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Recent progress of gene circuit designs in immune cell therapies.

Authors :
Lee S
Khalil AS
Wong WW
Source :
Cell systems [Cell Syst] 2022 Nov 16; Vol. 13 (11), pp. 864-873.
Publication Year :
2022

Abstract

The success of chimeric antigen receptor (CAR) T cell therapy against hematological cancers has convincingly demonstrated the potential of using genetically engineered cells as therapeutic agents. Although much progress has been achieved in cell therapy, more beneficial capabilities have yet to be fully explored. One of the unique advantages afforded by cell therapies is the possibility to implement genetic control circuits, which enables diverse signal sensing and logical processing for optimal response in the complex tumor microenvironment. In this perspective, we will first outline design considerations for cell therapy control circuits that address clinical demands. We will compare and contrast key design features in some of the latest control circuits developments and conclude by discussing potential future directions.<br />Competing Interests: Declaration of interests W.W.W. is a co-founder and shareholder of Senti Biosciences. A.S.K. is a shareholder of Senti Bioscience and Chroma Medicine. S.L. is a current employee of Sanofi.<br /> (Copyright © 2022 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
2405-4720
Volume :
13
Issue :
11
Database :
MEDLINE
Journal :
Cell systems
Publication Type :
Academic Journal
Accession number :
36395726
Full Text :
https://doi.org/10.1016/j.cels.2022.09.006