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Application of iron/barium ferrite/carbon-coated iron nanocrystal composites in transcatheter arterial chemoembolization of hepatocellular carcinoma
- Source :
- Journal of Colloid and Interface Science. 601:30-41
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Transcatheter arterial chemoembolization (TACE) has been widely used in clinical practice as a first-line treatment for unresectable hepatocellular carcinoma (HCC). However, the current therapeutic effect of TACE is far from satisfactory and thus requires further improvement. TACE combined with multifunctional magnetic particles may be a promising approach for the treatment of HCC. In this study, we designed a new magnetic drug carrier system consisting of micron-sized iron powder, barium ferrite (BaFe12O19), and carbon-coated iron nanocrystals (CCINs). CCINs possess properties, such as high drug loading and sustained release. BaFe12O19 could attract both CCINs and iron powder to form larger clusters after magnetization. Altogether, the triple therapeutic effects of chemotherapeutic enhancement, embolization, and thermal ablation could be realized herein. Further experiments indicate that the system has a high drug-loading capacity, good controlled-release effect, and no significant cytotoxicity. Under the action of a medium-frequency magnetic induction device, the magnetic induction temperature could reach 43 °C in one min while the maximum temperature of 70.8 °C could be reached in 2.5 hours. Overall, this new carrier system displayed excellent antitumor effects in a mouse model. Our findings demonstrate the great application prospects of this system in TACE for HCC.
- Subjects :
- Carcinoma, Hepatocellular
Materials science
Carrier system
Iron
medicine.medical_treatment
Barium Compounds
02 engineering and technology
010402 general chemistry
Ferric Compounds
01 natural sciences
Iron powder
Biomaterials
Mice
chemistry.chemical_compound
Colloid and Surface Chemistry
medicine
Animals
Embolization
Chemoembolization, Therapeutic
Transcatheter arterial chemoembolization
Barium ferrite
Liver Neoplasms
021001 nanoscience & nanotechnology
Combined Modality Therapy
Carbon
0104 chemical sciences
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Magnetic hyperthermia
chemistry
Barium
Nanoparticles
Magnetic nanoparticles
0210 nano-technology
Drug carrier
Biomedical engineering
Subjects
Details
- ISSN :
- 00219797
- Volume :
- 601
- Database :
- OpenAIRE
- Journal :
- Journal of Colloid and Interface Science
- Accession number :
- edsair.doi.dedup.....3d1c358ce9d5f66cc4c67cad46cb8907
- Full Text :
- https://doi.org/10.1016/j.jcis.2021.05.102