552 results on '"N, Lelong"'
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2. Linking a European cohort of children born with congenital anomalies to vital statistics and mortality records: A EUROlinkCAT study.
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M Loane, J E Given, J Tan, A Reid, D Akhmedzhanova, G Astolfi, I Barišić, N Bertille, L B Bonet, C C Carbonell, O Mokoroa Carollo, A Coi, J Densem, E Draper, E Garne, M Gatt, S V Glinianaia, A Heino, E Den Hond, S Jordan, B Khoshnood, S Kiuru-Kuhlefelt, K Klungsøyr, N Lelong, L R Lutke, A J Neville, L Ostapchuk, A Puccini, A Rissmann, M Santoro, I Scanlon, G Thys, D Tucker, S K Urhoj, H E K de Walle, D Wellesley, O Zurriaga, and J K Morris
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Medicine ,Science - Abstract
EUROCAT is a European network of population-based congenital anomaly (CA) registries. Twenty-one registries agreed to participate in the EUROlinkCAT study to determine if reliable information on the survival of children born with a major CA between 1995 and 2014 can be obtained through linkage to national vital statistics or mortality records. Live birth children with a CA could be linked using personal identifiers to either their national vital statistics (including birth records, death records, hospital records) or to mortality records only, depending on the data available within each region. In total, 18 of 21 registries with data on 192,862 children born with congenital anomalies participated in the study. One registry was unable to get ethical approval to participate and linkage was not possible for two registries due to local reasons. Eleven registries linked to vital statistics and seven registries linked to mortality records only; one of the latter only had identification numbers for 78% of cases, hence it was excluded from further analysis. For registries linking to vital statistics: six linked over 95% of their cases for all years and five were unable to link at least 85% of all live born CA children in the earlier years of the study. No estimate of linkage success could be calculated for registries linking to mortality records. Irrespective of linkage method, deaths that occurred during the first week of life were over three times less likely to be linked compared to deaths occurring after the first week of life. Linkage to vital statistics can provide accurate estimates of survival of children with CAs in some European countries. Bias arises when linkage is not successful, as early neonatal deaths were less likely to be linked. Linkage to mortality records only cannot be recommended, as linkage quality, and hence bias, cannot be assessed.
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- 2021
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3. Reports Outline Aerosol Medicine and Pulmonary Drug Delivery Findings from N. Lelong and Colleagues
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Respiratory agents -- Research ,Pharmaceuticals and cosmetics industries - Abstract
By a News Reporter-Staff News Editor at Drug Week -- Investigators publish new report on Drugs and Therapies. According to news reporting originating in Monts, France, by NewsRx journalists, research [...]
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- 2014
4. WITHDRAWN: L’évolution des pratiques médicales durant le travail et l’accouchement à partir des données des enquêtes nationales périnatales
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H. Cinelli, N. Lelong, and C. Le Ray
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Reproductive Medicine ,Obstetrics and Gynecology - Published
- 2023
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5. L’évolution des pratiques médicales durant le travail et l’accouchement à partir des données des Enquêtes nationales périnatales
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H. Cinelli, N. Lelong, and C. Le Ray
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Reproductive Medicine ,Obstetrics and Gynecology - Published
- 2023
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6. Facteurs associés à un défaut de supplémentation en acide folique pour la prévention des anomalies de fermeture du tube neural dans huit maternités parisiennes
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O Anselem, T Rousseau, A A Chantry, François Goffinet, and N Lelong
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03 medical and health sciences ,030219 obstetrics & reproductive medicine ,0302 clinical medicine ,Reproductive Medicine ,Obstetrics and Gynecology ,030226 pharmacology & pharmacy - Abstract
Resume Objectifs Malgre les recommandations, le taux de femmes recevant une supplementation en acide folique en France est insuffisant. L’objectif principal etait d’identifier les facteurs associes une supplementation inadequate en acide folique. L’objectif secondaire etaient d’evaluer les connaissances des femmes sur la prevention des anomalies de fermeture du tube neural (AFTN). Methode Nous avons realise une enquete sur 400 femmes de 8 maternites parisiennes. La supplementation en acide folique etait definie comme inadequate lorsqu’elle etait debutee apres le debut de la grossesse. Resultats Parmi les femmes interrogees, 68 % avaient une supplementation inadequate en acide folique. Les facteurs associes a une supplementation inadequate etaient un âge inferieur a 35 ans (ORa = 1,8 ; 95 % IC [1,1–2,8]), l’absence de couverture sociale (ORa = 3,9 ; 95 % IC [1,5–10,1]), un niveau d’etude n’allant pas au-dela du baccalaureat (ORa = 2,9 ; 95 % IC [1,2–6,9]), et l’absence de suivi gynecologique regulier (ORa = 3,0 ; 95 %IC [1,6–5,6]). Plus de la moitie (55,5 %) des femmes de l’etude n’avaient pas une bonne connaissance des benefices de l’acide folique et les facteurs associes etaient l’absence de suivi gynecologique regulier et l’absence de couverture sociale. Conclusion Des facteurs individuels associes a un defaut de supplementation ont ete identifies. Ces resultats apportent aux professionnels et tutelles de sante des elements utiles pour developper des strategies adaptees a certains sous-groupes de femmes pour une meilleure prevention des AFTN dans ces populations.
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- 2021
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7. Rupture des membranes à terme avant travail : prévalence et facteurs associés à un délai prolongé de rupture
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C. Renaudin, C. Diguisto, E. Tavernier, N. Lelong, and C. Le Ray
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Reproductive Medicine ,Obstetrics and Gynecology - Published
- 2023
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8. Cord-blood vitamin D level and night sleep duration in preschoolers in the EDEN mother-child birth cohort
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Chu Yan Yong, Eve Reynaud, Anne Forhan, Patricia Dargent-Molina, Barbara Heude, Marie-Aline Charles, Sabine Plancoulaine, I. Annesi-Maesano, J.Y. Bernard, J. Botton, M.A. Charles, P. Dargent-Molina, B. de Lauzon-Guillain, P. Ducimetière, M. de Agostini, B. Foliguet, A. Forhan, X. Fritel, A. Germa, V. Goua, R. Hankard, B. Heude, M. Kaminski, B. Larroque, N. Lelong, J. Lepeule, G. Magnin, L. Marchand, C. Nabet, F. Pierre, R. Slama, M.J. Saurel-Cubizolles, M. Schweitzer, O. Thiebaugeorges, Institut National de la Santé et de la Recherche Médicale (INSERM), Equipe 6 : ORCHAD - Origines précoces de la santé du développement de l'enfant (CRESS - U1153), Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Sorbonne Paris Cité (USPC)
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FOS: Computer and information sciences ,Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Longitudinal study ,Population ,Mothers ,Statistics - Applications ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Epidemiology ,medicine ,Vitamin D and neurology ,Humans ,Applications (stat.AP) ,Longitudinal Studies ,Vitamin D ,Child ,education ,Multinomial logistic regression ,[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics ,education.field_of_study ,pediatric sleep ,business.industry ,cohort ,General Medicine ,Fetal Blood ,Vitamin D Deficiency ,medicine.disease ,Sleep in non-human animals ,Obstructive sleep apnea ,Cross-Sectional Studies ,030228 respiratory system ,Quantitative Biology - Neurons and Cognition ,FOS: Biological sciences ,Child, Preschool ,Cohort ,Neurons and Cognition (q-bio.NC) ,epidemiology ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Female ,France ,Sleep ,business ,030217 neurology & neurosurgery - Abstract
International audience; Objective: 25-hydroxyvitamin D (25OHD) deficiency has been associated with sleep disorders in adults. Only three cross-sectional studies were performed in children and showed an association between 25OHD deficiency and both obstructive sleep apnea syndrome and primary snoring. No longitudinal study has been performed in children from the general population. We analyzed the association between cord-blood vitamin D level at birth and night-sleep duration trajectories for children between 2 and 5-6 years old in a non-clinical cohort.Method: We included 264 children from the French EDEN mother-child birth-cohort with both cord-blood 25OHD level determined by radio-immunoassay at birth, and night-sleep trajectories for children between 2 and 5-6 years old obtained by the group-based trajectory modeling method. Associations between 25OHD and sleep trajectories were assessed by multinomial logistic regression adjusted for maternal and child characteristics.Results: The trajectories short sleep (
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- 2019
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9. Respiratory morbidity in children with congenital heart disease
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Damien Bonnet, François Goffinet, Babak Khoshnood, S Guerin, M Lebourgeois, N. Lelong, D Khraiche, Christophe Delacourt, and N Bertille
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Heart Defects, Congenital ,Male ,medicine.medical_specialty ,Heart disease ,Population ,Respiratory Tract Diseases ,Comorbidity ,Pulmonary function testing ,Cohort Studies ,Internal medicine ,medicine ,Humans ,Respiratory function ,Lung volumes ,Prospective Studies ,education ,Child ,Asthma ,education.field_of_study ,Lung ,business.industry ,medicine.disease ,medicine.anatomical_structure ,Pediatrics, Perinatology and Child Health ,Cardiology ,Female ,Complication ,business - Abstract
Objective To evaluate the respiratory outcome in children with congenital heart disease (CHD), considering recent management procedures and the CHD pathophysiology. Design and Setting Clinical and functional respiratory outcome were evaluated in 8-year-old children with isolated CHD followed up from birth in the prospective population-based EPICARD cohort. Patients Children were assigned to two groups, based on the pathophysiology of the CHD: CHDs with left-to-right shunt (n = 212) and CHDs with right outflow tract obstruction (n = 113). Results Current wheezing episodes were observed in 15% of the children with isolated CHD and left-to-right shunt, and 11% of the children with isolated CHD and right outflow tract obstruction (not significant). Total lung capacity (TLC) was the only respiratory function parameter that significantly differed between the two groups. It was lower in children with left-to-right shunt (88.72 ± 0.65% predicted) than in those with right outflow tract obstruction (91.84 ± 0.96, p = 0.006). In multivariate analysis, CHD with left-to-right shunt (coeff. [95% CI]: -3.17 [-5.45; -0.89]) and surgery before the age of 2 months (-6.52 [-10.90; -2.15]) were identified as independent factors associated with significantly lower TLC values. Conclusion Lower TLC remains a long-term complication in CHD, particularly in cases with left-to-right shunt and in patients requiring early repair. These findings suggest that an increase in pulmonary blood flow may directly impair lung development.
