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Background/Objectives: Enfortumab vedotin (EV) is an antibody-drug conjugate (ADC) that combines monomethyl auristatin E (MMAE), a potent cytotoxic agent, with a monoclonal antibody targeting Nectin-4. It has emerged as a promising therapy for metastatic urothelial carcinoma (mUC), either as monotherapy or in combination with pembrolizumab, improving significantly the overall survival of these patients. EV is associated with common adverse events, including skin reactions, glucose imbalance, and peripheral neuropathy, which are usually mild in severity and easily manageable. Methods: Following an initial case of pleuro-pneumopathy occurring in a patient treated with EV, we conducted a retrospective analysis of EV effects on pulmonary imaging. Results: In a cohort of 20 all-comers mUC patients, we identified three cases of potentially EV-related lung toxicity, resulting in a pleuro-pneumopathy rate of 15%. Two of these cases appeared highly symptomatic and required high steroid doses, with a rapid resolution of symptoms and normalization of radiological findings. In one patient, rechallenge of EV was associated with reoccurrence of pneumopathy. We described the clinical and radiological features of these cases, as well as their evolution after EV discontinuation and rechallenge. Conclusions: This case series underscores the importance of close pulmonary monitoring during EV treatment. [ABSTRACT FROM AUTHOR]

The recent discovery of nickelate superconductivity represents an important step toward understanding the four‐decade mastery of unconventional high‐temperature superconductivity. However, the synthesis of the infinite‐layer nickelate superconductors shows great challenges. Particularly, surface capping layers are usually unitized to facilitate the sample synthesis. This leads to an important question whether nickelate superconductors with d9 configuration and ultralow valence of Ni1+ are in metastable state and whether nickelate superconductivity can be robust? In this work, a series of redox cycling experiments are performed across the phase transition between perovskite Nd0.8Sr0.2NiO3 and infinite‐layer Nd0.8Sr0.2NiO2. The infinite‐layer Nd0.8Sr0.2NiO2 is quite robust in the redox environment and can survive the cycling experiments with unchanged crystallographic quality. However, as the cycling number goes on, the perovskite Nd0.8Sr0.2NiO3 shows structural degradation, suggesting stability of nickelate superconductivity is not restricted by the ultralow valence of Ni1+, but by the quality of its perovskite precursor. The observed robustness of infinite‐layer Nd0.8Sr0.2NiO2 up to ten redox cycles further indicates that if an ideal high‐quality perovskite precursor can be obtained, infinite‐layer nickelate superconductivity can be very stable and sustainable under environmental conditions. This work provides important implications for potential device applications for nickelate superconductors. [ABSTRACT FROM AUTHOR]

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Enzyme immobilization has emerged as one of the pivotal technologies in enzyme engineering, offering substantial cost reductions associated with enzyme isolation and utilization. However, efficient catalysis of solid substrates with solid immobilized enzymes remains a challenge, typically exemplified by the hydrolysis of cellulose using immobilized cellulase. In this study, a novel system of reversible release and recycling of cellulase on the surface of low-density polyethylene (LDPE) "hull" was developed, inspired by the operational dynamics of carrier-based aircraft. The reversible formation and disruption of multiple hydrogen bonds between the grafted gelatin molecular chain on the LDPE surface and the modification arm of cellulase (poly (methacrylic acid-propenoic acid; PAA-PMAA) can be achieved through temperature control, thus enabling the reversible release and recycling of modified cellulase molecules on the LDPE surface. Results demonstrated that the release of modified cellulase (PLANE) from the LDPE surface overcame the mass transfer barrier inherent in traditional immobilized enzyme systems for catalyzing insoluble substrates. This was attributed to the dissolution of PLANE in the developed system, rendering its hydrolysis of the insoluble cellulose substrate comparable to that of the free enzyme. Upon completion of the reaction, the PLANE could be reversibly recycled on the surface of the macroscopic LDPE membrane, facilitated by the regeneration of multiple hydrogen bonds. Furthermore, the facile removal of the membrane aided in the convenient recycling of cellulase. Notably, the cellulase molecules in the system retained more than 50% of their biological activity even after 8 batches of reuse, making the process cost-effective. This method addressed the limitations of traditional immobilized enzymes, allowing the catalysis of solid substrates with elevated mass transfer and simultaneous easy recovery, thus standing out as a universal immobilization method. [ABSTRACT FROM AUTHOR]

Focal imaging abnormalities in patients with parkinsonism suggest secondary etiology and require a distinctive clinical approach to diagnosis and treatment. We review different entities presenting as secondary parkinsonism associated with structural brain lesions, with emphasis on the clinical course and neuroimaging findings. Secondary parkinsonism may be due to vascular causes, hydrocephalus, space-occupying lesions, metabolic causes (including acquired hepatocerebral degeneration, diabetic uremic encephalopathy, basal ganglia calcifications, osmotic demyelination syndrome), hypoxic-ischaemic brain injury, intoxications (including methanol, carbon monoxide, cyanide, carbon disulfide, manganese poisoning and illicit drugs), infections and immune causes. The onset can vary from acute to chronic. Both uni-and bilateral presentations are possible. Rigidity, bradykinesia and gait abnormalities are more common than rest tremor. Coexisting other movement disorders and additional associated neurological signs may point to the underlying diagnosis. Neuroimaging studies are an essential part in the diagnostic work-up of secondary parkinsonism and may point directly to the underlying etiology. We focus primarily on magnetic resonance imaging to illustrate how structural imaging combined with neurological assessment can lead to diagnosis. It is crucial that typical imaging abnormalities are recognized within the relevant clinical context. Many forms of secondary parkinsonism are reversible with elimination of the specific cause, while some may benefit from symptomatic treatment. This heterogeneous group of acquired disorders has also helped shape our knowledge of Parkinson's disease and basal ganglia pathophysiology, while more recent findings in the field garner support for the network perspective on brain function and neurological disorders. [ABSTRACT FROM AUTHOR]

