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Application of iron/barium ferrite/carbon-coated iron nanocrystal composites in transcatheter arterial chemoembolization of hepatocellular carcinoma

Authors :
Xinyue Tu
Guoxun Zeng
Xiang Tang
Peng Zhao
Lingmin Jiang
Yunfei Deng
Qiang Tao
Shangshang Zhang
Leen Liao
Yun Zheng
Haiyan Zhang
Juanjuan Zhao
Zonghao Liu
Yizhou Jiang
Source :
Journal of Colloid and Interface Science. 601:30-41
Publication Year :
2021
Publisher :
Elsevier BV, 2021.

Abstract

Transcatheter arterial chemoembolization (TACE) has been widely used in clinical practice as a first-line treatment for unresectable hepatocellular carcinoma (HCC). However, the current therapeutic effect of TACE is far from satisfactory and thus requires further improvement. TACE combined with multifunctional magnetic particles may be a promising approach for the treatment of HCC. In this study, we designed a new magnetic drug carrier system consisting of micron-sized iron powder, barium ferrite (BaFe12O19), and carbon-coated iron nanocrystals (CCINs). CCINs possess properties, such as high drug loading and sustained release. BaFe12O19 could attract both CCINs and iron powder to form larger clusters after magnetization. Altogether, the triple therapeutic effects of chemotherapeutic enhancement, embolization, and thermal ablation could be realized herein. Further experiments indicate that the system has a high drug-loading capacity, good controlled-release effect, and no significant cytotoxicity. Under the action of a medium-frequency magnetic induction device, the magnetic induction temperature could reach 43 °C in one min while the maximum temperature of 70.8 °C could be reached in 2.5 hours. Overall, this new carrier system displayed excellent antitumor effects in a mouse model. Our findings demonstrate the great application prospects of this system in TACE for HCC.

Details

ISSN :
00219797
Volume :
601
Database :
OpenAIRE
Journal :
Journal of Colloid and Interface Science
Accession number :
edsair.doi.dedup.....3d1c358ce9d5f66cc4c67cad46cb8907
Full Text :
https://doi.org/10.1016/j.jcis.2021.05.102