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- 2020
10. [Factors associated with inadequate folic acid supplementation for the prevention of neural tube defects in eight Parisian maternity units]
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T, Rousseau, O, Anselem, A A, Chantry, N, Lelong, and F, Goffinet
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Folic Acid ,Gynecology ,Pregnancy ,Dietary Supplements ,Humans ,Female ,France ,Neural Tube Defects - Abstract
Despite the guidelines in effect, too few women in France receive folic acid supplementation. The principal objective of this study was to identify the factors associated with the inadequacy of this supplementation in the periconceptional period. The secondary objective was to assess women's knowledge about the prevention of neural tube defects (NTDs).This study included 400 women and took place in 8 Parisian maternity. Folic acid supplementation was inadequate when started after the beginning of the pregnancy.Among the women questioned, 68% had inadequate folic acid supplementation. They were significantly younger (ORa= 1,8; 95% IC [1,1-2,8]), didn't had health insurance (ORa=3,9; 95% IC [1,5-10,1]), had not studied after high school (ORa=2,9; 95% IC [1,2-6,9]) and had regular gynecological care less often than the women with adequate supplementation (ORa=3,0; 95% IC [1,6-5,6]). More than half (55.5%) had insufficient knowledge of the benefits of folic acid; the factors related to this lack of knowledge were the absence of regular gynecological care and of health insurance.Individual factors associated with a lack of supplementation have been identified. These results provide health professionals and supervisors with useful information for developing strategies adapted to certain subgroups of women for better prevention of AFTN in these populations.
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- 2020
11. VP21.05: Prevalence of growth restriction at birth for newborns with congenital heart defects: a population‐based prospective cohort study
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M. Rahshenas, N. Derridj, Babak Khoshnood, A. Ghanchi, François Goffinet, N. Lelong, Damien Bonnet, and Laurent Salomon
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Pediatrics ,medicine.medical_specialty ,Reproductive Medicine ,Radiological and Ultrasound Technology ,Growth restriction ,business.industry ,Obstetrics and Gynecology ,Medicine ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Population based ,business ,Prospective cohort study - Published
- 2021
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12. Night sleep duration trajectories and associated factors among preschool children from the EDEN cohort
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Sabine Plancoulaine, Eve Reynaud, Anne Forhan, Sandrine Lioret, Barbara Heude, Marie-Aline Charles, I. Annesi-Maesano, J.Y. Bernard, J. Botton, M.A. Charles, P. Dargent-Molina, B. de Lauzon-Guillain, P. Ducimetière, M. de Agostini, B. Foliguet, A. Forhan, X. Fritel, A. Germa, V. Goua, R. Hankard, B. Heude, M. Kaminski, B. Larroque, N. Lelong, J. Lepeule, G. Magnin, L. Marchand, C. Nabet, F. Pierre, R. Slama, M.J. Saurel-Cubizolles, M. Schweitzer, O. Thiebaugeorges, Institut National de la Santé et de la Recherche Médicale (INSERM), Equipe 6 : ORCHAD - Origines précoces de la santé du développement de l'enfant (CRESS - U1153), Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Sorbonne Paris Cité (USPC), and Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)
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Male ,Parents ,FOS: Computer and information sciences ,Epidemiology ,Psychological intervention ,Logistic regression ,Cohort Studies ,0302 clinical medicine ,Risk Factors ,Surveys and Questionnaires ,Medicine ,Night sleep ,Longitudinal Studies ,Duration (project management) ,Child ,2. Zero hunger ,Public health ,Cohort ,General Medicine ,3. Good health ,Child, Preschool ,Female ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Neurons and Cognition (q-bio.NC) ,France ,Sleep duration ,Sleep Wake Disorders ,Statistics - Applications ,Child health ,03 medical and health sciences ,Sex Factors ,030225 pediatrics ,Humans ,Applications (stat.AP) ,Life Style ,Socioeconomic status ,[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics ,Preschoolers ,business.industry ,Socioeconomic Factors ,Quantitative Biology - Neurons and Cognition ,FOS: Biological sciences ,Fast Foods ,Group-based trajectory modeling ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business ,030217 neurology & neurosurgery ,Demography - Abstract
International audience; Objective. Sleep duration may vary inter-individually and intra-individually over time. We aimed at both identifying night-sleep duration (NSD) trajectories among preschoolers and studying associated factors. Methods. NSD were collected within the French birth-cohort study EDEN at ages 2, 3 and 5-6 years through parental questionnaires, and were used to model NSD trajectories among 1205 children. Familial socioeconomic factors, maternal sociodemographic, health and lifestyle characteristics as well as child health, lifestyle, and sleep characteristics at birth and/or at age 2 years were investigated in association with NSD using multinomial logistic regressions. Results. Five distinct NSD trajectories were identified: short (SS
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- 2019
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13. Night-waking and behavior in preschoolers: a developmental trajectory approach
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Eve Reynaud, Anne Forhan, Barbara Heude, Marie-Aline Charles, Sabine Plancoulaine, I. Annesi-Maesano, J.Y. Bernard, J. Botton, M.A. Charles, P. Dargent-Molina, B. de Lauzon-Guillain, P. Ducimetière, M. de Agostini, B. Foliguet, A. Forhan, X. Fritel, A. Germa, V. Goua, R. Hankard, B. Heude, M. Kaminski, B. Larroque, N. Lelong, J. Lepeule, G. Magnin, L. Marchand, C. Nabet, F. Pierre, R. Slama, M.J. Saurel-Cubizolles, M. Schweitzer, and O. Thiebaugeorgeson
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Persistence (psychology) ,Male ,Parents ,Population ,Emotions ,Child Behavior ,Logistic regression ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Child Development ,030225 pediatrics ,Sleep Initiation and Maintenance Disorders ,Surveys and Questionnaires ,Medicine ,Humans ,education ,Association (psychology) ,Problem Behavior ,education.field_of_study ,business.industry ,Repeated measures design ,General Medicine ,Odds ratio ,Strengths and Difficulties Questionnaire ,Night waking ,Child, Preschool ,Female ,France ,business ,030217 neurology & neurosurgery ,Demography - Abstract
Objective The aim was to study, with a developmental approach, the longitudinal association between night-waking from age 2 to 5–6 years and behavior at age 5–6 years. Methods Within the French birth cohort study Etude sur les Determinants pre et post natals du developpement et de la sante de l'ENfant (EDEN), repeated measures of children's night-waking were collected at age 2, 3 and 5–6 through parental questionnaires and were used to model night-waking trajectories. Behavior was assessed with the “Strengths and Difficulties Questionnaire,” which provides five subscales measuring a child's conduct problems, emotional symptoms, peer relation problems, antisocial behavior, and hyperactivity/attention problems. The behavioral subscales were dichotomized at the tenth percentile. Multivariable logistic regressions, adjusted for parents' socio-economic factors, parental characteristics, and children's characteristics and sleep habits allowed us to study, in 1143 children, the association between night-waking trajectories from 2 to 5–6 years and behavior at age 5–6 years. Results The “2 to 5–6 rare night-waking” trajectory represented 78% of the included population (n = 896), and the “2 to 5–6 common night-waking” 22% (n = 247%). Children belonging to the “2 to 5–6 common night-waking trajectory” had, at age 5–6, increased risk of presenting emotional symptoms (odds ratio [OR] = 2.17, 95% CI = 1.27–3.70, p = 0.004), conduct problems (OR = 1.63, 95% CI = 1.00–2.65, p = 0.050), and hyperactivity/attention problems (OR = 1.61, 95% CI = 1.00–2.57, p = 0.049). After adjusting for baseline behavior at age two years, only the association with emotional symptoms remained significant (OR = 2.02, 95% CI = 1.15–3.55, p = 0.015). Results did not differ according to sex. Conclusion Results suggest that the persistence of night-waking difficulties in early years is positively associated with emotional symptoms, hyperactivity/inattention, and conduct problems.