Background: Wernicke's encephalopathy (WE) is an acute neurological syndrome resulting from thiamine (vitamin B1) deficiency. It has been recognized increasingly in non-alcoholic patients, such as in the condition of malnutrition. Recent literature has shed light on uncommon symptoms and neuroimaging findings. Case report: We reported a case of a 44-year-old male who initially presented with bilateral hearing loss, and exhibited abnormality in the splenium of the corpus callosum on magnetic resonance imaging (MRI) diffusion-weighted imaging sequence. On the following day the patient developed new symptoms, including unstable walking, double vision and hallucination. The subsequent brain MRI demonstrated lesions involving periaqueductal grey matter and bilateral medial thalamus, indicating the diagnosis of WE. Empirical treatment with intravenous thiamine resulted in complete clinical and radiological resolution. Conclusion: To the best of our knowledge, the current case is the first report of WE in literature with uncommon but reversible manifestations. This case warns us to maintain a heightened level of suspicion for WE in malnourished patients with neurological deficits, despite the possibility of atypical presentations encompassing bilateral hearing disturbances and unusual neuroradiological results. Early diagnosis and timely administration of thiamine in WE are likely to lead to a favorable outcome and full recovery. [ABSTRACT FROM AUTHOR]

A promising alternative for the CMOS technology is the Quantum-dot Cellular Automata (QCA) technology. In this technology, the low-latency, ultra-dense, and low-power consumption digital circuits are designed. Until now, many digital circuits are designed and improved in the QCA technology. The Arithmetic Logic Unit (ALU) is an important digital circuit that designed in this technology. The reversible logic gates such as NOT, Feynman, and Fredkin gates are important elements in the arithmetic circuits and processors design. In addition, considering the cell arrangements has a great influence on the area and speed of execution of computing devices in the QCA technology. This paper's goal is to build a new multilayer QCA Reversible ALU (RALU). In this paper, we used one HN and three Fredkin gates to design and implement a new and efficient RALU circuit in the QCA technology. The proposed QCA RALU circuit is simulated and tested using QCADesigner tool. The simulation results demonstrate that the developed QCA multilayer RALU has 489 cells, 0.36 µm2 area, 3.75 clock cycles delay, 2.02 meV average energy, and 5.41 nW power dissipation. In addition, the comparison indicates that the developed QCA RALU circuit has advantages compared to other QCA RALU circuits with regards to energy, area, latency, and cost. [ABSTRACT FROM AUTHOR]

Rationale: Conventionally considered irreversible, bronchiectasis has been demonstrated to be reversible in children in small studies. However, the factors associated with radiographic reversibility of bronchiectasis have yet to be defined. Objectives: In a large cohort of children with bronchiectasis, we aimed to determine: 1) if and to what extent bronchiectasis is reversible and 2) factors associated with radiographic chest high-resolution computed tomography (cHRCT) resolution. Methods: We identified children with bronchiectasis who had a repeat multidetector cHRCT scan between 2010 and 2021. We excluded those with cystic fibrosis, surgical pulmonary resection, traction bronchiectasis only, or lobar opacification. Measurements and Main Results: cHRCT scans were scored using the modified Reiff score (MRS) with a pediatric correction. Resolution was defined as an absence of abnormal bronchoarterial ratio (>0.8) on the second cHRCT scan. We included 142 children (median age, 5 years; IQR, 2.6–7.4). Inter- and intrarater agreement in MRSs was excellent (weighted κ = 0.83–0.86 and 0.95, respectively). There was radiographic resolution in 57 of 142 patients (40.1%), improvement in 56 of 142 (39.4%), and no change or worsening in 29 of 142 (20.4%). Pseudomonas aeruginosa (PsA) was absolutely associated with a lack of resolution. On multivariable regression, in those without PsA cultured, younger age at the time of diagnosis (risk ratio [RR], 0.94; 95% confidence interval [CI], 0.88–0.99), lower MRS (RR, 0.89; 95% CI, 0.82–0.97), and lower annual rate of exacerbations requiring intravenous antibiotic therapy (RR, 0.60; 95% CI, 0.37–0.98) increased the likelihood of radiographic resolution. Conclusions: This first large cohort confirms that bronchiectasis in children is often reversible with appropriate management. Younger children and those with lesser radiographic severity at diagnosis were most likely to exhibit radiographic reversibility, whereas those with PsA infection were least likely. [ABSTRACT FROM AUTHOR]

Abstract The recent discovery of nickelate superconductivity represents an important step toward understanding the four‐decade mastery of unconventional high‐temperature superconductivity. However, the synthesis of the infinite‐layer nickelate superconductors shows great challenges. Particularly, surface capping layers are usually unitized to facilitate the sample synthesis. This leads to an important question whether nickelate superconductors with d9 configuration and ultralow valence of Ni1+ are in metastable state and whether nickelate superconductivity can be robust? In this work, a series of redox cycling experiments are performed across the phase transition between perovskite Nd0.8Sr0.2NiO3 and infinite‐layer Nd0.8Sr0.2NiO2. The infinite‐layer Nd0.8Sr0.2NiO2 is quite robust in the redox environment and can survive the cycling experiments with unchanged crystallographic quality. However, as the cycling number goes on, the perovskite Nd0.8Sr0.2NiO3 shows structural degradation, suggesting stability of nickelate superconductivity is not restricted by the ultralow valence of Ni1+, but by the quality of its perovskite precursor. The observed robustness of infinite‐layer Nd0.8Sr0.2NiO2 up to ten redox cycles further indicates that if an ideal high‐quality perovskite precursor can be obtained, infinite‐layer nickelate superconductivity can be very stable and sustainable under environmental conditions. This work provides important implications for potential device applications for nickelate superconductors.

Abstract Metallosis with subsequent cardiac involvement is a possible long‐term complication of hip arthroplasty. We report the case of a young female referred to our centre for the suspicion of cardiac amyloidosis presenting with low electrocardiogram voltage, left ventricular hypertrophy, pericardial effusion, and global and longitudinal systolic impairment with apical sparing pattern. Her medical history was remarkable for arthroplasty in the context of congenital hip dysplasia. Two years prior to presentation, she underwent revision surgery for prosthesis malfunction, and tissue metallosis was initially documented. At the current presentation, cobalt metallosis was confirmed, as the circulating cobalt and chromium levels were severely elevated. The accurate diagnosis prompted the removal of the cobalt source with extensive tissue debridement and the use of chelating agents. Reversal of the cardiac abnormalities occurred as the circulating cobalt levels returned to normal.

