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In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR120) in Aspergillus fumigatus cyp51A, Denmark
- Source :
- Emerging Infectious Diseases, Vol 25, Iss 3, Pp 577-580 (2019)
- Publication Year :
- 2019
- Publisher :
- Centers for Disease Control and Prevention, 2019.
-
Abstract
- We report a fatal aspergillosis case in which STRAf typing and whole-genome sequencing substantiated in vivo emergence of an azole-resistant Aspergillus fumigatus with a 120-bp tandem repeat in the promoter region of cyp51A. This event, previously restricted to the environment, challenges current understanding of azole resistance development in A. fumigatus.
Details
- Language :
- English
- ISSN :
- 10806040 and 10806059
- Volume :
- 25
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Emerging Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.183ec7c70df4d2d9e2afabf6c4a9ca2
- Document Type :
- article
- Full Text :
- https://doi.org/10.3201/eid2503.180297