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Objective To systematically evaluate the efficacy and safety of linaclotide combined with polyethylene glycol（PEG） electrolyte powder in bowel preparation.Methods PubMed, Web of Science, the Cochrane Library, Embase, China National Knowledge Infrastructure（CNKI）,China Biomedical Literature Database（CBM）,Wanfang and VIP databases were searched by computer to collect clinical studies on linaclotide combined with PEG as a bowel preparation regimen.The search time was from the establishment of the databases to May 2023.Two researchers independently extracted data and assessed the quality of the included studies.Meta-analysis was performed using RveMan5.4 software.Results A total of 11 articles were included, with a total of 2 381 patients, including 1 193 cases in the linaclotide combined with PEG group and 1 188 cases in the PEG group.The results of meta-analysis showed that there was no significant difference in Boston bowel preparation score [mean difference（MD）=-0.02,95% confidence interval（95%CI）-0.10-0.07,P=0.69] and adenoma detection rate [relative risk（RR）=0.95,95%CI 0.78-1.16,P=0.61] between linaclotide combined with PEG group and PEG group.In terms of safety, the incidence of nausea（RR=0.48,95%CI 0.39-0.58,P＜0.001）,abdominal distension（RR=0.46,95%CI 0.33-0.63,P＜0.001）,abdominal pain（RR=0.27,95%CI 0.16-0.43,P＜0.001） and vomiting（RR=0.32,95%CI 0.19-0.52,P＜0.001） in the linaclotide combined with PEG group were significantly lower than those in the PEG group.Conclusion As a bowel preparation regimen, linaclotide combined with PEG can not only reduce the amount of PEG,but also reduce the incidence of gastrointestinal adverse reactions. [ABSTRACT FROM AUTHOR]

Objective To observe the efficacy and safety of vonoprazan (VNP) and omeprazole in the treatment of helicobacter pylori (Hp). Methods A total of 240 patients with chronic gastritis confirmed by gastroscopy as Hp infection admitted to Department of Gastroenterology of this hospital from August 2021 to May 2022 were divided into the proton pump inhibitor (PPI) 14 d group, VNP 14 d group and the VNP 7 d group by the random number sequence generated by STATA 9. 0 statistical software, with 80 cases in each group. There were two, three and four cases of shedding in the PPI 14 d group, VNP 14 d group and VNP 7 d group due to missing follow-up, respectively, and two and two cases of shedding in the PPI 14 d group and VNP 7 d group due to irregular medication, respectively, with a shedding rate of 5.4%. A total of 76,77, and 74 patients in the PPI 14 d group, VNP 14 d group and VNP 7 d group were finally included. All patients in the three groups were given anti-Hp treatment, they received 2.0 g bismuth potassium citrate granule, twice a day + amoxicillin capsule 500 mg, twice a day+clarithromycin tablet 500 mg, twice a day, and a combination of 7 d VNP 20 mg twice a day (the VNP 7 d group), 14 d omeprazole 20 mg twice a day (the PPI 14 d group), or VNP 20 mg twice a day(the VNP 14 d group). Four to six weeks after the end of treatment. fasting carbon 13 urea breath test was performed to re-examine Hp. The eradication rate of Hp and the incidence of adverse re- actions in the three groups were compared. Results The eradication rates of intentional treatment analysis of the PPI 14 d group, VNP 14 d group and VNP 7 d group were 80.0%.83.8% and 76.2%, respectively, and the eradication rates of experimental protocol analysis were 84. 2%, 87.0% and 82. 4%, respectively. There was no significant difference in Hp clearance among the three groups (P>0.05). All adverse events were mild, and there was no significant difference in the incidence of adverse events among the three groups (P＞0.05) Conclusion The VNP 7 d regimen is well tolerated, and its efficacy and safety are similar to the PPI 14 d regimen and VNP 14 d regimen. Therefore, the VNP 7 d regimen may be one of the recommended programs to eradicate Hp. [ABSTRACT FROM AUTHOR]