This study focuses on understanding the kinetics and mechanism of a specific reaction between HCN and C2H5CHO. The existing literature presents conflicting interpretations of the reaction. According to traditional kinetics concepts, it is assumed that the reaction is a irreversible, first-order one with respect to both [HCN] and [C2H5CHO]. However, contradicting this assumption, organic chemistry principles suggest that the reaction is reversible. Additionally, the mechanisms proposed for both the forward and backward rate laws do not align with both kinetics and thermodynamics concepts. To address these discrepancies, this theoretical study aims to propose alternative interpretations and solutions to the data. Furthermore, based on a combination of kinetics concepts and organic chemistry principles, alternative mechanisms are presented. The results demonstrate that these alternative interpretations and mechanisms are more rational and consistent with the available data. [ABSTRACT FROM AUTHOR]

Light can be used to design stimuli–responsive systems. We induce transient changes in the assembly of a low molecular weight gelator solution using a merocyanine photoacid. Through our approach, reversible viscosity changes can be achieved via irradiation, delivering systems where flow can be controlled non‐invasively on demand. [ABSTRACT FROM AUTHOR]

In this paper, based on reversibility and approximation concepts, full adder (FA) circuits are designed for fault-tolerant applications. Area saving along with power reduction is the main objectives in the design and implementation of the proposed FAs. So, the basic reversible gates including Toffoli, Fredkin, Feynman, and Thapliyal Ranganathan (TR) are realized based on the gate diffusion input (GDI) technique. Subsequently, three approximate reversible FAs are designed with 3, 2, and 1 gates, respectively, which have special features such as 0 constant input (CI) and minimum garbage output and transistor counts. The circuitry performance and the quality of output images are extracted, when the FAs are placed in the approximate ripple carry adder (RCA) for image addition. The results show the superiority of the proposed FAs. Comprehensive results are extracted from the defined figure of merits (FoMs), which consists of area, power-delay product (PDP), peak signal-to-noise ratio (PSNR), and normalized mean error distance (NMED). The Pro-2 FA is selected as the best option due to its significant superiority compared to other circuits. The Pro-2 has 61.47% and 73.51% savings of PDP and PDP-area product (PDAP), respectively, compared to the exact circuit. [ABSTRACT FROM AUTHOR]

In ameaningful secret image-sharing scheme, the distribution of an image among participants occurs without arousing suspicion from potential adversaries. In this paper, we introduce two secret image-sharing schemes based on the learning-with-error (LWE) problem. Both schemes use the integer wavelet transform (IWT) domain of the cover image to embed the generated hidden values. The first scheme is reversible and allows accurate recovery of the cover image after extracting the secret image. In the second scheme, we use color overlay images in the frequency domain with meaningful representation. In this scheme, Joseph's problem is also used for embedding shadow images. Theoretical analysis and experimental results show that both schemes provide increased embedding capacity and produce superior steganographic overlay image quality compared to similar schemes. [ABSTRACT FROM AUTHOR]

Metallosis with subsequent cardiac involvement is a possible long‐term complication of hip arthroplasty. We report the case of a young female referred to our centre for the suspicion of cardiac amyloidosis presenting with low electrocardiogram voltage, left ventricular hypertrophy, pericardial effusion, and global and longitudinal systolic impairment with apical sparing pattern. Her medical history was remarkable for arthroplasty in the context of congenital hip dysplasia. Two years prior to presentation, she underwent revision surgery for prosthesis malfunction, and tissue metallosis was initially documented. At the current presentation, cobalt metallosis was confirmed, as the circulating cobalt and chromium levels were severely elevated. The accurate diagnosis prompted the removal of the cobalt source with extensive tissue debridement and the use of chelating agents. Reversal of the cardiac abnormalities occurred as the circulating cobalt levels returned to normal. [ABSTRACT FROM AUTHOR]

Focal imaging abnormalities in patients with parkinsonism suggest secondary etiology and require a distinctive clinical approach to diagnosis and treatment. We review different entities presenting as secondary parkinsonism associated with structural brain lesions, with emphasis on the clinical course and neuroimaging findings. Secondary parkinsonism may be due to vascular causes, hydrocephalus, space-occupying lesions, metabolic causes (including acquired hepatocerebral degeneration, diabetic uremic encephalopathy, basal ganglia calcifications, osmotic demyelination syndrome), hypoxic-ischaemic brain injury, intoxications (including methanol, carbon monoxide, cyanide, carbon disulfide, manganese poisoning and illicit drugs), infections and immune causes. The onset can vary from acute to chronic. Both uni-and bilateral presentations are possible. Rigidity, bradykinesia and gait abnormalities are more common than rest tremor. Coexisting other movement disorders and additional associated neurological signs may point to the underlying diagnosis. Neuroimaging studies are an essential part in the diagnostic work-up of secondary parkinsonism and may point directly to the underlying etiology. We focus primarily on magnetic resonance imaging to illustrate how structural imaging combined with neurological assessment can lead to diagnosis. It is crucial that typical imaging abnormalities are recognized within the relevant clinical context. Many forms of secondary parkinsonism are reversible with elimination of the specific cause, while some may benefit from symptomatic treatment. This heterogeneous group of acquired disorders has also helped shape our knowledge of Parkinson’s disease and basal ganglia pathophysiology, while more recent findings in the field garner support for the network perspective on brain function and neurological disorders.

Preserving the high pressure states and properties of large-sized materials under ambient conditions without external pressure loading devices is crucial for their practical applications. Here, we propose an approach to seal large-sized materials at high pressure within bulk diamond containers (BDCs) and preserve the high pressure states of the large-sized materials by recovering the BDC-sealed materials under ambient conditions. We have demonstrated that a reversible high-pressure BiIII phase with millimeter size could be preserved back to ambient conditions. This work opens a potential way to study the materials with relatively large structural feature sizes under the pressure of few GPa without external pressure loading devices.

