1. Topical dorzolamide for macular holes: A randomised, double-blind, placebo-controlled trial.
- Author
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Lee YM, Bahrami B, Baranage D, Sivagurunathan PD, Wong W, Bausili MM, Agrawal S, Gilhotra JS, Durkin S, Sia D, Selva D, Lake S, Casson RJ, and Chan WO
- Abstract
Background: To assess topical dorzolamide as medical therapy for idiopathic full-thickness macular holes (FTMHs)., Methods: Randomised, double-blinded, placebo-controlled, single-centre clinical trial involving 32 patients with idiopathic small FTMHs (<400 μm $$ \upmu \mathrm{m} $$ ). Participants in both arms used topical dorzolamide 2% or saline thrice daily for 8 weeks with monthly OCT. Those with persisting FTMH underwent vitrectomy with ILM peel and gas tamponade. The primary outcome was the rate of FTMH closure at the end of treatment., Results: Between 6 March 2020 and 16 June 2023, 32 eligible patients were enrolled: 16 participants in each arm. All participants in both groups were included in the final analysis. At the final visit, 3 of 16 (18.8%) patients in both the topical dorzolamide and placebo group demonstrated closure. There was no statistically significant difference in the proportion of FTMH closure between the control and treatment group (p = 1.00), nor statistically significant difference in the mean change in best corrected visual acuity (BCVA; p = 0.909). There was no difference in the change in FTMH diameter between groups (p = 0.225). No serious adverse events were reported in either group., Conclusion: Topical dorzolamide was safe but not superior to placebo in the functional and anatomical outcomes of FTMH., (© 2024 The Author(s). Clinical & Experimental Ophthalmology published by John Wiley & Sons Australia, Ltd on behalf of Royal Australian and New Zealand College of Ophthalmologists.)
- Published
- 2024
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