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390 results on '"van der Werf, Marieke J"'

2. Trends in new HIV diagnoses and factors contributing to late diagnosis among migrant populations in EU/EEA countries, 2014 to 2023.

Author

Reyes-Urueña, Juliana, Stoppa, Giorgia, Pizzolato, Federica, van der Werf, Marieke J., Deogan, Charlotte, Cabral-Veríssimo, Vítor, Cortes-Martins, Helena, Deblonde, Jessika, Diaz, Asuncion, Hernando, Victoria, Milunka-Kojic, Erna, Mossong, Joël, O'Donnell, Kate, Op de Coul, Eline, Tsiara, Chrysa, van Leest, Lilian, Van Beckhoven, Dominique, Wessman, Maria, and Whittaker, Robert

Published
2024
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4. A cluster of multidrug-resistant Mycobacterium tuberculosis among patients arriving in Europe from the Horn of Africa: a molecular epidemiological study

Author

Avsar, Korkut, Bauer, Christoph, Bernasconi, Enos, Borroni, Emanuele, Brusin, Sergio, Coscollá Dévis, Mireia, Crook, Derrick W., Dedicoat, Martin, Fitzgibbon, Margaret, Gagneux, Sébastien, Geiger, Francisca, Guthmann, Jean-Paul, Hendrickx, David, Hoffmann-Thiel, Sabine, van Ingen, Jakko, Jackson, Sarah, Jaton, Katia, Lange, Christoph, Mazza Stalder, Jessica, O'Donnell, Joan, Opota, Onya, Peto, Tim E.A., Preiswerk, Benjamin, Roycroft, Emma, Sato, Mariko, Schacher, Regina, Schulthess, Bettina, Smith, E. Grace, Soini, Hanna, Sougakoff, Wladimir, Tagliani, Elisa, Utpatel, Christian, Veziris, Nicolas, Wagner-Wiening, Christiane, Witschi, Mark, Walker, Timothy M, Merker, Matthias, Knoblauch, Astrid M, Helbling, Peter, Schoch, Otto D, van der Werf, Marieke J, Kranzer, Katharina, Fiebig, Lena, Kröger, Stefan, Haas, Walter, Hoffmann, Harald, Indra, Alexander, Egli, Adrian, Cirillo, Daniela M, Robert, Jérôme, Rogers, Thomas R, Groenheit, Ramona, Mengshoel, Anne T, Mathys, Vanessa, Haanperä, Marjo, Soolingen, Dick van, Niemann, Stefan, Böttger, Erik C, and Keller, Peter M

Published
2018
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5. Limited Capability for Testing Mycobacterium tuberculosis for Susceptibility to New Drugs

Author

Farooq, Hamzah Z., Cirillo, Daniela M., Hillemann, Doris, Wyllie, David, van der Werf, Marieke J., Kodmon, Csaba, and Nikolayevskyy, Vlad

Subjects
Microbial sensitivity tests -- Research, Drug resistance in microorganisms -- Identification and classification, Mycobacterium tuberculosis -- Health aspects, Health
Abstract

Mycobacterium tuberculosis is a major cause of death globally, and increasing predicted deaths from tuberculosis (TB) are caused by delays in diagnosis and treatment of new cases associated with coronavirus [...]

Published
2021
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6. Barriers and facilitators to the uptake of tuberculosis diagnostic and treatment services by hard-to-reach populations in countries of low and medium tuberculosis incidence: a systematic review of qualitative literature

Author

de Vries, Sophia G, Cremers, Anne L, Heuvelings, Charlotte C, Greve, Patrick F, Visser, Benjamin J, Bélard, Sabine, Janssen, Saskia, Spijker, René, Shaw, Beth, Hill, Ruaraidh A, Zumla, Alimuddin, van der Werf, Marieke J, Sandgren, Andreas, and Grobusch, Martin P

Published
2017
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13. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