Energy efficiency considerations in terms of reduced power dissipation are a significant issue in the design of digital circuits for very large-scale integration (VLSI) systems. Quantum-dot cellular automata (QCA) is an emerging ultralow power dissipation approach, distinct from traditional, complementary metal-oxide semiconductor (CMOS) technology, for building digital computing circuits. Developing fully reversible QCA circuits has the potential to significantly reduce energy dissipation. Multiplexers are fundamental elements in the construction of useful digital circuits. In this paper, a novel, multilayer, fully reversible QCA 8:1 multiplexer circuit with ultralow energy dissipation is introduced. The power dissipation of the proposed multiplexer is simulated using the QCADesigner-E version 2.2 tool, describing the microscopic physical mechanisms underlying the QCA operation. The results show that the proposed reversible QCA 8:1 multiplexer consumes 89% less energy than the most energy-efficient 8:1 multiplexer circuit previously presented in the literature.

Background/Objectives: Enfortumab vedotin (EV) is an antibody-drug conjugate (ADC) that combines monomethyl auristatin E (MMAE), a potent cytotoxic agent, with a monoclonal antibody targeting Nectin-4. It has emerged as a promising therapy for metastatic urothelial carcinoma (mUC), either as monotherapy or in combination with pembrolizumab, improving significantly the overall survival of these patients. EV is associated with common adverse events, including skin reactions, glucose imbalance, and peripheral neuropathy, which are usually mild in severity and easily manageable. Methods: Following an initial case of pleuro-pneumopathy occurring in a patient treated with EV, we conducted a retrospective analysis of EV effects on pulmonary imaging. Results: In a cohort of 20 all-comers mUC patients, we identified three cases of potentially EV-related lung toxicity, resulting in a pleuro-pneumopathy rate of 15%. Two of these cases appeared highly symptomatic and required high steroid doses, with a rapid resolution of symptoms and normalization of radiological findings. In one patient, rechallenge of EV was associated with reoccurrence of pneumopathy. We described the clinical and radiological features of these cases, as well as their evolution after EV discontinuation and rechallenge. Conclusions: This case series underscores the importance of close pulmonary monitoring during EV treatment.

Several breakthrough articles have recently confirmed the ability of tumor cells to escape the stable cell cycle arrest imposed by Therapy-Induced Senescence (TIS). Subsequently, accepting the hypothesis that TIS is escapable should encourage serious reassessments of the fundamental roles of senescence in cancer treatment. The potential for escape from TIS undermines the well-established tumor suppressor function of senescence, proposes it as a mechanism of tumor dormancy leading to disease recurrence and invites for further investigation of its unfavorable contribution to cancer therapy outcomes. Moreover, escaping TIS strongly indicates that the elimination of senescent tumor cells, primarily through pharmacological means, is a suitable approach for increasing the efficacy of cancer treatment, one that still requires further exploration. This commentary provides an overview of the recent evidence that unequivocally demonstrated the ability of therapy-induced senescent tumor cells in overcoming the terminal growth arrest fate and provides future perspectives on the roles of TIS in tumor biology. [ABSTRACT FROM AUTHOR]

Energy efficiency considerations in terms of reduced power dissipation are a significant issue in the design of digital circuits for very large-scale integration (VLSI) systems. Quantum-dot cellular automata (QCA) is an emerging ultralow power dissipation approach, distinct from traditional, complementary metal-oxide semiconductor (CMOS) technology, for building digital computing circuits. Developing fully reversible QCA circuits has the potential to significantly reduce energy dissipation. Multiplexers are fundamental elements in the construction of useful digital circuits. In this paper, a novel, multilayer, fully reversible QCA 8:1 multiplexer circuit with ultralow energy dissipation is introduced. The power dissipation of the proposed multiplexer is simulated using the QCADesigner-E version 2.2 tool, describing the microscopic physical mechanisms underlying the QCA operation. The results show that the proposed reversible QCA 8:1 multiplexer consumes 89% less energy than the most energy-efficient 8:1 multiplexer circuit previously presented in the literature. [ABSTRACT FROM AUTHOR]

Consumer product manufacturers utilise a spectrum of alternative ocular irritation assays, as these tests do not require the use of live animals. Despite their usefulness, no regulatory-accepted assay assesses the reversibility of ocular damage, a key criterion of GHS ocular classification, like the rabbit eye test (i.e., Draize Rabbit Eye Test [DRET]). The Porcine Corneal Opacity Reversibility Assay (PorCORA), an ex vivo intact corneal tissue culture model, predicts the reversibility of damage by ocular irritants. Inclusion of the damage reversibility endpoint in the PorCORA supplements other alternative test methods for ocular irritation, by assessing induced eye damage and the ability of this damage to reverse (heal) without the use of live animals to distinguish between Globally Harmonised System of Classification and Labelling of Chemicals (GHS) ocular classifications. In this focused study, results of a Bovine Corneal Opacity and Permeability (BCOP) test of a laundry detergent, neat and 10% dilution, (product mixture from S.C. Johnson & Son, Inc. [SCJ]) classified the product into GHS Category 1; however, the BCOP test cannot assess the reversibility of ocular damage. The laundry detergent was evaluated using the PorCORA, where ocular damage induced by the detergent was fully reversed within seven days. Evaluation of the reversibility of ocular damage using the PorCORA in this focused study can add strength to the weight-of-evidence (WoE) analysis approach in ocular hazard assessment. This WoE approach strengthens the argument that the PorCORA can be used to supplement BCOP data, and that this laundry detergent is not an irreversible eye irritant. [ABSTRACT FROM AUTHOR]

