In Vivo Selection of a Unique Tandem Repeat Mediated Azole Resistance Mechanism (TR120) in Aspergillus fumigatus cyp51A, Denmark.

Authors :: Hare, Rasmus K.
Gertsen, Jan B.
Astvad, Karen M. T.
Degn, Kristine B.
Løkke, Anders
Stegger, Marc
Andersen, Paal S.
Kristensen, Lise
Arendrup, Maiken C.
Source :: Emerging Infectious Diseases; Mar2019, Vol. 25 Issue 3, p577-580, 4p
Publication Year :: 2019
Abstract: We report a fatal aspergillosis case in which STRAf typing and whole-genome sequencing substantiated in vivo emergence of an azole-resistant Aspergillus fumigatus with a 120-bp tandem repeat in the promoter region of cyp51A. This event, previously restricted to the environment, challenges current understanding of azole resistance development in A. fumigatus. [ABSTRACT FROM AUTHOR]

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