Author

Vos, Theo, Flaxman, Abraham D, Naghavi, Mohsen, Lozano, Rafael, Michaud, Catherine, Ezzati, Majid, Shibuya, Kenji, Salomon, Joshua A, Abdalla, Safa, Aboyans, Victor, Abraham, Jerry, Ackerman, Ilana, Aggarwal, Rakesh, Ahn, Stephanie Y, Ali, Mohammed K, AlMazroa, Mohammad A, Alvarado, Miriam, Anderson, H Ross, Anderson, Laurie M, Andrews, Kathryn G, Atkinson, Charles, Baddour, Larry M, Bahalim, Adil N, Barker-Collo, Suzanne, Barrero, Lope H, Bartels, David H, Basáñez, Maria-Gloria, Baxter, Amanda, Bell, Michelle L, Benjamin, Emelia J, Bennett, Derrick, Bernabé, Eduardo, Bhalla, Kavi, Bhandari, Bishal, Bikbov, Boris, Abdulhak, Aref Bin, Birbeck, Gretchen, Black, James A, Blencowe, Hannah, Blore, Jed D, Blyth, Fiona, Bolliger, Ian, Bonaventure, Audrey, Boufous, Soufiane, Bourne, Rupert, Boussinesq, Michel, Braithwaite, Tasanee, Brayne, Carol, Bridgett, Lisa, Brooker, Simon, Brooks, Peter, Brugha, Traolach S, Bryan-Hancock, Claire, Bucello, Chiara, Buchbinder, Rachelle, Buckle, Geoffrey, Budke, Christine M, Burch, Michael, Burney, Peter, Burstein, Roy, Calabria, Bianca, Campbell, Benjamin, Canter, Charles E, Carabin, Hélène, Carapetis, Jonathan, Carmona, Loreto, Cella, Claudia, Charlson, Fiona, Chen, Honglei, Cheng, Andrew Tai-Ann, Chou, David, Chugh, Sumeet S, Coffeng, Luc E, Colan, Steven D, Colquhoun, Samantha, Colson, K Ellicott, Condon, John, Connor, Myles D, Cooper, Leslie T, Corriere, Matthew, Cortinovis, Monica, de Vaccaro, Karen Courville, Couser, William, Cowie, Benjamin C, Criqui, Michael H, Cross, Marita, Dabhadkar, Kaustubh C, Dahiya, Manu, Dahodwala, Nabila, Damsere-Derry, James, Danaei, Goodarz, Davis, Adrian, De Leo, Diego, Degenhardt, Louisa, Dellavalle, Robert, Delossantos, Allyne, Denenberg, Julie, Derrett, Sarah, Des Jarlais, Don C, Dharmaratne, Samath D, Dherani, Mukesh, Diaz-Torne, Cesar, Dolk, Helen, Dorsey, E Ray, Driscoll, Tim, Duber, Herbert, Ebel, Beth, Edmond, Karen, Elbaz, Alexis, Ali, Suad Eltahir, Erskine, Holly, Erwin, Patricia J, Espindola, Patricia, Ewoigbokhan, Stalin E, Farzadfar, Farshad, Feigin, Valery, Felson, David T, Ferrari, Alize, Ferri, Cleusa P, Fèvre, Eric M, Finucane, Mariel M, Flaxman, Seth, Flood, Louise, Foreman, Kyle, Forouzanfar, Mohammad H, Fowkes, Francis Gerry R, Franklin, Richard, Fransen, Marlene, Freeman, Michael K, Gabbe, Belinda J, Gabriel, Sherine E, Gakidou, Emmanuela, Ganatra, Hammad A, Garcia, Bianca, Gaspari, Flavio, Gillum, Richard F, Gmel, Gerhard, Gosselin, Richard, Grainger, Rebecca, Groeger, Justina, Guillemin, Francis, Gunnell, David, Gupta, Ramyani, Haagsma, Juanita, Hagan, Holly, Halasa, Yara A, Hall, Wayne, Haring, Diana, Haro, Josep Maria, Harrison, James E, Havmoeller, Rasmus, Hay, Roderick J, Higashi, Hideki, Hill, Catherine, Hoen, Bruno, Hoffman, Howard, Hotez, Peter J, Hoy, Damian, Huang, John J, Ibeanusi, Sydney E, Jacobsen, Kathryn H, James, Spencer L, Jarvis, Deborah, Jasrasaria, Rashmi, Jayaraman, Sudha, Johns, Nicole, Jonas, Jost B, Karthikeyan, Ganesan, Kassebaum, Nicholas, Kawakami, Norito, Keren, Andre, Khoo, Jon-Paul, King, Charles H, Knowlton, Lisa Marie, Kobusingye, Olive, Koranteng, Adofo, Krishnamurthi, Rita, Lalloo, Ratilal, Laslett, Laura L, Lathlean, Tim, Leasher, Janet L, Lee, Yong Yi, Leigh, James, Lim, Stephen S, Limb, Elizabeth, Lin, John Kent, Lipnick, Michael, Lipshultz, Steven E, Liu, Wei, Loane, Maria, Ohno, Summer Lockett, Lyons, Ronan, Ma, Jixiang, Mabweijano, Jacqueline, MacIntyre, Michael F, Malekzadeh, Reza, Mallinger, Leslie, Manivannan, Sivabalan, Marcenes, Wagner, March, Lyn, Margolis, David J, Marks, Guy B, Marks, Robin, Matsumori, Akira, Matzopoulos, Richard, Mayosi, Bongani M, McAnulty, John H, McDermott, Mary M, McGill, Neil, McGrath, John, Medina-Mora, Maria Elena, Meltzer, Michele, Memish, Ziad A, Mensah, George A, Merriman, Tony R, Meyer, Ana-Claire, Miglioli, Valeria, Miller, Matthew, Miller, Ted R, Mitchell, Philip B, Mocumbi, Ana Olga, Moffitt, Terrie E, Mokdad, Ali A, Monasta, Lorenzo, Montico, Marcella, Moradi-Lakeh, Maziar, Moran, Andrew, Morawska, Lidia, Mori, Rintaro, Murdoch, Michele E, Mwaniki, Michael K, Naidoo, Kovin, Nair, M Nathan, Naldi, Luigi, Narayan, KM Venkat, Nelson, Paul K, Nelson, Robert G, Nevitt, Michael C, Newton, Charles R, Nolte, Sandra, Norman, Paul, Norman, Rosana, O'Donnell, Martin, O'Hanlon, Simon, Olives, Casey, Omer, Saad B, Ortblad, Katrina, Osborne, Richard, Ozgediz, Doruk, Page, Andrew, Pahari, Bishnu, Pandian, Jeyaraj Durai, Rivero, Andrea Panozo, Patten, Scott B, Pearce, Neil, Padilla, Rogelio Perez, Perez-Ruiz, Fernando, Perico, Norberto, Pesudovs, Konrad, Phillips, David, Phillips, Michael R, Pierce, Kelsey, Pion, Sébastien, Polanczyk, Guilherme V, Polinder, Suzanne, Pope, C Arden, III, Popova, Svetlana, Porrini, Esteban, Pourmalek, Farshad, Prince, Martin, Pullan, Rachel L, Ramaiah, Kapa D, Ranganathan, Dharani, Razavi, Homie, Regan, Mathilda, Rehm, Jürgen T, Rein, David B, Remuzzi, Guiseppe, Richardson, Kathryn, Rivara, Frederick P, Roberts, Thomas, Robinson, Carolyn, De Leòn, Felipe Rodriguez, Ronfani, Luca, Room, Robin, Rosenfeld, Lisa C, Rushton, Lesley, Sacco, Ralph L, Saha, Sukanta, Sampson, Uchechukwu, Sanchez-Riera, Lidia, Sanman, Ella, Schwebel, David C, Scott, James Graham, Segui-Gomez, Maria, Shahraz, Saeid, Shepard, Donald S, Shin, Hwashin, Shivakoti, Rupak, Silberberg, Donald, Singh, David, Singh, Gitanjali M, Singh, Jasvinder A, Singleton, Jessica, Sleet, David A, Sliwa, Karen, Smith, Emma, Smith, Jennifer L, Stapelberg, Nicolas JC, Steer, Andrew, Steiner, Timothy, Stolk, Wilma A, Stovner, Lars Jacob, Sudfeld, Christopher, Syed, Sana, Tamburlini, Giorgio, Tavakkoli, Mohammad, Taylor, Hugh R, Taylor, Jennifer A, Taylor, William J, Thomas, Bernadette, Thomson, W Murray, Thurston, George D, Tleyjeh, Imad M, Tonelli, Marcello, Towbin, Jeffrey A, Truelsen, Thomas, Tsilimbaris, Miltiadis K, Ubeda, Clotilde, Undurraga, Eduardo A, van der Werf, Marieke J, van Os, Jim, Vavilala, Monica S, Venketasubramanian, N, Wang, Mengru, Wang, Wenzhi, Watt, Kerrianne, Weatherall, David J, Weinstock, Martin A, Weintraub, Robert, Weisskopf, Marc G, Weissman, Myrna M, White, Richard A, Whiteford, Harvey, Wiersma, Steven T, Wilkinson, James D, Williams, Hywel C, Williams, Sean RM, Witt, Emma, Wolfe, Frederick, Woolf, Anthony D, Wulf, Sarah, Yeh, Pon-Hsiu, Zaidi, Anita KM, Zheng, Zhi-Jie, Zonies, David, Lopez, Alan D, and Murray, Christopher JL

