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Controlling the perovskite morphology and defects at the buried perovskite-substrate interface is challenging for inverted perovskite solar cells. In this work, we report an amphiphilic molecular hole transporter, (2-(4-(bis(4-methoxyphenyl)amino)phenyl)-1-cyanovinyl)phosphonic acid, that features a multifunctional cyanovinyl phosphonic acid group and forms a superwetting underlayer for perovskite deposition, which enables high-quality perovskite films with minimized defects at the buried interface. The resulting perovskite film has a photoluminescence quantum yield of 17% and a Shockley-Read-Hall lifetime of nearly 7 microseconds and achieved a certified power conversion efficiency (PCE) of 25.4% with an open-circuit voltage of 1.21 volts and a fill factor of 84.7%. In addition, 1–square centimeter cells and 10–square centimeter minimodules show PCEs of 23.4 and 22.0%, respectively. Encapsulated modules exhibited high stability under both operational and damp heat test conditions.

A pre-embedding mixed A-cation halide strategy is developed to eliminate the residual unstable PbI2 and lattice strain near the buried interface of the perovskite layer for the stability improvement of formamidinium-based perovskite solar cells.

Herein, we report the use of pyridine anchoring group functionalized poly(triarylamine) (p-PY) as a hole transport layer at buried interfaces between the ITO and formamidinium–cesium perovskite layer to enhance the efficiency and stability of inverted PSCs.

Additive engineering, dimensionality engineering, doping engineering and quantum dot technology can effectively improve the efficiency and stability of the most eye-catching all-inorganic CsPbI3 based PSCs.

Transcatheter arterial chemoembolization (TACE) has been widely used in clinical practice as a first-line treatment for unresectable hepatocellular carcinoma (HCC). However, the current therapeutic effect of TACE is far from satisfactory and thus requires further improvement. TACE combined with multifunctional magnetic particles may be a promising approach for the treatment of HCC. In this study, we designed a new magnetic drug carrier system consisting of micron-sized iron powder, barium ferrite (BaFe12O19), and carbon-coated iron nanocrystals (CCINs). CCINs possess properties, such as high drug loading and sustained release. BaFe12O19 could attract both CCINs and iron powder to form larger clusters after magnetization. Altogether, the triple therapeutic effects of chemotherapeutic enhancement, embolization, and thermal ablation could be realized herein. Further experiments indicate that the system has a high drug-loading capacity, good controlled-release effect, and no significant cytotoxicity. Under the action of a medium-frequency magnetic induction device, the magnetic induction temperature could reach 43 °C in one min while the maximum temperature of 70.8 °C could be reached in 2.5 hours. Overall, this new carrier system displayed excellent antitumor effects in a mouse model. Our findings demonstrate the great application prospects of this system in TACE for HCC.

Besides barrier functions, skin possesses multiple sentiences to external stimuli (e.g., temperature, force, and humidity) for human-outside interaction. Thus, skincare should be taken very seriously, especially by patients with sensory disorders. However, currently available skin-mimicking devices are always limited by so much insufficient response functions and nontunable interface behaviors so as not to realize precise health monitoring and self-defense against injury. Herein, a bioinspired cutaneous receptor-perceptual system (CRPS) patch is presented, integrating hybrid pH indicators and triboelectric nanogenerators into biointerface film-adhesives that are fabricated through facile layer-by-layer (LBL) self-assembly of amide and Schiff-base linkages between alginate grafted with N-hydroxysuccinimide ester (AN), tannic acid (TA), and polyethylenimine (PEI). This CRPS patch is adhered robustly to the soft-curved skin surface without failure via "molecular suturing," and amino acid enables its benign peel-on-demand from tissue interfaces. Postdamage self-healing brings it without surgical reoperation, avoiding extra cost, pain, as well as infection risks. Significantly, CRPS patches as artificial chemo/mechanoreceptors can remotely visualize skin physiological status by pH-induced chromism using smartphones and prevent skin contact injury by tactility-driven self-powered electrical signals. Overall, the LBL-based strategy to create controllably biointerface-adhesive CRPS patches will usher in a new era of the mobihealth care platform supporting smart diagnosis and self-protection.

