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Respiratory morbidity in children with congenital heart disease
- Source :
- Archives de pediatrie : organe officiel de la Societe francaise de pediatrie. 28(7)
- Publication Year :
- 2020
-
Abstract
- Objective To evaluate the respiratory outcome in children with congenital heart disease (CHD), considering recent management procedures and the CHD pathophysiology. Design and Setting Clinical and functional respiratory outcome were evaluated in 8-year-old children with isolated CHD followed up from birth in the prospective population-based EPICARD cohort. Patients Children were assigned to two groups, based on the pathophysiology of the CHD: CHDs with left-to-right shunt (n = 212) and CHDs with right outflow tract obstruction (n = 113). Results Current wheezing episodes were observed in 15% of the children with isolated CHD and left-to-right shunt, and 11% of the children with isolated CHD and right outflow tract obstruction (not significant). Total lung capacity (TLC) was the only respiratory function parameter that significantly differed between the two groups. It was lower in children with left-to-right shunt (88.72 ± 0.65% predicted) than in those with right outflow tract obstruction (91.84 ± 0.96, p = 0.006). In multivariate analysis, CHD with left-to-right shunt (coeff. [95% CI]: -3.17 [-5.45; -0.89]) and surgery before the age of 2 months (-6.52 [-10.90; -2.15]) were identified as independent factors associated with significantly lower TLC values. Conclusion Lower TLC remains a long-term complication in CHD, particularly in cases with left-to-right shunt and in patients requiring early repair. These findings suggest that an increase in pulmonary blood flow may directly impair lung development.
- Subjects :
- Heart Defects, Congenital
Male
medicine.medical_specialty
Heart disease
Population
Respiratory Tract Diseases
Comorbidity
Pulmonary function testing
Cohort Studies
Internal medicine
medicine
Humans
Respiratory function
Lung volumes
Prospective Studies
education
Child
Asthma
education.field_of_study
Lung
business.industry
medicine.disease
medicine.anatomical_structure
Pediatrics, Perinatology and Child Health
Cardiology
Female
Complication
business
Subjects
Details
- ISSN :
- 1769664X
- Volume :
- 28
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
- Accession number :
- edsair.doi.dedup.....005111ed235c10ecf5e221b04a757499