Objective To investigate the efficacy of "probiotics No. 1" in the treatment of irritable bowel syndrome(IBS). A total of 300 patients with diarrhen type IRS (IBS-D) and constipation type IBS (IBS-C) who were diagnosed and trea ted in the hospital from July to December 2020 were randomly divided into test group with 154 cases (IBS C test subgroup 40 cases, IBS-D test subgroup 114 cases) and control group with 146 cases (IBS-C control subgroup 36 cases. IBS-D control subgroup 110 cases) respectively orally take "probiotics No. 1 and placebo for 2 weeks. The IRS severity questionnaire (IBS SSS) score and the Bristol classification (Bristol) classification score of the patients in each group were evaluated at 0,1,2 weeks of medication and 1 week of drug withdrawal. The IBS quality of life scale (IBS-QOL) score of each group - evaluated for 2 weeks, and the occur rence of adverse reactions during the medication was recorded. Results A total of 264 cases were completed, including 134 cases in the test group (37 cases in the IBS-C test subgroup. 97 cases in the IBS-D test subgroup) 130 cases in the control group (35 cases in the IBS-C control subgroup, and 95 cases in the IBS-D control subgroup). IBS-SSS scores of patients in the test group. control group. IBS-D test subgroup and IBS-D control subgroup at after 1 and 2 weeks of medication, and the stool Bristol scores of patients in the IBS-D test subgroup and control subgroup at after 1 and 2 weeks of medication were significantly lower than those before medication, and the decline in the test group and IBS-D test subgroup were more significant than those of the control group and IBS D control subgroup, and the differences were statistically significant (P<0,05), The IBS-SSS scores of patients in the IBS-C test subgroup was only significantly lower after 2 weeks of medication than that before medication, and the difference was statistically significant (P<0, 05). The response rate of IBS-SSS score in the test group was significantly higher than that in the control group, and the difference was statistically significant (P<0, 05), One week after the drug was stopped, IBS SSS score of the control group and IBS-D control subgroups had a significant increase, IBS-C control subgroups had a significant decrease in stool Bristol classification scores compared with those at after 2 weeks of medication, and the differences were statistically significant (P<0.05). The test group and IBS-D, IBS-C test subgroups had no significant changes compared with the previous ones. After taking the drug for 2 weeks, the IBS QOL scores of the patients in test group.control group, IBS-D test subgroup and IBS-D control subgroup were significantly lower than those before medication and the test group and IBS-D test subgroup decreased compared with the control group and IBS-D control subgroup were more obvious, and the differences were statistically significant (P<0, 05). The changes in IBS QOL scores before and after medication in the IBS-C test and control subgroups were statistically significant (P<0.05) and there were no differences between the groups. Conclusion Compared with placebo, taking "probiotics No. 1 for 2 weeks can improve the overall symptoms, stool characteristics and quality of life of IBS patients especially in IBS-D patients. It is worthy of climcal promotion. [ABSTRACT FROM AUTHOR]

The adaptive dynamic surface control is proposed for a class of uncertain nonlinear strict-feedback systems proceeded by unknown input dead-zone. Unlike the low-order filters used in CSCD, the nonlinear filters with time-varying integral function are utilized to cope with the virtual controls. The proposed control method not only overcomes the “explosion of terms” and reduces the computational complexity, but also simplify the structure of the controller. Furthermore, it compensates the boundary layer error inherent in the dynamic surface procedure. Theoretical analysis proves that the proposed control scheme can eliminate the influence of dead zone nonlinearity and ensure the stability of the closed-loop system. Taking the simulation of a single-arm manipulator as an example, the transient performance can be improved by the tuning of design parameters, and the asymptotic convergence of the tracking error can be achieved, which verifies the effectiveness of the proposed method. [ABSTRACT FROM AUTHOR]

由于回盲部有着复杂的符剖结构、淋巴结丰富及食物在此处停留时间长，使得该处成为溃疡性疾病的好发部位。 但是回盲部溃疡包含的疾病种类味多， 如肠结核、炎症性肠病、肠道白塞病等，且不同的疾病其治疗方法截然不同， 因而出现误诊、 误治时对患者的预后也截然不同。该义拟就回盲部溃疡性疾病的组成、诊断现状、鉴别诊断进行综述， 旨在总结不同疾病的诊断 特点， 以期为临床医生诊断回育部溃疡性疾病提供帮助。 [ABSTRACT FROM AUTHOR]

