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The antituberculosis drugs isoniazid (INH), rifampicin (RMP), pyrazinamide (PZA), and ethambutol (EMB) usually expose patients to the risk of fulminant hepatic failure (FHF). This report presents a case of liver transplantation in antituberculosis drugs-induced FHF and reviews the relevant literature. A 39-year-old woman with pelvic and salpinx tuberculosis experienced complex pelvic exenteration. After the operation, she was administrated INH, RMP, PZA, and EMB to prevent tuberculosis. Two months later, examination revealed severe FHF and the antituberculosis therapy regimen was changed to ciprofloxacin and streptomycin. Subsequently, urgent orthotopic liver transplantation was performed. Posttransplantation, her serum transaminases improved gradually, but her total bilirubin level and direct bilirubin level continued to worsen, which may have been related to the rejection. However, irreversible damage from antituberulosis drugs was note excluded. Two liver biopsies and histological examinations were performed. One year after transplantation, she died as a consequence of ischemic cholangitis and pulmonary infection. A literature review revealed 9 other published cases of antituberculosis drugs-associated FHF with liver transplantation. This report suggests that, in most cases of antituberculosis drugs-induced FHF, discontinuation of toxic drugs and orthotopic liver transplantation are always sufficient treatment.

Objective To review the clinic significances of the penile brachial index (PBI) in the diagnosis of vascular erectile dysfunction. Methods Fifty four patients complaining for erectile dysfunction at least 3 months, 25–55 years old, were included in the study. All patients underwent detailed history. After the patient rested for 20 min, systolic pressure of the dorsal artery of penis was measured by DT-2010 Doppler ultrasonic blood stream detector. Systolic pressures of the hibateral brachial arteries were measured by mercurial sphygmomanometer, then PBI was calculated (PBI=systolic pressure of the dorsal artery of penis/Systolic pressures of the hibateral brachial arteries). All patients were examined by colour duplex sonography at the same time. Results The levels of PBI of these ED patients were 0.78±0.32, from 0.58–0.92. The levels of PBI of 46 patients ‘were higher than 0.75 and these patients had no abnormality in the examination by colour duplex sonography. 6 patients of the levels of PBI between 0.60 and 0.75 were diagnosed as mix-type ED. Two cases with the PBI of were less than 0.60 and majored for arterial ED. One patient got intermittent claudication and lower extremity arterial occlusions were found by Doppler ultrasonic blood stream detector. The other patient was found by heart colour Doppler ultrasound by supplemental examinations and received the treatment of percutaneous coronary intervention. Conclusion PBI has screening significance for the diagnosis of the vascular erectile dysfunction. It9s a powerful method that the nurse helps the doctor to better understand the patient9s condition.

Objectives Nausea and Vomiting are the most common complaints for patients with haematological neoplasia during chemotherapy. The poor disease prognosis always cause people in anxiety and depression, which add patients’ discomforts. The aim of this study is to observe the effect of lupentixol melitracen combined with ondansetron on nausea and vomiting. Methods 105 patients with haematological neoplasia in the state of complete remmission were included in this study and self-controlled method was used. 30 minutes before infusion of chemotherapeutics, the patients received recommended-dose of single ondansetron during first consolidation chemotherapy cycle (single group) and lupentixol melitracen 1 piece combined with ondansetron (combined group) during the second one. For every patient, the chemotherapy regimen and dosage in the two groups were same. The incidence of nausea and vomiting was evaluated beofore, during and after chemotherapeutics infusion. Results Totally 97 patients could be evaluated. The incidence of nausea beofore, during and immediately after chemotherapeutics infusion was respectively 10.2%, 42.5%, 40.6% in the single group and 1.6%, 23.3%, 18.5% in the combined one, and the difference was significant between the two groups (P 0.05). Conclusions Flupentixol melitracen combined with ondansetron is more effective to prevent nausea than single ondansetron but no more effect for vomiting in our study.

Objectives This trial assessed the efficacy and vascular responses of combination therapy of statin with angiotensin-converting enzyme inhibitor in hypertensive hypercholesterolemic patients. Methods This was a randomised, double-blind, placebo-controlled study of atorvastatin alone, captopril alone and atorvastatin combined with captopril in 95 hypertensive hypercholesterolemic patients for 2 months with 2 months washout. Results Captopril alone did not significantly change C-reactive protein levels and lipoproteins, however, atorvastatin and atorvastatin combined with captopril significantly changed those, and atorvastatin combined with captopril showed significantly more improvement than captopril alone (P vs 6.2 ± 0.3 vs 10.2 ± 0.5, P vs 1.6 ± 0.2 vs 0.8 ± 0.01, P vs 167 ± 8 vs 127 ± 3, P vs 70 ± 5 vs 43 ± 6, P Conclusions Atorvastatin combined with captopril significantly improves endothelial function and reduces inflammatory markers in hypertensive hypercholesterolemic patients.

Objectives Evidence is emerging that serum soluble cellular adhesion molecules contributes to the development and progression of atherosclerosis and cardiovascular disease. Little is known, however, regarding an association between soluble cellular adhesion molecules levels and total cholesterol and lipoproteins in humans. Methods We investigated the relationship between serum soluble cellular adhesion molecules and total cholesterol and lipoproteins in 106 cases patients referred to atherosclerosis (AS), among which 56 cases were diagnosed as unstable angina pectoris (UAP) and 50 cases as acute myocardial infarction (AMI), moreover, 50 cases were selected as normal people. ELISA was used to detect serum protein levels of soluble intercellular adhesion molecule type 1 (sICAM-1), soluble vascular cell adhesion molecule type 1 (sVCAM-1) and endothelial leukocyte adhesion molecule (E-selectin) of patients. Serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were measured for analyses. Results Compared with normal people, the expression of serum sICAM-1, sVCAM-1 and E-selectin of UAP and AMI patients was obviously increased, and there were higher expression in AMI patients than in UAP patients. Pearson correlation analysis as well as age and gender adjusted partial correlation analysis revealed a positive association between sICAM-1, sVCAM-1 and E- with TG and LDL-C and a negative association with HDL-C, but not with TC. Conclusions Soluble cellular adhesion molecules might be involved in the process of atherosclerosis; our findings warrant further interventional studies which should evaluate anti-atherosclerotic effects of soluble cellular adhesion molecules blocking treatment strategies in humans.

Objectives To explore the effects of simvastatin on NF-κB activation in cholesterol diet rabbit artery and the underlying mechanisms of the beneficial effects of simvastatin on atherosclerosis (AS). Methods Twenty-four male rabbits were randomly divided into three groups: normal diet groups, cholesterol diet groups and the simvastatin groups which received both cholesterol diet and simvastatin 5 mg/kg/days intragastrically, After 16 weeks rabbits were executed and the aortas were harvested for the pathologic and morphologic observations. Western blot was used to determine cytoplasmic p-I-κB α, I-κB α protein expression and cytoplasmic and nuclear NF-κB p65 protein expression of rabbit aortas. Results Compared with normal diet groups, cholesterol diet groups demonstrated remarkably atherosclerosis in the arteries. And the expression of cytoplasmic p-I-κBа and nuclear NF-κB p65 expression was obviously increased, but I-κB α was markedly decreased in cholesterol diet groups (n=6; p Conclusions NF-κB activation might be involved in the process of atherosclerosis in high cholesterol diet rabbits. Simvastatin could ameliorates atherosclerosis (AS) through interfering NF-κB activation and translocation