The development of adhesives with excellent reversibility is necessary for the removal, recycling and reusing of precision components under specific conditions in electronics manufacturing. The integration of photosensitive cycloaddition reactions into common adhesive systems is a viable alternative for reversible modification. In this contribution, a novel reversible acrylate adhesive was successfully prepared by doping thiol-functionalized anthracene derivatives in situ, and its characteristic structure, photophysical properties and mechanical performance were systematically evaluated. As expected, the reversible dimers structure of anthracene provides remarkable bonding and debonding properties for adhesives. Sample #3 achieved an excellent shear strength of 1.67 ± 0.07 MPa and 91% debonding rate, with 283.03% and 89.58% improvement over the control sample #0 without anthracene modification, respectively. Furthermore, the shear strength and debonding rate for secondary bonding were up to 2.37 ± 0.07 MPa and 82%. We believe that our paradigm can provide a feasible approach for reversible adhesive design. [ABSTRACT FROM AUTHOR]

Preserving the high pressure states and properties of large-sized materials under ambient conditions without external pressure loading devices is crucial for their practical applications. Here, we propose an approach to seal large-sized materials at high pressure within bulk diamond containers (BDCs) and preserve the high pressure states of the large-sized materials by recovering the BDC-sealed materials under ambient conditions. We have demonstrated that a reversible high-pressure BiIII phase with millimeter size could be preserved back to ambient conditions. This work opens a potential way to study the materials with relatively large structural feature sizes under the pressure of few GPa without external pressure loading devices. The high pressure states of millimeter-sized materials and the reversible high-pessure phase have been preserved within bulk diamond containers under ambient conditions. [ABSTRACT FROM AUTHOR]

In this study, encrypted image transmission was carried out with a secure communication application using reversible chaotic image encryption with the synchronization of two identical chaotic systems. Encryption and decryption of the image can be done with the same algorithm using the same chaotic signal. The image can be encrypted using the same chaotic signal on the sending side and decoded with the encryption algorithm and chaotic signal on the receiving side. Experimental results show that the proposed encryption algorithm can securely encrypt and transfer images in 24-bit RGB and 8-bit grayscale images. In the study, histogram, histogram variance, salt & pepper, speckle, NPCR and UACI, four classical types of attacks, NIST, key sensitive and crop visual and statistical attacks were made on encrypted images and the robustness of the encryption method was tested. In addition, PSNR, SSIM, UIQ, BER and NCC image quality criteria were used and the results of attacks on chaotic encrypted images were measured. As a result of visual and statistical attacks, it has been seen that the proposed chaotic encryption algorithm is resistant to attacks. The NPCR and UACI analysis results of the proposed method were compared with the results of similar studies in the literature. According to similar chaotic image coding studies in the literature, the NPCR and UACI values of the proposed method gave better results than most. As a result of the tests, with the secure communication application of the proposed method, image encryption and decryption can be performed by using a common chaotic signal on the sender and receiver sides. [ABSTRACT FROM AUTHOR]

We examine smooth four-dimensional vector fields reversible under some smooth involution that has a smooth two-dimensional submanifold of fixed points. Our main interest here is in the orbit structure of such a system near two types of heteroclinic connections involving saddle-foci and heteroclinic orbits connecting them. In both cases we found families of symmetric periodic orbits, multi-round heteroclinic connections and countable families of homoclinic orbits of saddle-foci. All this suggests that the orbit structure near such connections is very complicated. A non-variational version of the stationary Swift – Hohenberg equation is considered, as an example, where such structure has been found numerically. [ABSTRACT FROM AUTHOR]

To improve the security, robustness and embedding rate of reversible hiding in encrypted domain in the distributed environment, a multiple embedding algorithm based on cipher-feedback secret sharing was proposed.Firstly, the additional data were embedded into the polynomial coefficients redundancy generated in the process of secret image sharing.Secondly, the extra secrets were embedded by using the additive homomorphism of secret sharing.Experimental results demonstrate that a better security and robustness has been obtained by improving the diffusion characteristic of secret sharing using the feedback mechanism.In the (3,4) and (3,5) threshold, the embedding rates can reach 6.00 bit per pixel and 4.80 bit per pixel respectively.The proposed algorithm can not only maintain the strong security and separability, but also obtain a better embedding capacity.Meanwhile, the embedding rate of the scheme is not affected by the carrier image and is only related to the selection of algorithm parameters.

Quantum-dot cellular automata (QCA) nanotechnology is the best suited technology for the nanocomputing applications. The limitations of the conventional transistors in nanoscale region can be removed by QCA nanotechnology. Hence, this paper proposes a novel design and implementation of a 3 × 3 universal and reversible gate in QCA nanotechnology. The proposed gate requires only 39 cells and has a total area of 0.029 µm2 with a latency of 0.25. The proposed gate is evaluated for the various possible defects and the performance parameters. The proposed gate is also compared with the existing gates and the proposed gate is established as the most efficient and productive.

Perylene diimide radical anions (PDI–•) prepared by through photoelectric doping are capable of reducing aromatic halides and achieving aromatic hydrocarbon coupling. The active of electrically doped PDI–• is dependent on the conditions of electroreduction (e.g. electrode material), but little attention has been paid to the influence of electrode material, voltage, and electroreduction time on the activity of PDI–•. In this paper, we compared the active of PDI–• produced by different electrode materials, different reduction voltages and different reduction times based on the difference in UV-vis absorption spectra. In contrast to the characteristic absorption spectra of the anion of the PDI–•, the metal electrodes with certain reducing properties, such as zinc and magnesium, stabilize the radical anion and reduce the PDI–• activity due to the generation of positive zinc and magnesium ions during the electroreduction process. [ABSTRACT FROM AUTHOR]

The phototoxicity of photosensitizers (PSs) pre and post photodynamic therapy (PDT), and the hypoxic tumor microenvironment are two major problems limiting the application of PDT. While activatable PSs can successfully address the PS phototoxicity pre PDT, and type I PS can generate reactive oxygen species (ROS) effectively in hypoxic environment, very limited approaches are available for addressing the phototoxicity post PDT. There is virtually no solution available to address all these issues using a single design. Herein, we propose a proof‐of‐concept on‐demand switchable photosensitizer with quenched photosensitization pre and post PDT, which could be activated only in tumor hypoxic environment. Particularly, a hypoxia‐normoxia cycling responsive type I PS TPFN‐AzoCF3 was designed to demonstrate the concept, which was further formulated into TPFN‐AzoCF3 nanoparticles (NPs) using DSPE‐PEG‐2000 as the encapsulation matrix. The NPs could be activated only in hypoxic tumors to generate type I ROS during PDT treatment, but remain non‐toxic in normal tissues, pre or after PDT, thus minimizing side effects and improving the therapeutic effect. With promising results in in vitro and in vivo tumor treatment, this presented strategy will pave the way for the design of more on‐demand switchable photosensitizers with minimized side effects in the future. [ABSTRACT FROM AUTHOR]