Objective To observe the effects of different treatment regimens on clinical symptoms and quality of life in patients with functional dyspepsia (FD) combined with Helicobacter pylori (Hp) infection and mild to moderate anxiety and depression. Methods From Jun. 2018 to Jun. 2019.90 FD patients with Hp infection and mild to moderate anxiety and depression were randomly divided into group A,B,and C. Group A was treated with quadruple Hp eradication treatment for 2 weeks,and then continued to be treated with antacid drug for 1 weeks. Group B was treated with flupentixol and melitracen tablets for 6 weeks. Group C was treated with quadruple Hp eradication treatment for 2 weeks and at the same time treated with flupentixol and mclitracen tablets for 6 weeks. The dyspepsia symptom score, anxiety score, depression score, and quality of life score were evaluated before treatment and after 6 weeks of treatment. Results Compared with before treatment, the average scores of dyspepsia symptom was reduced in group A, B and C(P<0. 05), and the total effective rate on dyspepsia symptoms was 16. 67%,82. 00% and 83. :33%. After 6 weeks of treatment,there was no significant change of anxiety,depression and quality of life scores in group A (CP>0. 05), the scores of anxiety and depression in group B and C were significantly lower, and the quality of life score was significantly higher (CP<0. 05). Compared with group A. there were significant differences of all the scores in group Band group C after 6 weeks of treatment (P <0. 05), but there was no significant difference between group B and group C (P>0. 05). Conclusion For patients with FD, combined with Hp infection and mild to moderate anxiety and depression, routine Hp eradication therapy might be with limited improvement in symptoms, while anti-anxiety or depression treatment could effectively improve the clinical symptoms, which might have the same effect with anti-anxiety or depression treatment combined with Hp eradication treatment. [ABSTRACT FROM AUTHOR]

Objective To investigate the effect of Inula britannica flower total flavonoids (IBFTF) on autophagy of aging L929 cells by detecting the levels of autophagy in the process of senescence of L929 cells for better development of the medicinal value of IBFTF. Methods Cell senescence models were established by using D-galactose (D-gal) solutions (0, 5, 10, 20 and 40 g/L) on L929 cells to find out the most appropriate concentration of D-gal for inducing senescence in L929 cells. IBFTF solutions (25, 50, 100 mg/L) were applied to aging L929 cells to investigate the effect of IBFTF on L929 cell senescence and autophagy. The effect of D-gal on the viability of L929 cells was detected with MTT. β-galactosidase staining was used to detect the effect of D-gal at different concentrations on the senescence process of L929 cells. Fluorescence microscopy was used to detect the effect of IBFTF on ROS production in senescent L929 cells. The effects of IBFTF on the number of lysosomes and the expression of LC3 protein in senescent L929 cells were examined with acridine orange staining and immunofluorescence. The levels of autophagy-related proteins were detected with Western-Blot. Results IBFTF delayed the senescence process of aging L929 cells in a dose-dependent manner, and the autophagy level of L929 cells also increased in a dose-dependent manner during the aging delay process. Conclusion IBFTF delayed the senescence of D-gal-induced senescent cells, which may be related to the elevated levels of autophagy. [ABSTRACT FROM AUTHOR]

Because of the competition among retailers, it becomes difficult to share and transfer of inventory in the market, which results in a great waste of resources. In order to achieve the inventory transshipment and share among competitors, a manufacturer-oriented transshipment mechanism (referred as MOT) is designed to analyze the coordination strategy of the transshipment system by this study. Assuming that market demand is random, and there exists customer transfer, considering two sales periods, for a supply chain system of a single manufacturer and two retailers, the equilibrium game model of Stackelberg-Nash is built to characterize the supply chain distribution system first. And then, the MOT mechanism is designed to obtain the proactive transshipment among competitive retailers. The optimal equilibrium strategies of production, ordering, replenishment, transshipment, etc. of the decentralized nontransshipment, decentralized transshipment, and centralized transshipment systems are given by using the game analysis method, respectively. Lastly, a combination mechanism composing of the wholesales price contract, adjustment price contract, and franchise fee contract is designed to achieve the efficiency improvement of the decentralized supply chain system. The results show that the MOT mechanism can obtain effectively proactive transshipment among the competitive retailers. The combination mechanism under reasonable settings of the wholesale price, adjustment price, and fixed franchise fee can obtain the effective coordination of the supply chain distribution and transshipment system. Therefore, a more reasonable basis of inventory decision is provided by this study for firms. [ABSTRACT FROM AUTHOR]

