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Nesfatin-1: A Biomarker and Potential Therapeutic Target in Neurological Disorders.

Authors :
Zhou, Siyu
Nao, Jianfei
Source :
Neurochemical Research. Jan2024, Vol. 49 Issue 1, p38-51. 14p.
Publication Year :
2024

Abstract

Nesfatin-1 is a novel adipocytokine consisting of 82 amino acids with anorexic and anti-hyperglycemic properties. Further studies of nesfatin-1 have shown it to be closely associated with neurological disorders. Changes in nesfatin-1 levels are closely linked to the onset, progression and severity of neurological disorders. Nesfatin-1 may affect the development of neurological disorders and can indicate disease evolution and prognosis, thus informing the choice of treatment options. In addition, regulation of the expression or level of nesfatin-1 can improve the level of neuroinflammation, apoptosis, oxidative damage and other indicators. It is demonstrated that nesfatin-1 is involved in neuroprotection and may be a therapeutic target for neurological disorders. In this paper, we will also discuss the role of nesfatin-1 as a biomarker in neurological diseases and its potential mechanism of action in neurological diseases, providing new ideas for the diagnosis and treatment of neurological diseases. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03643190
Volume :
49
Issue :
1
Database :
Academic Search Index
Journal :
Neurochemical Research
Publication Type :
Academic Journal
Accession number :
174685159
Full Text :
https://doi.org/10.1007/s11064-023-04037-0