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- 2017
14. Évolution de la consommation de tabac des femmes pendant la grossesse en France de 1972 à 2003
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N. Lelong, M. Kaminski, and Béatrice Blondel
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Reproductive Medicine ,Obstetrics and Gynecology ,General Medicine - Abstract
Resume But Etudier l’evolution de l’usage du tabac des femmes avant et pendant la grossesse en France a partir d’enquetes en population, decrire l’evolution des caracteristiques sociodemographiques des fumeuses et les liens entre tabac et croissance du nouveau-ne en 2003, compte tenu de cette evolution. Patients et methodes Les enquetes nationales perinatales sont effectuees periodiquement sur des echantillons representatifs des naissances. L’analyse a ete realisee sur les naissances uniques et vivantes en metropole en 1972, 1981, 1995, 1998 et 2003. La premiere partie de l’etude a porte sur l’evolution de l’usage du tabac au cours des 30 dernieres annees, la deuxieme partie sur l’evolution du tabagisme entre 1998 et 2003 en fonction des caracteristiques maternelles. Puis, pour l’annee 2003, nous avons etudie les caracteristiques des fumeuses, les liens entre l’usage du tabac et l’etat de l’enfant a la naissance. Resultats L’usage du tabac chez les femmes enceintes est a la baisse, mais le taux reste eleve, 21 % en 2003. La baisse a principalement concerne les femmes en situation plus favorable pour l’issue de la grossesse et les differences sociales se sont accrues. Une forte relation dose-effet est retrouvee entre l’usage du tabac pendant la grossesse et les mensurations a la naissance. Conclusion Il est necessaire de verifier si la baisse de la consommation de tabac chez les femmes enceintes se confirme et d’encourager le sevrage tabagique, notamment pour les populations les plus exposees.
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- 2011
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15. Is the probability of prenatal diagnosis or termination of pregnancy different for fetuses with congenital anomalies conceived following assisted reproductive techniques? A population-based evaluation of fetuses with congenital heart defects
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K, Tararbit, N, Lelong, J-M, Jouannic, F, Goffinet, B, Khoshnood, and Marcel, Voyer
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Adult ,Heart Defects, Congenital ,medicine.medical_specialty ,Pediatrics ,Reproductive Techniques, Assisted ,Population ,Prenatal diagnosis ,Gestational Age ,Young Adult ,Pregnancy ,Risk Factors ,Prenatal Diagnosis ,medicine ,Humans ,education ,reproductive and urinary physiology ,education.field_of_study ,Fetus ,Obstetrics ,business.industry ,Confounding ,Obstetrics and Gynecology ,Gestational age ,Abortion, Induced ,medicine.disease ,Fetal Diseases ,Cohort ,Observational study ,Female ,business - Abstract
Objective To compare the probability of prenatal diagnosis (PND) and termination of pregnancy for fetal anomaly (TOPFA) between fetuses conceived by assisted reproductive techniques (ART) and spontaneously-conceived fetuses with congenital heart defects (CHD). Design Population-based observational study. Setting Paris and surrounding suburbs. Population Fetuses with CHD in the Paris registry of congenital malformations and cohort of children with CHD (Epicard). Methods Comparison of ART-conceived and spontaneously conceived fetuses taking into account potential confounders (maternal characteristics, multiplicity and year of birth or TOPFA). Main outcome measures Probability and gestational age at PND and TOPFA for ART-conceived versus spontaneously conceived fetuses. Results The probability of PND (28.1% versus 34.6%, P = 0.077) and TOPFA (36.2% versus 39.2%, P = 0.677) were not statistically different between ART-conceived (n = 171) and spontaneously conceived (n = 4620) fetuses. Estimates were similar after adjustment for potential confounders. Gestational age at PND tended to be earlier for ART fetuses (23.1 versus 24.8 weeks, P = 0.05) but no statistical difference was found after adjustment for confounders. Gestational age at TOPFA was comparable between ART-conceived and spontaneously conceived fetuses. Conclusions In our population, ART conception was not significantly associated with the probability of PND or TOPFA for CHD. One implication of our results is that live births may be adequate for assessing the overall risk of CHD related to ART. However, total prevalence, in particular of severe CHD, would not be adequately assessed if TOPFA are not included.
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- 2015
16. Prise en charge de l’IVG en France : résultats de l’enquête COCON
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N. Lelong, C. Moreau, and M. Kaminski
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Reproductive Medicine ,Obstetrics and Gynecology ,General Medicine - Abstract
Resume But L’objet de cet article est de decrire les conditions de prise en charge de l’IVG en France. Materiel et methodes Les donnees proviennent de l’enquete COCON, realisee aupres d’un echantillon representatif de 2 863 femmes âgees de 18 a 44 ans, residant en France metropolitaine. Les femmes ont ete interrogees par telephone. L’analyse porte sur un sous-echantillon de 320 femmes ayant eu une IVG entre 1996 et 2000. Les resultats ont ete compares a ceux du bulletin statistique d’IVG (BIG). Resultats Dans l’ensemble, les conditions de prise en charge de l’IVG sont bonnes, mais des differences de pratiques sont observees selon le type d’etablissement : l’acces a l’IVG est plus facile dans le secteur prive, mais ce dernier realise moins souvent l’entretien pre-IVG et propose moins souvent un entretien post-IVG. Par ailleurs, en public comme en prive, les femmes sont rarement associees au choix de la technique d’IVG ou au mode d’anesthesie, en cas d’IVG chirurgicale. Conclusion L’enquete COCON est la premiere enquete en population generale a etudier les conditions de prise en charge de l’IVG et montre la persistance de differences de pratiques entre le secteur public et le secteur prive.