Objective To investigate the clinical effects of different courses of venlafaxine treatment in patients with central mediated abdominal pain syndrome(CAPS). Methods From July 2018 to July 2019.120 patients with CAPS were randomly divided into group A, B, C and D, and venlafaxine(75 mg, once a day) were given for 1,3,6 and 9 months respectively in each group. The Hamilton anxiety scale( HAMA) score and visual analogue scale (VAS) pain score were evaluated in all patients before. after and 6 months after the treatment. Results After treatment, HAMA scores of all patients decreased compared with those before treatment (CP<0. 05),and compared with group A, HAMA scores of group B were with no difference( P>0. 05), but those of group C and D were significantly lower (CP<0. 05) .while there was no significant difference between group C and D (P>0. 05). After treatment, VAS pain scores of group B, C and D were significantly lower than those before treatment (P<0. 05), and were also significantly lower than group A (CP<0. 05). Six months after drug withdrawal, HAMA scores in group A were significantly increased compared with the scores by the end of treatment (P<0. 05). and both HAMA and VAS pain scores in group B were obviously increased (CP<0. 05),while neither HAMA nor VAS pain scores in group C and D were with significantly changes compared with those by the end of treatment(P>0. 05). Conclusion The course of 6 months of venlafaxine treatment in patients with CAPS could be with fine economic efficiency, curative effect and low recurrence rate. [ABSTRACT FROM AUTHOR]

Objective: To translate and evaluate the validity and reliability the Self Reflection and Insight Scale (SRIS) in patients with mental disorders. Method: A sample of 363 subjects were selected, including 140 patients with schizophrenia, 92 patients with depression, and 131 healthy people. All of them were assessed for the project analysis and exploratory factor analysis. The criterion validity was tested with the Toronto Alexithymia Scale-20 (TAS-20). Totally 20 patients were retested for test-retest reliability with 2 week interval. Results: Two factors were established in the exploratory factor analysis. The total mutation rate was 48.87% and the load was 0.34 -0. 81. The scores of difficulty in external oriental thinking in TAS-20 were negatively correlated with the scores of self-reflection in SRIS respectively (ICC = -0. 31, P < 0. 01). The scores of difficulty in identity feelings, difficulty in describe feelings and external oriental thinking in TAS-20 were negatively correlated with the scores of insight in SRIS respectively (ICC = - 0. 66, - 0. 23, - 0. 21, P < 0. 05). Cronbach' s alpha coefficient of total scale was 0.83, and the Cronbach's alpha coefficients of subscales were between 0. 86 and 0.65. The test-retest reliability were 0. 80 for total scale, 0. 81 and 0. 61 for subscales. Conclusion: The validity and reliability of the translated questionnaire are satisfactory, which could be used in the measurement of patients' perception of meta-cognitive processes such as self-reflection and insight. [ABSTRACT FROM AUTHOR]

Objective: To optimize the extraction process parameter of globulin Brucea javanica seeds, obtain the polypeptide components by enzymatic hydrolysis, and evaluate its cytotoxicity. Methods: The orthogonal experiment of L9 (33) was firstly applied to obtain the optimal parameter for globulin extraction. The protein was then primarily purified by isoelectric precipitation. Different kinds of proteases were applied to hydrolyze B. javanica globulin followed by ultrafiltration with the molecular weight cut-off of 3 kDa to collect the permeate. MTT assay was then conducted to evaluate the cytotoxicity of low molecular weight hydrolysates (S 3kDa) on B16 cell line. Results: The optimal process parameters of the globulins extraction were as follows: 5 % of NaCl concentration, 1.5 h of extraction time and solid liquid ratio of 1:12; The hydrolysates (S 3kDa) of B. javanica globulin produced by pepsin showed significantly high growth inhibitory activity on B16 cells, with the IC50 value of 1.08 p.g -mL"1 after 72 h incubation. Conclusion: The peptides of B. javanica globulin demonstrated specific cytotoxicity on melanoma cell line in vitro, suggesting antitumor peptides could be further obtained from B. javanica seeds. [ABSTRACT FROM AUTHOR]

