Back to Search
Start Over
L-Histidine Decarboxylase and Tourette's Syndrome.
- Source :
-
New England Journal of Medicine . 5/20/2010, Vol. 362 Issue 20, p1901-1908. 8p. 3 Diagrams. - Publication Year :
- 2010
-
Abstract
- Tourette's syndrome is a common developmental neuropsychiatric disorder characterized by chronic motor and vocal tics. Despite a strong genetic contribution, inheritance is complex, and risk alleles have proven difficult to identify. Here, we describe an analysis of linkage in a two-generation pedigree leading to the identification of a rare functional mutation in the HDC gene encoding L-histidine decarboxylase, the rate-limiting enzyme in histamine biosynthesis. Our findings, together with previously published data from model systems, point to a role for histaminergic neurotransmission in the mechanism and modulation of Tourette's syndrome and tics. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00284793
- Volume :
- 362
- Issue :
- 20
- Database :
- Academic Search Index
- Journal :
- New England Journal of Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 50724728
- Full Text :
- https://doi.org/10.1056/NEJMoa0907006