The fabricated VS 4 /Ni 3 S 2 /NF NBs was prepared by self-templated strategy, with exposed abundant hetero-interfaces and high active disulfide (S 2 2-) sites. The density functional theory revealed the reversible conversion catalysis mechanism of bridge S 2 2- during HER process, jointly promoting the HER performance. [Display omitted] • A novel VS 4 nanoparticle decorated Ni 3 S 2 nanobelt array was synthesized via one-step organic ligand-assisted solvothermal method. • The abundant disulfide (S 2 2-) moieties grafted on the hetero-interfaces of VS 4 /Ni 3 S 2 led to strong electronic interaction and promote the chemisorption of H-containing intermediates. • The density functional theory reveals the reversible conversion catalysis mechanism about disulfide (S 2 2-) sites during HER process. • The findings provide fresh insights for developing potential polysulfides as high-performance hydrogen-evolving electrocatalysts from water splitting. Elaborate and rational design of cost-effective and high-efficiency non-noble metal electrocatalysts for pushing forward the sustainable hydrogen fuel production is of great significance. Herein, a novel VS 4 nanoparticle decorated Ni 3 S 2 nanobelt array in-situ grown on nickel foam (VS 4 /Ni 3 S 2 /NF NBs) was prepared by a self-templated synthesis strategy. Benefitting from the unique nanobelt array structure, abundant highly active bridge S 2 2- sites and strong electronic interaction between VS 4 and Ni 3 S 2 on the heterointerface, the integrated VS 4 /Ni 3 S 2 /NF NBs exhibited excellent electrocatalytic hydrogen evolution activity and robust stability. The density functional theory (DFT) further revealed the reversible conversion catalysis mechanism of bridging S 2 2- sites in VS 4 /Ni 3 S 2 /NF NBs during HER process. Notably, bidentate bridging S S bonds as the predominant catalytically active centers can spontaneously open once H adsorbed its surface, leading to the aggregation of negative charges on S atoms and thus facilitating the generation of H* intermediates, and spontaneously close when H* desorption is going to form H 2. Our work provides fresh insights for developing potential polysulfides as high-performance hydrogen-evolving electrocatalysts for prospective clean energy production from water splitting. [ABSTRACT FROM AUTHOR]

In the biomedical field, there is a demand for the development of novel approaches for the investigation of optical epithelial anatomical features with biomimetic materials. These materials are not only required to replicate structures but also enable dynamic modelling for disease states such as limbal stem cell deficiency and ageing. In the present study, the effective generation of reversible wrinkled polydimethylsiloxane (PDMS) substrates was undertaken to mimic the undulating anatomy of the limbal epithelial stem cell niche. This undulating surface pattern was formed through a dual treatment with acid oxidation and plasma using an innovatively designed stretching frame. This system enabled the PDMS substrate to undergo deformation and relaxation, creating a reversible and tuneable wrinkle pattern with cell culture applications. The crypt-like pattern exhibited a width of 70–130 µm and a depth of 17–40 µm, resembling the topography of a limbal epithelial stem cell niche, which is characterised by an undulating anatomy. The cytocompatibility of the patterned substrate was markedly improved using a gelatin methacrylate polymer (GelMa) coating. It was also observed that these wrinkled PDMS surfaces were able to dictate cell growth patterns, showing alignment in motile cells and colony segregation in colony-forming cells when using human and porcine limbal cells, respectively. [ABSTRACT FROM AUTHOR]

Seasonal deformation of mountain rock slopes can be driven by groundwater infiltration and depletion. Such processes could explain our field observation in the Aletsch Valley, Switzerland, where GNSS‐derived 3D annual displacement amplitudes reach 3.4 cm. However, the physical mechanisms behind such groundwater‐driven surface displacements are not well understood. Here, we develop a fully coupled hydromechanical model to simulate the relevant processes in a valley slope embedded with numerous fractures of variable sizes. The magnitude and orientation of transient annual slope surface displacement obtained from our model are in overall agreement with the field observations. The key geological factors controlling the type and magnitude of reversible mountain slope deformations are fracture network geometry, fracture aperture, and regional stress field. We show that the heterogeneity and anisotropy of bedrock hydromechanical responses, originating from depth‐dependent variations of fracture properties, play a critical role in groundwater recharge and valley slope deformation. During recharge events, pore pressure perturbations migrate downward from the groundwater table and toward the receiving stream and the deep subsurface. This process driven by pressure diffusion and poroelastic stressing develops in the subsurface with a great reach of up to a few kilometers, called critical hydromechanical response zone, and controls surface deformation patterns. During groundwater recession, this hydromechanical response zone expands downward and ground surface displacement vectors rotate upwards. Our results suggest that slope surface deformation can inform about subsurface permeability structures and pore pressure fluctuations, which have important implications for understanding groundwater flow in fractured bedrock slopes. Plain Language Summary: Groundwater recharge in alpine valleys mainly occurs during snowmelt and/or rainstorm events. When recharge raises groundwater table in the slope, the bedrock can deform, and centimeter‐scale surface displacements can be observed. Here, we model this process in an alpine valley and investigate how bedrock fractures and regional stresses affect the surface displacement pattern. We show that slope surface deformation is controlled by a so‐called hydromechanical response zone reaching up to a few kilometers below the valley ridges. The shape and location of this zone change throughout the year. We compare our modeling results with long‐term deformation records from the lower Aletsch Valley, Switzerland, and show that they are in general agreement. The results of this work and insights obtained advance our fundamental understanding of the mechanisms of groundwater‐driven deformations in fractured rock slopes. Our research opens an avenue to use the information of surface deformation patterns to infer subsurface hydrogeological processes. Key Points: Coupled hydromechanical simulations are compared to surface displacement magnitude, orientation and hysteresis observed at Aletsch, SwitzerlandGroundwater recharge‐related pressure diffusion and poroelastic stressing in subsurface rock drive slope surface displacementCentimeter‐scale slope surface displacements occur in fractured crystalline rock with permeability in the narrow range of 10−16–10−14 m2 [ABSTRACT FROM AUTHOR]

