1. Seizure remission in adults with long-standing intractable epilepsy: An extended follow-up
- Author
-
Choi, Hyunmi, Heiman, Gary A., Munger Clary, Heidi, Etienne, Mill, Resor, Stanley R., and Hauser, W. Allen
- Subjects
- *
EPILEPSY , *SPASMS , *FOLLOW-up studies (Medicine) , *COHORT analysis , *DISEASE relapse ,DISEASES in adults - Abstract
Summary: Recent studies have provided much needed data on the probability of seizure remission among adults with chronic intractable epilepsy treated medically. Here we provide an extended follow-up to our earlier study in order to provide a more comprehensive picture of long-term prognosis in this patient population during medical treatment. The prevalence cohort was followed for two outcomes—complete seizure remission for ≥12 months and subsequent seizure relapse among those attaining a seizure remission. The study outcomes were estimated using Kaplan–Meier analysis. We found that the probability of attaining a ≥12 months of complete seizure freedom to be approximately 3–4% per year through 8 years of follow-up. By year 5 since the start of seizure remission, the cumulative probability of seizure relapse was 81%, although only half of the patients with seizure relapse went on to experience their previous seizure frequency. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF