning by increasing relevance of content to parents’ daily experiences. However, this approach requires a detailed understanding of the common parenting situations and issues that parents face day-to-day, which is currently lacking.Objective: We sought to identify the most common parenting situations discussed by parents on parenting-specific forums of the free online discussion forum, Reddit, one of the most popular social media platforms in the world. We aimed to understand perspectives from both mothers and fathers, and therefore retrieved publicly available data from two parenting-specific ‘subreddits’ (r/Daddit; r/Mommit).Methods: We used latent Dirichlet allocation (LDA) to identify the most common topics discussed in the Reddit posts. Once topics were identified, we completed a manual text analysis of the 10 posts ranked as most relevant to each topic, and summarized the parenting situations that were described. Our pre-specified definition of a parenting situation required that the post involve a parent and their child aged 0-18 years and describe a potential or actual difficulty or issue.Results: We retrieved 340 (r/Daddit) and 578 (r/Mommit) original posts. A model with 31 LDA topics was found to be the best fitting model. Of these, 24 topics included posts that met our inclusion criteria for manual review. From these, we identified 45 unique but broadly-defined parenting situations. The majority of parenting situations were either focused on basic childcare situations relating to eating, sleeping, routines, sickness and toilet training; or related to how to respond to child negative emotions or difficult behavior. Most situations were discussed in relation to infant or toddler age children, and on the whole, there was a high level of consistency in the themes raised in r/Daddit and r/Mommit.Conclusions: Our text analysis of the r/Daddit and r/Mommit posts highlighted two overarching themes in topics commonly discussed in online parenting forums; basic childcare, and management of child emotions and behavior. Our results offer potential to tailor parenting interventions in a meaningful way, creating opportunities to develop content and resources that are directly relevant to parents’ lived experiences.
Published: 2022

45. sj-pdf-1-jcb-10.1177_0271678X221107871 - Supplemental material for Female-specific neuroprotection after ischemic stroke by vitronectin-focal adhesion kinase inhibition

Author: Jia, Cuihong, Lovins, Chiharu, Malone, Hannah M, Keasey, Matthew P, and Hagg, Theo
Subjects: 110320 Radiology and Organ Imaging, FOS: Clinical medicine, FOS: Biological sciences, Medicine, Cell Biology, 110305 Emergency Medicine, 110306 Endocrinology, Biochemistry, 69999 Biological Sciences not elsewhere classified, 110904 Neurology and Neuromuscular Diseases, Neuroscience
Abstract: Supplemental material, sj-pdf-1-jcb-10.1177_0271678X221107871 for Female-specific neuroprotection after ischemic stroke by vitronectin-focal adhesion kinase inhibition by Cuihong Jia, Chiharu Lovins, Hannah M Malone, Matthew P Keasey and Theo Hagg in Journal of Cerebral Blood Flow & Metabolism
Published: 2022
Full Text: View/download PDF

46. Glaciology and Glacial Geomorphology

Author: Wilfried Hagg
Published: 2022

47. Origin of Glaciers

Author: Wilfried Hagg
Published: 2022

48. Measuring RF-accelerated fast ions with DD and DT neutron spectroscopy: comparison of velocity-space sensitivity

Author: Eriksson J., Andersson-Sunden E., Conroy S., Dal Molin A., Ericsson G., Eriksson B., Hjalmarsson A., Hagg L., Jarleblad H., Nocente M., Rigamonti D., Salewski M., and Tardocchi M.
Subjects: neutron spectroscopy, fusion plasma reactions, RF-accelerated fast ions
Published: 2022

49. Glacial Erosion

Author: Wilfried Hagg
Published: 2022

50. Mass and Energy Balance of Glaciers

Author: Wilfried Hagg
Published: 2022

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