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BACKGROUND: Metastasis to the oral cavity is infrequent, representing 1 to 3% of head and neck cases. The types of cancer that commonly cause metastasis to the mouth are lung, kidney, and prostate for men, and breast, kidney, and colon for women. The clinical presentation depends on the affected site and varies from an evident tumor to a slight swallow mimicking a reactive lesion, accompanied by pain and paresthesia. CLINICAL CASE: A 59-year-old woman evaluated in the Pathology and Oral Medicine Clinic of the Autonomous Metropolitan University of the City, diagnosticated with oral metastasis from renal carcinoma. CONCLUSION: Clinical findings lead to an accurate diagnosis; it is important to offer the appropriate treatment, by the specialist in Pathology and Oral Medicine, as part of the multidisciplinary team, to ensure a better quality of life in this type of patient. [ABSTRACT FROM AUTHOR]

The clear cell renal carcinoma cutaneous metastases are mainly located in the head and thorax. Its presence establishes a poor prognosis, since it is indicative that the disease is advanced. These lesions are usually asymptomatic and rapidly growing, erythematous or violaceous, with prominent vasculature and well circumscribed; determined by histopathology and immunohistochemistry. Treatment consists of surgical excision and/or chemotherapy in case of multiple lesions. Although skin cell metastases of clear cell renal carcinoma are rare, it is necessary the dermatological description in terms of topography and morphology to relate it to this type of carcinoma, although it is not a good prognosis to find them, it could be a diagnosis of renal carcinoma of clear cells, which might not have had other manifestations. Follow-up skin assessment is suggested for all patients diagnosed with renal cancer. [ABSTRACT FROM AUTHOR]

Background: Ductal cell carcinoma is an uncommon subtype of aggressive renal neoplasia arising from the medullary collecting ducts, which have been described in different countries and ethnic groups. Very few series of this tumor have been reported, and most publications in the medical literature deal with single cases. Patients and method: We present the clinicopathological findings of 10 cases collected during the last decade. The patients were 6 males and 4 females that ranged in age from 34 to 65 years (mean: 51.3 years). Hematuria, hidronephrosis, lumbar pain, renal lithiasis and weight loss were the main clinical symptoms related to the renal tumors. Four patients died due to the neoplasia, and in three of them widespread metastases were found in the postmortem examination. Results: Histologically, all the tumors showed a high Fuhrman nuclear-grade and were composed of a varied pattern of tubular, tubulopapillary, microcystic and trabecular epithelial cells growing in a desmoplastic stroma with mixed inflammation. Additionally in three tumors, we observed secretory metaplasia with signet ring cells, sarcomatoid changes and hyaline globules respectively. The tumor cells exhibited typical and consistent immunohistochemical positive staining with antibodies for cytokeratin 7, cytokeratin AE1/AE3 and Ulex europaeus lectin. Conclusions: Histopathological features together with the immunohistochemical staining for cytokeratin 7 and Ulex europaeus are in our view, the most important findings for the identification of renal ductal carcinoma that is an entity not yet well recognized by some clinicians and pathologists. [ABSTRACT FROM AUTHOR]

We have presented a case of an angiogenic renal tumor in a patient from a family with von Hippel Lindau' syndrome (VHL). The patient has bilateral clear cell carcinoma (CCC) .Molecular mechanisms recently discovered are described in order to require a better understanding of the development of this disease. The knowledge of these mechanisms, may allow to achieve better therapeutic approaches to neutralize the tumors of VHL disease. In this patient, an antiproliferative, antiangiogenic therapy was preferred. Rapamycin was chosen due to the lack of information regarding the use of antitumoral monoclonal antibodies in dialysis patients. VHL disease needs to be early detected, because many of its effects can be readily treated assuring a better survival for these patients. Antiangiogenic therapy can be used for CCC in this disease with promising results. [ABSTRACT FROM AUTHOR]

Objective: To present the initial experience on lumboscopic radical nephrectomy in our hospital. Materials and methods: We reviewed the clinical files of 18 patients who underwent a radical lumboscopic nephrectomy at Urology Service of the Hospital de Especialidades del Centro Médico Nacional Siglo XXI from October 2003 to October 2005. Results: In total, 18 patients underwent a lumboscopic radical nephrectomy. The mean operative time was 2 hours 50 min and transoperatory bleeding of 80 cc. In two cases was necessary to convert to open surgery for the completion of the procedure. There was no perioperative mortality. The hospital stay was 2.6 days, the 24 hour postoperative pain rate, measured by an analogous pain scale from 0 to 10 was 3.5. The mean tumoral diameter was 5.6 cm. The pathological study showed renal clear cell carcinoma in 17 cases and a sarcomatoid renal cell carcinoma in one patient. The final pathological stages of the patients with renal clear cell carcinoma, according to the TNM classification system were: T1, N0, M0 in 9 cases, T2, N0, M0 in 6 and T3a, N0, M0 in 2. Conclusions: The lumboscopic radical nephrectomy has several advantages over the open approach: less transoperatory bleeding, shorter hospital stay and lower analgesic requirement. Compared to the transperitoneal approach lumboscopy reduces the incidence of intra-abdominal complications. In our country, this is the first series of lumboscopic radical nephrectomy. A larger number of cases as well as a longer follow-up are necessary to precisely assess this surgical approach. [ABSTRACT FROM AUTHOR]

Laparoscopic radical nephrectomy has been introduced like a standard procedure in urology. The hand-assisted procedure gives the urologist a better tactile sensation; therefore, it makes the procedure easier and with a smaller learning curve. Materials and methods: We evaluated the use of laparoscopy in a man with a small tumor (3 cm) in the lateral portion of the right kidney. The characteristics of the patient, as well as the tumor size, were examined taking into account the easiness of the surgical dissection and its results. The CT scan was used to identify the tumor size. Results: A laparoscopic right radical nephrectomy without the necessity of converting to open was done to the patient. A 7 cm incision was made to place the left hand and the subsequent extraction of the kidney. The patient was 59 years old. Tumor size was 3 cm, located towards the lateral portion of the right kidney. Surgical time was 290 minutes. Blood loss was 350 cc Conclusions: The hand-assisted laparoscopic radical nephrectomy is a reproducible technique of minimally invasive surgery that shortens the learning curve for urologists, because they are familiarized with this kind of procedure. [ABSTRACT FROM AUTHOR]

Laparoscopic radical nephrectomy has gained acceptance since its introduction in 1991. It is considered nowadays as a good alternative for treating small tumors in most of the medical centers in the United States. Material and method: We report the first laparoscopic radical nephrectomy made in our hospital on a 48 year-old female with a small tumor (3 cm) in the right kidney found during follow-up of a breast cancer diagnosed and treated four years earlier. Patient characteristics and size of the tumor were examined and correlated with ease of surgical dissection and surgical outcome. Computed tomography was used to identify the tumor size. Result: The patient underwent successful laparoscopic radical nephrectomy without the need for an open conversion. We made a 7 cm incision for the extraction of the kidney at the level of lateral trocar. The size of the tumor was 3.0 cm located on the lower pole. The operative time was 340 minutes. The estimated blood loss was 250 cc. Conclusions: Laparoscopic radical nephrectomy is a reproducible technique of minimally invasive surgery that is a lengthy and demanding procedure today. [ABSTRACT FROM AUTHOR]