1. 'Histological evaluation of the ovary and some vital variables in women with polycystic ovary syndrome'.
- Author
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Al-Badri, Ibrahim Samer, Alabbasy, Raghad Hazem, and Muhamed ALSAMMARRAIE, Hanan Waleed
- Subjects
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POLYCYSTIC ovary syndrome , *LEUKOCYTE count , *LEUCOCYTES , *SEXUAL cycle , *FOLLICLE-stimulating hormone - Abstract
Polycystic ovary syndrome (PCOS) is a medical condition that affects the function of the ovaries and hormone production in women. It causes symptoms such as irregular menstruation, increased testosterone secretion, weight gain, excessive hair growth and insulin resistance. The causes are not completely known, but genetic, environmental and lifestyle factors play a role. Possible complications include increased risk of heart disease, diabetes, and high blood pressure. It is diagnosed through laboratory tests, such as examining hormones and white blood cells. Recently, studies are focusing on the level of nesfatin-1 protein in PCOS patients, and the results indicate that its levels differ between patients and healthy people, and it is considered a diagnostic tool that needs extensive study. This study aims: Evaluating the histological changes in the ovaries of women with polycystic ovary syndrome and some vital variables. Materials and working methods: 270 blood samples were collected, divided into two groups. The first group included 180 blood samples from women with polycystic ovary syndrome, and the second group included 90 blood samples from healthy women (control samples). The results between the two groups were carefully evaluated, including evaluating the levels of testosterone and follicle-stimulating hormone. As well as evaluating the level of nesfatin-1 and white blood cells between women with polycystic ovary syndrome and healthy women. Results: Our results showed a relatively high level of nesfatin-1 in polycystic ovary syndrome patients compared to healthy controls. The results showed statistically significant differences at the P≤0.05 level The levels of testosterone, follicle-stimulating hormone, luteinizing hormone, and progesterone also showed an increase in affected patients, and it also showed that there was a significant difference at the p level ≥0.05. While the levels of estrogen (E2) and prolactin showed no significant differences at the level of P>0.05. Women with this syndrome had relatively high white blood cell counts compared to unaffected women. Conclusions: Our results indicate a decreased level of nesfatin-1, as nesfatin-1 is a metabolic regulatory protein. The results also showed an increase in both follicle-stimulating hormone and testosterone and a slight increase in white blood cells, which leads to an imbalance in the regulation of hormones and the menstrual cycle and a threat to the reproductive process. [ABSTRACT FROM AUTHOR]
- Published
- 2024