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- 2005
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17. Early oral exposure to house dust mite allergen through breast milk: A potential risk factor for allergic sensitization and respiratory allergies in children
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Nour Baïz, Patricia Macchiaverni, Meri K. Tulic, Akila Rekima, Isabella Annesi-Maesano, Valérie Verhasselt, I. Annesi-Maesano, J.Y. Bernard, J. Botton, M.A. Charles, P. Dargent-Molina, B. de Lauzon-Guillain, P. Ducimetière, M. de Agostini, B. Foliguet, A. Forhan, X. Fritel, A. Germa, V. Goua, R. Hankard, B. Heude, M. Kaminski, B. Larroque, N. Lelong, J. Lepeule, G. Magnin, F. Pierre, L. Marchand, C. Nabet, R. Slama, M.J. Saurel-Cubizolles, M. Schweitzer, and O. Thiebaugeorges
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0301 basic medicine ,Allergy ,House dust mite allergen ,business.industry ,Potential risk ,Immunology ,Breast milk ,medicine.disease ,Allergic sensitization ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,030228 respiratory system ,medicine ,Immunology and Allergy ,Respiratory system ,business ,Prospective cohort study ,Breast feeding - Published
- 2017
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18. Screening for fetal spina bifida at the 11-13-week scan using three anatomical features of the posterior brain
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R, Mangione, F, Dhombres, N, Lelong, S, Amat, F, Atoub, S, Friszer, B, Khoshnood, and J-M, Jouannic
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Pregnancy Trimester, First ,Spina Bifida Cystica ,Pregnancy ,Cisterna Magna ,Brain ,Humans ,Female ,Nuchal Translucency Measurement ,Echoencephalography ,Sensitivity and Specificity ,Ultrasonography, Prenatal ,Brain Stem ,Retrospective Studies - Abstract
To evaluate the contribution of examination of specific anatomical features of the fetal posterior brain on mid-sagittal first-trimester ultrasound examination to the early detection of open spina bifida.Four independent observers reviewed a series of 260 mid-sagittal first-trimester ultrasound images from 52 cases of open spina bifida and 208 normal fetuses. The following analysis was performed by each reviewer for each image: Herman score calculation, intracranial translucency score (CFEF-IT) calculation and determination of presence or absence of three anatomical criteria: intracranial translucency (IT), caudal displacement of the brainstem and cisterna magna. The sensitivity and the false-positive rate for spina bifida detection were calculated for each of the latter three criteria. A secondary analysis was performed on the subset of images achieving a Herman score ≥ 7.The highest detection rate for spina bifida was achieved by non-visualization of the cisterna magna, with associated sensitivity of 50-73% and 39-76%, respectively, for all images and for the subset of images achieving a Herman score ≥ 7. Posterior shift of the brainstem achieved the highest detection rate (86%), but for a single reviewer only. The level of variation in performance between observers was also greatest for this sign. Absence of IT was associated with a lower detection rate for all observers. Overall, an abnormal posterior brain presenting at least one of these three criteria was associated with a detection rate ranging from 50 to 90%.In the detection of spina bifida, non-visualization of the cisterna magna achieved the best screening performance. Both non-visualization of the IT and posterior shift of the brainstem were associated with acceptable but lower detection rates. A prospective evaluation of changes in the posterior brain is needed to allow assessment of the most pertinent criteria for first-trimester screening for spina bifida.
- Published
- 2013
19. [Epidemiological surveillance and prenatal diagnosis of congenital anomalies in the Parisian population, 1981-2007]
- Author
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N, Lelong, A-C, Thieulin, V, Vodovar, F, Goffinet, and B, Khoshnood
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Adult ,Chromosome Aberrations ,Male ,Paris ,Abortion, Induced ,Paternal Age ,Congenital Abnormalities ,Young Adult ,Pregnancy ,Population Surveillance ,Prenatal Diagnosis ,Prevalence ,Humans ,Female ,Registries ,Maternal Age - Abstract
To assess overall and malformation-specific trends in the prevalence and prenatal diagnosis of congenital anomalies in the Parisian population.The Paris Registry of Congenital Malformations is population-based and since 1981 has registered all cases with structural birth defects or chromosomal anomalies in the Parisian population. The total and livebirth prevalence and the proportion of cases with prenatal diagnosis were calculated for all anomalies and 20 malformations selected based on their higher frequency and their impact on health outcomes.The overall prevalence was 3.30% (95% CI 3.27-3.33), and the livebirth prevalence 2.42% (95% CI 2.39-2.45). The proportion of cases diagnosed prenatally increased from 16.5% (95% CI 14.1-19.1) in 1983 to 70.7% (95% CI 68.3-73.1) in 2007. Terminations of pregnancy for fetal anomaly (TOPFA) increased from 8.8% (95% CI 7.0-10.8) in 1983 to 35.6% (95% CI 33.1-38.1) in 2007. These results varied substantially for the 20 congenital anomalies studied.We found an increase in the overall prevalence of all anomalies, especially for chromosomal abnormalities. The observed increase is at least to a large extent due to trends in delayed childbearing and an increase in both pre- and postnatal diagnosis of congenital anomalies in our population.
- Published
- 2011
20. [Trends in perinatal health in France between 1995 and 2010: Results from the National Perinatal Surveys]
- Author
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B, Blondel, N, Lelong, M, Kermarrec, F, Goffinet, and Annick, Vilain
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Adult ,Pregnancy Rate ,Cesarean Section ,Smoking ,Infant, Newborn ,Delivery, Obstetric ,Health Surveys ,Body Mass Index ,Pregnancy Complications ,Perinatal Care ,Pregnancy ,Birth Weight ,Humans ,Premature Birth ,Female ,France ,Maternal Welfare ,Maternal Age - Abstract
To study trends in the main indicators of health, medical practice and risk factors in France.A sample of all births during one week was set-up in 1995 (n=13,318), 1998 (n=13,718), 2003 (n=14,737) and 2010 (n=14,903), and we compared data from these four years.Between 1995 and 2010, maternal age and body mass index increased steadily, but tobacco smoking decreased. In 2010, 39.4% of pregnant women had a visit with a midwife in maternity unit, versus 26.6% in 2003. Deliveries occurred in large public hospitals more and more frequently. The increase in caesarean sections was no longer significant between 2003 and 2010. In general medical decisions during pregnancy and delivery were closer to professional recommendations in 2010 than in the previous years. Live births before 37 weeks increased steadily from 5.4% in 1995 to 6.6% in 2010, but the proportion of births below 2500g or under the 10th percentile stopped increasing since 2003.Routine national perinatal surveys highlight major trends in maternal characteristics, obstetric practice, organisation of services and perinatal health.
- Published
- 2011
21. [Smoking during pregnancy in France between 1972 to 2003: Results from the national perinatal surveys]
- Author
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N, Lelong, B, Blondel, and M, Kaminski
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Adult ,Young Adult ,Time Factors ,Pregnancy ,Smoking ,Humans ,Female ,France ,Maternal Behavior - Abstract
To study trends in smoking before and during pregnancy in national samples of pregnant women and changes in characteristics of smokers over time, and describe the current relation between maternal smoking during pregnancy and fetal growth.Five nationally representative samples of singleton live births in metropolitan France (1972, 1981, 1995, 1998 and 2003) were used to study the change in smoking rates during pregnancy over the past 30 years. We further examined changes in smoking rates between 1998 and 2003 according to maternal characteristics. Finally, we estimated the effect of smoking on fetal growth in 2003.Prevalence of smoking decreased over time, but the rate remained high, 21 % in 2003. The decrease was more important among women at low risk of adverse pregnancy outcomes, resulting in increased social disparities. We confirmed the strong dose-response relation between tobacco use during pregnancy and fetal growth.It is important to verify that smoking during pregnancy is still decreasing and to develop policies to encourage women to quit smoking during pregnancy, especially for highly exposed groups.
- Published
- 2010
22. [Familial violence during pregnancy]
- Author
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M-J, Saurel-Cubizolles and N, Lelong
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Adult ,Europe ,Adolescent ,Pregnancy ,Data Collection ,Spouse Abuse ,Humans ,Female - Abstract
After a review of medical literature on domestic violence during pregnancy, this paper shows the results of a survey carried out in 16 European countries. The percentage of women reporting domestic violence during pregnancy varies with the country; it is specially high in Russia, Poland and Czech Republic. Women who live without partner, those whose the couple has been separated during the pregnancy or those living in an overcrowded house have been more often victim of domestic violence. Domestic violence is significantly related to preterm birth risk.