Objective To explore the value of network-based management in the diagnosis and treatment of patients with gastroesophageal reflux disease(GERD).Methods Totally 215 GERD patients who visited the department of gastroenterology of the First Affiliated Hospital of Chongqing Medical Universityfrom October 2016 to April 2017 were selected as research objects,and they were randomly divided into experimental group(103 cases)and control group(112 cases).The control group adopted the outpatient diagnosis management,and the experimental group added WeChat follow-up(the networked management)on the basis of outpatient diagnosis.The follow-up rate and drug compliance of the two groups were recorded and compared.Efficacy of the two groups were assessed by the GERDQ scale.Results After 8 weeks of treatment,the return visit rate,the medication compliance and the treatment efficiency of the experimental group were higher than those of the control group,the differences were statistically significant(P<0.05).Conclusion The network-based management can increase the return visit rate of the patients with GERD,which can improve the patients′medication compliance and therapeutic effect. [ABSTRACT FROM AUTHOR]

AIM: Based on the Cre-LoxP recombinase system, Metrnl gene in β cells of islet was knockout （Metrnl-KO） to provide an animal model for further investigating the pathogenesis of Metrnl gene in diabetic diseases. METHODS: Male mice and female Metrnlfloxp/+ mice were hybridized to obtain Metrnlfloxp/floxp mice, which were then crossed with mice specifically expressing β cell Cre recombinase （Ins-2） to obtain Metrnlfloxp/+;Cre+ mice. Finally, the target mice with the genotype Metrnlfloxp/floxp;Cre+ were obtained from the crosses between Metrnlfloxp/+;Cre+ mice and Metrnlfloxp/floxp mice. The mRNA levels of Metrnl and insulin （Ins-1 and Ins-2） were measured using RT-qPCR. The protein expression of Metrnl and insulin in the islets was observed using immunohistochemistry and immunofluorescence. The body weight, and the glucose and insulin tolerance of the mice were recorded. RESULTS: Both RT-qPCR and immunohistochemistry showed that the Metrnl mRNA and protein levels in the islets of Metrnl-KO mice were significantly lower than those of control mice （P<0.01）. The body weight of Metrnl-KO mice did not show a significant change compared with control mice, but Metrnl-KO mice exhibited impaired glucose tolerance and reduced sensitivity to insulin （P<0. 01）. The mRNA levels of Ins-1 and Ins-2 in the islets of Metrnl-KO mice significantly decreased according to RT-qPCR（ P<0. 01）, and the insulin protein expression in the islets was lower than that in control mice according to immunofluorescence （P<0. 05）. The glucose-stimulated insulin secretion experiment showed that Metrnl knockout decreased insulin secretion in mice （P<0. 05）. CONCLUSION: We successfully generated and validated an Metrnl gene knockout mouse model in β cells of the islets. Our findings demonstrate that Metrnl knockout in β cells affects the glucose and insulin tolerance, and impairs the insulin secretion in mice. This model provides a basis for further investigating the mechanism of Metrnl in diabetes. [ABSTRACT FROM AUTHOR]

In order to strengthen the relevant understanding of underwater blasting damage to aquatic organisms and guide underwater blasting construction, a large number of documents were consulted, and the previous research on the damage mechanism of underwater blasting to aquatic organisms was summarized. The related technical research progress was introduced in detail from the aspects of Underwater explosion energy release and propagation law, underwater explosion damage mechanism and effect evaluation, and underwater explosion protection measures. The results show that the energy generated by underwater explosion is mainly released in the form of shock wave energy and bubble energy, and finally attenuates into acoustic energy, but the generation, transmission and transformation mechanism of each energy is still unclear. The shock wave and sound wave generated by blasting can cause varying degrees of damage to internal organs such as the liver, spleen, and kidneys of fish, and even damage the hearing and nervous system of fish. However, the aquatic damage model of blasting is mainly based on the damage to the swim bladder, and the damage model affecting different vulnerable organs of the fish body has not been established yet. The evaluation of the damage model on the species and size of the fish population is insufficient. Underwater blasting can also cause disturbance to the water environment, affecting the respiration, feeding, hatching rate, and survival rate of fish. Therefore, the long-term biological effects of blasting induced changes in the water environment are a key research direction, and the impact of underwater blasting on biodiversity is also of great research significance. At present, the active protection measures for aquatic organisms mainly focus on improving the detonation method of the charging structure and driving away aquatic organisms. Passive protection methods include bubbles and polymer curtains, pre cracks, and vibration reduction grooves. For the protection of aquatic organisms, new types of explosives or non explosive means can be developed to replace active reduction of shock waves. Acoustic based fish repellent methods are an important means, but combined with underwater visual systems, visualization and evaluable “ clearing” can be achieved. Passive protection measures mainly focus on bubble curtain protection technology, while other methods lack relevant experimental and theoretical research. The combination of active and passive protection can achieve good protective effects, but the research on the synergistic mechanism between the two is also an important direction of research. [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the efficacy of tigecycline in treatment of pulmonary infection induced by multiple resistant bacteria. METHODS: 120 patients with pulmonary infection induced by multiple resistant bacteria admitted from Aug.2015 to Aug.2016 were selected and divided into observation group and control group, with 60 cases in each group. The control group was treated with imipenem-cilastatin, while the observation group was given tigecycline, efficacy, bacteria clearance and incidence of adverse drug reactions of two groups were observed. RESULTS: The total effective rate of observation group ( 80.00%, 48/60 ) was significantly higher than that of the control group (60.00%, 36/60), with statistically significant difference (P<0.05);rates of bacteria clearance and bacteria replacement of observation group were respectively 86.67%(52/60) and 0 (0/60), which were significantly better than those of the control group ( 63.33%, 38/60; 6.67%, 4/60 ), with statistically significant differences ( P<0.05 );the incidence of adverse drug reactions of observation group was 3.33%( 2/60 ), which was significantly lower than that of the control group ( 23.33%, 14/60 ), with statistically significant difference ( P <0.05 ). CONCLUSIONS: The efficacy of tigecycline in treatment of pulmonary infection induced by multiple resistant bacteria is remarkable , which can significantly increase the rate of bacteria clearance, with higher safety . [ABSTRACT FROM AUTHOR]