Background The members of the cell division cycle-associated (CDCA) gene family are significant regulators of cell proliferation known to play key roles in various cancers. However, the function of CDCA genes in hepatocellular carcinoma (HCC) is unclear. The aim of this research was to clarify the roles of CDCA family members in HCC using bioinformatics analysis tools. Methods We studied data on the mRNA and protein expression of CDCA genes and survival in patients with HCC using the Oncomine, UALCAN, HPA, CCLE, LinkedOmics, cBioPortal, and Metascape databases. Results Significant overexpression of all CDCA members was found in HCC tissues. The expression levels of CDCAs were related to the tumor stage, and high expression levels were correlated with a low survival rate in patients with HCC. Also, we observed a high mutation rate (45%) of CDCAs in the HCC samples, which manifested as deep deletion, amplification, or increased mRNA expression. In the correlation analysis, we found that any 2 CDCA members were significantly positively correlated with each other. Cycle-related genes including AHCTF1, AKT1, BIRC5, CENPF, CENPL, and CENPQ were closely associated with CDCA gene alterations. Conclusions The findings of this study indicate that CDCAs may be potential therapeutic targets and prognostic indicators for patients with HCC.

Defect-induced charge carrier recombination at the interfaces between perovskite and adjacent charge transport layers restricts further improvements in the device performance of perovskite solar cells (PSCs). Defect passivation at these interfaces can reduce trap states and inhibit the induced nonradiative recombination. Herein, we report a double-sided interfacial passivation via simply evaporating potassium chloride (DIP-KCl) at both the hole transport layer (HTL)/perovskite and perovskite/electron transport layer (ETL) interfaces in inverted planar PSCs. We demonstrate that the bottom KCl layer at the HTL/perovskite interface not only reduces the interfacial defects and improves the interfacial contact, but also leads to increased perovskite crystallinity, while the top KCl layer at the perovskite/ETL interface efficiently passivates the perovskite top surface defects and facilitates electron extraction at this interface. Thus, suppressed nonradiative recombination and faster charge extraction at both interfaces close to the perovskite layer can be achieved by using our DIP-KCl strategy. As a result, inverted PSCs based on DIP-KCl present an increased efficiency from 17.1% to 19.2% and enhanced stability, retaining over 90% of their initial efficiency after aging at maximum power point tracking for 1000 h. This work provides a simple and efficient way for defect passivation to further increase the efficiency and stability of PSCs.

The electron transport layer (ETL) plays a critical role in charge extraction and perovskite thin film growth in planar n–i–p heterojunction perovskite solar cells. Herein, we modulated the nucleation and growth rate of CsPbI3 crystals by using a Mo doping strategy to synthesize high-quality SnO2 crystals as an ETL nano-film in n–i–p heterojunction perovskite solar cells. We revealed that such a nano-film with low surface energy and high roughness induced by Mo doping provides seed-like nucleation sites for CsPbI3 inorganic perovskite growth, leading to improved perovskite film morphology. The charge extraction at the ETL/perovskite interface is also enhanced due to the improved energy level alignment. As a result, a high power conversion efficiency of 17.41% can be achieved under one sun irradiation for a planar n–i–p heterojunction structured CsPbI3 solar cell by using this novel Mo–SnO2 ETL. This work provides a simple pathway to simultaneously modulate CsPbI3 inorganic perovskite crystallization and interfacial charge extraction in planar heterojunction perovskite devices.

Peptides found in marine life have various specific activities due to their special growth environment, and there is increasing interest in the isolation and concentration of these biofunctional compounds. In this study, the protein hydrolysate of the marine worm Urechis unicinctus was prepared by enzymolysis and enriched by using mesoporous materials of silica MCM-41 and SBA-15 and carbon CMK-3. The differences in pore structures and elemental composition of these materials lead to differences in surface area and hydrophobicity. The adsorption capacities of peptides were 459.5 mg g-1, 431.3 mg g-1, and 626.3 mg g-1 for MCM-41, SBA-15 and CMK-3, respectively. Adsorption kinetics studies showed that the pseudo-second-order model fit the adsorption process better, where both external mass transfer and intraparticle diffusion affected the adsorption, while the Langmuir model better fit the adsorption of peptides on MCM-41 and SBA-15 and the Freundlich model was more suitable for CMK-3. Aqueous acetonitrile (ACN, 50/50, v/v) yielded the most extracted peptides. MALDI-TOF mass spectrometry of the extracted peptides showed that the three mesoporous materials, especially the CMK-3, gave good enrichment results. This study demonstrates the great potential of mesoporous materials in the enrichment of marine biofunctional peptides.