- Published
- 2005
23. [Induced abortion in France: results of the COCON study]
- Author
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N, Lelong, C, Moreau, M, Kaminski, N, Bajos, J, Bouyer, B, Ducot, M, Ferrand, H, Goulard, D, Hassoun, N, Job-Spira, H, Leridon, P, Oustry, N, Razafindratsima, C, Rossier, J, Warszawski, Recherches épidémiologiques en santé périnatale et santé des femmes, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epidémiologie, Démographie et Sciences Sociales: santé reproductive, sexualité et infection à VIH (Inserm U569), Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d'études démographiques (INED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Kaniewski, Nadine
- Subjects
Adult ,MESH: Contraception ,Adolescent ,[SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics ,MESH: Research Support, Non-U.S. Gov't ,MESH: Pregnancy ,Pregnancy ,Surveys and Questionnaires ,Humans ,MESH: English Abstract ,reproductive and urinary physiology ,MESH: Adolescent ,MESH: Humans ,MESH: Questionnaires ,Abortion, Induced ,MESH: Adult ,MESH: France ,[SDV.MHEP.GEO] Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics ,Contraception ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,embryonic structures ,Female ,MESH: Abortion, Induced ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,France ,MESH: Female - Abstract
OBJECTIVE: The aim of this article is to describe conditions of abortions practices in France. MATERIALS AND METHODS: The study was based on the COCON survey. This survey was carried out among a representative sample of 2863 women aged 18 to 44 living in metropolitan France. Women were interviewed by telephone. The analysis was performed among a sub-sample of 320 women who had had an abortion between 1996 and 2000. Results were compared with those of the national notification of induced abortions. RESULTS: Altogether, the way in which abortions were carried out was appropriate, but differences were observed according to the type of hospital: access to care was easier in the private sector; however a pre-abortion interview was less often carried out and a post-abortion interview less often proposed in the private sector. Besides, in both sectors, women were rarely allowed to choose the abortion technique, or the type of anesthesia in the case of a surgical abortion. CONCLUSION: The COCON study is the first population based survey describing the characteristics of care regarding voluntary abortion. It shows the persistence of differences in practices between the public and the private sectors.
- Published
- 2005
24. Assistance médicale à la procréation et cardiopathies congénitales : une étude en population
- Author
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K. Tararbit, L. Houyel, D. Bonnet, C. de Vigan, N. Lelong, F. Goffineta, and B. Khoshnood
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Gynecology ,medicine.medical_specialty ,Epidemiology ,business.industry ,Public Health, Environmental and Occupational Health ,Medicine ,business - Abstract
A partir de donnees en population, nous avons: 1) evalue le risque de cardiopathies congenitales (CC) chez les fœtus concus par assistance medicale a la procreation (AMP); et 2) determine les effets de l’AMP sur la prise en charge prenatale et le devenir perinatal des fœtus porteurs de CC. Nous avons observe que l'AMP etait associee a une augmentation de 40% du risque de CC sans anomalies chromosomiques associees (OR ajuste = 1,4 IC95% 1,1-1,7). Nous avons egalement retrouve qu'il existait des associations variables selon la categorie de CC et la methode d'AMP considerees. Nous avons observe que l'AMP etait associee a une multiplication par 2,4 du risque de tetralogie de Fallot (OR ajuste = 2,4 IC95% 1,5-3,7), alors que nous n’avons pas retrouve d’association statistiquement significative pour les trois autres CC specifiques etudiees. Dans notre population, l'exposition a l'AMP ne semblait pas modifier le recours au diagnostic prenatal et a l'interruption medicale de grossesse chez les fœtus porteurs de CC compares aux fœtus porteurs de CC concus spontanement. Nous avons par ailleurs observe que le risque de prematurite des fœtus porteurs de CC concus par AMP etait environ 5 fois plus eleve que celui des fœtus porteurs de CC concus spontanement (OR ajuste = 5,0 IC95% 2,9-8,6). En nous basant sur une methodologie d'analyses de cheminement, nous avons retrouve que les grossesses multiples contribuaient pour environ 20% au risque plus eleve de tetralogie de Fallot associe a l'AMP que nous avons observe. Enfin, les grossesses multiples contribuaient pour environ 2/3 du risque de prematurite associe a l'AMP chez les fœtus porteurs de CC.
- Published
- 2010
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25. [Mothers of triplets and their children: course from 4 to 7 years after birth]
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M, Garel, C, Salobir, N, Lelong, and B, Blondel
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Time Factors ,Triplets ,Depression ,Humans ,Mothers ,Sibling Relations ,Female ,Mother-Child Relations ,Follow-Up Studies - Abstract
To study the psychological health of the mothers and their difficulties seven years after the birth of triplets and to compare these results with those obtained at four years.Eleven mothers of triplets were followed up from birth to seven. At four and seven years the psychological status of the mothers and their relationships with the triplets were evaluated using a semi-structured interview and the level of depression was measured using a standardized scale (CES-D). At seven years the scores were compared to those of mothers having a singleton child of the same age.At seven years three mothers of triplets out of 11 still suffered of depressive symptoms. These symptoms were more frequent than among control mothers but non significantly. One mother of triplets out of two (6/11), twice more than at four years, appreciated the increase of her educative tasks and the decrease of practical problems. In the other half of the sample problems still persisted between adults and children.Although the situation seemed to improve at seven years, the mother's psychological distress and quality of relationship with the children remained preoccupying in one family out of two.
- Published
- 2000
26. [Duration of maternal breastfeeding in France]
- Author
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N, Lelong, M J, Saurel-Cubizolles, M H, Bouvier-Colle, and M, Kaminski
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Adult ,Breast Feeding ,Cultural Characteristics ,Time Factors ,Age Factors ,Humans ,Female ,France ,Demography ,Education - Published
- 2000
27. Analysis of the underestimation of induced abortions in a survey of the general population in France
- Author
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Henri Leridon, N. Lelong, Monique Kaminski, Michèle Ferrand, J. Warszwawski, Béatrice Ducot, D. Hassoun, C. de Guibert-Lantoine, S. Houzard, and Nathalie Bajos
- Subjects
Adult ,medicine.medical_specialty ,Adolescent ,Population ,Pilot Projects ,Abortion ,Annual incidence ,Interviews as Topic ,Age Distribution ,Pregnancy ,Surveys and Questionnaires ,Medicine ,Humans ,Pharmacology (medical) ,education ,reproductive and urinary physiology ,Gynecology ,education.field_of_study ,business.industry ,Incidence ,Significant difference ,Obstetrics and Gynecology ,Abortion, Induced ,Induced Abortions ,medicine.disease ,Confidence interval ,Therapeutic abortion ,Telephone ,Reproductive Medicine ,Female ,France ,business ,Demography - Abstract
A pilot study has been conducted in France to estimate the extent of underreporting of induced abortion and the factors linked to underreporting.A representative random sample of 300 women aged between 18 and 44 years of age who had been pregnant during the previous 2 years and 100 women who had not was selected from the telephone directory. Interviews were conducted by telephone.The annual incidence of induced abortion for the 18-44-year-old age group was 6.9 per 1000 (95% confidence interval 2.2-11.6), while the rate derived from national statistics was 15 per 1000. Five women who reported a therapeutic abortion in their lifetime had confused induced abortion and therapeutic abortion. There was no significant difference in the proportion of women reporting induced abortion in their lifetime between those answering with another adult present and those who were alone when answering (13.1% versus 11.1%, p = 0.8). There was also no significant difference according to the sex of the interviewer (10.0% for men versus 12.2% for women, p = 0.6).The results suggest that the context in which the questions were asked does not affect the validity of the answers and that there is a problem in the comprehension of the terminology used. Extensive rewriting and reformulation of the questions is required to minimize the underreporting of induced abortion.
- Published
- 2000
28. [Marital violence after birth]
- Author
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M J, Saurel-Cubizolles, B, Blondel, N, Lelong, and P, Romito
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Adult ,Depressive Disorder ,Paris ,Postpartum Period ,Social Support ,Abortion, Spontaneous ,Parity ,Pregnancy ,Unemployment ,Surveys and Questionnaires ,Spouse Abuse ,Prevalence ,Humans ,Female - Abstract
The purpose was to estimate the prevalence of marital violence during the year after childbirth in France.a survey has been carried out in three maternity units among primipara and secondipara women in 1993-1994. The women were interviewed in the three days after the delivery and they received a postal questionnaire 5 and 12 months later. The analysis includes 706 women.the prevalence of marital violence during the 12 months after childbirth is equal to 4.1% (2.6%-5.6%). This percentage is higher among women living an unstable relationship with their partner or when the partner has not a job. These women who reported marital violence had a higher prevalence of previous miscarriage. They used more often psychotropic drugs and reported more often depressive symptoms than the other women.physicians may be helpful by listening and counseling these women who receive low emotional and social support.