Objective To investigate the change of some specific serological indicator between nonalcoholic simple fatty liver （ NASFL ） group and nonalcoholic steatohepatitis （ NASH ） group， and to establish noninvasive method and evaluation system for clinical differential diagnosis of NASFL and NASH. Methods Totally 156 cases of non-alcoholic fatty liver disease （ NAFLD ） were divided into NASFL group and NASH group according to the biopsy results from january to December 2010， 78 cases in each group. The serum levels of alanine aminotransferase （ ALT， aspertate aminotransferase （ AST， triglyceride （ TG， cytokeratin 18 （ CK-18， hypersensitive creactive protein （ hs-CRP， adiponectin， leptin， serum transforming growth factor β1 （ TGF-β1， metalloproteinases 1 tissue inhibitor （ TIMP-1， hyaluronic acid （ HA ） and typeⅢ collagen peptide （ PcⅢ ） were detected. Results Compared with NASFL group， the serum levels of CK-18， hs-CRP， leptin， HA， PcⅢ ， TIMP-1 and TGF-β1 in patients of NASH group were increased significantly， while adiponectin levels were decreased significantly， the difference had statistical significance （ P< 0.05 ）. Conclusion Different expressions of several specific serological indicators were observed between NASFL and NASH patients， which might be served as the potential biomarkers for noninvasive differential diagnosis for evaluate of NASFL and NASH. [ABSTRACT FROM AUTHOR]

Objective To investigate the molecular mechanism of the anti-liver fibrosis effect of curcumol by observing the effect of curcumol on the TLR4/NF-κB signaling pathway in liver sinusoidal endothelial cells. Methods A total of 50 mice were randomly divided into blank group,model group,and curcumol group,and cells were divided into blank control group,LPS positive control group,curcumol intervention group,and PDTC group. HE staining and Masson staining were used to observe the change in liver structure; Western blot and quantitative real-time PCR (RT-PCR) were used to measure the protein and mRNA expression of the key molecules TLR4 and NF-κB in the TLR4/NF-κB signaling pathway; immunofluorescence assay was used to observe the expression and nuclear import of NF-κB in cells. A one-way analysis of variance was used for comparison between multiple groups,and the least significant difference t-test was used for further comparison between two groups. Results RT-PCR showed that compared with the positive control group,the curcumol intervention group had significant reductions in the mRNA expression of TLR4 and NF-κB (both P<0.05). Western blot showed that compared with the positive control group,the curcumol intervention group had significant reductions in the expression of TLR4 and NF-κB (both P <0.05). Immunofluorescence assay showed that compared with the positive control group,the curcumol intervention group had significant improvement in NF-κB nuclear import. Conclusion Curcumol can exert an anti-liver fibrosis effect possibly by inhibiting the activity of the TLR4/NF-κB signaling pathway. [ABSTRACT FROM AUTHOR]