Published
2012
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14. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010

Author

Murray, Christopher J L, Vos, Theo, Lozano, Rafael, Naghavi, Mohsen, Flaxman, Abraham D, Michaud, Catherine, Ezzati, Majid, Shibuya, Kenji, Salomon, Joshua A, Abdalla, Safa, Aboyans, Victor, Abraham, Jerry, Ackerman, Ilana, Aggarwal, Rakesh, Ahn, Stephanie Y, Ali, Mohammed K, AlMazroa, Mohammad A, Alvarado, Miriam, Anderson, H Ross, Anderson, Laurie M, Andrews, Kathryn G, Atkinson, Charles, Baddour, Larry M, Bahalim, Adil N, Barker-Collo, Suzanne, Barrero, Lope H, Bartels, David H, Basáñez, Maria-Gloria, Baxter, Amanda, Bell, Michelle L, Benjamin, Emelia J, Bennett, Derrick, Bernabé, Eduardo, Bhalla, Kavi, Bhandari, Bishal, Bikbov, Boris, Abdulhak, Aref Bin, Birbeck, Gretchen, Black, James A, Blencowe, Hannah, Blore, Jed D, Blyth, Fiona, Bolliger, Ian, Bonaventure, Audrey, Boufous, Soufiane, Bourne, Rupert, Boussinesq, Michel, Braithwaite, Tasanee, Brayne, Carol, Bridgett, Lisa, Brooker, Simon, Brooks, Peter, Brugha, Traolach S, Bryan-Hancock, Claire, Bucello, Chiara, Buchbinder, Rachelle, Buckle, Geoffrey, Budke, Christine M, Burch, Michael, Burney, Peter, Burstein, Roy, Calabria, Bianca, Campbell, Benjamin, Canter, Charles E, Carabin, Hélène, Carapetis, Jonathan, Carmona, Loreto, Cella, Claudia, Charlson, Fiona, Chen, Honglei, Cheng, Andrew Tai-Ann, Chou, David, Chugh, Sumeet S, Coffeng, Luc E, Colan, Steven D, Colquhoun, Samantha, Colson, K Ellicott, Condon, John, Connor, Myles D, Cooper, Leslie T, Corriere, Matthew, Cortinovis, Monica, de Vaccaro, Karen Courville, Couser, William, Cowie, Benjamin C, Criqui, Michael H, Cross, Marita, Dabhadkar, Kaustubh C, Dahiya, Manu, Dahodwala, Nabila, Damsere-Derry, James, Danaei, Goodarz, Davis, Adrian, Leo, Diego De, Degenhardt, Louisa, Dellavalle, Robert, Delossantos, Allyne, Denenberg, Julie, Derrett, Sarah, Des Jarlais, Don C, Dharmaratne, Samath D, Dherani, Mukesh, Diaz-Torne, Cesar, Dolk, Helen, Dorsey, E Ray, Driscoll, Tim, Duber, Herbert, Ebel, Beth, Edmond, Karen, Elbaz, Alexis, Ali, Suad Eltahir, Erskine, Holly, Erwin, Patricia J, Espindola, Patricia, Ewoigbokhan, Stalin E, Farzadfar, Farshad, Feigin, Valery, Felson, David T, Ferrari, Alize, Ferri, Cleusa P, Fèvre, Eric M, Finucane, Mariel M, Flaxman, Seth, Flood, Louise, Foreman, Kyle, Forouzanfar, Mohammad H, Fowkes, Francis Gerry R, Fransen, Marlene, Freeman, Michael K, Gabbe, Belinda J, Gabriel, Sherine E, Gakidou, Emmanuela, Ganatra, Hammad A, Garcia, Bianca, Gaspari, Flavio, Gillum, Richard F, Gmel, Gerhard, Gonzalez-Medina, Diego, Gosselin, Richard, Grainger, Rebecca, Grant, Bridget, Groeger, Justina, Guillemin, Francis, Gunnell, David, Gupta, Ramyani, Haagsma, Juanita, Hagan, Holly, Halasa, Yara A, Hall, Wayne, Haring, Diana, Haro, Josep Maria, Harrison, James E, Havmoeller, Rasmus, Hay, Roderick J, Higashi, Hideki, Hill, Catherine, Hoen, Bruno, Hoffman, Howard, Hotez, Peter J, Hoy, Damian, Huang, John J, Ibeanusi, Sydney E, Jacobsen, Kathryn H, James, Spencer L, Jarvis, Deborah, Jasrasaria, Rashmi, Jayaraman, Sudha, Johns, Nicole, Jonas, Jost B, Karthikeyan, Ganesan, Kassebaum, Nicholas, Kawakami, Norito, Keren, Andre, Khoo, Jon-Paul, King, Charles H, Knowlton, Lisa Marie, Kobusingye, Olive, Koranteng, Adofo, Krishnamurthi, Rita, Laden, Francine, Lalloo, Ratilal, Laslett, Laura L, Lathlean, Tim, Leasher, Janet L, Lee, Yong Yi, Leigh, James, Levinson, Daphna, Lim, Stephen S, Limb, Elizabeth, Lin, John Kent, Lipnick, Michael, Lipshultz, Steven E, Liu, Wei, Loane, Maria, Ohno, Summer Lockett, Lyons, Ronan, Mabweijano, Jacqueline, MacIntyre, Michael F, Malekzadeh, Reza, Mallinger, Leslie, Manivannan, Sivabalan, Marcenes, Wagner, March, Lyn, Margolis, David J, Marks, Guy B, Marks, Robin, Matsumori, Akira, Matzopoulos, Richard, Mayosi, Bongani M, McAnulty, John H, McDermott, Mary M, McGill, Neil, McGrath, John, Medina-Mora, Maria Elena, Meltzer, Michele, Memish, Ziad A, Mensah, George A, Merriman, Tony R, Meyer, Ana-Claire, Miglioli, Valeria, Miller, Matthew, Miller, Ted R, Mitchell, Philip B, Mock, Charles, Mocumbi, Ana Olga, Moffitt, Terrie E, Mokdad, Ali A, Monasta, Lorenzo, Montico, Marcella, Moradi-Lakeh, Maziar, Moran, Andrew, Morawska, Lidia, Mori, Rintaro, Murdoch, Michele E, Mwaniki, Michael K, Naidoo, Kovin, Nair, M Nathan, Naldi, Luigi, Narayan, K M Venkat, Nelson, Paul K, Nelson, Robert G, Nevitt, Michael C, Newton, Charles R, Nolte, Sandra, Norman, Paul, Norman, Rosana, O'Donnell, Martin, O'Hanlon, Simon, Olives, Casey, Omer, Saad B, Ortblad, Katrina, Osborne, Richard, Ozgediz, Doruk, Page, Andrew, Pahari, Bishnu, Pandian, Jeyaraj Durai, Rivero, Andrea Panozo, Patten, Scott B, Pearce, Neil, Padilla, Rogelio Perez, Perez-Ruiz, Fernando, Perico, Norberto, Pesudovs, Konrad, Phillips, David, Phillips, Michael R, Pierce, Kelsey, Pion, Sébastien, Polanczyk, Guilherme V, Polinder, Suzanne, Pope, C Arden, III, Popova, Svetlana, Porrini, Esteban, Pourmalek, Farshad, Prince, Martin, Pullan, Rachel L, Ramaiah, Kapa D, Ranganathan, Dharani, Razavi, Homie, Regan, Mathilda, Rehm, Jürgen T, Rein, David B, Remuzzi, Guiseppe, Richardson, Kathryn, Rivara, Frederick P, Roberts, Thomas, Robinson, Carolyn, De Leòn, Felipe Rodriguez, Ronfani, Luca, Room, Robin, Rosenfeld, Lisa C, Rushton, Lesley, Sacco, Ralph L, Saha, Sukanta, Sampson, Uchechukwu, Sanchez-Riera, Lidia, Sanman, Ella, Schwebel, David C, Scott, James Graham, Segui-Gomez, Maria, Shahraz, Saeid, Shepard, Donald S, Shin, Hwashin, Shivakoti, Rupak, Silberberg, Donald, Singh, David, Singh, Gitanjali M, Singh, Jasvinder A, Singleton, Jessica, Sleet, David A, Sliwa, Karen, Smith, Emma, Smith, Jennifer L, Stapelberg, Nicolas JC, Steer, Andrew, Steiner, Timothy, Stolk, Wilma A, Stovner, Lars Jacob, Sudfeld, Christopher, Syed, Sana, Tamburlini, Giorgio, Tavakkoli, Mohammad, Taylor, Hugh R, Taylor, Jennifer A, Taylor, William J, Thomas, Bernadette, Thomson, W Murray, Thurston, George D, Tleyjeh, Imad M, Tonelli, Marcello, Towbin, Jeffrey A, Truelsen, Thomas, Tsilimbaris, Miltiadis K, Ubeda, Clotilde, Undurraga, Eduardo A, van der Werf, Marieke J, van Os, Jim, Vavilala, Monica S, Venketasubramanian, N, Wang, Mengru, Wang, Wenzhi, Watt, Kerrianne, Weatherall, David J, Weinstock, Martin A, Weintraub, Robert, Weisskopf, Marc G, Weissman, Myrna M, White, Richard A, Whiteford, Harvey, Wiebe, Natasha, Wiersma, Steven T, Wilkinson, James D, Williams, Hywel C, Williams, Sean RM, Witt, Emma, Wolfe, Frederick, Woolf, Anthony D, Wulf, Sarah, Yeh, Pon-Hsiu, Zaidi, Anita KM, Zheng, Zhi-Jie, Zonies, David, and Lopez, Alan D