- Published
- 1997
29. [Epidemiological study of sequelae of injuries in adolescents]
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J, Yacoubovitch, N, Lelong, M, Cosquer, and A, Tursz
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Adult ,Male ,Paris ,Adolescent ,Accidents ,Humans ,Wounds and Injuries ,Female ,Longitudinal Studies ,Prospective Studies ,Child ,Students - Abstract
In all industrialized countries, injuries constitute the primary public health problem during adolescence; study of long-term outcome of injuries to adolescents remains poor.A longitudinal epidemiological study performed on 8,140 students in 17 secondary schools in Paris and the Department of the Côte-d'Or followed the development over one year of 777 adolescents who had injuries in 1990. All injuries, both within and outside school, were included if they fulfilled the following criteria: school absence or excused from vocational training exceeding or equal to 2 days, or excused from physical education classes for at least 14 days.One year after the injury, 13% of the adolescents were still bothered by their injury, especially those who were older and the girls. Among described impairments, musculo-skeletal problems (88% of cases) were the major difficulty. These impairments were primarily in the lower limbs (53%). Unaesthetic scars were found in 17% of cases, and a psychological impact was found in 16.5% of the adolescents. The presence of sequelae was related to the type of initial lesion (present in 24% of head injuries and in 16% of cases affecting the lower limbs). The most serious difficulties were caused by dislocations, serious sprains and fractures. One year after the injury, sequelae were serious in 10% of those adolescents still experiencing problems; they had some impact on the daily life of the adolescents in 36% of cases, that is, 5% of all adolescents experiencing an injury. These sequelae were responsible for a high level of consumption of medical services.Although observed sequelae were relatively minor, the high frequency of injuries during adolescence, as well as their high economic costs, justify the most appropriate care available for victims of injuries, even those which appear benign. In addition, longitudinal studies should be prepared using adapted tools (scales for the evaluation of the gravity of injury sequelae).
- Published
- 1995
30. [Maternal consequences of cesarean delivery. Results of a 4-year follow-up]
- Author
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M, Garel, N, Lelong, A, Marchand, and M, Kaminski
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Mental Health ,Cesarean Section ,Pregnancy ,Health Status ,Surveys and Questionnaires ,Humans ,Female ,Follow-Up Studies - Abstract
This study is of a 4-year follow-up of two groups of mothers, the first having had caesarean operations and the second vaginal deliveries. We have already published studies of the results after delivery, after two months and after one year. The purpose of this 4-year follow-up after delivery is to determine the effects of caesarean operation on the numbers of future pregnancies and their results and to look at the long-term consequences for the physical and psychological health of the mothers. Fifty-eight mothers who had had caesarean operations and fifty mothers as controls replied to a postal questionnaire. The response level was 52%. From the social and the medical point of view there was no significant difference between those who replied and those who did not. The results indicate that mothers who had had a caesarean operation were less likely to have another baby or did so in lower numbers. They further had more difficulty in conceiving another pregnancy than did the control mothers (the differences were not statistically significant). After four years they were often more tired than the others, apart from objective medical and social differences. The use of health services was not linked to the method of delivery, but 9% of women who had had a caesarean consulted a psychiatrist in the last three years but none of the controls did. The replies show that caesarean section contributed to or re-awoke a labile psychological state. The data do not make it possible for us to say that women who had had a caesarean operation had particular psychological characteristics.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1990
31. Development and behaviour of seven-year-old triplets
- Author
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Garel, C Salobir, N Lelong, B Blond, M, primary
- Published
- 2001
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32. Depressive disorders after a spontaneous abortion
- Author
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Monique Kaminski, N. Lelong, Béatrice Blondel, and M. Carel
- Subjects
medicine.medical_specialty ,Text mining ,business.industry ,medicine ,Obstetrics and Gynecology ,Abortion ,Psychiatry ,business - Published
- 1993
- Full Text
- View/download PDF
33. Study protocol for a multicenter randomized controlled trial on simulation-based communication training for pediatric cardiology trainees (SIMUL-CHD).
- Author
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Padovani, Paul, Hauet, Quentin, Lefort, Bruno, Chauviré-Drouard, Anne, Letellier, Marine, Bergé, Marie, Marguin, Gaëlle, Titos, Myriam, Grain, Audrey, Babonneau, Marie-Lise, Michon, Claire-Cécile, Trosdorf, Mathilde, Lejus-Bourdeau, Corinne, Lwin, Naychi, Picot, Marie-Christine, Amedro, Pascal, and Baruteau, Alban-Elouen
- Subjects
PHYSICIAN-patient relations ,CONGENITAL heart disease ,PEDIATRIC cardiology ,MEDICAL education ,MEDICAL care standards - Abstract
Background: Effective physician-patient communication is crucial to compassionate healthcare, particularly when conveying life-altering diagnoses such as those associated with congenital heart diseases. Despite its importance, medical practitioners often face challenges in communicating effectively. Because of these gaps, we aim to introduce a simulation-based training protocol to improve pediatric cardiology trainee's communication skills. This study will be conducted in collaboration with associations supporting caregivers of children with congenital heart disease. It strives to demonstrate how specific training programs can efficiently foster humanistic, patient-centered care in standard medical practice. Methods: This multicenter, open-label randomized controlled trial will be conducted in pediatric cardiac units and simulation centers of across 10 universities in France. The study population comprises pediatric cardiologists in training (including pediatric cardiac fellows or specialist assistants). The SIMUL-CHD intervention will consist of simulation-based training with standardized patients, focusing on improving communication skills for pediatric cardiology trainees during diagnostic counselling. Patients and caregivers have been recruited from a National Patient Association named "Petit Cœur de Beurre". The primary outcome is the quality of physicians' communication skills. The evaluation committee, which will review video recordings of the sessions, will be blinded to which participants received simulation-based training (group of interest) and which received theory-based training (control group). Secondary outcomes are the effect of SIMUL-CHD on empathy and anxiety levels in young pediatric cardiologists. Baseline scores pre and post-intervention will be compared, and skill improvement resulting from the intervention measured. Discussion: Simulation-based training has proven efficacy in teaching technical skills in various scenarios however its application to communication skills in pediatric cardiology remains unexplored. The involvement of experienced parents provides a unique perspective, incorporating their profound understanding of the emotional challenges and specific hurdles faced by families dealing with congenital heart disease. Trial registration: This trial is registered with the OSF registry (registered https://osf.io/ed78q). [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
34. Efferocytosis dysfunction in CXCL4-induced M4 macrophages: phenotypic insights in systemic sclerosis in vitro and in vivo.
- Author
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Le Tallec, Erwan, Bellamri, Nessrine, Lelong, Marie, Morzadec, Claudie, Frenger, Quentin, Ballerie, Alice, Cazalets, Claire, Lescoat, Alain, Gros, Frédéric, and Lecureur, Valérie
- Subjects
ALVEOLAR macrophages ,ANTIBODY formation ,SYSTEMIC scleroderma ,INTRADERMAL injections ,PHAGOCYTOSIS - Abstract
Introduction: Systemic sclerosis (SSc) is an autoimmune disease characterized by antinuclear antibody production, which has been linked to an excess of apoptotic cells, normally eliminated by macrophages through efferocytosis. Additionally, circulating levels of CXCL4, a novel SSc biomarker, correlate with more severe fibrotic manifestations of the disease. Considering the defective efferocytosis of macrophages in SSc and the CXCL4-related M4 macrophage phenotype, we hypothesized that CXCL4 could be involved in the alteration of phagocytic functions of macrophages in SSc, including LC3-associated phagocytosis (LAP), another phagocytic process requiring autophagy proteins and contributing to immune silencing. Methods: In this study, CXCL4 levels were measured by ELISA in vitro in the serum of SSc patients, and also in vivo in the serum and lungs of C57BL/6J SSc mice induced by intradermal injections of hypochloric acid (HOCl) or Bleomycin (BLM), with evaluation of M4 markers. Circulating monocytes from healthy donors were also differentiated in vitro into M4 monocytes-derived macrophages (MDMs) in the presence of recombinant CXCL4. In M4-MDMs, phagocytosis of fluorescent beads and expression level of efferocytic receptors were evaluated by flow cytometry in vitro, while efferocytosis of pHrodo-stained apoptotic Jurkat cells was evaluated by real-time fluorescence microscopy. LAP quantification was made by fluorescence microscopy in M4-MDMs exposed to IgG-coated beads as well as apoptotic Jurkat cells. Results: Our results demonstrated that efferocytosis was significantly reduced in M0-MDMs from healthy donors exposed to the CXCL4-rich plasma of SSc patients. In vivo, CXCL4 expression was increased in the lungs of both SScmouse models, along with elevated M4 markers, while efferocytosis of BLM-mice alveolar macrophages was decreased. In vitro, M4-MDMs exhibited reduced efferocytosis compared to M0-MDMs, notably attributable to lower CD36 receptor expression and impaired phagocytosis capacities, despite enhanced LAP. Autophagic gene expression was increased both in vitro in SSc MDMs and in vivo in BLM mice, thus acting as a potential compensatory mechanism. Discussion: Altogether, our results support the role of CXCL4 on the impaired efferocytosis capacities of human macrophages from SSc patients and in SSc mice. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