Because of the widespread double marginalized phenomenon in green supply chain and dual externality of product green innovation, it needs coordination mechanisms to motivate member cooperation to make investment in eco-design. In view of it, this article formulated supplier-dominated cost sharing mechanism and revenue distribution mechanism based on information sharing using game models, and then investigated their impacts on the eco-design effort and supply chain benefits. Results show that the cost sharing mechanism leaded by suppliers has little incentive effects, however, increasing the level of shared information can greatly improve the revenue distribution proportion and eco-design effort of supply chain members. Furthermore, the green R&D investments of non-core members can be significantly stimulated by more green information shared by core enterprises, which plays a positive role in improving the environmental benefits of green supply chain, in other words, leading innovation and coordinating partnership. From the perspective of eco-design, this study provided the theoretical suggestion and decision support for optimizing the green supply chain performance and promoting industrial green transformation. [ABSTRACT FROM AUTHOR]

Objective: To explore the difference of cognitive fusion and empirical avoidance level between depression patients and normal people and the relationship between cognitive fusion and empirical avoidance and depression level in all subjects. Methods: Totally 124 patients with depression were selected from outpatients and hospitalized depressive patients in a hospital, and 99 normal participants were recruited online at the same time. The second edition of the Action Questionnaire (AAQ-II), Cognitive Fusion Scale (CFQ), Depression Self-Assessment Scale (SDS) were used to investigate cognitive fusion, empirical avoidance and depression. Results: The average scores of CFQ, AAO-II and SDS were higher in patients with depression than in the normal group (Ps<0.01). Cognitive fusion scores and empirical avoidance scores could positively predict depression scores ((β = 0.40,0. 25, Ps <0.05). Conclusion: The cognitive fusion level and experiential avoidance level are higher in patients with depression than in normal people. Cognitive fusion and empirical avoidance are positively correlated with depression level. [ABSTRACT FROM AUTHOR]

Objective Deep eutectic solvent (DES) has a certain research foundation in the field of gas absorption. In view of its cheap and easy-to-obtain raw materials, simple preparation method, and green environmental protection, it is an industrial solvent which can replace ionic liquids. The solvent has broad application prospects which can be used to solve the industrial problem of H2S removal in small and medium-scale conventional sour natural gas. Methods FeCl3/EG deep eutectic solvent was prepared by ferric chloride hexahydrate and ethylene glycol (EG), and anhydrous copper chloride (CuCl2) was added in it to promote H2S absorption, and finally FeCl3/EG-CuCl2 was synthesized as a DES desulfurizer. The influence of factors such as the ratio of desulfurizer raw materials, reaction temperature and CuCl2 concentration on the desulfurization performance was focused on, and the regeneration conditions were explored. Results The FeCl3/EG deep eutectic solvent with a raw material molar ratio of 1∶1 had a better desulfurization effect. Appropriately increasing the reaction temperature and CuCl2 concentration was more conductive to promoting H2S absorption. The desulfurizer could be regenerated by introducing oxygen, and the desulfurization performance would not change much after repeated desulfurization-regeneration. The desulfurization product was characterized by XRD as rhombic sulfur (α-sulfur). Conclusions The DES desulfurizer can efficiently absorb H2S and convert it into elemental sulfur, realize the recycling of sulfur and provide a reference for the process of removing H2S from natural gas. [ABSTRACT FROM AUTHOR]

Objective To assess the effects of multifaceted follow-up study on the standard quadruple therapy for H. Pylori (Hp) infection. Methods A total of 240 Up positive patients were divided into three groups by random number table: the outpatient follow-up group, the telephone follow-up group and the weChat follow-up group (80 cases in each group). and all patients were on the 14-day standard quadruple therapy of eradicating Hp. The telephone and weChat follow-up group received structured telephone or weChat follow-up after discharge on regular days and routine health care instruction and the outpatient follow-up group received routine health care instruction only at the time of first clinical visit. On the first day after 14 days of treatment, the three groups were reminded by telephone of the time of Hp reexamination. At the 4th and 6th weeks after the treatment, the results of Hp review and adverse reactions during the treatment were collected by telephone. The compliance of the three groups was evaluated and the reasons for discontinuation were found out. The eradication rate.compliance and adverse reactions of Hp in the three groups were evaluated. Results The eradication rates of Hp in the telephone and weChat follow-up group were significantly higher than that in the outpatient follow-up group,and the difference was statistically significant (P<0.05). While compliance on medicine-taken in each group was similar, but the telephone and weChat follow-up group had better compliance on post-treatment confirmation than outpatient follow-up group, and the difference was statistically significant (P<0.05). Adverse events were mild in each group, with no significant difference (P>0.05). Conclusion The weChat follow-up combined with specific and systematic health education can increase the eradication rate and follow-up rte after treatment of Hp. [ABSTRACT FROM AUTHOR]