BACKGROUND: Total pancreatectomy (TP) for pancreatic cancer (PC) has been limited historically for fear of elevated perioperative morbidity and mortality. With advances in perioperative care, TP may be an alternative option to partial pancreatectomy (PP). Limited evidence clarified the indication for these two procedures in PC patients, especially in patients with different tumor staging and location. Thus, this study aims to compare the outcomes after TP and PP for PCs of different T stages and locations. METHODS: The study identified 14,456 PC patients with potentially curable primary tumor (T1–3) who received TP or PP from the Surveillance, Epidemiology, and End Results (SEER) database during 2000 to 2016. Detailed clinical and tumor covariates were all collected. Overall survival (OS) and cancer-specific survival (CSS) were the primary endpoints of interest in this study. OS and CSS were compared between patients after TP and PP using log-rank analysis. RESULTS: For all patients, except for tumor location, TP group was comparable to the PP group. OS and CSS of the TP group were worse than of the PP group (median OS: 19 vs. 20 months, P=0.0058; median CSS: 24 vs. 26 months, P=0.00098, respectively). In stratifying analyses, TP was significantly related to worse OS and CSS than PP in pancreatic head and neck cancer patients with T2-stage tumors (median OS: 18 vs. 19 months, P=0.0016; median CSS: 22 vs. 24 months, P=0.00055, respectively), whereas for patients with T1- or T3-stage pancreatic head and neck cancer as well as T1- to T3-stage pancreatic body and tail cancer or overlapping location cancer, OS and CSS of the two groups were similar (all P>0.05). CONCLUSIONS: Compared with PP, TP offered worse prognosis in pancreatic head and neck cancer patients with T2-stage tumors, furthermore, TP and PP achieved comparable prognosis in patients with T1- or T3-stage pancreatic head and neck cancer as well as T1- to T3-stage pancreatic body and tail cancer or overlapping location cancer.

The upscaling of perovskite solar cells to module scale and long-term stability have been recognized as the most important challenges for the commercialization of this emerging photovoltaic technology. In a perovskite solar module, each interface within the device contributes to the efficiency and stability of the module. Here, we employed a holistic interface stabilization strategy by modifying all the relevant layers and interfaces, namely the perovskite layer, charge transporting layers and device encapsulation, to improve the efficiency and stability of perovskite solar modules. The treatments were selected for their compatibility with low-temperature scalable processing and the module scribing steps. Our unencapsulated perovskite solar modules achieved a reverse-scan efficiency of 16.6% for a designated area of 22.4 cm2. The encapsulated perovskite solar modules, which show efficiencies similar to the unencapsulated one, retained approximately 86% of the initial performance after continuous operation for 2,000 h under AM1.5G light illumination, which translates into a T90 lifetime (the time over which the device efficiency reduces to 90% of its initial value) of 1,570 h and an estimated T80 lifetime (the time over which the device efficiency reduces to 80% of its initial value) of 2,680 h. The upscaling of layer treatments and processing that afford high efficiency and stability in small-area perovskite solar cells remains challenging. Liu et al. show how the efficiency and stability of perovskite modules can be improved using an integrated approach to interface and layer engineering.

The booming growth of organic-inorganic hybrid lead halide perovskite solar cells have made this promising photovoltaic technology to leap towards commercialization. One of the most important issues for the evolution from research to practical application of this technology is to achieve high-throughput manufacturing of large-scale perovskite solar modules. In particular, realization of scalable fabrication of large-area perovskite films is one of the essential steps. During the past ten years, a great number of approaches have been developed to deposit high quality perovskite films, to which additives are introduced during the fabrication process of perovskite layers in terms of the perovskite grain growth control, defect reduction, stability enhancement, etc. Herein, we first review the recent progress on additives during the fabrication of large area perovskite films for large scale perovskite solar cells and modules. We then focus on a comprehensive and in-depth understanding of the roles of additives for perovskite grain growth control, defects reduction, and stability enhancement. Further advancement of the scalable fabrication of high-quality perovskite films and solar cells using additives to further develop large area, stable perovskite solar cells are discussed.

Zinc (Zn) is an essential micronutrient for most organisms including humans, and Zn deficiency is widespread in human populations, particularly in underdeveloped regions. Cereals such as rice (Oryza sativa) are the major dietary source of Zn for most people. However, the molecular mechanism underlying Zn uptake in rice is still not fully understood. Here, we report that a member of the ZIP (ZRT, IRT-like protein) family, OsZIP9, contributes to Zn uptake in rice. It was expressed in the epidermal and exodermal cells of lateral roots, localized in the plasma membrane and induced during Zn deficiency. Yeast-expressed OsZIP9 showed much higher Zn influx transport activity than other rice ZIP proteins in a wide range of Zn concentrations. OsZIP9 knockout rice plants showed a significant reduction in growth at low Zn concentrations, but could be rescued by a high Zn supply. Compared with the wild type, accumulation of Zn in root, shoot and grain was much lower in knockout lines, particularly with a low supply of Zn under both hydroponic and paddy soil conditions. OsZIP9 also showed Co uptake activity. Natural variation of OsZIP9 expression level is highly associated with Zn content in milled grain among rice varieties in the germplasm collection. Taken together, these results show that OsZIP9 is an important influx transporter responsible for the take up of Zn and Co from external media into root cells.