35. Characteristics of infant formula consumed in the first months of life and allergy in the EDEN mother–child cohort.
- Author
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Adjibade, Moufidath, Vigneron, Lucille, Delvert, Rosalie, Adel‐Patient, Karine, Divaret‐Chauveau, Amandine, Annesi‐Maesano, Isabella, Heude, Barbara, Charles, Marie‐Aline, and de Lauzon‐Guillain, Blandine
- Subjects
RESPIRATORY disease risk factors ,RISK assessment ,RESEARCH funding ,PREBIOTICS ,LOGISTIC regression analysis ,UNSATURATED fatty acids ,OMEGA-3 fatty acids ,QUESTIONNAIRES ,FOOD allergy ,STRUCTURAL equation modeling ,CHI-squared test ,DESCRIPTIVE statistics ,INFANT formulas ,INFANT nutrition ,LONGITUDINAL method ,ODDS ratio ,RESPIRATORY allergy ,PROBIOTICS ,CONFIDENCE intervals ,ASTHMA ,DISEASE risk factors ,CHILDREN - Abstract
The evidence regarding the association between infant formula (IF) composition and the prevention of allergy and respiratory diseases remains sparse and inconclusive. This study aimed to evaluate whether some IF characteristics were associated with the risk of allergy or respiratory diseases in childhood. Among 1243 formula‐fed children from the EDEN mother–child cohort, IF characteristics concerning long‐chain polyunsaturated fatty acids (LCPUFAs) enrichment, prebiotic/probiotic enrichment, and hydrolysis of proteins were identified from the ingredients list. Eczema, wheezing, food allergy, asthma, and allergic rhinitis up to age 8 years were prospectively collected and summarized into four allergic and respiratory multimorbidity clusters. Associations between 4‐month IF characteristics and risk of allergy or respiratory diseases were tested using logistic regressions adjusted on main confounders. The consumption of LCPUFA‐enriched formula was not linked to allergic and respiratory multimorbidity clusters, but to a lower risk of any allergy, eczema, and wheezing. Probiotic‐enriched formula consumption was associated with a lower risk of belonging to the 'Allergy without asthma' cluster (odds ratio [OR] [95% confidence interval, CI] = 0.63 [0.40–0.99]), and consumption of a formula enriched in Bifidobacterium lactis was associated with a lower risk of any allergy (OR [95% CI] = 0.59 [0.41–0.85]). Partially hydrolysed formula (pHF) consumption was associated with a higher risk of belonging to the 'Allergy without asthma' cluster (OR [95% CI] = 2.73 [1.65–4.51]). This study confirms the positive association between pHF consumption and the risk of allergy found in previous observational studies and suggests that consumption of LCPUFA‐enriched or probiotic‐enriched formula was associated with a lower risk of allergy. Key messages: The study aimed to explore, among formula‐fed infants, the association between infant formula characteristics and allergic or respiratory multimorbidity clusters in early childhood.Probiotic‐enriched formula consumption was associated with a lower risk of belonging to the 'Allergy without asthma' cluster.Partially hydrolysed formula consumption was associated with a higher risk of belonging to the 'Allergy without asthma' cluster, even after exclusion of cases reported at 1 year. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
36. Associations between perinatal biomarkers of maternal dairy fat intake and child cognitive development: results from the EDEN mother-child cohort
- Author
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Yuan, Wen Lun, Armand, Martine, Peyre, Hugo, Sarté, Catherine, Charles, Marie Aline, Heude, Barbara, and Bernard, Jonathan Y.
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- 2024
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37. JANUS KINASE INHIBITORS IN SYSTEMIC SCLEROSIS: A SCOPING REVIEW.
- Author
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Başıbüyük, Fatma and Birlik, Merih
- Subjects
PATIENT safety ,TREATMENT effectiveness ,CELLULAR signal transduction ,JANUS kinases ,FIBROSIS ,SYSTEMIC scleroderma ,NEUROTRANSMITTER uptake inhibitors ,INFLAMMATION - Abstract
Systemic sclerosis (SSc) is a rare multisystemic chronic immune-mediated rheumatic disease. Although it is not common, it has the highest mortality and morbidity rate among systemic rheumatic diseases. This review aimed to analyze the results of multiple preclinical trials and clinical data on Janus kinase (JAK) inhibitors in SSc treatment and provides a comprehensive overview of JAK inhibitors as a new treatment option in SSc. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
38. Temperature Dependent near Infrared Spectroscopy of Electron Irradiated Ceria Single Crystals.
- Author
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Costantini, Jean-Marc, Béneut, Keevin, Guillaumet, Maxime, and Lelong, Gérald
- Subjects
NEAR infrared spectroscopy ,ELECTRON spectroscopy ,CERIUM oxides ,BAND gaps ,ELASTIC scattering - Abstract
The FTIR absorption bands of virgin and electron-irradiated CeO
2 single crystals were measured from 20 K to 500 K between 4000 cm−1 and 12,000 cm−1 (~830 nm to 2500 nm). Three broad bands centered at about 6100 cm−1 (~0.75 eV), 7000 cm−1 (~0.87 eV), and 10,500 cm−1 (~1.3 eV) were recorded above 100 K for the 2.5 MeV electron energy. Two smaller bands at about 4300 cm−1 (~0.53 eV) and 5500 cm−1 (~0.68 eV) were also recorded below 100 K. Similar broad bands centered at about 4100 cm−1 (~0.52 eV), 6400 cm−1 (~0.79 eV), 7600 cm−1 (~0.94 eV), and 10,500 cm−1 (~1.3 eV) are also found for the 1.4 MeV electron energy above 300 K. The evolution of these absorption bands was followed as a function of temperature. The plots of band intensity ratios show a thermally activated process corresponding to the ionization of the deep electronic levels of point defects in the band gap of ceria of ~26,000 cm−1 (~3.2 eV). These five bands are assigned to the different charge states (0, −1, −2, −3, −4) of the Ce vacancies produced by elastic collisions above 1.0 MeV. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
39. Computational Modeling Study of the Molecular Basis of dNTP Selectivity in Human Terminal Deoxynucleotidyltransferase.
- Author
-
Ukladov, Egor O., Tyugashev, Timofey E., and Kuznetsov, Nikita A.
- Subjects
BASE pairs ,AMINO acid residues ,ENZYME kinetics ,SINGLE-stranded DNA ,OLIGONUCLEOTIDE synthesis - Abstract
Human terminal deoxynucleotidyl transferase (TdT) can catalyze template-independent DNA synthesis during the V(D)J recombination and DNA repair through nonhomologous end joining. The capacity for template-independent random addition of nucleotides to single-stranded DNA makes this polymerase useful in various molecular biological applications involving sequential stepwise synthesis of oligonucleotides using modified dNTP. Nonetheless, a serious limitation to the applications of this enzyme is strong selectivity of human TdT toward dNTPs in the order dGTP > dTTP ≈ dATP > dCTP. This study involved molecular dynamics to simulate a potential impact of amino acid substitutions on the enzyme's selectivity toward dNTPs. It was found that the formation of stable hydrogen bonds between a nitrogenous base and amino acid residues at positions 395 and 456 is crucial for the preferences for dNTPs. A set of single-substitution and double-substitution mutants at these positions was analyzed by molecular dynamics simulations. The data revealed two TdT mutants—containing either substitution D395N or substitutions D395N+E456N—that possess substantially equalized selectivity toward various dNTPs as compared to the wild-type enzyme. These results will enable rational design of TdT-like enzymes with equalized dNTP selectivity for biotechnological applications. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
40. Pulsed Dipolar EPR for Self-Limited Complexes of Oligonucleotides Studies.
- Author
-
Chubarov, Alexey S., Endeward, Burkhard, Kanarskaya, Maria A., Polienko, Yuliya F., Prisner, Thomas F., and Lomzov, Alexander A.