Published
2012
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15. Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010

Author

Salomon, Joshua A, Vos, Theo, Hogan, Daniel R, Gagnon, Michael, Naghavi, Mohsen, Mokdad, Ali, Begum, Nazma, Shah, Razibuzzaman, Karyana, Muhammad, Kosen, Soewarta, Farje, Mario Reyna, Moncada, Gilberto, Dutta, Arup, Sazawal, Sunil, Dyer, Andrew, Seiler, Jason, Aboyans, Victor, Baker, Lesley, Baxter, Amanda, Benjamin, Emelia J, Bhalla, Kavi, Abdulhak, Aref Bin, Blyth, Fiona, Bourne, Rupert, Braithwaite, Tasanee, Brooks, Peter, Brugha, Traolach S, Bryan-Hancock, Claire, Buchbinder, Rachelle, Burney, Peter, Calabria, Bianca, Chen, Honglei, Chugh, Sumeet S, Cooley, Rebecca, Criqui, Michael H, Cross, Marita, Dabhadkar, Kaustubh C, Dahodwala, Nabila, Davis, Adrian, Degenhardt, Louisa, Díaz-Torné, Cesar, Dorsey, E Ray, Driscoll, Tim, Edmond, Karen, Elbaz, Alexis, Ezzati, Majid, Feigin, Valery, Ferri, Cleusa P, Flaxman, Abraham D, Flood, Louise, Fransen, Marlene, Fuse, Kana, Gabbe, Belinda J, Gillum, Richard F, Haagsma, Juanita, Harrison, James E, Havmoeller, Rasmus, Hay, Roderick J, Hel-Baqui, Abdullah, Hoek, Hans W, Hoffman, Howard, Hogeland, Emily, Hoy, Damian, Jarvis, Deborah, Jonas, Jost B, Karthikeyan, Ganesan, Knowlton, Lisa Marie, Lathlean, Tim, Leasher, Janet L, Lim, Stephen S, Lipshultz, Steven E, Lopez, Alan D, Lozano, Rafael, Lyons, Ronan, Malekzadeh, Reza, Marcenes, Wagner, March, Lyn, Margolis, David J, McGill, Neil, McGrath, John, Mensah, George A, Meyer, Ana-Claire, Michaud, Catherine, Moran, Andrew, Mori, Rintaro, Murdoch, Michele E, Naldi, Luigi, Newton, Charles R, Norman, Rosana, Omer, Saad B, Osborne, Richard, Pearce, Neil, Perez-Ruiz, Fernando, Perico, Norberto, Pesudovs, Konrad, Phillips, David, Pourmalek, Farshad, Prince, Martin, Rehm, Jürgen T, Remuzzi, Guiseppe, Richardson, Kathryn, Room, Robin, Saha, Sukanta, Sampson, Uchechukwu, Sanchez-Riera, Lidia, Segui-Gomez, Maria, Shahraz, Saeid, Shibuya, Kenji, Singh, David, Sliwa, Karen, Smith, Emma, Soerjomataram, Isabelle, Steiner, Timothy, Stolk, Wilma A, Stovner, Lars Jacob, Sudfeld, Christopher, Taylor, Hugh R, Tleyjeh, Imad M, van der Werf, Marieke J, Watson, Wendy L, Weatherall, David J, Weintraub, Robert, Weisskopf, Marc G, Whiteford, Harvey, Wilkinson, James D, Woolf, Anthony D, Zheng, Zhi-Jie, and Murray, Christopher JL

Published
2012
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18. Treatment and outcomes in children with multidrug-resistant tuberculosis: A systematic review and individual patient data meta-analysis