Quantum-Dot-Cellular-Automata (QCA) using Spintronic electrons is a promising alternative to the traditional CMOS technology in this modern era to design any nano-sized electronic structure. The majority of the current digital components are being designed using QCA-cell-interaction. In some cases, reversible logic with the Spintronic-QCA-technique is also being explored to design various digital components. Because of this, the various aspects for the design of a novel hybrid QCA-based Spintronic advance reversible adder and its efficiency measures are presented in this research work by investigating area-occupation, temperature-tolerance, delay, power dissipation, and output strength. The results obtained in this work establish that the proposed design is more efficient in all respect compared to existing designs reported in recent literature. In this paper, 18nm quantum cells are used to design the proposed structure and when the power dissipation based on the total occupied cell area is calculated (100W/cm2), it is found that there is an assurance to get an adder structure with the less occupied area, less power dissipation and higher speed compared to previously published referred design. The temperature-tolerance and output-strength increment with layer separation gap reduction in multilayer platforms are also some additional advancements of the proposed structure, which are also clearly reflected. In this paper, QCA-based "Ripple-Carry-Adder (RCA)" is designed using Spintronic reversible logic in multilayer mode with different composite elements along with a "3-input-majority-voter-gate (MG)" to make the design more compact. QCADesigner 4.0 tool is used as widespread simulation trains to validate the design outcomes and measure different parameters individually. [ABSTRACT FROM AUTHOR]

Under the background of energy crisis, hydrogen owns the advantage of high combustion and shows considerable environment friendliness; however, to fully utilize this novel resource, the major hurdle lies in its delivery and storage. The development of the in-depth yet systematical methodology for two-dimensional (2D) storage media evaluation still remains to be challenging for computational scientists. In this study, we tried our proposed evaluation protocol on a 2D material, g-C3N5, and its hydrogen storage performance was characterized; and with addition of Li atoms, the changes of its electronical and structural properties were detected. First-principles simulations were conducted to verify its thermodynamics stability; and, its hydrogen adsorption capacity was investigated qualitatively. We found that the charges of the added Li atoms were transferred to the adjacent nitrogen atoms from g-C3N5, with the formation of chemical interactions. Thus, the isolated metallic sites tend to show considerable electropositivity, and can easily polarize the adsorbed hydrogen molecules, and the electrostatic interactions can be enhanced correspondingly. The maximum storage capacity of each primitive cell can be as high as 20 hydrogen molecules with a gravimetric capacity of 8.65 wt%, which surpasses the 5.5 wt% target set by the U.S. Department of Energy. The average adsorption energy is ranged from −0.22 to −0.13 eV. We conclude that the complex 2D material, Li-decorated g-C3N5 (Li@C3N5), can serve as a promising media for hydrogen storage. This methodology provided in this study is fundamental yet instructive for future 2D hydrogen storage materials development.

Quantum-dot cellular automata (QCA) are a promising nanoscale computing technology that exploits the quantum mechanical tunneling of electrons between quantum dots in a cell and electrostatic interaction between dots in neighboring cells. QCA can achieve higher speed, lower power, and smaller areas than conventional, complementary metal-oxide semiconductor (CMOS) technology. Developing QCA circuits in a logically and physically reversible manner can provide exceptional reductions in energy dissipation. The main challenge is to maintain reversibility down to the physical level. A crucial component of a computer's central processing unit (CPU) is the arithmetic logic unit (ALU), which executes multiple logical and arithmetic functions on the data processed by the CPU. Current QCA ALU designs are either irreversible or logically reversible; however, they lack physical reversibility, a crucial requirement to increase energy efficiency. This paper shows a new multilayer design for a QCA ALU that can carry out 16 different operations and is both logically and physically reversible. The design is based on reversible majority gates, which are the key building blocks. We use QCADesigner-E software to simulate and evaluate energy dissipation. The proposed logically and physically reversible QCA ALU offers an improvement of 88.8% in energy efficiency. Compared to the next most efficient 16-operation QCA ALU, this ALU uses 51% fewer QCA cells and 47% less area. [ABSTRACT FROM AUTHOR]

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Mechanically driven polarization switching via scanning probe microscopy provides a valuable voltage‐free strategy for designing ferroelectric nanodomain structures. However, it is still challenging to realize reversible polarization switching with mechanical forces. Here, the mechanically driven reversible polarization switching observed in imprinted ferroelectric BiFeO3 thin films is reported, i.e., up‐to‐down switching by a sharp scanning tip and down‐to‐up switching by a blunt tip. Free energy calculations, phase‐field simulations, and piezoresponse force microscopy reveal that reversible mechanical switching arises from the interplay among the flexoelectric effect, the piezoelectric effect, and the internal upward built‐in field in BiFeO3 films. This study gains a deeper insight into the mechanism and control of mechanically driven polarization switching, and provides guidance for exploring potential ferroelectric‐based electro‐mechanical microelectronics. [ABSTRACT FROM AUTHOR]

[1] Our focus will be recent reports of -carbon elimination reactions of cyclopropylcarbinyl intermediates from VCP or ACP starting materials using palladium and rhodium catalysis 5.1 Palladium-Catalyzed -Carbon Eliminations Driven by Release of Ring Strain A commonly used strategy to access cyclopropylcarbinyl palladium species involves the addition of an Ar-Pd(II)-X species to a VCP. [17] Larock [17] and Zhu [17][17] had reported that neopentyl-Pd(II) species can undergo 1,4-palladium migration reactions, which can generate polycyclic scaffolds similar to B int-A b (Scheme 9). The palladium catalyst reacts with the cyclobutanol to effect a C-C bond cleavage that is driven by the release of ring strain to afford an alkyl-Pd(II) species that undergoes reductive elimination to afford the I ipso i -alkylated products. Keywords: catalysis; -carbon elimination; palladium; rhodium; reversible EN catalysis -carbon elimination palladium rhodium reversible 2285 2303 19 07/14/23 20230801 NES 230801 Graph 1 Introduction Transition-metal-catalyzed methodologies have typically sought to forge C-C bonds in order to build molecular complexity. [Extracted from the article]