- Subjects
ELECTRON paramagnetic resonance spectroscopy ,NUCLEIC acids ,MOLECULAR dynamics ,OLIGONUCLEOTIDES ,HUMAN body ,SPIN labels - Abstract
Pulsed electron–electron double resonance (PELDOR) spectroscopy is a powerful method for determining nucleic acid (NA) structure and conformational dynamics. PELDOR with molecular dynamics (MD) simulations opens up unique possibilities for defining the conformational ensembles of flexible, three-dimensional, self-assembled complexes of NA. Understanding the diversity and structure of these complexes is vital for uncovering matrix and regulative biological processes in the human body and artificially influencing them for therapeutic purposes. To explore the reliability of PELDOR and MD simulations, we site-specifically attached nitroxide spin labels to oligonucleotides, which form self-assembled complexes between NA chains and exhibit significant conformational flexibility. The DNA complexes assembled from a pair of oligonucleotides with different linker sizes showed excellent agreement between the distance distributions obtained from PELDOR and calculated from MD simulations, both for the mean inter-spin distance and the distance distribution width. These results prove that PELDOR with MD simulations has significant potential for studying the structure and dynamics of conformational flexible complexes of NA. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
41. Estimation of Systemic Shortfall Risk Measure Using Stochastic Algorithms.
- Author
-
Kaaka, Sarah, Matoussi, Anis, and Tamtalini, Achraf
- Published
- 2024
- Full Text
- View/download PDF
42. Associations between symptoms of attention-deficit hyperactivity disorder, socioeconomic status and asthma in children
- Author
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Omura, Makiko, Cortese, Samuele, Bailhache, Marion, Navarro, Marie C., Melchior, Maria, van der Waerden, Judith, Heude, Barbara, de Lauzon-Guillain, Blandine, and Galera, Cédric
- Published
- 2024
- Full Text
- View/download PDF
43. [Consequences of peridural analgesia for the Cesarean experience and initial mother-child relations]
- Author
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M, Garel, N, Lelong, and M, Kaminski
- Subjects
Anesthesia, Epidural ,Fathers ,Patient Education as Topic ,Cesarean Section ,Pregnancy ,Anesthesia, Obstetrical ,Humans ,Female ,Anesthesia, General ,Patient Participation ,Mother-Child Relations - Abstract
Semi-directed interviews were conducted with 103 primiparous women between the 3rd and the 6th day after delivery to compare the effects of the two methods of anaesthesia on the way they experienced caesarean operation. Analysis of the contents of the interviews show that the mothers who had caesarean operation under general anaesthesia were more often depressed than those who had an epidural. Overall, the experience of delivery was more satisfying when the caesarean took place under an epidural because it enabled the mother to take part in the delivery. The mothers who were unconscious because they had a general anaesthetic felt sorrow that they deprived of the experience of the delivery. All the same, it must be said that one-third of the women felt ill-at-ease owing to delivery under epidural, both physically and psychologically. The first contacts with the infant are earlier and less disagreeable after epidural analgesia, but in the days following the delivery the interactions between mother and baby and the comments the mothers make about their child do not differ markedly whichever form of anaesthesia has been used.
- Published
- 1987
44. [Population registry of childhood accidents: value, difficulties and limitations]
- Author
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A, Tursz, M, Crost, and N, Lelong
- Subjects
Adolescent ,Accidents ,Child, Preschool ,Infant, Newborn ,Humans ,Infant ,Wounds and Injuries ,France ,Registries ,Child - Published
- 1987
45. [Epidemiologic study of injuries in infants]
- Author
-
A, Tursz, N, Lelong, and M, Crost
- Subjects
Male ,Time Factors ,Accidents, Home ,Accidents ,Child, Preschool ,Humans ,Infant ,Wounds and Injuries ,Female ,France - Abstract
Eight hundred fifty-four injuries to children under 2 years of age were analysed. Injuries were more frequent in the second year than in younger infants. No major male predominance was observed. Most injuries were related to home accidents and mainly to mechanical trauma. Burns and poisonings were less frequent but their percentage was higher during the second year. Most lesions were benign, except in case of fall from a height (window falls, falls from baby furniture). Medical cost was rather high due to a 17% rate of hospital admissions and a 4 days average length of stay. Two fatal cases were registered. Sequelae appeared to be rare. Child abuse was seldom suspected and reason for that remains unclear. The study of accidents mechanism leads to think that teaching young children the control of hazardous situations should play a large part in prevention.
- Published
- 1988
46. Study of the Myosin Relay Helix Peptide by Molecular Dynamics Simulations, Pump-Probe and 2D Infrared Spectroscopy.
- Author
-
Freedman, Holly and Tuszynski, Jack A.
- Subjects
PEPTIDES ,MOLECULAR dynamics ,INFRARED spectroscopy ,MYOSIN ,FREE surfaces ,HYDROGEN bonding - Abstract
The Davydov model was conjectured to describe how an amide I excitation created during ATP hydrolysis in myosin might be significant in providing energy to drive myosin's chemomechanical cycle. The free energy surfaces of the myosin relay helix peptide dissolved in 2,2,2-trifluoroethanol (TFE), determined by metadynamics simulations, demonstrate local minima differing in free energy by only ~2 kT, corresponding to broken and stabilized hydrogen bonds, respectively. Experimental pump-probe and 2D infrared spectroscopy were performed on the peptide dissolved in TFE. The relative heights of two peaks seen in the pump-probe data and the corresponding relative volumes of diagonal peaks seen in the 2D-IR spectra at time delays between 0.5 ps and 1 ps differ noticeably from what is seen at earlier or later time delays or in the linear spectrum, indicating that a vibrational excitation may influence the conformational state of this helix. Thus, it is possible that the presence of an amide I excitation may be a direct factor in the conformational state taken on by the myosin relay helix following ATP hydrolysis in myosin. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
47. Toward a Theology of Compassionate Release: Orthodox Christianity and the Dilemma of Assisted Dying.
- Author
-
CIOCAN, Tudor-Cosmin
- Published
- 2024
- Full Text
- View/download PDF
48. Stochastic optimization with dynamic probabilistic forecasts.
- Author
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Tankov, Peter and Tinsi, Laura
- Subjects
FORECASTING ,DECISION making ,PRODUCTION scheduling ,WIND power ,STOCHASTIC models - Abstract
We consider a sequential decision making process such as energy trading or electrical production scheduling whose outcome depends on the future realization of a random factor, such as a meteorological variable. Assuming that the decision maker has access to a dynamically updated probabilistic forecast (predictive distribution) of the random factor, we propose several stochastic models for the evolution of the probabilistic forecast of a given quantity, and show how these models may be calibrated from ensemble forecasts, commonly provided by weather centers. We then show how these stochastic models can be used to determine optimal decision making strategies to maximize a specific gain functional. Applications to wind energy trading are given. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
49. Structural insights into the morpholino nucleic acid/RNA duplex using the new XNA builder Ducque in a molecular modeling pipeline.
- Author
-
Rihon, Jérôme, Mattelaer, Charles-Alexandre, Montalvão, Rinaldo Wander, Froeyen, Mathy, Pinheiro, Vitor Bernardes, and Lescrinier, Eveline
- Published
- 2024
- Full Text
- View/download PDF
50. Fragile X Messenger Ribonucleoprotein Protein and Its Multifunctionality: From Cytosol to Nucleolus and Back.
- Author
-
Taha, Mohamed S. and Ahmadian, Mohammad Reza
- Subjects
FRAGILE X syndrome ,RNA-binding proteins ,DNA repair ,ORGANELLE formation ,NUCLEOLUS ,STRESS granules ,GENETIC translation - Abstract
Silencing of the fragile X messenger ribonucleoprotein 1 (FMR1) gene and a consequent lack of FMR protein (FMRP) synthesis are associated with fragile X syndrome, one of the most common inherited intellectual disabilities. FMRP is a multifunctional protein that is involved in many cellular functions in almost all subcellular compartments under both normal and cellular stress conditions in neuronal and non-neuronal cell types. This is achieved through its trafficking signals, nuclear localization signal (NLS), nuclear export signal (NES), and nucleolar localization signal (NoLS), as well as its RNA and protein binding domains, and it is modulated by various post-translational modifications such as phosphorylation, ubiquitination, sumoylation, and methylation. This review summarizes the recent advances in understanding the interaction networks of FMRP with a special focus on FMRP stress-related functions, including stress granule formation, mitochondrion and endoplasmic reticulum plasticity, ribosome biogenesis, cell cycle control, and DNA damage response. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
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