Author

Harausz, Elizabeth P., Garcia-Prats, Anthony J., Law, Stephanie, Schaaf, H. Simon, Kredo, Tamara, Seddon, James A., Menzies, Dick, Turkova, Anna, Achar, Jay, Amanullah, Farhana, Barry, Pennan, Becerra, Mercedes, Chan, Edward D., Chan, Pei Chun, Ioana Chiotan, Domnica, Crossa, Aldo, Drobac, Peter C., Fairlie, Lee, Falzon, Dennis, Flood, Jennifer, Gegia, Medea, Hicks, Robert M., Isaakidis, Petros, Kadri, SM, Kampmann, Beate, Madhi, Shabir A., Marais, Else, Mariandyshev, Andrei, Méndez-Echevarría, Ana, Moore, Brittany Kathryn, Nargiza, Parpieva, Ozere, Iveta, Padayatchi, Nesri, ur-Rehman, Saleem-, Rybak, Natasha, Santiago-Garcia, Begoña, Shah, N. Sarita, Sharma, Sangeeta, Shim, Tae Sun, Skrahina, Alena, Soriano-Arandes, Antoni, van den Boom, Martin, van der Werf, Marieke J., van der Werf, Tjip S., Williams, Bhanu, Yablokova, Elena, Yim, Jae-Joon, Furin, Jennifer, and Hesseling, Anneke C.

Subjects
Pediatric research, Meta-analysis, Pediatric diseases -- Care and treatment -- Patient outcomes -- Research, Microbial drug resistance -- Research, Biological sciences
Abstract

Background An estimated 32,000 children develop multidrug-resistant tuberculosis (MDR-TB; Mycobacterium tuberculosis resistant to isoniazid and rifampin) each year. Little is known about the optimal treatment for these children. Methods and findings To inform the pediatric aspects of the revised World Health Organization (WHO) MDR-TB treatment guidelines, we performed a systematic review and individual patient data (IPD) meta-analysis, describing treatment outcomes in children treated for MDR-TB. To identify eligible reports we searched PubMed, LILACS, Embase, The Cochrane Library, PsychINFO, and BioMedCentral databases through 1 October 2014. To identify unpublished data, we reviewed conference abstracts, contacted experts in the field, and requested data through other routes, including at national and international conferences and through organizations working in pediatric MDR-TB. A cohort was eligible for inclusion if it included a minimum of three children (aged Conclusions This study suggests that children respond favorably to MDR-TB treatment. The low success rate in children infected with HIV who did not receive ART during their MDR-TB treatment highlights the need for ART in these children. Our findings of individual drug effects on treatment outcome should be further evaluated., Author(s): Elizabeth P. Harausz 1,2,*, Anthony J. Garcia-Prats 1, Stephanie Law 3, H. Simon Schaaf 1, Tamara Kredo 4, James A. Seddon 5, Dick Menzies 3, Anna Turkova 6, Jay [...]

Published
2018
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19. Multidrug-resistant tuberculosis, People's Republic of China, 2007-2009

Author

He, Guang Xue, Wang, Hai Ying, Borgdorff, Martien W., van Soolingen, Dick, van der Werf, Marieke J., Liu, Zhi Min, Li, Xue Zheng, Guo, Hui, Zhao, Yan Lin, Varma, Jay K., Tostado, Christopher P., and van den Hof, Susan

Subjects
Medical research -- Analysis, Medicine, Experimental -- Analysis, Drug resistance in microorganisms -- Genetic aspects -- Risk factors -- Analysis, Tuberculosis -- Genetic aspects -- Risk factors -- Analysis, Disease transmission -- Genetic aspects -- Risk factors -- Analysis, Health, World Health Organization
Abstract

Multidrug-resistant tuberculosis (MDR TB), defined as resistance to at least isoniazid and rifampin, has emerged as a global public health problem (1). The People's Republic of China has the second [...]

Published
2011
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21. Vaccine-induced immunity circumvented by typical Mycobacterium tuberculosis Beijing strains

Author

Kremer, Kristin, van der Werf, Marieke J., Au, Betty K.Y., Anh, Dang D., Kam, Kai M., van Doorn, H. Rogier, Borgdorff, Martien W., and van Soolingen, Dick

Subjects
Vaccination -- Analysis, Tuberculosis -- Analysis, Drug resistance -- Analysis, Medical research -- Analysis, Medicine, Experimental -- Analysis, Antitubercular agents -- Analysis
Abstract

The frequency of typical and atypical Beijing strains of Mycobacterium tuberculosis was determined in the Netherlands; Vietnam; and Hong Kong Special Administrative Region, People's Republic of China. The strains' associations [...]

Published
2009

23. Use of a Whole Genome Sequencing-based approach for Mycobacterium tuberculosis surveillance in Europe in 2017-2019: an ECDC pilot study

Author

Tagliani, Elisa, Anthony, Richard, Kohl, Thomas A, de Neeling, Albert, Nikolayevskyy, Vlad, Ködmön, Csaba, Maurer, Florian P, Niemann, Stefan, van Soolingen, Dick, van der Werf, Marieke J, and Cirillo, Daniela Maria

Abstract

Whole genome sequencing (WGS) can be used for molecular typing and characterisation of Mycobacterium tuberculosis complex (MTBC) strains. We evaluated the systematic use of a WGS-based approach for MTBC surveillance involving all European Union/European Economic Area (EU/EEA) countries and highlight the challenges and lessons learned to be considered for the future development of a WGS-based surveillance system.WGS and epidemiological data of patients with rifampicin (RR) and multi-drug resistant (MDR)-tuberculosis (TB) were collected from EU/EEA countries between January 2017 and December 2019. WGS-based genetic relatedness analysis was performed using a standardised approach including both core genome multilocus sequence typing (cgMLST), and single nucleotide polymorphism (SNP)-based calculation of distances on all WGS data that fulfilled minimum quality criteria to ensure data comparability.From 25 countries, 2218 RR/MDR-MTBC isolates were collected. Fifty-six cross-border clusters with increased likelihood of recent transmission (≤5 SNPs distance) comprising a total of 316 RR/MDR-MTBC isolates were identified. The cross-border clusters included between two and thirty resistant isolates from two to six countries unravelling different RR/MDR-TB transmission patterns in Western and Eastern EU.This pilot study shows that a WGS-based surveillance system is not only feasible but can efficiently elucidate the dynamics of in-country and cross-border RR/MDR-TB transmission across EU/EEA countries. Lessons learned from this study highlight how the establishment of an EU/EEA centralised WGS-based surveillance system for TB will require strengthening of national integrated systems performing prospective WGS surveillance and the development of clear procedures to facilitate international collaboration for the investigation of cross-border clusters.

