利那洛肽联合聚乙二醇电解质散在肠道准备中的 有效性及安全性 meta分析.

Objective To systematically evaluate the efficacy and safety of linaclotide combined with polyethylene glycol（PEG） electrolyte powder in bowel preparation.Methods PubMed, Web of Science, the Cochrane Library, Embase, China National Knowledge Infrastructure（CNKI）,China Biomedical Literature Database（CBM）,Wanfang and VIP databases were searched by computer to collect clinical studies on linaclotide combined with PEG as a bowel preparation regimen.The search time was from the establishment of the databases to May 2023.Two researchers independently extracted data and assessed the quality of the included studies.Meta-analysis was performed using RveMan5.4 software.Results A total of 11 articles were included, with a total of 2 381 patients, including 1 193 cases in the linaclotide combined with PEG group and 1 188 cases in the PEG group.The results of meta-analysis showed that there was no significant difference in Boston bowel preparation score [mean difference（MD）=-0.02,95% confidence interval（95%CI）-0.10-0.07,P=0.69] and adenoma detection rate [relative risk（RR）=0.95,95%CI 0.78-1.16,P=0.61] between linaclotide combined with PEG group and PEG group.In terms of safety, the incidence of nausea（RR=0.48,95%CI 0.39-0.58,P＜0.001）,abdominal distension（RR=0.46,95%CI 0.33-0.63,P＜0.001）,abdominal pain（RR=0.27,95%CI 0.16-0.43,P＜0.001） and vomiting（RR=0.32,95%CI 0.19-0.52,P＜0.001） in the linaclotide combined with PEG group were significantly lower than those in the PEG group.Conclusion As a bowel preparation regimen, linaclotide combined with PEG can not only reduce the amount of PEG,but also reduce the incidence of gastrointestinal adverse reactions. [ABSTRACT FROM AUTHOR]