Control of forward and inverse reactions between perovskites and precursor materials is key to attaining high-quality perovskite materials. Many techniques focus on synthesizing nanostructured CsPbX3 materials (e.g., nanowires) via a forward reaction (CsX + PbX2 → CsPbX3). However, low solubility of inorganic perovskites and complex phase transition make it difficult to realize the precise control of composition and length of nanowires using the conventional forward approach. Herein, we report the self-assembly inverse growth of CsPbBr3 micronanowires (MWs) (CsPb2Br5 → CsPbBr3 + PbBr2↑) by controlling phase transition from CsPb2Br5 to CsPbBr3. The two-dimensional (2D) structure of CsPb2Br5 serves as nucleation sites to induce initial CsPbBr3 MW growth. Also, phase transition allows crystal rearrangement and slows down crystal growth, which facilitates the MW growth of CsPbBr3 crystals along the 2D planes of CsPb2Br5. A CsPbBr3 MW photodetector constructed based on the inverse growth shows a high responsivity of 6.44 A W–1 and detectivity of ∼1012 Jones. Large grain size, high crystallinity, and large thickness can effectively alleviate decomposition/degradation of perovskites, which leads to storage stability for over 60 days in humid environment (relative humidity = 45%) and operational stability for over 3000 min under illumination (wavelength = 400 nm, light intensity = 20.06 mW cm–2).

All-inorganic halide perovskites are promising materials for optoelectronic applications. The surface or interface structure of the perovskites plays a crucial role in determining the optoelectronic conversion efficiency, as well as the material stability. A thorough understanding of surface atomic structures of the inorganic perovskites and their contributions to their optoelectronic properties and stability is lacking. Here we show a scanning tunneling microscopy investigation on the atomic and electronic structure of CsPbBr3 perovskite. Two different surface structures with a stripe and an armchair domain are identified, which originates from a complex interplay between Cs cations and Br anions. Our findings are further supported and correlated with density functional theory calculations and photoemission spectroscopy measurements. The stability evaluation of photovoltaic devices indicates a higher stability for CsPbBr3 in comparison with MAPbBr3, which is closely related to the low volatility of Cs from the perovskite surface.

Lead-free double perovskite materials have attracted much interest for optoelectronic applications due to their nontoxicity and high stability. In this work, centimetre-sized Cs2AgBiBr6 single crystals were successfully grown using methylammonium bromide (MABr) as the flux by a top-seeded solution growth (TSSG) method. The low-temperature crystal structure of Cs2AgBiBr6 single crystals was determined and refined. To investigate the interface problems between Cs2AgBiBr6 single crystals and electrodes, the optical band gap, X-ray photoelectron spectroscopy (XPS), and ultraviolet photoemission spectroscopy (UPS) measurements were performed on Cs2AgBiBr6 single crystals. More importantly, we investigated the photodetectors based on Cs2AgBiBr6 single crystals with different contact electrodes (Au, Ag, and Al). It is found that a good Ohmic contact with Ag electrodes enables excellent photo-response behaviors. Furthermore, we studied the photodetectors based on Cs2AgBiBr6 single crystals using Ag electrodes under room and low temperature conditions, which underwent phase transition. Cs2AgBiBr6 single crystal photodetectors show clear differences at room and low temperatures, which is caused by the work function changes of Cs2AgBiBr6 single crystals induced by the reversible phase transition. These attractive properties may enable opportunities to apply emerging double perovskite single-crystalline materials for high-performance optoelectronic devices.

Hybrid chemical vapor deposition (HCVD) has been employed in the fabrication of perovskite solar cells (PSCs) and modules (PSMs), and it shows strong promise for upscalable fabrication. The conventional HCVD process needs a relatively long processing time (e.g., several hours) and the fabricated PSCs often exhibit salient hysteresis, which impedes utilization of this technology for mass production. Herein, we demonstrate a rapid HCVD (RHCVD) fabrication process for PSCs using a rapid thermal process, which not only significantly reduces the deposition time to less than 10 min, but also effectively suppresses hysteresis. This markedly reduced deposition time is comparable to that of solution-coating processes. Furthermore, the shorter processing time inside the furnace reduces the exposure time of the glass/ITO/SnO2 substrates under vacuum, which helps maintain the high quality of the SnO2 electron-transport layer and results in a lower density of gap states. Finally, PSMs with a designated area of 22.4 cm2 fabricated via RHCVD achieved an efficiency of 12.3%, and maintained 90% of the initial value after operation under continuous light illumination for over 800 h.