Published
2020

24. Completeness of tuberculosis (TB) notification: inventory studies and capture-recapture analyses, six European Union countries, 2014 to 2016

Author

Straetemans, Masja, Bakker, Mirjam I, Alba, Sandra, Mergenthaler, Christina, Rood, Ente, Andersen, Peter H, Schimmel, Henrieke, Simunovic, Aleksandar, Svetina, Petra, Carvalho, Carlos, Lyytikäinen, Outi, Abubakar, Ibrahim, Harris, Ross J, Ködmön, Csaba, van der Werf, Marieke J, and van Hest, Rob

Subjects
Portugal, tuberculosis, Croatia, statistics, Denmark, Slovenia, surveillance, epidemiology, Finland, Netherlands
Published
2020

25. Determining the burden of tuberculosis in Eritrea: a new approach/Une nouvelle approche pour la determination de la charge de tuberculose en Erythree/Nuevo metodo para determinar la carga de tuberculosis en Eritrea

Author

Sebhatu, Mineab, Kiflom, Bahlbi, Seyoum, Melles, Kassim, Nuredin, Negash, Tesfazion, Tesfazion, Andeberhan, Borgdorff, Martien W., and van der Werf, Marieke J.

Subjects
Pulmonary tuberculosis -- Statistics, Pulmonary tuberculosis -- Care and treatment, Infection control -- Evaluation, Prevalence studies (Epidemiology) -- Methods, Prevalence studies (Epidemiology) -- Analysis
Abstract

Objective To obtain an estimate of the prevalence of new cases of smear-positive tuberculosis in Eritrea using a new low-cost approach. Methods The study was designed to include a sample of 35 000 people divided between 40 clusters. The clusters were selected by sampling proportional to population size. In each cluster, census data were obtained from eligible individuals. Individuals aged 15 years or more were questioned about cough and its duration and smoking and were asked to provide two samples of sputum (spot and morning) for examination by fluorescence microscopy. Findings A total of 38 032 individuals were included in the study. Of the 19 197 individuals aged 15 years or more, 18 152 (94.6%) provided at least one sample of sputum. Fifteen individuals fulfilled the case definition, providing a prevalence of new cases of smear-positive tuberculosis of 90 per 100 000 (95% confidence interval, CI, 35-145 per 100 000) individuals aged 15 years or more and 50 per 100 000 (95% CI, 19-80 per 100 000)in the total population. Conclusion The estimated prevalence of new cases of smear-positive tuberculosis obtained from our study is considerably lower than the estimate published by the World Health Organization. The new methodology for surveys to determine the prevalence of tuberculosis that we used is feasible in the field. This methodology should be validated in other countries and compared with other methods for measuring prevalence. Objectif Obtenir une estimation de la prevalence des nouveaux cas de tuberculose a frottis positif en Erythree par une demarche nouvelle et economique. Methodes L'etude a ete concue pour porter sur un echantillon de 35 000 personnes, reparties en 40 groupes. Les groupes ont ete constitues par tirage proportionnel a la taille de la population. Dans chaque groupe, on a obtenu des donnees de recensement pour les personnes repondant aux criteres d'inclusion. On a demande aux sujets de 15 ans et plus s'ils toussaient et depuis combien de temps et d'autre part s'ils fumaient. On leur a egalement demande de fournir deux echantillons d'expectoration pour examen par microscopie de fluorescence. Resultats Au total, 38 032 personnes ont ete incluses dans l'etude. Parmi les 19 197 sujets de 15 ans ou plus, 18 152 (94,6 %) ont fourni au moins un echantillon d'expectoration. Quinze personnes remplissaient les criteres de la definition de cas, d'ou une prevalence des nouveaux cas de tuberculose a frottis positif de 90 pour 100 000 [intervalle de confiance a 95 % (IC): 35-145 pour 100 000] parmi les personnes de 15 ans ou plus et de 50 pour 100 000 [intervalle de confiance a 95 % (IC) : 19-80 pour 100 000] parmi la population totale. Conclusion L'estimation de la prevalence des nouveaux cas de tuberculose a frottis positif obtenue par notre etude est considerablement inferieure a celle publiee par l'Organisation mondiale de la Sante. La nouvelle methodologie d'enquete utilisee pour determiner la prevalence de la tuberculose est applicable sur le terrain. Cette methodologie doit etre validee dans d'autres pays et comparee a d'autres techniques de mesure de la prevalence. Objetivo Obtener una estimacion de la prevalencia de nuevos casos de tuberculosis con baciloscopia positiva en Eritrea empleando un nuevo metodo de bajo costo. Metodos El estudio se diseno de manera que abarcara una muestra de unas 35 000 personas repartidas entre 40 conglomerados. Estos fueron seleccionados mediante la tecnica de muestreo proporcional al tamano de la poblacion. En cada conglomerado se obtuvieron datos censales sobre las personas que reunian las condiciones. Se encuesto a los individuos de 15 o mas anos acerca de la tos y su duracion y sobre su consumo de tabaco, pidiendoseles que proporcionaran dos muestras de esputo (in situ y por la manana) para someterlas a microscopia de fluorescencia. Resultados En total participaron en el estudio 38 032 personas. De los 19 197 individuos de 15 o mas anos que habia entre ellas, 18 152 (94,6%) proporcionaron al menos una muestra de esputo. Quince cumplian la definicion de caso, lo que arroja una prevalencia de nuevos casos baciliferos de tuberculosis de 90 por 100 000 (intervalo de confianza [IC] del 95%: 35-145 por 100 000) personas de 15 anos o mas, y de 50 por 100 000 (IC95%: 19-80 por 100 000) en la poblacion total. Conclusion La prevalencia de casos nuevos de tuberculosis con baciloscopia positiva estimada a partir de nuestro estudio es considerablemente inferior a la estimacion publicada por la Organizacion Mundial de la Salud. La nueva metodologia que empleamos en las encuestas para determinar la prevalencia de la tuberculosis es viable sobre el terreno, pero deberia ser validada en otros paises y comparada con otros metodos de medicion de la prevalencia., Introduction In 2004, 84% of the population of Eritrea was covered by the directly-observed treatment, short-course (DOTS) programme for the management of tuberculosis (TB) and WHO was notified of 720 [...]

Published
2007

26. Targets for tuberculosis control: how confident can we be about the data?/Objectifs de la lutte antituberculeuse: quelle confiance pouvons-nous accorder aux donnees?/Metas de control de la tuberculosis: que fiabilidad tienen los datos?

Author

van der Werf, Marieke J. and Borgdorff, Martien W.