The redevelopment of abandoned coal mine industry square (ACMIS) has become an important issue, as the number of abandoned sites has been increasing. Meanwhile, redeveloping the ACMIS is the basic requirement of the Chinese urban renovation and restoration strategy. Since reusing ACMIS is time-consuming and cost-consuming, developing an assessment tool to prioritize the renewal processes is necessary. Many existing assessment tools are not appropriate because they mainly focus on ecological aspects, while neglecting urban planning issues. Thus, this paper proposes a driving force-state-response (DSR) model of ACMIS which integrates planning, land rehabilitation and ecology, and analyzes the factors influencing the DSR framework. Then, the paper creates a comprehensive assessment system for prioritizing the redevelopment of ACMIS, which includes stakeholders' requalification objectives and perspectives related to the ACMIS regeneration process. The assessment system takes into account 3 pillars, which are 6 driving force factors (agglomeration degree of ecological agriculture, agglomeration degree of culture-oriented travel, high-way status, public transportation status, distance from downtown, accessibility of public service facilities), 9 state factors (soil conditions, soil pH value, damage degree, degree of heavy metal pollution, risk degree of geologic hazard, architectural integrity, historic and cultural value of modern architectures, status of underground space, municipal infrastructure status), and response (planning and policy). The point scoring framework is used to quantify and classify indicators, while four-quadrant method is used to couple evaluation results. Based on the evaluation results, ACMIS has been divided into 4 classes, high driving force - high state (HDFHS), high driving force - low state (HDFLS), low driving force - high state (LDFHS) and low driving force - low state (LDFLS). According to the land use planning, the development sequence is divided into 3 stages: The first development sequence is composed of HDFHS, the second development sequence is composed of HDFLS and LDFHS, and the third one is composed of LDFLS. The method has been applied to the Jingxi coal mine case study (Beijing, China), and the result showed that 3 sites named Changgouyu (D=3.818, S=3.848; D is driving force and S is state), Datai (D=3.732, S=3.732) and Muchengjian (D=2.646, S=4.522) in the city inventory were included in the first redevelopment sequence, and Wangping (D=4.240, S=3.187), Qianjuntai (D=2.248, S=3.887) and Daanshan (D=1.792, S=4.39) in the second redevelopment sequence, while Anjiatan (D=2.118, S=1.464) and Huapogen (D=2.798, S=1.907) in the third redevelopment sequence. It reveals that an adapted and structured assessment approach truly contributes to integrating urban planning into ACMIS regeneration. The resulting assessment should be a valuable aid to cities and governments as they plan their ACMIS regeneration projects. [ABSTRACT FROM AUTHOR]

Objective: To explore the clinical efficacy of hysteroscopy combined with laparoscope in the treatment of tubal infertility, and to provide reference for clinical therapy. Methods: A total of 120 patients with tubal infertility, who were treated in Air Force General Hospital from January 2011 to January 2013, were selected and averagely divided into group A(treated with hysteroscopy),group B(treated with laparoscope), group C(treated with hysteroscopy combined with laparoscope), and group D(treated with open surgery) according to the corresponding surgery. The surgery indexes(including operation time, blood loss and hospitalization days), tubal recanalization rate and pregnancy rates in the four groups were compared. Results: The operation time, blood loss and hospitalization days of group A, B, C, and D were increased in turn, the differences were statistically significant(P<0.05). The tubal recanalization rate and pregnancy rate of group C were higher than those of group A, B, and D, the differences were statistically significant(P<0.05).Conclusions: Hysteroscopy combined with laparoscope has a good efficacy in the treatment of tubal infertility, with the advantages of fewer traumas, rapid postoperative recovery, high tubal recanalization rate and pregnancy rate, which is worthy of popularization and application in the clinical field. [ABSTRACT FROM AUTHOR]