While hormonal contraceptives are efficacious and available in several forms for women, perception of safety and concern over side effects are a deterrent for many. Existing non-hormonal contraceptives include permanent sterilization, copper intrauterine devices (IUDs), chemical/physical barriers such as spermicides and condoms, as well as traditional family planning methods including withdrawal and the rhythm method. Individuals who wish to retain their fertility in the future can achieve highest adherence and efficacy with long-acting, reversible contraceptives (LARCs), though there is only one, the copper IUD, that is non-hormonal. As rates of unintended pregnancies remain high with existing contraceptive options, it is becoming increasingly attractive to develop novel pregnancy prevention methods for both women and men. Non-hormonal contraceptives can target a variety of critical reproductive processes discussed here. This review focuses on identified non-hormonal contraceptive targets and subsequent drug candidates in development. [ABSTRACT FROM AUTHOR]

Quantum-dot cellular automata (QCA) is a technological approach to implement digital circuits with exceptionally high integration density, high switching frequency, and low energy dissipation. QCA circuits are a potential solution to the energy dissipation issues created by shrinking microprocessors with ultra-high integration densities. Current QCA circuit designs are irreversible, yet reversible circuits are known to increase energy efficiency. Thus, the development of reversible QCA circuits will further reduce energy dissipation. This paper presents novel reversible and irreversible sequential QCA set/reset (SR), data (D), Jack Kilby (JK), and toggle (T) flip-flop designs based on the majority gate that utilizes the universal, standard, and efficient (USE) clocking scheme, which allows the implementation of feedback paths and easy routing for sequential QCA-based circuits. The simulation results confirm that the proposed reversible QCA USE sequential flip-flop circuits exhibit energy dissipation less than the Landauer energy limit. Irreversible QCA USE flip-flop designs, although having higher energy dissipation, sometimes have floorplan areas and delay times less than those of reversible designs; therefore, they are also explored. The trade-offs between the energy dissipation versus the area cost and delay time for the reversible and irreversible QCA circuits are examined comprehensively. [ABSTRACT FROM AUTHOR]

The Venezuelan equine encephalitis virus (VEEV) nonstructural protein 2 (nsP2) cysteine protease (EC 3.4.22.B79) is essential for viral replication. High throughput in silico/in vitro screening using a focused set of known cysteine protease inhibitors identified two epoxysuccinyl prodrugs, E64d and CA074 methyl ester (CA074me) and a reversible oxindole inhibitor. Here, we determined the X-ray crystal structure of the CA074-inhibited nsP2 protease and compared it with our E64d-inhibited structure. We found that the two inhibitors occupy different locations in the protease. We designed hybrid inhibitors with improved potency. Virus yield reduction assays confirmed that the viral titer was reduced by >5 logs with CA074me. Cell-based assays showed reductions in viral replication for CHIKV, VEEV, and WEEV, and weaker inhibition of EEEV by the hybrid inhibitors. The most potent was NCGC00488909-01 which had an EC50 of 1.76 µM in VEEV-Trd-infected cells; the second most potent was NCGC00484087 with an EC50 = 7.90 µM. Other compounds from the NCATS libraries such as the H1 antihistamine oxatomide (>5-log reduction), emetine, amsacrine an intercalator (NCGC0015113), MLS003116111-01, NCGC00247785-13, and MLS00699295-01 were found to effectively reduce VEEV viral replication in plaque assays. Kinetic methods demonstrated time-dependent inhibition by the hybrid inhibitors of the protease with NCGC00488909-01 (Ki = 3 µM) and NCGC00484087 (Ki = 5 µM). Rates of inactivation by CA074 in the presence of 6 mM CaCl2, MnCl2, or MgCl2 were measured with varying concentrations of inhibitor, Mg2+ and Mn2+ slightly enhanced inhibitor binding (3 to 6-fold). CA074 inhibited not only the VEEV nsP2 protease but also that of CHIKV and WEEV. [ABSTRACT FROM AUTHOR]

Thermochromic cellulose membrane materials were prepared by vacuum assisted impregnation, and the properties of thermochromic cellulose membrane were characterized. These results showed that the reversible thermotropic cellulose film had appropriate phase transition temperature, large latent heat and goodthermal stability. More importantly, the thermochromic cellulose film had excellent reversible thermochromic ability. Through the change of color from dark blue to gray white, the phase transition process and temperature can be obviously observed. Because of the excellent reversible thermochromism ability and thermal stability,thermochromic cellulose films will have great application potential in thermal insulation, decoration, furniture and storage. [ABSTRACT FROM AUTHOR]

Calculation of square root will be an essential mathematical operation that will have broad applications. In Hardware, the square root will be designed in order to gain power which will be quite low. Similarly, there are also other advantages that comes with gaining of low power that is high speed and also low area. A trade-off will also occur with the three metrics which is quite natural. As we know that the present technology is very advanced so it will aim for low power and architectural modification will be required by the relative designs. This sheet represents an energy efficient square rooter by using reversible logic. (RCSM) Reversible Controlled Subtract Multiplexer will be designing and it also plays an important part in implementing the binary square rooter. Saimur Rahman Gate will also be implementing the binary square rooter in order to improve and develop it. The Improvements such as cost of the quanta, inputs given by constants and also garbage outputs. The approaches such as conventional approach and SRG are used for designing the binary square rooter and it will be completed using non-restoring algorithm. Xilinx Software will be responsible for carrying out simulations and Synopsys Design Compiler will be the factor for obtaining power. The gate count which has been 75 will be decreased to 35. There will be an improvement of 20% in terms of power which will be obtained in this paper. [ABSTRACT FROM AUTHOR]