Subjects
Millennium Development Goals (Report), Tuberculosis -- Control, Tuberculosis -- Health aspects, Tuberculosis -- Surveys, Medical research -- Health aspects, Medical research -- Surveys, Medicine, Experimental -- Health aspects, Medicine, Experimental -- Surveys, Antitubercular agents -- Surveys, Antitubercular agents -- Health aspects, Mortality -- Surveys
Abstract

The targets of tuberculosis (TB) control programmes are to detect 70% of new sputum smear-positive cases of TB and to cure 85% of these. The Stop TB Partnership has set additional targets related to the Millennium Development Goals: to halve TB prevalence and mortality between 1990 and 2015. This paper assesses how confident we can be about the data on TB case detection, cure rates, prevalence and mortality. Countries were grouped into those with good, limited or poor information on the burden of TB (based on notification data, population surveys and vital registration systems). Of 211 countries with a total population of 6.4 billion and an estimated 8.9 million cases of TB, 27 countries with a total population of 2.2 billion and an estimated 1.8 million cases of TB had estimates based on good information (i.e. a good-quality surveillance system detecting > 70% of all cases, or a good-quality TB prevalence survey). Of the 22 countries with a high burden of TB and bearing 80% of the global burden, none had a good surveillance system in 1997. Vital registration systems were good in 81 countries with a total population of 2.7 billion. This paper suggests that globally and in the 22 countries with a high burden of TB there is considerable uncertainty about indicators to measure progress towards the Millennium Development Goals. Routine surveillance and vital registration systems need to be strengthened. We recommend that national TB prevalence surveys be performed in selected high-burden countries, in Africa in particular. Resume Les programmes nationaux de lutte antituberculeuse ont pour objectifs de detecter 70 % des nouveaux cas de tuberculose (TB) a frottis positif et de guerir 80 % des cas detectes. Dans le cadre de la realisation des objectifs du Millenaire pour le developpement, le Partenariat Halte a la tuberculose a defini un objectif supplementaire : diviser par deux, entre 1990 et 2015, la prevalence de la tuberculose et la mortalite due a cette maladie. Le present article evalue le degre de fiabilite des donnees concernant la detection des cas de TB, les taux de guerison, la prevalence de la TB et la mortalite due a cette maladie. Les pays ont ete repartis en trois categories selon que l'on disposait de donnees satisfaisantes, limitees ou insatisfaisantes sur la charge de TB qu'ils supportent (d'aprs les donnees de notification, les enquetes en population et les systmes d'enregistrement des donnees d'etat-civil). Parmi 211 pays representant une population totale de 6,4 milliard d'habitants et un nombre total de cas de TB estime a 8,9 millions, 27 (regroupant au total 2,2 milliard d'habitants et un nombre de cas de TB estime a 1,8 million) disposaient Q estimations reposam sur des donnees satisfaisantes (c'est-a-dire fournies par un bon systme de surveillance, detectant plus de 70 % des cas, ou par une enquete sur la prevalence de la TB de bonne qualite). Parmi les 22 pays supportant une forte charge de TB et totalisant a eux seuls 80 % de la charge mondiale de tuberculose, aucun ne pouvait compter en 1997 sur un bon systme de surveillance. Les systmes d'enregistrement des donnees d'etat-civil etaient satisfaisants dans 81 pays regroupant au total 2,7 milliards d'habitants. L'article fait observer qu'a l'echelle mondiale et dans les 22 pays fortement touches par la TB, les indicateurs servant a mesurer les progrs dans la realisation des objectifs du Millenaire pour le developpement sont entaches d'une grande incertitude. La surveillance de routine et les systemes d'enregistrement des donnees d'etat-civil doivent etre renforces. Nous recommandons de proceder a des enquetes sur la prevalence nationale de la TB dans un certain nombre de pays fortement touches par la tuberculose, notamment en Afrique. Resumen Las metas de los programas de control de la tuberculosis consisten en detectar un 70% de los nuevos casos baciliferos y curar el 85% de esos casos. La Alianza Alto a la Tuberculosis ha establecido nuevas metas relacionadas con los Objetivos de Desarrollo del Milenio: reducir a la mitad la prevalencia de tuberculosis y la mortalidad por esa causa entre 1990 y 2015. En este articulo se evalua la fiabilidad de los datos sobre la deteccion de casos de tuberculosis y las tasas de curacion, la prevalencia y la mortalidad correspondientes. Se clasifico a los paises en funcion de la calidad de su informacion -buena, escasa o mala- sobre la carga de tuberculosis (calibrada a partir de los datos de notificacion, las encuestas de poblacion y los sistemas de registro civil). De 211 paises con una poblacion total de 6400 millones de personas y una cifra estimada de 8,9 millones de casos de tuberculosis, 27 paises con una poblacion total de 2200 millones de habitantes y unos 1,8 millones de casos estimados disponian de estimaciones basadas en una buena informacion (es decir, un sistema de vigilancia de buena calidad que detectaba mas del 70% de todos los casos, o una encuesta de buena calidad sobre la prevalencia de la tuberculosis). De los 22 paises con una alta carga de tuberculosis, que suponen el 80% de la carga mundial, ninguno tenia un buen sistema de vigilancia en 1997. Los sistemas de registro civil eran satisfactorios en 81 paises que totalizaban una poblacion de 2700 millones de personas. En el presente articulo se sugiere que tanto a nivel mundial como en los 22 paises que presentan una alta carga de tuberculosis existe una incertidumbre considerable sobre los indicadores empleados para medir los progresos hacia los Objetivos de Desarrollo del Milenio. Es preciso reforzar la vigilancia sistematica y los sistemas de registro civil. Recomendamos que se lleven a cabo encuestas nacionales sobre la prevalencia de la tuberculosis en algunos de los paises con alta carga de la enfermedad, en Africa en particular. [TEXT NOT REPRODUCIBLE IN ASCI.], Introduction Tuberculosis (TB) is an important cause of illness and death globally, accounting for an estimated 8.8 million new cases and 1.6 million deaths each year. (1) Mycobacterium tuberculosis, the [...]

Published
2007

27. Tuberculosis elimination in the Netherlands

Author

Borgdorff, Martien W., van der Werf, Marieke J., de Haas, Petra E.W. Kremer, Kristin, and van Soolingen, Dick

Subjects
Tuberculosis -- Case studies, Communicable diseases -- Case studies
Abstract

This study assessed progress towards tuberculosis (TB) elimination in the Netherlands by using DNA finger-printing. Mycobacterium tuberculosis strains were defined as new if the IS6110 restriction fragment length polymorphism pattern [...]

