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Your search keyword '"tandem repeat resistance mechanism"' showing total 2 results
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2 results on '"tandem repeat resistance mechanism"'

1. In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR120) in Aspergillus fumigatus cyp51A, Denmark

Author

Rasmus K. Hare, Jan B. Gertsen, Karen M.T. Astvad, Kristine B. Degn, Anders Løkke, Marc Stegger, Paal S. Andersen, Lise Kristensen, and Maiken C. Arendrup

Subjects
promoter TR120, azole resistance, whole-genome sequencing, tandem repeat resistance mechanism, in vivo selection, fungal infections, Medicine, Infectious and parasitic diseases, RC109-216
Abstract

We report a fatal aspergillosis case in which STRAf typing and whole-genome sequencing substantiated in vivo emergence of an azole-resistant Aspergillus fumigatus with a 120-bp tandem repeat in the promoter region of cyp51A. This event, previously restricted to the environment, challenges current understanding of azole resistance development in A. fumigatus.

Published
2019
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2. In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR120) in Aspergillus fumigatus cyp51A, Denmark.

Author

Hare, Rasmus K., Gertsen, Jan B., Astvad, Karen M. T., Degn, Kristine B., Løkke, Anders, Stegger, Marc, Andersen, Paal S., Kristensen, Lise, and Arendrup, Maiken C.

Subjects
TANDEM repeats, ASPERGILLUS fumigatus, AZOLES
Abstract

We report a fatal aspergillosis case in which STRAf typing and whole-genome sequencing substantiated in vivo emergence of an azole-resistant Aspergillus fumigatus with a 120-bp tandem repeat in the promoter region of cyp51A. This event, previously restricted to the environment, challenges current understanding of azole resistance development in A. fumigatus. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

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