Published
2005

32. Use of a Whole Genome Sequencing-based approach for Mycobacterium tuberculosis surveillance in Europe in 2017–2019: an ECDC pilot study

Author

Tagliani, Elisa, primary, Anthony, Richard, additional, Kohl, Thomas A., additional, de Neeling, Albert, additional, Nikolayevskyy, Vlad, additional, Ködmön, Csaba, additional, Maurer, Florian P., additional, Niemann, Stefan, additional, van Soolingen, Dick, additional, van der Werf, Marieke J., additional, and Cirillo, Daniela Maria, additional

Published
2020
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33. Epidemic and pandemic viral infections: impact on tuberculosis and the lung

Author

Ong, Catherine Wei Min, primary, Migliori, Giovanni Battista, additional, Raviglione, Mario, additional, MacGregor-Skinner, Gavin, additional, Sotgiu, Giovanni, additional, Alffenaar, Jan-Willem, additional, Tiberi, Simon, additional, Adlhoch, Cornelia, additional, Alonzi, Tonino, additional, Archuleta, Sophia, additional, Brusin, Sergio, additional, Cambau, Emmanuelle, additional, Capobianchi, Maria Rosaria, additional, Castilletti, Concetta, additional, Centis, Rosella, additional, Cirillo, Daniela M., additional, D'Ambrosio, Lia, additional, Delogu, Giovanni, additional, Esposito, Susanna M.R., additional, Figueroa, Jose, additional, Friedland, Jon S., additional, Ho, Benjamin Choon Heng, additional, Ippolito, Giuseppe, additional, Jankovic, Mateja, additional, Kim, Hannah Yejin, additional, Rosales Klintz, Senia, additional, Ködmön, Csaba, additional, Lalle, Eleonora, additional, Leo, Yee Sin, additional, Leung, Chi-Chiu, additional, Märtson, Anne-Grete, additional, Melazzini, Mario Giovanni, additional, Najafi Fard, Saeid, additional, Penttinen, Pasi, additional, Petrone, Linda, additional, Petruccioli, Elisa, additional, Pontali, Emanuele, additional, Saderi, Laura, additional, Santin, Miguel, additional, Spanevello, Antonio, additional, van Crevel, Reinout, additional, van der Werf, Marieke J., additional, Visca, Dina, additional, Viveiros, Miguel, additional, Zellweger, Jean-Pierre, additional, Zumla, Alimuddin, additional, and Goletti, Delia, additional

Published
2020
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34. Completeness of tuberculosis (TB) notification: inventory studies and capture-recapture analyses, six European Union countries, 2014 to 2016

Author

Straetemans, Masja, primary, Bakker, Mirjam I, additional, Alba, Sandra, additional, Mergenthaler, Christina, additional, Rood, Ente, additional, Andersen, Peter H, additional, Schimmel, Henrieke, additional, Simunovic, Aleksandar, additional, Svetina, Petra, additional, Carvalho, Carlos, additional, Lyytikäinen, Outi, additional, Abubakar, Ibrahim, additional, Harris, Ross J, additional, Ködmön, Csaba, additional, van der Werf, Marieke J, additional, and van Hest, Rob, additional

Published
2020
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35. Role and value of whole genome sequencing in studying tuberculosis transmission

Author

Nikolayevskyy, Vlad, Niemann, Stefan, Anthony, Richard, Van Soolingen, Dick, Tagliani, Elisa, Ködmön, Csaba, van der Werf, Marieke J, and Cirillo, Daniela Maria

Abstract

Tuberculosis (TB) remains a serious public health threat worldwide. Theoretically ultimate resolution of whole genome sequencing (WGS) for Mycobacterium tuberculosis complex (MTBC) strain classification makes this technology very attractive for epidemiological investigations. To summarise the evidence available in peer-reviewed publications on the role and place of WGS in detection of TB transmission. 69 peer-reviewed publications identified in Pubmed database. Evidence from >30 publications suggests that a cut-off value of

Published
2019

36. Isoniazid (INH) mono-resistance and tuberculosis (TB) treatment success: analysis of European surveillance data, 2002 to 2014

Author

Karo, Basel, Kohlenberg, Anke, Hollo, Vahur, Duarte, Raquel, Fiebig, Lena, Jackson, Sarah, Kearns, Cathriona, Ködmön, Csaba, Korzeniewska-Kosela, Maria, Papaventsis, Dimitrios, Solovic, Ivan, van Soolingen, Dick, and van der Werf, Marieke J

Subjects
isoniazid mono-resistance, TB, tuberculosis, anti-tuberculous treatment, surveillance, epidemiology
Abstract

Isoniazid (INH) is an essential drug for tuberculosis (TB) treatment. Resistance to INH may increase the likelihood of negative treatment outcome. We aimed to determine the impact of INH mono-resistance on TB treatment outcome in the European Union/European Economic Area and to identify risk factors for unsuccessful outcome in cases with INH mono-resistant TB. In this observational study, we retrospectively analysed TB cases that were diagnosed in 2002-14 and included in the European Surveillance System (TESSy). Multilevel logistic regression models were applied to identify risk factors and correct for clustering of cases within countries. A total of 187,370 susceptible and 7,578 INH mono-resistant TB cases from 24 countries were included in the outcome analysis. Treatment was successful in 74.0% of INH mono-resistant and 77.4% of susceptible TB cases. In the final model, treatment success was lower among INH mono-resistant cases (Odds ratio (OR): 0.7; 95% confidence interval (CI): 0.6-0.9; adjusted absolute difference in treatment success: 5.3%). Among INH mono-resistant TB cases, unsuccessful treatment outcome was associated with age above median (OR: 1.3; 95% CI: 1.2-1.5), male sex (OR: 1.3; 95% CI: 1.1-1.4), positive smear microscopy (OR: 1.3; 95% CI: 1.1-1.4), positive HIV status (OR: 3.3; 95% CI: 1.6-6.5) and a prior TB history (OR: 1.8; 95% CI: 1.5-2.2).

Published
2019

46. Evaluating tuberculosis case detection in Eritrea

Author

van der Werf, Marieke J., Sebhatu, Mineab, and Borgdorff, Martien W.

Subjects
World Health Organization -- Surveys, Tuberculosis -- Control, Tuberculosis -- Surveys, Public health -- Surveys
Abstract

We used results from a national tuberculosis prevalence survey in Eritrea to calculate case detection rate (CDR) and compared it with the published CDR. The CDR obtained from the survey [...]

Published
2007

50. Isoniazid (INH) mono-resistance and tuberculosis (TB) treatment success: analysis of European surveillance data, 2002 to 2014

Author

Karo, Basel, primary, Kohlenberg, Anke, additional, Hollo, Vahur, additional, Duarte, Raquel, additional, Fiebig, Lena, additional, Jackson, Sarah, additional, Kearns, Cathriona, additional, Ködmön, Csaba, additional, Korzeniewska-Kosela, Maria, additional, Papaventsis, Dimitrios, additional, Solovic, Ivan, additional, van Soolingen, Dick, additional, and van der Werf, Marieke J., additional

Published
2019
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